KEGG   Homo sapiens (human): 9252
Entry
9252              CDS       T01001                                 

Gene name
RPS6KA5, MSK1, MSPK1, RLPK
Definition
(RefSeq) ribosomal protein S6 kinase A5
  KO
K04445  ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04713  Circadian entrainment
hsa04722  Neurotrophin signaling pathway
hsa05131  Shigellosis
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05219  Bladder cancer
Network
nt06123  TNF signaling (viruses and bacteria)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
nt06210  ERK signaling
nt06265  Bladder cancer
  Element
N00011  Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00077  HRAS-overexpression to ERK signaling pathway
N00078  Mutation-activated HRAS to ERK signaling pathway
N00444  TNF-p38 signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    9252 (RPS6KA5)
   04668 TNF signaling pathway
    9252 (RPS6KA5)
 09150 Organismal Systems
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    9252 (RPS6KA5)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    9252 (RPS6KA5)
  09159 Environmental adaptation
   04713 Circadian entrainment
    9252 (RPS6KA5)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    9252 (RPS6KA5)
   05206 MicroRNAs in cancer
    9252 (RPS6KA5)
  09162 Cancer: specific types
   05219 Bladder cancer
    9252 (RPS6KA5)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    9252 (RPS6KA5)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    9252 (RPS6KA5)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     9252 (RPS6KA5)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  RSK family [OT]
   9252 (RPS6KA5)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like Kdo APH Pkinase_C Pkinase_fungal FTA2 RIO1 Choline_kinase SR-25
Other DBs
NCBI-GeneID: 9252
NCBI-ProteinID: NP_004746
OMIM: 603607
HGNC: 10434
Ensembl: ENSG00000100784
Vega: OTTHUMG00000171055
Pharos: O75582(Tchem)
UniProt: O75582
Structure
PDB: 
3KN6 3KN5 1VZO

Position
14q32.11
AA seq 802 aa
MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAY
GKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYA
FQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKL
ENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS
LGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKK
RLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYS
PAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFY
QHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPN
IVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV
VHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD
ESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEA
KDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFH
AFNKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTL
QPSNPADSNNPETLFQFSDSVA
NT seq 2409 nt   +upstreamnt  +downstreamnt
atggaggaggagggtggcagcagcggcggcgccgcggggaccagcgcggacggcggcgac
ggaggagagcagctcctcactgtcaagcacgagctgcggactgctaatttgacaggacat
gctgagaaggtgggaatagaaaattttgagctcctgaaggtcctaggaactggagcttat
ggaaaagtatttctagttcgtaaaataagtggccatgatactggaaagctgtatgccatg
aaagttttgaaaaaggcaacaatcgttcaaaaggccaaaaccacagagcatacaaggaca
gaacgacaagtcctggaacacattaggcagtcgccatttttggtaacattacattatgct
ttccagacagaaaccaaacttcatctcattttagattatataaatggtggtgaacttttt
actcatctttctcaaagagagcgtttcacagagcatgaggtgcagatttatgttggagag
attgtgcttgccctcgaacatctccacaagttggggattatatatcgtgatattaagctt
gagaatattctacttgattctaatggccatgtggtgctgacagattttggtctgagtaag
gagtttgtggctgatgaaactgaaagagcatattccttttgtggaactattgaatacatg
gcaccagatattgtcagagggggagattcaggacatgacaaggcagttgactggtggagt
ttgggtgttctaatgtatgaattactaactggagcatctcctttcactgttgatggagaa
aaaaattcccaagctgagatatctaggagaatattaaaaagtgagcctccatatccccaa
gaaatgagtgctttagcgaaagacctaattcagcgtcttttgatgaaagatcccaagaag
agattgggatgtggtccacgtgatgcagatgaaatcaaagaacatctcttctttcagaaa
ataaattgggatgatttagccgccaaaaaagtgcctgcaccatttaagccagtcattcga
gatgaattagatgtgagtaactttgcagaagagttcacagaaatggatcccacttattct
cccgcagccctgccccagagttctgagaagctgtttcagggctattcctttgttgctcct
tccatcctattcaagcgtaatgcagctgtcatagaccctcttcagtttcacatgggagtt
gaacgtcctggagtgacaaatgttgccaggagtgcaatgatgaaggactctccattctat
caacactatgacctagatttgaaggacaaacccctgggagaaggtagtttttcaatttgt
cgaaagtgtgtgcataaaaaaagtaaccaagcttttgcagtcaaaataatcagcaaaagg
atggaagccaatactcaaaaggaaataacagctctgaaactctgtgaaggacaccccaat
attgtgaagttgcatgaagtttttcatgatcagcttcacacgtttctagtgatggaactt
ctgaatggaggagaactgtttgagcgcattaagaaaaagaagcacttcagtgagacggaa
gccagctacatcatgaggaagcttgtttcagctgtaagccacatgcatgatgttggagtg
gtgcacagggatctgaaacctgagaatttattgttcaccgatgaaaatgacaatttggaa
attaaaataattgattttggatttgcacggctaaagccaccggataatcagcccctgaag
actccatgcttcacccttcattatgccgccccagagctcttgaatcagaacggctacgat
gagtcctgtgacctgtggagcttgggcgtcattttgtacacaatgttgtcaggacaggtt
cccttccaatctcatgaccgaagtttgacgtgtaccagcgcggtggaaatcatgaagaaa
attaaaaagggagatttctcctttgaaggagaagcctggaagaatgtatcccaagaggct
aaagatttgatccaaggacttctcacagtagatccaaacaaaaggcttaaaatgtctggc
ttgaggtacaatgaatggctacaagatggaagtcagctgtcctccaatcctctgatgact
ccggatattctaggatcttccggagctgccgtgcatacctgtgtgaaagcaaccttccac
gcctttaacaaatacaagagagaggggttttgccttcagaatgttgataaggcccctttg
gctaagagaagaaaaatgaaaaagactagcaccagtaccgagacgcgcagcagttccagt
gagagttcccattcttcttcctctcattctcacggtaaaactacacccaccaagacactg
cagcccagcaatcctgccgacagcaataacccggagaccctcttccagttctcggactca
gtagcttag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (9)   
   KEGG PATHWAY (9)   
Network (4)   
   KEGG NETWORK (4)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (17)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (15)   
DNA sequence (33)   
   RefSeq(nuc) (15)   
   GenBank (9)   
   EMBL (9)   
Protein domain (11)   
   Pfam (11)   
All databases (101)   

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