KEGG   Homo sapiens (human): 8833
Entry
8833              CDS       T01001                                 

Gene name
GMPS, GATD7
Definition
(RefSeq) guanine monophosphate synthase
  KO
K01951  GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
Module
hsa_M00050  Guanine ribonucleotide biosynthesis IMP => GDP,GTP
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    8833 (GMPS)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    8833 (GMPS)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    8833 (GMPS)
Enzymes [BR:hsa01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.2  GMP synthase (glutamine-hydrolysing)
     8833 (GMPS)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C26: gamma-glutamyl hydrolase family
   8833 (GMPS)
SSDB
Motif
Pfam: GATase GMP_synt_C NAD_synthase Peptidase_C26 QueC tRNA_Me_trans ATP_bind_3 Asn_synthase PAPS_reduct ThiI Arginosuc_synth Pyr_redox_2
Other DBs
NCBI-GeneID: 8833
NCBI-ProteinID: NP_003866
OMIM: 600358
HGNC: 4378
Ensembl: ENSG00000163655
Vega: OTTHUMG00000158551
Pharos: P49915(Tbio)
UniProt: P49915 A0A140VJK6
Structure
PDB: 
2VPI 2VXO

Position
3q25.31
AA seq 693 aa
MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETP
AFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHK
KSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANE
SKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVL
VLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAA
HSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPE
EVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVR
ILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPH
TLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDW
ESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILR
ESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVE
VVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE
NT seq 2082 nt   +upstreamnt  +downstreamnt
atggctctgtgcaacggagactccaagctggagaatgctggaggagaccttaaggatggc
caccaccactatgaaggagctgttgtcattctggatgctggtgctcagtacgggaaagtc
atagaccgaagagtgagggaactgttcgtgcagtctgaaattttccccttggaaacacca
gcatttgctataaaggaacaaggattccgtgctattatcatctctggaggacctaattct
gtgtatgctgaagatgctccctggtttgatccagcaatattcactattggcaagcctgtt
cttggaatttgctatggtatgcagatgatgaataaggtatttggaggtactgtgcacaaa
aaaagtgtcagagaagatggagttttcaacattagtgtggataatacatgttcattattc
aggggccttcagaaggaagaagttgttttgcttacacatggagatagtgtagacaaagta
gctgatggattcaaggttgtggcacgttctggaaacatagtagcaggcatagcaaatgaa
tctaaaaagttatatggagcacagttccaccctgaagttggccttacagaaaatggaaaa
gtaatactgaagaatttcctttatgatatagctggatgcagtggaaccttcaccgtgcag
aacagagaacttgagtgtattcgagagatcaaagagagagtaggcacgtcaaaagttttg
gttttactcagtggtggagtagactcaacagtttgtacagctttgctaaatcgtgctttg
aaccaagaacaagtcattgctgtgcacattgataatggctttatgagaaaacgagaaagc
cagtctgttgaagaggccctcaaaaagcttggaattcaggtcaaagtgataaatgctgct
cattctttctacaatggaacaacaaccctaccaatatcagatgaagatagaaccccacgg
aaaagaattagcaaaacgttaaatatgaccacaagtcctgaagagaaaagaaaaatcatt
ggggatacttttgttaagattgccaatgaagtaattggagaaatgaacttgaaaccagag
gaggttttccttgcccaaggtactttacggcctgatctaattgaaagtgcatcccttgtt
gcaagtggcaaagctgaactcatcaaaacccatcacaatgacacagagctcatcagaaag
ttgagagaggagggaaaagtaatagaacctctgaaagattttcataaagatgaagtgaga
attttgggcagagaacttggacttccagaagagttagtttccaggcatccatttccaggt
cctggcctggcaatcagagtaatatgtgctgaagaaccttatatttgtaaggactttcct
gaaaccaacaatattttgaaaatagtagctgatttttctgcaagtgttaaaaagccacat
accctattacagagagtcaaagcctgcacaacagaagaggatcaggagaagctgatgcaa
attaccagtctgcattcactgaatgccttcttgctgccaattaaaactgtaggtgtgcag
ggtgactgtcgttcctacagttacgtgtgtggaatctccagtaaagatgaacctgactgg
gaatcacttatttttctggctaggcttatacctcgcatgtgtcacaacgttaacagagtt
gtttatatatttggcccaccagttaaagaacctcctacagatgttactcccactttcttg
acaacaggggtgctcagtactttacgccaagctgattttgaggcccataacattctcagg
gagtctgggtatgctgggaaaatcagccagatgccggtgattttgacaccattacatttt
gatcgggacccacttcaaaagcagccttcatgccagagatctgtggttattcgaaccttt
attactagtgacttcatgactggtatacctgcaacacctggcaatgagatccctgtagag
gtggtattaaagatggtcactgagattaagaagattcctggtatttctcgaattatgtat
gacttaacatcaaagcccccaggaactactgagtgggagtaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Disease (1)   
   OMIM (1)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (46)   
   KEGG ORTHOLOGY (1)   
   RefGene (25)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (13)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (23)   
   RefSeq(nuc) (3)   
   GenBank (10)   
   EMBL (10)   
Protein domain (12)   
   Pfam (12)   
All databases (111)   

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