KEGG   Homo sapiens (human): 930
Entry
930               CDS       T01001                                 
Symbol
CD19, B4, CVID3
Name
(RefSeq) CD19 molecule
  KO
K06465  B-lymphocyte antigen CD19
Organism
hsa  Homo sapiens (human)
Pathway
hsa04151  PI3K-Akt signaling pathway
hsa04640  Hematopoietic cell lineage
hsa04662  B cell receptor signaling pathway
hsa05169  Epstein-Barr virus infection
hsa05340  Primary immunodeficiency
Network
nt06537  TCR/BCR signaling
  Element
N01695  BCR-BCAP/CD19-PI3K signaling pathway
Disease
H00088  Common variable immunodeficiency
Drug target
Axicabtagene ciloleucel: D11144<US>
Blinatumomab: D09325<JP/US>
Brexucabtagene autoleucel: D11880<US>
Denintuzumab: D11231
Denintuzumab mafodotin: D11232
Duvortuxizumab: D11372
Inebilizumab: D11757<JP/US>
Lisocabtagene maraleucel: D11990<US>
Loncastuximab: D11333
Loncastuximab tesirine: D11338<US>
Obecabtagene autoleucel: D13022<US>
Obexelimab: D11496
Tafasitamab: D11601<US>
Tisagenlecleucel: D11386<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    930 (CD19)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    930 (CD19)
   04662 B cell receptor signaling pathway
    930 (CD19)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    930 (CD19)
  09163 Immune disease
   05340 Primary immunodeficiency
    930 (CD19)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    930 (CD19)
CD molecules [BR:hsa04090]
 Proteins
  930 (CD19)
SSDB
Motif
Pfam: Ig_3 V-set Ig_2
Other DBs
NCBI-GeneID: 930
NCBI-ProteinID: NP_001761
OMIM: 107265
HGNC: 1633
Ensembl: ENSG00000177455
UniProt: P15391
Structure
Position
16:28931971..28939342
AA seq 556 aa
MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKP
FLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGE
LFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSL
NQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMW
VMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKVSAVTLAYL
IFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGNVLSLPTPTSG
LGRAQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEF
YENDSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMDFLS
PHGSAWDPSREATSLGSQSYEDMRGILYAAPQLRSIRGQPGPNHEEDADSYENMDNPDGP
DPAWGGGGRMGTWSTR
NT seq 1671 nt   +upstreamnt  +downstreamnt
atgccacctcctcgcctcctcttcttcctcctcttcctcacccccatggaagtcaggccc
gaggaacctctagtggtgaaggtggaagagggagataacgctgtgctgcagtgcctcaag
gggacctcagatggccccactcagcagctgacctggtctcgggagtccccgcttaaaccc
ttcttaaaactcagcctggggctgccaggcctgggaatccacatgaggcccctggccatc
tggcttttcatcttcaacgtctctcaacagatggggggcttctacctgtgccagccgggg
cccccctctgagaaggcctggcagcctggctggacagtcaatgtggagggcagcggggag
ctgttccggtggaatgtttcggacctaggtggcctgggctgtggcctgaagaacaggtcc
tcagagggccccagctccccttccgggaagctcatgagccccaagctgtatgtgtgggcc
aaagaccgccctgagatctgggagggagagcctccgtgtctcccaccgagggacagcctg
aaccagagcctcagccaggacctcaccatggcccctggctccacactctggctgtcctgt
ggggtaccccctgactctgtgtccaggggccccctctcctggacccatgtgcaccccaag
gggcctaagtcattgctgagcctagagctgaaggacgatcgcccggccagagatatgtgg
gtaatggagacgggtctgttgttgccccgggccacagctcaagacgctggaaagtattat
tgtcaccgtggcaacctgaccatgtcattccacctggagatcactgctcggccagtacta
tggcactggctgctgaggactggtggctggaaggtctcagctgtgactttggcttatctg
atcttctgcctgtgttcccttgtgggcattcttcatcttcaaagagccctggtcctgagg
aggaaaagaaagcgaatgactgaccccaccaggagattcttcaaagtgacgcctccccca
ggaagcgggccccagaaccagtacgggaacgtgctgtctctccccacacccacctcaggc
ctcggacgcgcccagcgttgggccgcaggcctggggggcactgccccgtcttatggaaac
ccgagcagcgacgtccaggcggatggagccttggggtcccggagcccgccgggagtgggc
ccagaagaagaggaaggggagggctatgaggaacctgacagtgaggaggactccgagttc
tatgagaacgactccaaccttgggcaggaccagctctcccaggatggcagcggctacgag
aaccctgaggatgagcccctgggtcctgaggatgaagactccttctccaacgctgagtct
tatgagaacgaggatgaagagctgacccagccggtcgccaggacaatggacttcctgagc
cctcatgggtcagcctgggaccccagccgggaagcaacctccctggggtcccagtcctat
gaggatatgagaggaatcctgtatgcagccccccagctccgctccattcggggccagcct
ggacccaatcatgaggaagatgcagactcttatgagaacatggataatcccgatgggcca
gacccagcctggggaggagggggccgcatgggcacctggagcaccaggtga

  All links  
Disease (3)   
   OMIM (3)   
Gene (24)   
   RefGene (18)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (32)   
   RefSeq(nuc) (8)   
   GenBank (12)   
   EMBL (12)   
3D Structure (4)   
   PDB (4)   
Protein domain (3)   
   Pfam (3)   
All databases (73)   

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