KEGG   Homo sapiens (human): 8893
Entry
8893              CDS       T01001                                 
Symbol
EIF2B5, CACH, CLE, EIF-2B, EIF2Bepsilon, LVWM, VWM5
Name
(RefSeq) eukaryotic translation initiation factor 2B subunit epsilon
  KO
K03240  translation initiation factor eIF-2B subunit epsilon
Organism
hsa  Homo sapiens (human)
Pathway
hsa05168  Herpes simplex virus 1 infection
Network
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
  Element
N00571  PKR-eIF2alpha signaling pathway
Disease
H00869  Leukoencephalopathy with vanishing white matter
Drug target
Fosigotifator (DG03349): D13118 D13119
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    8893 (EIF2B5)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03012 Translation factors [BR:hsa03012]
    8893 (EIF2B5)
Translation factors [BR:hsa03012]
 Eukaryotic type
  Initiation factors
   eIF-2B
    8893 (EIF2B5)
SSDB
Motif
Pfam: LbH_EIF2B W2 Hexapep Hexapep_GlmU GMPPB_C Hexapep_2 DUF4954 Fucose_pyrophosphorylase
Other DBs
NCBI-GeneID: 8893
NCBI-ProteinID: NP_003898
OMIM: 603945
HGNC: 3261
Ensembl: ENSG00000145191
UniProt: Q13144
Structure
Position
3:184135358..184145311
AA seq 721 aa
MAAPVVAPPGVVVSRANKRSGAGPGGSGGGGARGAEEEPPPPLQAVLVADSFDRRFFPIS
KDQPRVLLPLANVALIDYTLEFLTATGVQETFVFCCWKAAQIKEHLLKSKWCRPTSLNVV
RIITSELYRSLGDVLRDVDAKALVRSDFLLVYGDVISNINITRALEEHRLRRKLEKNVSV
MTMIFKESSPSHPTRCHEDNVVVAVDSTTNRVLHFQKTQGLRRFAFPLSLFQGSSDGVEV
RYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGLLVNEEILGNQIHMHVTAKEYGARV
SNLHMYSAVCADVIRRWVYPLTPEANFTDSTTQSCTHSRHNIYRGPEVSLGHGSILEENV
LLGSGTVIGSNCFITNSVIGPGCHIGDNVVLDQTYLWQGVRVAAGAQIHQSLLCDNAEVK
ERVTLKPRSVLTSQVVVGPNITLPEGSVISLHPPDAEEDEDDGEFSDDSGADQEKDKVKM
KGYNPAEVGAAGKGYLWKAAGMNMEEEEELQQNLWGLKINMEEESESESEQSMDSEEPDS
RGGSPQMDDIKVFQNEVLGTLQRGKEENISCDNLVLEINSLKYAYNISLKEVMQVLSHVV
LEFPLQQMDSPLDSSRYCALLLPLLKAWSPVFRNYIKRAADHLEALAAIEDFFLEHEALG
ISMAKVLMAFYQLEILAEETILSWFSQRDTTDKGQQLRKNQQLQRFIQWLKEAEEESSED
D
NT seq 2166 nt   +upstreamnt  +downstreamnt
atggcggcccctgtagtggcgccgcctggtgtggtggttagtcgggctaacaagcgcagc
ggcgcggggccgggaggcagcggtggcgggggagccagaggggcggaggaggaaccgccg
ccgcccctacaagcagttctggtggccgatagcttcgatcgccgcttcttccccatctcc
aaggaccagcctcgggtcctcttgcccctggccaatgtggcattaattgactacactctg
gaattcctgactgccacaggtgtacaggaaacatttgtcttttgttgctggaaagctgct
caaatcaaagaacatttactgaagtcaaagtggtgccgccctacatctctcaatgtggtt
cgaataattacatcagagctctatcgatcactgggagatgtcctccgtgatgttgatgcc
aaggctttggtgcgctctgactttcttctggtgtatggggatgtcatctcaaacatcaat
atcaccagagcccttgaggaacacaggttgagacggaagctagaaaaaaatgtttctgtg
atgacgatgatcttcaaggagtcatcccccagccacccaactcgttgccacgaagacaat
gtggtagtggctgtggatagtaccacaaacagggttctccattttcagaagacccagggt
ctccggcgttttgcatttcctctgagcctgtttcagggcagtagtgatggagtggaggtt
cgatatgatttactggattgtcatatcagcatctgttctcctcaggtggcacaactcttt
acagacaactttgactaccaaactcgagatgactttgtgcgaggtctcttagtgaatgag
gagatcctagggaaccagatccacatgcacgtaacagctaaggaatatggtgcccgtgtc
tccaacctacacatgtactcagctgtctgtgctgacgtcatccgccgatgggtctaccct
ctcaccccagaggcgaacttcactgacagcaccacccagagctgcactcattcccggcac
aacatctaccgagggcctgaggtcagcctgggccatggcagcatcctagaggaaaatgtg
ctcctgggctctggcactgtcattggcagcaattgctttatcaccaacagtgtcattggc
cccggctgccacattggtgataacgtggtgctggaccagacctacctgtggcagggtgtt
cgagtggcggctggagcacagatccatcagtctctgctttgtgacaatgctgaggtcaag
gaacgagtgacactgaaaccacgctctgtcctcacttcccaggtggtcgtgggcccaaat
atcacgctgcctgagggctcggtgatctctttgcaccctccagatgcagaggaagatgaa
gatgatggcgagttcagtgatgattctggggctgaccaagaaaaggacaaagtgaagatg
aaaggttacaatccagcagaagtaggagctgctggcaagggctacctctggaaagctgca
ggcatgaacatggaggaagaggaggaactgcagcagaatctgtggggactcaagatcaac
atggaagaagagagtgaaagtgaaagtgagcaaagtatggattctgaggagccggacagc
cggggaggctcccctcagatggatgacatcaaagtgttccagaatgaagttttaggaaca
ctacagcggggcaaagaggagaacatttcttgtgacaatctcgtcctggaaatcaactct
ctcaagtatgcctataacataagtctaaaggaggtgatgcaggtactgagccacgtggtc
ctggagttccccctgcaacagatggattccccgcttgactcaagccgctactgtgccctg
ctgcttcctctgctaaaggcctggagccctgtttttaggaactacataaagcgcgcagcc
gaccatttggaagcgttagcagccattgaggacttcttcctagagcatgaagctcttggt
atttccatggccaaggtactgatggctttctaccagctggagatcctggctgaggaaaca
attctgagctggttcagccaaagagatacaactgacaagggccagcagttgcgcaagaat
caacagctgcagaggttcatccagtggctaaaagaggcagaagaggagtcatctgaagat
gactga

  All links  
Disease (2)   
   OMIM (2)   
Gene (22)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (11)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (29)   
   RefSeq(nuc) (7)   
   GenBank (11)   
   EMBL (11)   
3D Structure (23)   
   PDB (23)   
Protein domain (8)   
   Pfam (8)   
All databases (93)   

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