KEGG   Homo sapiens (human): 8660
Entry
8660              CDS       T01001                                 
Symbol
IRS2, IRS-2
Name
(RefSeq) insulin receptor substrate 2
  KO
K07187  insulin receptor substrate 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04068  FoxO signaling pathway
hsa04081  Hormone signaling
hsa04140  Autophagy - animal
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04910  Insulin signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04935  Growth hormone synthesis, secretion and action
hsa05010  Alzheimer disease
hsa05206  MicroRNAs in cancer
Network
nt06325  Hormone/cytokine signaling
  Element
N01708  INS-AKT signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    8660 (IRS2)
   04022 cGMP-PKG signaling pathway
    8660 (IRS2)
   04152 AMPK signaling pathway
    8660 (IRS2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    8660 (IRS2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    8660 (IRS2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    8660 (IRS2)
   04923 Regulation of lipolysis in adipocytes
    8660 (IRS2)
   04920 Adipocytokine signaling pathway
    8660 (IRS2)
   04935 Growth hormone synthesis, secretion and action
    8660 (IRS2)
  09149 Aging
   04211 Longevity regulating pathway
    8660 (IRS2)
   04213 Longevity regulating pathway - multiple species
    8660 (IRS2)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    8660 (IRS2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    8660 (IRS2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    8660 (IRS2)
   04932 Non-alcoholic fatty liver disease
    8660 (IRS2)
   04931 Insulin resistance
    8660 (IRS2)
SSDB
Motif
Pfam: IRS PH PH_11 MEKK4_N
Other DBs
NCBI-GeneID: 8660
NCBI-ProteinID: NP_003740
OMIM: 600797
HGNC: 6126
Ensembl: ENSG00000185950
UniProt: Q9Y4H2 Q9P084
Structure
Position
13:complement(109752695..109786583)
AA seq 1338 aa
MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEA
TAGGGSAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDE
YFAVAAENEQEQEGWYRALTDLVSEGRAAAGDAPPAAAPAASCSASLPGALGGSAGAAGA
EDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTL
QLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEF
RPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCR
VRTASEGDGGAAAGAAAAGARPVSVAGSPLSPGPVRAPLSRSHTLSGGCGGRGSKVALLP
AGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPPLPHPLHHGPGQR
PSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGGGGGEFY
GYMTMDRPLSHCGRSYRRVSGDAAQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTL
MRATFSGSAGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGA
ALAGSGSGSCRSDDYMPMSPASVSAPKQILQPRAAAAAAAAVPSAGPAGPAPTSAAGRTF
PASGGGYKASSPAESSPEDSGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAVTTGTP
PDFFSAALHPGGEPLRGVPGCCYSSLPRSYKAPYTCGGDSDQYVLMSSPVGRILEEERLE
PQATPGPSQAASAFGAGPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTRLSLEGLPS
LPSMHEYPLPPEPKSPGEYINIDFGEPGARLSPPAPPLLASAASSSSLLSASSPASSLGS
GTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGLLSPEASSPYPPLPPR
PSASPSSSLQPPPPPPAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVA
ATPPQPIAAPPKPEAARVASPTSGVKRLSLMEQVSGVEAFLQASQPPDPHRGAKVIRADP
QGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEP
PTSPRQLQPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNYIAIDVRE
EPGLPPQPQPPPPPLPQPGDKSSWGRTRSLGGLISAVGVGSTGGGCGGPGPGALPPANTY
ASIDFLSHHLKEATIVKE
NT seq 4017 nt   +upstreamnt  +downstreamnt
atggcgagcccgccgcggcacgggccgcccgggccggcgagcggagacggccccaacctc
aacaacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag
aagcatggccacaagcgcttcttcgtgctgcgcggacccggcgcgggcggcgacgaggcg
acggcgggcggggggtcggcgccgcaaccgccgcggctcgagtactacgagagcgagaaa
aagtggcggagcaaggcaggcgcgccgaaacgggtgatcgctctcgactgctgcctgaac
atcaacaagcgcgccgacgccaagcacaagtacctgatcgccctctacaccaaggacgag
tacttcgccgtggccgccgagaacgagcaggagcaggagggctggtaccgcgcgctcacc
gacctggtcagcgagggccgcgcggccgccggagacgcgccccccgccgccgcgcccgcc
gcgtcctgcagcgcctccctgcccggcgccctgggcggctctgccggcgccgccggggcc
gaggacagctacgggctggtggctcccgccacggccgcctaccgtgaggtgtggcaggtg
aacctgaagcccaagggtctgggccagagcaagaacctgacgggggtgtaccgtctgtgc
ctgtctgcgcgcaccatcggcttcgtgaagctcaactgcgagcagccgtcggtgacgctg
cagctcatgaacatccgccgctgcggccactcggacagcttcttcttcatcgaggtgggc
cgctcggccgtcacaggccccggcgagctgtggatgcaggcggacgactcggtggtggcg
cagaacatccacgagaccatcctggaggccatgaaggcgctcaaggagctcttcgagttc
cggccgcgcagtaagagccaatcgtcggggtcgtcggccacgcaccccatcagcgtcccc
ggcgcgcgccgccaccaccacctggtcaacctgccccccagccagacgggcctggtgcgc
cgctcgcgcaccgacagcctggccgccaccccgccggcggccaagtgcagctcgtgccgg
gtgcgcaccgccagcgagggcgacggcggcgcggcggcgggagcggcggccgcgggcgcc
aggccggtgtcggtggctgggagccccctgagccccgggccggtgcgcgcgcccctgagc
cgctcgcacaccctgagcggcggctgcggcggccgcgggagcaaggtggcgctgctgccg
gcagggggcgcgctgcaacacagccgctccatgtccatgcccgtggcgcactcgccgccc
gccgccaccagccccggctccctgtcgtccagcagcggccacggctcgggctcctacccg
ccgccgcccggcccgcacccgcctctgccgcatccgctgcaccacggccccggccagcgg
ccctccagcggcagcgcctccgcctcgggctcccccagcgaccccggcttcatgtccctg
gacgagtacggctccagcccaggcgacctgcgcgccttctgcagccaccgaagcaacacg
cccgagtccatcgcggagacgcccccggcccgagacggcggcggcggcggtgagttctac
gggtacatgaccatggacaggcccctgagccactgtggccgctcctaccgccgggtctcg
ggggacgcggcccaggacctggaccgagggctgcgcaagaggacctactccctgaccacg
ccagcccggcagcggccggtgccccagccctcctctgcctcgctggatgaatacaccctg
atgcgggccaccttctcgggcagcgcgggccgcctctgcccgtcctgccccgcgtcctct
cccaaggtggcctaccacccctacccagaggactacggagacatcgagatcggctcccac
aggagctccagcagcaacctgggggcagacgacggctacatgcccatgacgcccggcgcg
gccctcgcgggcagtgggagcggcagctgcaggagcgacgactacatgcccatgagcccc
gccagcgtgtccgcccccaagcagatcttgcagcccagggccgccgccgccgccgccgcc
gccgtgccttctgcggggcctgcggggccagcacccacctctgcggcgggcaggacattc
ccggcgagcgggggcggctacaaggccagctcgcccgccgagagctcccccgaggacagt
gggtacatgcgcatgtggtgcggttccaagctgtccatggagcatgcagatggcaagctg
ctgcccaacggggactacctcaacgtgtcccccagcgacgcggtcaccacgggcaccccg
cccgacttcttctccgcagccctgcaccccggcggggagccgctcaggggcgttcccggc
tgctgctacagctccttgccccgctcctacaaggccccctacacctgtggcggggacagc
gaccagtacgtgctcatgagctcccccgtggggcgcatcctggaggaggagcgtctggag
cctcaggccacgccagggcccagccaggcggccagcgccttcggggccggccccacgcag
ccccctcaccctgtagtgccttcgcccgtgcggcctagcggcggccgcccggagggcttc
ttgggccagcgcggccgggcggtgaggcccacgcgcctgtccctggaggggctgcccagc
ctgcccagcatgcacgagtacccactgccaccggagcccaagagccccggcgagtacatc
aacatcgactttggcgagcccggggcccgcctgtcgccgcccgcgcctcccctgctggcg
tcggcggcctcgtcctcctcgctcttgtccgccagcagcccggcctcgtcgctgggctca
ggcaccccgggcaccagcagcgacagccggcagcggtctccgctctccgactacatgaac
ctcgacttcagctcccccaagtctcctaagccgggcgccccgagcggccaccccgtgggc
tccttggacggcctcctgtcccccgaggcctcctccccgtatccgccgttgcccccgcgt
ccgtccgcgtccccgtcgtcgtctctgcagccgccgccaccgccgccggccccgggggag
ctgtaccgcctgccccccgcctcggccgttgccaccgcccagggcccgggcgccgcctca
tcgttgtcctcggacaccggggacaatggtgactacaccgagatggcttttggtgtggcc
gccaccccgccgcaacctatcgcggcccccccgaagccagaagctgcccgcgtggccagc
ccgacgtcgggcgtgaagaggctgagcctcatggagcaggtgtcgggagtcgaggccttc
ctgcaggccagccagcccccggacccccaccgcggcgccaaggtcatccgcgcagacccg
caggggggccgccgccgccacagttccgagaccttctcctccaccacgacggtcaccccc
gtgtccccgtccttcgcccacaaccccaagcgccacaactcggcctccgtggaaaatgtc
tctctcaggaaaagcagcgagggcggcgtgggtgtcggccctggagggggcgacgagccg
cccacctccccacgacagttgcagccggcgccccctttggcaccgcagggccggccgtgg
accccgggtcagcccgggggcttggtcggttgtcctgggagcggtggatcgcccatgcgc
agagagacctctgccggcttccagaatggtctcaactacatcgccatcgacgtgagggag
gagcccgggctgccaccccagccgcagccgccgccgccgccgcttcctcagccgggagac
aagagctcctggggccggacccgaagcctcgggggtctcatcagcgctgtgggcgtcggc
agcaccggcggcgggtgcggggggccgggtcccggtgccctgccccctgccaacacctac
gccagcattgacttcttgtcccaccacttgaaggaggccaccatcgtgaaagagtga

  All links  
Disease (2)   
   OMIM (2)   
Gene (60)   
   RefGene (52)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
3D Structure (2)   
   PDB (2)   
Protein domain (4)   
   Pfam (4)   
All databases (93)   

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