KEGG   Homo sapiens (human): 930
Entry
930               CDS       T01001                                 

Gene name
CD19, B4, CVID3
Definition
(RefSeq) CD19 molecule
  KO
K06465  B-lymphocyte antigen CD19
Organism
hsa  Homo sapiens (human)
Pathway
hsa04151  PI3K-Akt signaling pathway
hsa04640  Hematopoietic cell lineage
hsa04662  B cell receptor signaling pathway
hsa05169  Epstein-Barr virus infection
hsa05340  Primary immunodeficiency
Disease
H00088  Common variable immunodeficiency
Drug target
Axicabtagene ciloleucel: D11144<US>
Blinatumomab: D09325<JP/US>
Denintuzumab: D11231
Denintuzumab mafodotin: D11232
Duvortuxizumab: D11372
Inebilizumab: D11757<US>
Loncastuximab: D11333
Loncastuximab tesirine: D11338
Obexelimab: D11496
Tafasitamab: D11601
Tisagenlecleucel-T: D11386<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    930 (CD19)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    930 (CD19)
   04662 B cell receptor signaling pathway
    930 (CD19)
 09160 Human Diseases
  09163 Immune disease
   05340 Primary immunodeficiency
    930 (CD19)
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    930 (CD19)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    930 (CD19)
CD molecules [BR:hsa04090]
 Proteins
  930 (CD19)
SSDB
Motif
Pfam: Ig_3 V-set
Other DBs
NCBI-GeneID: 930
NCBI-ProteinID: NP_001761
OMIM: 107265
HGNC: 1633
Ensembl: ENSG00000177455
Vega: OTTHUMG00000097049
Pharos: P15391(Tclin)
UniProt: P15391
Structure
PDB: 
6AL5

Position
16p11.2
AA seq 556 aa
MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKP
FLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGE
LFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSL
NQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMW
VMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKVSAVTLAYL
IFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGNVLSLPTPTSG
LGRAQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEF
YENDSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMDFLS
PHGSAWDPSREATSLGSQSYEDMRGILYAAPQLRSIRGQPGPNHEEDADSYENMDNPDGP
DPAWGGGGRMGTWSTR
NT seq 1671 nt   +upstreamnt  +downstreamnt
atgccacctcctcgcctcctcttcttcctcctcttcctcacccccatggaagtcaggccc
gaggaacctctagtggtgaaggtggaagagggagataacgctgtgctgcagtgcctcaag
gggacctcagatggccccactcagcagctgacctggtctcgggagtccccgcttaaaccc
ttcttaaaactcagcctggggctgccaggcctgggaatccacatgaggcccctggccatc
tggcttttcatcttcaacgtctctcaacagatggggggcttctacctgtgccagccgggg
cccccctctgagaaggcctggcagcctggctggacagtcaatgtggagggcagcggggag
ctgttccggtggaatgtttcggacctaggtggcctgggctgtggcctgaagaacaggtcc
tcagagggccccagctccccttccgggaagctcatgagccccaagctgtatgtgtgggcc
aaagaccgccctgagatctgggagggagagcctccgtgtctcccaccgagggacagcctg
aaccagagcctcagccaggacctcaccatggcccctggctccacactctggctgtcctgt
ggggtaccccctgactctgtgtccaggggccccctctcctggacccatgtgcaccccaag
gggcctaagtcattgctgagcctagagctgaaggacgatcgcccggccagagatatgtgg
gtaatggagacgggtctgttgttgccccgggccacagctcaagacgctggaaagtattat
tgtcaccgtggcaacctgaccatgtcattccacctggagatcactgctcggccagtacta
tggcactggctgctgaggactggtggctggaaggtctcagctgtgactttggcttatctg
atcttctgcctgtgttcccttgtgggcattcttcatcttcaaagagccctggtcctgagg
aggaaaagaaagcgaatgactgaccccaccaggagattcttcaaagtgacgcctccccca
ggaagcgggccccagaaccagtacgggaacgtgctgtctctccccacacccacctcaggc
ctcggacgcgcccagcgttgggccgcaggcctggggggcactgccccgtcttatggaaac
ccgagcagcgacgtccaggcggatggagccttggggtcccggagcccgccgggagtgggc
ccagaagaagaggaaggggagggctatgaggaacctgacagtgaggaggactccgagttc
tatgagaacgactccaaccttgggcaggaccagctctcccaggatggcagcggctacgag
aaccctgaggatgagcccctgggtcctgaggatgaagactccttctccaacgctgagtct
tatgagaacgaggatgaagagctgacccagccggtcgccaggacaatggacttcctgagc
cctcatgggtcagcctgggaccccagccgggaagcaacctccctggggtcccagtcctat
gaggatatgagaggaatcctgtatgcagccccccagctccgctccattcggggccagcct
ggacccaatcatgaggaagatgcagactcttatgagaacatggataatcccgatgggcca
gacccagcctggggaggagggggccgcatgggcacctggagcaccaggtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Drug (11)   
   KEGG DRUG (11)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (18)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (32)   
   RefSeq(nuc) (8)   
   GenBank (12)   
   EMBL (12)   
Protein domain (2)   
   Pfam (2)   
All databases (92)   

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