KEGG   Homo sapiens (human): 9448
Entry
9448              CDS       T01001                                 
Symbol
MAP4K4, FLH21957, HEL-S-31, HGK, MEKKK4, NIK
Name
(RefSeq) mitogen-activated protein kinase kinase kinase kinase 4
  KO
K04407  mitogen-activated protein kinase kinase kinase kinase 4 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    9448 (MAP4K4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    9448 (MAP4K4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     9448 (MAP4K4)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: STE group
  STE20 family
   9448 (MAP4K4)
SSDB
Motif
Pfam: Pkinase CNH PK_Tyr_Ser-Thr ABC1
Other DBs
NCBI-GeneID: 9448
NCBI-ProteinID: NP_001229488
OMIM: 604666
HGNC: 6866
Ensembl: ENSG00000071054
UniProt: O95819
Structure
Position
2:101697707..101894690
AA seq 1239 aa
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR
RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE
VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP
PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS
ESFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSIE
PRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRL
ENAVKKPEDKKEVFRPLKPADLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDD
VEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQT
QSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGS
VVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYP
LINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDL
EGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEE
GQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDE
GVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRA
QRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
NT seq 3720 nt   +upstreamnt  +downstreamnt
atggcgaacgactcccctgcaaaaagtctggtggacatcgacctctcctccctgcgggat
cctgctgggatttttgagctggtggaagtggttggaaatggcacctatggacaagtctat
aagggtcgacatgttaaaacgggtcagttggcagccatcaaagttatggatgtcactgag
gatgaagaggaagaaatcaaactggagataaatatgctaaagaaatactctcatcacaga
aacattgcaacatattatggtgctttcatcaaaaagagccctccaggacatgatgaccaa
ctctggcttgttatggagttctgtggggctgggtccattacagaccttgtgaagaacacc
aaagggaacacactcaaagaagactggatcgcttacatctccagagaaatcctgagggga
ctggcacatcttcacattcatcatgtgattcaccgggatatcaagggccagaatgtgttg
ctgactgagaatgcagaggtgaaacttgttgactttggtgtgagtgctcagctggacagg
actgtggggcggagaaatacgttcataggcactccctactggatggctcctgaggtcatc
gcctgtgatgagaacccagatgccacctatgattacagaagtgatctttggtcttgtggc
attacagccattgagatggcagaaggtgctccccctctctgtgacatgcatccaatgaga
gcactgtttctcattcccagaaaccctcctccccggctgaagtcaaaaaaatggtcgaag
aagttttttagttttatagaagggtgcctggtgaagaattacatgcagcggccctctaca
gagcagcttttgaaacatccttttataagggatcagccaaatgaaaggcaagttagaatc
cagcttaaggatcatatagatcgtaccaggaagaagagaggcgagaaagatgaaactgag
tatgagtacagtgggagtgaggaagaagaggaggaagtgcctgaacaggaaggagagcca
agttccattgtgaacgtgcctggtgagtctactcttcgccgagatttcctgagactgcag
caggagaacaaggaacgttccgaggctcttcggagacaacagttactacaggagcaacag
ctccgggagcaggaagaatataaaaggcaactgctggcagagagacagaagcggattgag
cagcagaaagaacagaggcgacggctagaagagcaacaaaggagagagcgggaagctaga
aggcagcaggaacgtgaacagcgaaggagagaacaagaagaaaagaggcgtctagaggag
ttggagagaaggcgcaaagaagaagaggagaggagacgggcagaagaagaaaagaggaga
gttgaaagagaacaggagtatatcaggcgacagctagaagaggagcagcggcacttggaa
gtccttcagcagcagctgctccaggagcaggccatgttactggagtgccgatggcgggag
atggaggagcaccggcaggcagagaggctccagaggcagttgcaacaagaacaagcatat
ctcctgtctctacagcatgaccataggaggccgcacccgcagcactcgcagcagccgcca
ccaccgcagcaggaaaggagcaagccaagcttccatgctcccgagcccaaagcccactac
gagcctgctgaccgagcgcgagaggtggaagatagatttaggaaaactaaccacagctcc
cctgaagcccagtctaagcagacaggcagagtattggagccaccagtgccttcccgatca
gagtctttttccaatggcaactccgagtctgtgcatcccgccctgcagagaccagcggag
ccacaggttcctgtgagaacaacatctcgctcccctgttctgtcccgtcgagattcccca
ctgcagggcagtgggcagcagaatagccaggcaggacagagaaactccaccagtattgag
cccaggcttctgtgggagagagtggagaagctggtgcccagacctggcagtggcagctcc
tcagggtccagcaactcaggatcccagcccgggtctcaccctgggtctcagagtggctcc
ggggaacgcttcagagtgagatcatcatccaagtctgaaggctctccatctcagcgcctg
gaaaatgcagtgaaaaaacctgaagataaaaaggaagttttcagacccctcaagcctgct
gatctgaccgcactggccaaagagcttcgagcagtggaagatgtacggccacctcacaaa
gtaacggactactcctcatccagtgaggagtcggggacgacggatgaggaggacgacgat
gtggagcaggaaggggctgacgagtccacctcaggaccagaggacaccagagcagcgtca
tctctgaatttgagcaatggtgaaacggaatctgtgaaaaccatgattgtccatgatgat
gtagaaagtgagccggccatgaccccatccaaggagggcactctaatcgtccgccagact
cagtccgctagtagcacactccagaaacacaaatcttcctcctcctttacaccttttata
gaccccagattactacagatttctccatctagcggaacaacagtgacatctgtggtggga
ttttcctgtgatgggatgagaccagaagccataaggcaagatcctacccggaaaggctca
gtggtcaatgtgaatcctaccaacactaggccacagagtgacaccccggagattcgtaaa
tacaagaagaggtttaactctgagattctgtgtgctgccttatggggagtgaatttgcta
gtgggtacagagagtggcctgatgctgctggacagaagtggccaagggaaggtctatcct
cttatcaaccgaagacgatttcaacaaatggacgtacttgagggcttgaatgtcttggtg
acaatatctggcaaaaaggataagttacgtgtctactatttgtcctggttaagaaataaa
atacttcacaatgatccagaagttgagaagaagcagggatggacaaccgtaggggatttg
gaaggatgtgtacattataaagttgtaaaatatgaaagaatcaaatttctggtgattgct
ttgaagagttctgtggaagtctatgcgtgggcaccaaagccatatcacaaatttatggcc
tttaagtcatttggagaattggtacataagccattactggtggatctcactgttgaggaa
ggccagaggttgaaagtgatctatggatcctgtgctggattccatgctgttgatgtggat
tcaggatcagtctatgacatttatctaccaacacatatccagtgtagcatcaaaccccat
gcaatcatcatcctccccaatacagatggaatggagcttctggtgtgctatgaagatgag
ggggtttatgtaaacacatatggaaggatcaccaaggatgtagttctacagtggggagag
atgcctacatcagtagcatatattcgatccaatcagacaatgggctggggagagaaggcc
atagagatccgatctgtggaaactggtcacttggatggtgtgttcatgcacaaaagggct
caaagactaaaattcttgtgtgaacgcaatgacaaggtgttctttgcctctgttcggtct
ggtggcagcagtcaggtttatttcatgaccttaggcaggacttctcttctgagctggtag

  All links  
Disease (1)   
   OMIM (1)   
Gene (39)   
   RefGene (29)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (53)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (51)   
DNA sequence (109)   
   RefSeq(nuc) (55)   
   GenBank (27)   
   EMBL (27)   
3D Structure (18)   
   PDB (18)   
Protein domain (4)   
   Pfam (4)   
All databases (224)   

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