KEGG   Homo sapiens (human): 9353
Entry
9353              CDS       T01001                                 

Symbol
SLIT2, SLIL3, Slit-2
Name
(RefSeq) slit guidance ligand 2
  KO
K06839  slit 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    9353 (SLIT2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    9353 (SLIT2)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Axon guidance molecules
   9353 (SLIT2)
SSDB
Motif
Pfam: LRR_8 LRR_5 LRR_4 EGF Laminin_G_1 Laminin_G_2 LRR_9 LRRNT LRRCT hEGF LRR_1 FXa_inhibition
Other DBs
NCBI-GeneID: 9353
NCBI-ProteinID: NP_004778
OMIM: 603746
HGNC: 11086
Ensembl: ENSG00000145147
Vega: OTTHUMG00000128551
Pharos: O94813(Tbio)
UniProt: O94813
Structure
PDB: 
2V9T 2WFH 2V9S 2V70

Position
4p15.31
AA seq 1529 aa
MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL
DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE
LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL
TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS
HLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE
TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI
TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR
AIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSA
KEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRL
NNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHK
MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLN
LLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNS
CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLT
LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV
PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTT
PSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA
CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY
TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC
QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI
NEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYK
GDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGN
PKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDF
QKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC
VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS
GYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRR
KYSFECTDGSSFVDEVEKVVKCGCTRCVS
NT seq 4590 nt   +upstreamnt  +downstreamnt
atgcgcggcgttggctggcagatgctgtccctgtcgctggggttagtgctggcgatcctg
aacaaggtggcaccgcaggcgtgcccggcgcagtgctcttgctcgggcagcacagtggac
tgtcacgggctggcgctgcgcagcgtgcccaggaatatcccccgcaacaccgagagactg
gatttaaatggaaataacatcacaagaattacgaagacagattttgctggtcttagacat
ctaagagttcttcagcttatggagaataagattagcaccattgaaagaggagcattccag
gatcttaaagaactagagagactgcgtttaaacagaaatcaccttcagctgtttcctgag
ttgctgtttcttgggactgcgaagctatacaggcttgatctcagtgaaaaccaaattcag
gcaatcccaaggaaagctttccgtggggcagttgacataaaaaatttgcaactggattac
aaccagatcagctgtattgaagatggggcattcagggctctccgggacctggaagtgctc
actctcaacaataacaacattactagactttctgtggcaagtttcaaccatatgcctaaa
cttaggacttttcgactgcattcaaacaacctgtattgtgactgccacctggcctggctc
tccgactggcttcgccaaaggcctcgggttggtctgtacactcagtgtatgggcccctcc
cacctgagaggccataatgtagccgaggttcaaaaacgagaatttgtctgcagtggtcac
cagtcatttatggctccttcttgtagtgttttgcactgccctgccgcctgtacctgtagc
aacaatatcgtagactgtcgtgggaaaggtctcactgagatccccacaaatcttccagag
accatcacagaaatacgtttggaacagaacacaatcaaagtcatccctcctggagctttc
tcaccatataaaaagcttagacgaattgacctgagcaataatcagatctctgaacttgca
ccagatgctttccaaggactacgctctctgaattcacttgtcctctatggaaataaaatc
acagaactccccaaaagtttatttgaaggactgttttccttacagctcctattattgaat
gccaacaagataaactgccttcgggtagatgcttttcaggatctccacaacttgaacctt
ctctccctatatgacaacaagcttcagaccatcgccaaggggaccttttcacctcttcgg
gccattcaaactatgcatttggcccagaacccctttatttgtgactgccatctcaagtgg
ctagcggattatctccataccaacccgattgagaccagtggtgcccgttgcaccagcccc
cgccgcctggcaaacaaaagaattggacagatcaaaagcaagaaattccgttgttcagct
aaagaacagtatttcattccaggtacagaagattatcgatcaaaattaagtggagactgc
tttgcggatctggcttgccctgaaaagtgtcgctgtgaaggaaccacagtagattgctct
aatcaaaagctcaacaaaatcccggagcacattccccagtacactgcagagttgcgtctc
aataataatgaatttaccgtgttggaagccacaggaatctttaagaaacttcctcaatta
cgtaaaataaactttagcaacaataagatcacagatattgaggagggagcatttgaagga
gcatctggtgtaaatgaaatacttcttacgagtaatcgtttggaaaatgtgcagcataag
atgttcaagggattggaaagcctcaaaactttgatgttgagaagcaatcgaataacctgt
gtggggaatgacagtttcataggactcagttctgtgcgtttgctttctttgtatgataat
caaattactacagttgcaccaggggcatttgatactctccattctttatctactctaaac
ctcttggccaatccttttaactgtaactgctacctggcttggttgggagagtggctgaga
aagaagagaattgtcacgggaaatcctagatgtcaaaaaccatacttcctgaaagaaata
cccatccaggatgtggccattcaggacttcacttgtgatgacggaaatgatgacaatagt
tgctccccactttctcgctgtcctactgaatgtacttgcttggatacagtcgtccgatgt
agcaacaagggtttgaaggtcttgccgaaaggtattccaagagatgtcacagagttgtat
ctggatggaaaccaatttacactggttcccaaggaactctccaactacaaacatttaaca
cttatagacttaagtaacaacagaataagcacgctttctaatcagagcttcagcaacatg
acccagctcctcaccttaattcttagttacaaccgtctgagatgtattcctcctcgcacc
tttgatggattaaagtctcttcgattactttctctacatggaaatgacatttctgttgtg
cctgaaggtgctttcaatgatctttctgcattatcacatctagcaattggagccaaccct
ctttactgtgattgtaacatgcagtggttatccgactgggtgaagtcggaatataaggag
cctggaattgctcgttgtgctggtcctggagaaatggcagataaacttttactcacaact
ccctccaaaaaatttacctgtcaaggtcctgtggatgtcaatattctagctaagtgtaac
ccctgcctatcaaatccgtgtaaaaatgatggcacatgtaatagtgatccagttgacttt
taccgatgcacctgtccatatggtttcaaggggcaggactgtgatgtcccaattcatgcc
tgcatcagtaacccatgtaaacatggaggaacttgccacttaaaggaaggagaagaagat
ggattctggtgtatttgtgctgatggatttgaaggagaaaattgtgaagtcaacgttgat
gattgtgaagataatgactgtgaaaataattctacatgtgtcgatggcattaataactac
acatgcctttgcccacctgagtatacaggtgagttgtgtgaggagaagctggacttctgt
gcccaggacctgaacccctgccagcacgattcaaagtgcatcctaactccaaagggattc
aaatgtgactgcacaccagggtacgtaggtgaacactgcgacatcgattttgacgactgc
caagacaacaagtgtaaaaacggagcccactgcacagatgcagtgaacggctatacgtgc
atatgccccgaaggttacagtggcttgttctgtgagttttctccacccatggtcctccct
cgtaccagcccctgtgataattttgattgtcagaatggagctcagtgtatcgtcagaata
aatgagccaatatgtcagtgtttgcctggctatcagggagaaaagtgtgaaaaattggtt
agtgtgaattttataaacaaagagtcttatcttcagattccttcagccaaggttcggcct
cagacgaacataacacttcagattgccacagatgaagacagcggaatcctcctgtataag
ggtgacaaagaccatatcgcggtagaactctatcgggggcgtgttcgtgccagctatgac
accggctctcatccagcttctgccatttacagtgtggagacaatcaatgatggaaacttc
cacattgtggaactacttgccttggatcagagtctctctttgtccgtggatggtgggaac
cccaaaatcatcactaacttgtcaaagcagtccactctgaattttgactctccactctat
gtaggaggcatgccagggaagagtaacgtggcatctctgcgccaggcccctgggcagaac
ggaaccagcttccacggctgcatccggaacctttacatcaacagtgagctgcaggacttc
cagaaggtgccgatgcaaacaggcattttgcctggctgtgagccatgccacaagaaggtg
tgtgcccatggcacatgccagcccagcagccaggcaggcttcacctgcgagtgccaggaa
ggatggatggggcccctctgtgaccaacggaccaatgacccttgccttggaaataaatgc
gtacatggcacctgcttgcccatcaatgcgttctcctacagctgtaagtgcttggagggc
catggaggtgtcctctgtgatgaagaggaggatctgtttaacccatgccaggcgatcaag
tgcaagcatgggaagtgcaggctttcaggtctggggcagccctactgtgaatgcagcagt
ggatacacgggggacagctgtgatcgagaaatctcttgtcgaggggaaaggataagagat
tattaccaaaagcagcagggctatgctgcttgccaaacaaccaagaaggtgtcccgatta
gagtgcagaggtgggtgtgcaggagggcagtgctgtggaccgctgaggagcaagcggcgg
aaatactctttcgaatgcactgacggctcctcctttgtggacgaggttgagaaagtggtg
aagtgcggctgtacgaggtgtgtgtcctaa

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