KEGG   Homo sapiens (human): 8833Help
Entry
8833              CDS       T01001                                 

Gene name
GMPS, GATD7
Definition
(RefSeq) guanine monophosphate synthase
  KO
K01951  GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
Module
hsa_M00050  Guanine ribonucleotide biosynthesis IMP => GDP,GTP
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Nucleotide metabolism
   00230 Purine metabolism
    8833 (GMPS)
  Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    8833 (GMPS)
Enzymes [BR:hsa01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.2  GMP synthase (glutamine-hydrolysing)
     8833 (GMPS)
Peptidases [BR:hsa01002]
 Cysteine Peptidases
  Family C26: gamma-glutamyl hydrolase family
   8833 (GMPS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: GATase GMP_synt_C Peptidase_C26 NAD_synthase QueC tRNA_Me_trans Asn_synthase ATP_bind_3 PAPS_reduct ThiI Arginosuc_synth rve
Motif
Other DBs
NCBI-GeneID: 8833
NCBI-ProteinID: NP_003866
OMIM: 600358
HGNC: 4378
Ensembl: ENSG00000163655
Vega: OTTHUMG00000158551
Pharos: P49915(Tbio)
UniProt: P49915 A0A140VJK6
Structure
PDB: 

Position
3q25.31
AA seq 693 aa AA seqDB search
MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETP
AFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHK
KSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANE
SKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVL
VLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAA
HSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPE
EVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVR
ILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPH
TLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDW
ESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILR
ESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVE
VVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE
NT seq 2082 nt NT seq  +upstreamnt  +downstreamnt
atggctctgtgcaacggagactccaagctggagaatgctggaggagaccttaaggatggc
caccaccactatgaaggagctgttgtcattctggatgctggtgctcagtacgggaaagtc
atagaccgaagagtgagggaactgttcgtgcagtctgaaattttccccttggaaacacca
gcatttgctataaaggaacaaggattccgtgctattatcatctctggaggacctaattct
gtgtatgctgaagatgctccctggtttgatccagcaatattcactattggcaagcctgtt
cttggaatttgctatggtatgcagatgatgaataaggtatttggaggtactgtgcacaaa
aaaagtgtcagagaagatggagttttcaacattagtgtggataatacatgttcattattc
aggggccttcagaaggaagaagttgttttgcttacacatggagatagtgtagacaaagta
gctgatggattcaaggttgtggcacgttctggaaacatagtagcaggcatagcaaatgaa
tctaaaaagttatatggagcacagttccaccctgaagttggccttacagaaaatggaaaa
gtaatactgaagaatttcctttatgatatagctggatgcagtggaaccttcaccgtgcag
aacagagaacttgagtgtattcgagagatcaaagagagagtaggcacgtcaaaagttttg
gttttactcagtggtggagtagactcaacagtttgtacagctttgctaaatcgtgctttg
aaccaagaacaagtcattgctgtgcacattgataatggctttatgagaaaacgagaaagc
cagtctgttgaagaggccctcaaaaagcttggaattcaggtcaaagtgataaatgctgct
cattctttctacaatggaacaacaaccctaccaatatcagatgaagatagaaccccacgg
aaaagaattagcaaaacgttaaatatgaccacaagtcctgaagagaaaagaaaaatcatt
ggggatacttttgttaagattgccaatgaagtaattggagaaatgaacttgaaaccagag
gaggttttccttgcccaaggtactttacggcctgatctaattgaaagtgcatcccttgtt
gcaagtggcaaagctgaactcatcaaaacccatcacaatgacacagagctcatcagaaag
ttgagagaggagggaaaagtaatagaacctctgaaagattttcataaagatgaagtgaga
attttgggcagagaacttggacttccagaagagttagtttccaggcatccatttccaggt
cctggcctggcaatcagagtaatatgtgctgaagaaccttatatttgtaaggactttcct
gaaaccaacaatattttgaaaatagtagctgatttttctgcaagtgttaaaaagccacat
accctattacagagagtcaaagcctgcacaacagaagaggatcaggagaagctgatgcaa
attaccagtctgcattcactgaatgccttcttgctgccaattaaaactgtaggtgtgcag
ggtgactgtcgttcctacagttacgtgtgtggaatctccagtaaagatgaacctgactgg
gaatcacttatttttctggctaggcttatacctcgcatgtgtcacaacgttaacagagtt
gtttatatatttggcccaccagttaaagaacctcctacagatgttactcccactttcttg
acaacaggggtgctcagtactttacgccaagctgattttgaggcccataacattctcagg
gagtctgggtatgctgggaaaatcagccagatgccggtgattttgacaccattacatttt
gatcgggacccacttcaaaagcagccttcatgccagagatctgtggttattcgaaccttt
attactagtgacttcatgactggtatacctgcaacacctggcaatgagatccctgtagag
gtggtattaaagatggtcactgagattaagaagattcctggtatttctcgaattatgtat
gacttaacatcaaagcccccaggaactactgagtgggagtaa

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