KEGG T01001: 898

Homo sapiens (human): 898

Entry

898               CDS       T01001

Symbol

CCNE1, CCNE, pCCNE1

Name

(RefSeq) cyclin E1

K06626

G1/S-specific cyclin-E1

Organism

hsa Homo sapiens (human)

Pathway

hsa04110

Cell cycle

hsa04114

Oocyte meiosis

hsa04115

p53 signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04218

Cellular senescence

hsa04934

Cushing syndrome

hsa05161

Hepatitis B

hsa05162

Measles

hsa05165

Human papillomavirus infection

hsa05166

Human T-cell leukemia virus 1 infection

hsa05169

Epstein-Barr virus infection

hsa05200

Pathways in cancer

hsa05203

Viral carcinogenesis

hsa05206

MicroRNAs in cancer

hsa05215

Prostate cancer

hsa05222

Small cell lung cancer

hsa05226

Gastric cancer

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06230  Cell cycle (cancer)
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06267  Small cell lung cancer
nt06272  Prostate cancer
nt06360  Cushing syndrome
nt06509  DNA replication

Element

N00091

p27-Cell cycle G1/S

N00092

Amplified MYC to p27-cell cycle G1/S

N00093

Loss of CDKN1B to p27-cell cycle G1/S

N00254

CDKN1B-reduced expression to p27-cell cycle G1/S

N00255

Amplified CCNE to cell cycle G1/S

N00264

EBV EBNA3C to p27-Cell cycle G1/S

N00316

Mutation-inactivated CDKN1B to p27-cell cycle G1/S

N00360

HPV E7 to p27-cell cycle G1/S

N00482

EBV EBNA3C to p27-Cell cycle G1/S

N00497

HTLV-1 Tax to p21-cell cycle G1/S

N00498

HTLV-1 Tax to p21-cell cycle G1/S

N00536

MDM2-p21-Cell cycle G1/S

N00537

HBV HBx to cell cycle G1/S

N01468

DNA replication licensing

Disease

H00018

Gastric cancer

H00055

Laryngeal cancer

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    898 (CCNE1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    898 (CCNE1)
   05206 MicroRNAs in cancer
    898 (CCNE1)
   05203 Viral carcinogenesis
    898 (CCNE1)
  09162 Cancer: specific types
   05226 Gastric cancer
    898 (CCNE1)
   05215 Prostate cancer
    898 (CCNE1)
   05222 Small cell lung cancer
    898 (CCNE1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    898 (CCNE1)
   05161 Hepatitis B
    898 (CCNE1)
   05162 Measles
    898 (CCNE1)
   05169 Epstein-Barr virus infection
    898 (CCNE1)
   05165 Human papillomavirus infection
    898 (CCNE1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    898 (CCNE1)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    898 (CCNE1)
   03036 Chromosome and associated proteins [BR:hsa03036]
    898 (CCNE1)
DNA replication proteins [BR:hsa03032]
Eukaryotic type
  DNA Replication Initiation Factors
   CDK (cyclin dependent kinase)
    898 (CCNE1)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Centrosome formation proteins
   Cyclins
    898 (CCNE1)

SSDB

Motif

Pfam:

Cyclin_N Cyclin_C

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

19:29811991..29824312

AA seq 410 aa
MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQ
PWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIM
LNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQ
ENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWR
LSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILA
ASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNI
QTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA

NT seq 1233 nt +upstreamnt +downstreamnt
atgccgagggagcgcagggagcgggatgcgaaggagcgggacaccatgaaggaggacggc
ggcgcggagttctcggctcgctccaggaagaggaaggcaaacgtgaccgtttttttgcag
gatccagatgaagaaatggccaaaatcgacaggacggcgagggaccagtgtgggagccag
ccttgggacaataatgcagtctgtgcagacccctgctccctgatccccacacctgacaaa
gaagatgatgaccgggtttacccaaactcaacgtgcaagcctcggattattgcaccatcc
agaggctccccgctgcctgtactgagctgggcaaatagagaggaagtctggaaaatcatg
ttaaacaaggaaaagacatacttaagggatcagcactttcttgagcaacaccctcttctg
cagccaaaaatgcgagcaattcttctggattggttaatggaggtgtgtgaagtctataaa
cttcacagggagaccttttacttggcacaagatttctttgaccggtatatggcgacacaa
gaaaatgttgtaaaaactcttttacagcttattgggatttcatctttatttattgcagcc
aaacttgaggaaatctatcctccaaagttgcaccagtttgcgtatgtgacagatggagct
tgttcaggagatgaaattctcaccatggaattaatgattatgaaggcccttaagtggcgt
ttaagtcccctgactattgtgtcctggctgaatgtatacatgcaggttgcatatctaaat
gacttacatgaagtgctactgccgcagtatccccagcaaatctttatacagattgcagag
ctgttggatctctgtgtcctggatgttgactgccttgaatttccttatggtatacttgct
gcttcggccttgtatcatttctcgtcatctgaattgatgcaaaaggtttcagggtatcag
tggtgcgacatagagaactgtgtcaagtggatggttccatttgccatggttataagggag
acggggagctcaaaactgaagcacttcaggggcgtcgctgatgaagatgcacacaacata
cagacccacagagacagcttggatttgctggacaaagcccgagcaaagaaagccatgttg
tctgaacaaaatagggcttctcctctccccagtgggctcctcaccccgccacagagcggt
aagaagcagagcagcgggccggaaatggcgtga

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