KEGG   Homo sapiens (human): 8989
Entry
8989              CDS       T01001                                 
Symbol
TRPA1, ANKTM1, FEPS, FEPS1, p120
Name
(RefSeq) transient receptor potential cation channel subfamily A member 1
  KO
K04984  transient receptor potential cation channel subfamily A member 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04750  Inflammatory mediator regulation of TRP channels
Disease
H01391  Familial episodic pain syndrome
Drug target
Menthol (DG01385): D00064<JP> D04849 D04918
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    8989 (TRPA1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    8989 (TRPA1)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Transient receptor potential channel (TRP)
   8989 (TRPA1)
SSDB
Motif
Pfam: Ank_2 Ank Ank_3 Ank_4 Ank_5 Ion_trans
Other DBs
NCBI-GeneID: 8989
NCBI-ProteinID: NP_015628
OMIM: 604775
HGNC: 497
Ensembl: ENSG00000104321
UniProt: O75762
Structure
Position
8:complement(72021250..72090010)
AA seq 1119 aa
MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD
DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR
GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA
LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA
TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD
IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL
LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA
CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL
HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC
TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII
RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF
KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM
MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS
SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY
FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS
PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA
VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF
CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED
DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP
NT seq 3360 nt   +upstreamnt  +downstreamnt
atgaagcgcagcctgaggaagatgtggcgccctggagaaaagaaggagccccagggcgtt
gtctatgaggatgtgccggacgacacggaggatttcaaggaatcgcttaaggtggttttt
gaaggaagtgcatatggattacaaaactttaataagcaaaagaaattaaaaagatgtgac
gatatggacaccttcttcttgcattatgctgcagcagaaggccaaattgagctaatggag
aagatcaccagagattcctctttggaagtgctgcatgaaatggatgattatggaaatacc
cctctgcattgtgctgtagaaaaaaaccaaattgaaagcgttaagtttcttctcagcaga
ggagcaaacccaaatctccgaaacttcaacatgatggctcctctccacatagctgtgcag
ggcatgaataatgaggtgatgaaggtcttgcttgagcatagaactattgatgttaatttg
gaaggagaaaatggaaacacagctgtgatcattgcgtgcaccacaaataatagcgaagca
ttgcagattttgcttaaaaaaggagctaagccatgtaaatcaaataaatggggatgtttc
cctattcaccaagctgcattttcaggttccaaagaatgcatggaaataatactaaggttt
ggtgaagagcatgggtacagtagacagttgcacattaactttatgaataatgggaaagcc
acccctctccacctggctgtgcaaaatggtgacttggaaatgatcaaaatgtgcctggac
aatggtgcacaaatagacccagtggagaagggaaggtgcacagccattcattttgctgcc
acccagggagccactgagattgttaaactgatgatatcgtcctattctggtagcgtggat
attgttaacacaaccgatggatgtcatgagaccatgcttcacagagcttcattgtttgat
caccatgagctagcagactatttaatttcagtgggagcagatattaataagatcgattct
gaaggacgctctccacttatattagcaactgcttctgcatcttggaatattgtaaatttg
ctactctctaaaggtgcccaagtagacataaaagataattttggacgtaattttctgcat
ttaactgtacagcaaccttatggattaaaaaatctgcgacctgaatttatgcagatgcaa
cagatcaaagagctggtaatggatgaagacaacgatgggtgtactcctctacattatgca
tgtagacaggggggccctggttctgtaaataacctacttggctttaatgtgtccattcat
tccaaaagcaaagataagaaatcacctctgcattttgcagccagttatgggcgtatcaat
acctgtcagaggctcctacaagacataagtgatacgaggcttctgaatgaaggtgacctt
catggaatgactcctctccatctggcagcaaagaatggacatgataaagtagttcagctt
cttctgaaaaaaggtgcattgtttctcagtgaccacaatggctggacagctttgcatcat
gcgtccatgggcgggtacactcagaccatgaaggtcattcttgatactaatttgaagtgc
acagatcgcctggatgaagacgggaacactgcacttcactttgctgcaagggaaggccac
gccaaagccgttgcgcttcttctgagccacaatgctgacatagtcctgaacaagcagcag
gcctcctttttgcaccttgcacttcacaataagaggaaggaggttgttcttacgatcatc
aggagcaaaagatgggatgaatgtcttaagattttcagtcataattctccaggcaataaa
tgtccaattacagaaatgatagaatacctccctgaatgcatgaaggtacttttagatttc
tgcatgttgcattccacagaagacaagtcctgccgagactattatatcgagtataatttc
aaatatcttcaatgtccattagaattcaccaaaaaaacacctacacaggatgttatatat
gaaccgcttacagccctcaacgcaatggtacaaaataaccgcatagagcttctcaatcat
cctgtgtgtaaagaatatttactcatgaaatggttggcttatggatttagagctcatatg
atgaatttaggatcttactgtcttggtctcatacctatgaccattctcgttgtcaatata
aaaccaggaatggctttcaactcaactggcatcatcaatgaaactagtgatcattcagaa
atactagataccacgaattcatatctaataaaaacttgtatgattttagtgtttttatca
agtatatttgggtattgcaaagaagcggggcaaattttccaacagaaaaggaattatttt
atggatataagcaatgttcttgaatggattatctacacgacgggcatcatttttgtgctg
cccttgtttgttgaaataccagctcatctgcagtggcaatgtggagcaattgctgtttac
ttctattggatgaatttcttattgtatcttcaaagatttgaaaattgtggaatttttatt
gttatgttggaggtaattttgaaaactttgttgaggtctacagttgtatttatcttcctt
cttctggcttttggactcagcttttacatcctcctgaatttacaggatcccttcagctct
ccattgctttctataatccagaccttcagcatgatgctaggagatatcaattatcgagag
tccttcctagaaccatatctgagaaatgaattggcacatccagttctgtcctttgcacaa
cttgtttccttcacaatatttgtcccaattgtcctcatgaatttacttattggtttggca
gttggcgacattgctgaggtccagaaacatgcatcattgaagaggatagctatgcaggtg
gaacttcataccagcttagagaagaagctgccactttggtttctacgcaaagtggatcag
aaatccaccatcgtgtatcccaacaaacccagatctggtgggatgttattccatatattc
tgttttttattttgcactggggaaataagacaagaaataccaaatgctgataaatcttta
gaaatggaaatattaaagcagaaataccggctgaaggatcttacttttctcctggaaaaa
cagcatgagctcattaaactgatcattcagaagatggagatcatctctgagacagaggat
gatgatagccattgttcttttcaagacaggtttaagaaagagcagatggaacaaaggaat
agcagatggaatactgtgttgagagcagtcaaggcaaaaacacaccatcttgagccttag

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