KEGG   Homo sapiens (human): 8837
Entry
8837              CDS       T01001                                 
Symbol
CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, cFLIP
Name
(RefSeq) CASP8 and FADD like apoptosis regulator
  KO
K04724  CASP8 and FADD-like apoptosis regulator
Organism
hsa  Homo sapiens (human)
Pathway
hsa04064  NF-kappa B signaling pathway
hsa04140  Autophagy - animal
hsa04210  Apoptosis
hsa04217  Necroptosis
hsa04668  TNF signaling pathway
hsa05142  Chagas disease
hsa05160  Hepatitis C
Network
nt06163  Hepatitis C virus (HCV)
nt06263  Hepatocellular carcinoma
nt06524  Apoptosis
  Element
N00528  HCV core to extrinsic apoptotic pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    8837 (CFLAR)
   04668 TNF signaling pathway
    8837 (CFLAR)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    8837 (CFLAR)
  09143 Cell growth and death
   04210 Apoptosis
    8837 (CFLAR)
   04217 Necroptosis
    8837 (CFLAR)
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    8837 (CFLAR)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    8837 (CFLAR)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    8837 (CFLAR)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C14: caspase family
   8837 (CFLAR)
SSDB
Motif
Pfam: Peptidase_C14 DED
Other DBs
NCBI-GeneID: 8837
NCBI-ProteinID: NP_001120655
OMIM: 603599
HGNC: 1876
Ensembl: ENSG00000003402
UniProt: O15519 A0A024R3Y4
Structure
Position
2:201116164..201176687
AA seq 480 aa
MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLY
RVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYM
GRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGT
SYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIP
EERYKMKSKPLGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMP
EHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNY
VVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSP
SLYLQCLSQKLRQERKRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT
NT seq 1443 nt   +upstreamnt  +downstreamnt
atgtctgctgaagtcatccatcaggttgaagaagcacttgatacagatgagaaggagatg
ctgctctttttgtgccgggatgttgctatagatgtggttccacctaatgtcagggacctt
ctggatattttacgggaaagaggtaagctgtctgtcggggacttggctgaactgctctac
agagtgaggcgatttgacctgctcaaacgtatcttgaagatggacagaaaagctgtggag
acccacctgctcaggaaccctcaccttgtttcggactatagagtgctgatggcagagatt
ggtgaggatttggataaatctgatgtgtcctcattaattttcctcatgaaggattacatg
ggccgaggcaagataagcaaggagaagagtttcttggaccttgtggttgagttggagaaa
ctaaatctggttgccccagatcaactggatttattagaaaaatgcctaaagaacatccac
agaatagacctgaagacaaaaatccagaagtacaagcagtctgttcaaggagcagggaca
agttacaggaatgttctccaagcagcaatccaaaagagtctcaaggatccttcaaataac
ttcaggctccataatgggagaagtaaagaacaaagacttaaggaacagcttggcgctcaa
caagaaccagtgaagaaatccattcaggaatcagaagcttttttgcctcagagcatacct
gaagagagatacaagatgaagagcaagcccctaggaatctgcctgataatcgattgcatt
ggcaatgagacagagcttcttcgagacaccttcacttccctgggctatgaagtccagaaa
ttcttgcatctcagtatgcatggtatatcccagattcttggccaatttgcctgtatgccc
gagcaccgagactacgacagctttgtgtgtgtcctggtgagccgaggaggctcccagagt
gtgtatggtgtggatcagactcactcagggctccccctgcatcacatcaggaggatgttc
atgggagattcatgcccttatctagcagggaagccaaagatgttttttattcagaactat
gtggtgtcagagggccagctggaggacagcagcctcttggaggtggatgggccagcgatg
aagaatgtggaattcaaggctcagaagcgagggctgtgcacagttcaccgagaagctgac
ttcttctggagcctgtgtactgcggacatgtccctgctggagcagtctcacagctcacca
tccctgtacctgcagtgcctctcccagaaactgagacaagaaagaaaacgcccactcctg
gatcttcacattgaactcaatggctacatgtatgattggaacagcagagtttctgccaag
gagaaatattatgtctggctgcagcacactctgagaaagaaacttatcctctcctacaca
taa

  All links  
Disease (1)   
   OMIM (1)   
Gene (20)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (26)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (23)   
DNA sequence (142)   
   RefSeq(nuc) (56)   
   GenBank (43)   
   EMBL (43)   
3D Structure (17)   
   PDB (17)   
Protein domain (2)   
   Pfam (2)   
All databases (208)   

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