KEGG   Homo sapiens (human): 942Help
Entry
942               CDS       T01001                                 

Gene name
CD86, B7-2, B7.2, B70, CD28LG2, LAB72
Definition
(RefSeq) CD86 molecule
  KO
K05413  CD86 antigen
Organism
hsa  Homo sapiens (human)
Pathway
hsa04514  Cell adhesion molecules (CAMs)
hsa04620  Toll-like receptor signaling pathway
hsa04672  Intestinal immune network for IgA production
hsa04940  Type I diabetes mellitus
hsa05167  Kaposi's sarcoma-associated herpesvirus infection
hsa05202  Transcriptional misregulation in cancer
hsa05320  Autoimmune thyroid disease
hsa05322  Systemic lupus erythematosus
hsa05323  Rheumatoid arthritis
hsa05330  Allograft rejection
hsa05332  Graft-versus-host disease
hsa05416  Viral myocarditis
Network
N00123  Amplified REL to transcription
N00185  KSHV MIR2 to cell surface molecule-endocytosis
N00210  KSHV MIR1/2 to host-cell-protein inhibition
Drug target
Abatacept: D03203
Belatacept: D03222
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    942 (CD86)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    942 (CD86)
   04672 Intestinal immune network for IgA production
    942 (CD86)
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    942 (CD86)
  Immune diseases
   05322 Systemic lupus erythematosus
    942 (CD86)
   05323 Rheumatoid arthritis
    942 (CD86)
   05320 Autoimmune thyroid disease
    942 (CD86)
   05330 Allograft rejection
    942 (CD86)
   05332 Graft-versus-host disease
    942 (CD86)
  Cardiovascular diseases
   05416 Viral myocarditis
    942 (CD86)
  Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    942 (CD86)
  Infectious diseases
   05167 Kaposi's sarcoma-associated herpesvirus infection
    942 (CD86)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   942 (CD86)
CD molecules [BR:hsa04090]
 Proteins
  942 (CD86)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Ig_2 V-set Ig_3 LAX I-set ig DUF4381 MAP17 DUF2681
Motif
Other DBs
NCBI-GeneID: 942
NCBI-ProteinID: NP_787058
OMIM: 601020
HGNC: 1705
Ensembl: ENSG00000114013
Vega: OTTHUMG00000159482
Pharos: P42081(Tclin)
UniProt: P42081 A8K632
Structure
PDB: 

Position
3q13.33
AA seq 329 aa AA seqDB search
MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQ
ENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGM
IRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTI
EYDGIMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQ
PPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREK
IHIPERSDEAQRVFKSSKTSSCDKSDTCF
NT seq 990 nt NT seq  +upstreamnt  +downstreamnt
atggatccccagtgcactatgggactgagtaacattctctttgtgatggccttcctgctc
tctggtgctgctcctctgaagattcaagcttatttcaatgagactgcagacctgccatgc
caatttgcaaactctcaaaaccaaagcctgagtgagctagtagtattttggcaggaccag
gaaaacttggttctgaatgaggtatacttaggcaaagagaaatttgacagtgttcattcc
aagtatatgggccgcacaagttttgattcggacagttggaccctgagacttcacaatctt
cagatcaaggacaagggcttgtatcaatgtatcatccatcacaaaaagcccacaggaatg
attcgcatccaccagatgaattctgaactgtcagtgcttgctaacttcagtcaacctgaa
atagtaccaatttctaatataacagaaaatgtgtacataaatttgacctgctcatctata
cacggttacccagaacctaagaagatgagtgttttgctaagaaccaagaattcaactatc
gagtatgatggtattatgcagaaatctcaagataatgtcacagaactgtacgacgtttcc
atcagcttgtctgtttcattccctgatgttacgagcaatatgaccatcttctgtattctg
gaaactgacaagacgcggcttttatcttcacctttctctatagagcttgaggaccctcag
cctcccccagaccacattccttggattacagctgtacttccaacagttattatatgtgtg
atggttttctgtctaattctatggaaatggaagaagaagaagcggcctcgcaactcttat
aaatgtggaaccaacacaatggagagggaagagagtgaacagaccaagaaaagagaaaaa
atccatatacctgaaagatctgatgaagcccagcgtgtttttaaaagttcgaagacatct
tcatgcgacaaaagtgatacatgtttttaa

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