KEGG   Homo sapiens (human): 9020
Entry
9020              CDS       T01001                                 
Symbol
MAP3K14, FTDCR1B, HS, HSNIK, IMD112, NIK
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 14
  KO
K04466  mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04064  NF-kappa B signaling pathway
hsa04210  Apoptosis
hsa04380  Osteoclast differentiation
hsa04625  C-type lectin receptor signaling pathway
hsa04660  T cell receptor signaling pathway
hsa04668  TNF signaling pathway
hsa04672  Intestinal immune network for IgA production
hsa04936  Alcoholic liver disease
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05208  Chemical carcinogenesis - reactive oxygen species
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06223  TNF signaling (cancer)
nt06516  TNF signaling
  Element
N00505  CD40-NFKB signaling pathway
Disease
H00093  Combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    9020 (MAP3K14)
   04064 NF-kappa B signaling pathway
    9020 (MAP3K14)
   04668 TNF signaling pathway
    9020 (MAP3K14)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    9020 (MAP3K14)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    9020 (MAP3K14)
   04660 T cell receptor signaling pathway
    9020 (MAP3K14)
   04672 Intestinal immune network for IgA production
    9020 (MAP3K14)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    9020 (MAP3K14)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    9020 (MAP3K14)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    9020 (MAP3K14)
   05169 Epstein-Barr virus infection
    9020 (MAP3K14)
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    9020 (MAP3K14)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    9020 (MAP3K14)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    9020 (MAP3K14)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     9020 (MAP3K14)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: STE group
  Other
   9020 (MAP3K14)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr APH Pkinase_fungal TCAD9
Other DBs
NCBI-GeneID: 9020
NCBI-ProteinID: NP_003945
OMIM: 604655
HGNC: 6853
Ensembl: ENSG00000006062
UniProt: Q99558 Q68D39
Structure
Position
17:complement(45263119..45317020)
AA seq 947 aa
MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILND
VITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNN
VAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQE
DESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVW
KLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPH
LSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTW
AARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDK
QTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQL
VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC
LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF
RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGG
LKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPE
PPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLN
SLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSS
SWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFS
LVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP
NT seq 2844 nt   +upstreamnt  +downstreamnt
atggcagtgatggaaatggcctgcccaggtgcccctggctcagcagtggggcagcagaag
gaactccccaaagccaaggagaagacgccgccactggggaagaaacagagctccgtctac
aagcttgaggccgtggagaagagccctgtgttctgcggaaagtgggagatcctgaatgac
gtgattaccaagggcacagccaaggaaggctccgaggcagggccagctgccatctctatc
atcgcccaggctgagtgtgagaatagccaagagttcagccccaccttttcagaacgcatt
ttcatcgctgggtccaaacagtacagccagtccgagagtcttgatcagatccccaacaat
gtggcccatgctacagagggcaaaatggcccgtgtgtgttggaagggaaagcgtcgcagc
aaagcccggaagaaacggaagaagaagagctcaaagtccctggctcatgcaggagtggcc
ttggccaaacccctccccaggacccctgagcaggagagctgcaccatcccagtgcaggag
gatgagtctccactcggcgccccatatgttagaaacaccccgcagttcaccaagcctctg
aaggaaccaggccttgggcaactctgttttaagcagcttggcgagggcctacggccggct
ctgcctcgatcagaactccacaaactgatcagccccttgcaatgtctgaaccacgtgtgg
aaactgcaccacccccaggacggaggccccctgcccctgcccacgcaccccttcccctat
agcagactgcctcatcccttcccattccaccctctccagccctggaaacctcaccctctg
gagtccttcctgggcaaactggcctgtgtagacagccagaaacccttgcctgacccacac
ctgagcaaactggcctgtgtagacagtccaaagcccctgcctggcccacacctggagccc
agctgcctgtctcgtggtgcccatgagaagttttctgtggaggaatacctagtgcatgct
ctgcaaggcagcgtgagctcaggccaggcccacagcctgaccagcctggccaagacctgg
gcagcaaggggctccagatcccgggagcccagccccaaaactgaggacaacgagggtgtc
ctgctcactgagaaactcaagccagtggattatgagtaccgagaagaagtccactgggcc
acgcaccagctccgcctgggcagaggctccttcggagaggtgcacaggatggaggacaag
cagactggcttccagtgcgctgtcaaaaaggtgcggctggaagtatttcgggcagaggag
ctgatggcatgtgcaggattgacctcacccagaattgtccctttgtatggagctgtgaga
gaagggccttgggtcaacatcttcatggagctgctggaaggtggctccctgggccagctg
gtcaaggagcagggctgtctcccagaggaccgggccctgtactacctgggccaggccctg
gagggtctggaatacctccactcacgaaggattctgcatggggacgtcaaagctgacaac
gtgctcctgtccagcgatgggagccacgcagccctctgtgactttggccatgctgtgtgt
cttcaacctgatggcctgggaaagtccttgctcacaggggactacatccctggcacagag
acccacatggctccggaggtggtgctgggcaggagctgcgacgccaaggtggatgtctgg
agcagctgctgtatgatgctgcacatgctcaacggctgccacccctggactcagttcttc
cgagggccgctctgcctcaagattgccagcgagcctccgcctgtgagggagatcccaccc
tcctgcgcccctctcacagcccaggccatccaagaggggctgaggaaagagcccatccac
cgcgtgtctgcagcggagctgggagggaaggtgaaccgggcactacagcaagtgggaggt
ctgaagagcccttggaggggagaatataaagaaccaagacatccaccgccaaatcaagcc
aattaccaccagaccctccatgcccagccgagagagctttcgccaagggccccagggccc
cggccagctgaggagacaacaggcagagcccctaagctccagcctcctctcccaccagag
cccccagagccaaacaagtctcctcccttgactttgagcaaggaggagtctgggatgtgg
gaacccttacctctgtcctccctggagccagcccctgccagaaaccccagctcaccagag
cggaaagcaaccgtcccggagcaggaactgcagcagctggaaatagaattattcctcaac
agcctgtcccagccattttctctggaggagcaggagcaaattctctcgtgcctcagcatc
gacagcctctccctgtcggatgacagtgagaagaacccatcaaaggcctctcaaagctcg
cgggacaccctgagctcaggcgtacactcctggagcagccaggccgaggctcgaagctcc
agctggaacatggtgctggcccgggggcggcccaccgacaccccaagctatttcaatggt
gtgaaagtccaaatacagtctcttaatggtgaacacctgcacatccgggagttccaccgg
gtcaaagtgggagacatcgccactggcatcagcagccagatcccagctgcagccttcagc
ttggtcaccaaagacgggcagcctgttcgctacgacatggaggtgccagactcgggcatc
gacctgcagtgcacactggcccctgatggcagcttcgcctggagctggagggtcaagcat
ggccagctggagaacaggccctaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (28)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (10)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (89)   
   RefSeq(nuc) (7)   
   GenBank (41)   
   EMBL (41)   
3D Structure (10)   
   PDB (10)   
Protein domain (5)   
   Pfam (5)   
All databases (144)   

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