KEGG   Homo sapiens (human): 916
Entry
916               CDS       T01001                                 
Symbol
CD3E, CD3epsilon, IMD18, T3E, TCRE
Name
(RefSeq) CD3 epsilon subunit of T-cell receptor complex
  KO
K06451  T-cell surface glycoprotein CD3 epsilon chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04640  Hematopoietic cell lineage
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa05142  Chagas disease
hsa05162  Measles
hsa05166  Human T-cell leukemia virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05340  Primary immunodeficiency
Network
nt06183  Yersinia
nt06537  TCR/BCR signaling
  Element
N01106  TCR-PLCG-ITPR signaling pathway
Disease
H00091  T-B+Severe combined immunodeficiency
Drug target
Acapatamab: D12121
Antithymocyte immunoglobulin (rabbit): D09190<JP/US>
Avitotamig: D12721
Blinatumomab: D09325<JP/US>
Catumaxomab: D09207
Cevostamab: D11984
Cibisatamab: D11489
Duvortuxizumab: D11372
Elranatamab: D12058<JP/US>
Emirodatamab: D12641
Epcoritamab: D12368<JP/US>
Etentamig: D12990
Flotetuzumab: D11306
Forimtamig: D12724
Glofitamab: D11833<US>
Imvotamab: D12567
Mosunetuzumab: D11463<JP/US>
Muromonab-CD3: D05092
Odronextamab: D11534
Otelixizumab: D08959
Pavurutamab: D11992
Plamotamab: D11686
Runimotamab: D12236
Talquetamab: D12180<US>
Tarlatamab: D12234<JP/US>
Tebentafusp: D12296<US>
Teclistamab: D12177<JP/US>
Teplizumab: D09013<US>
Tidutamab: D11845
Ubamatamab: D12007
Vibecotamab: D11841
Visilizumab: D06314
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    916 (CD3E)
   04660 T cell receptor signaling pathway
    916 (CD3E)
   04658 Th1 and Th2 cell differentiation
    916 (CD3E)
   04659 Th17 cell differentiation
    916 (CD3E)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    916 (CD3E)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    916 (CD3E)
   05170 Human immunodeficiency virus 1 infection
    916 (CD3E)
   05162 Measles
    916 (CD3E)
   05169 Epstein-Barr virus infection
    916 (CD3E)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    916 (CD3E)
  09163 Immune disease
   05340 Primary immunodeficiency
    916 (CD3E)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    916 (CD3E)
CD molecules [BR:hsa04090]
 Proteins
  916 (CD3E)
SSDB
Motif
Pfam: Ig_5 Ig_4 ITAM Ig_3 Ig_2
Other DBs
NCBI-GeneID: 916
NCBI-ProteinID: NP_000724
OMIM: 186830
HGNC: 1674
Ensembl: ENSG00000198851
UniProt: P07766
Structure
Position
11:118304730..118316173
AA seq 207 aa
MQSGTHWRVLGLCLLSVGVWGQDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQ
HNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCE
NCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERP
PPVPNPDYEPIRKGQRDLYSGLNQRRI
NT seq 624 nt   +upstreamnt  +downstreamnt
atgcagtcgggcactcactggagagttctgggcctctgcctcttatcagttggcgtttgg
gggcaagatggtaatgaagaaatgggtggtattacacagacaccatataaagtctccatc
tctggaaccacagtaatattgacatgccctcagtatcctggatctgaaatactatggcaa
cacaatgataaaaacataggcggtgatgaggatgataaaaacataggcagtgatgaggat
cacctgtcactgaaggaattttcagaattggagcaaagtggttattatgtctgctacccc
agaggaagcaaaccagaagatgcgaacttttatctctacctgagggcaagagtgtgtgag
aactgcatggagatggatgtgatgtcggtggccacaattgtcatagtggacatctgcatc
actgggggcttgctgctgctggtttactactggagcaagaatagaaaggccaaggccaag
cctgtgacacgaggagcgggtgctggcggcaggcaaaggggacaaaacaaggagaggcca
ccacctgttcccaacccagactatgagcccatccggaaaggccagcgggacctgtattct
ggcctgaatcagagacgcatctga

  All links  
Disease (2)   
   OMIM (2)   
Gene (18)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (12)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (15)   
   RefSeq(nuc) (1)   
   GenBank (7)   
   EMBL (7)   
3D Structure (28)   
   PDB (28)   
Protein domain (5)   
   Pfam (5)   
All databases (71)   

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