KEGG   Homo sapiens (human): 9453Help
Entry
9453              CDS       T01001                                 

Gene name
GGPS1, GGPPS, GGPPS1
Definition
(RefSeq) geranylgeranyl diphosphate synthase 1
  KO
K00804  geranylgeranyl diphosphate synthase, type III [EC:2.5.1.1 2.5.1.10 2.5.1.29]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00900  Terpenoid backbone biosynthesis
hsa01100  Metabolic pathways
Module
hsa_M00367  C10-C20 isoprenoid biosynthesis, non-plant eukaryotes
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    9453 (GGPS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases [BR:hsa01006]
    9453 (GGPS1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.1  dimethylallyltranstransferase
     9453 (GGPS1)
    2.5.1.10  (2E,6E)-farnesyl diphosphate synthase
     9453 (GGPS1)
    2.5.1.29  geranylgeranyl diphosphate synthase
     9453 (GGPS1)
Prenyltransferases [BR:hsa01006]
 Terpene biosynthesis
  Prenyl diphosphate synthase
   9453 (GGPS1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: polyprenyl_synt
Motif
Other DBs
NCBI-GeneID: 9453
NCBI-ProteinID: NP_001032354
OMIM: 606982
HGNC: 4249
Ensembl: ENSG00000152904
Vega: OTTHUMG00000037963
Pharos: O95749(Tchem)
UniProt: O95749 A0A024R3W4
Structure
PDB: 

Position
1q42.3
AA seq 300 aa AA seqDB search
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
NT seq 903 nt NT seq  +upstreamnt  +downstreamnt
atggagaagactcaagaaacagtccaaagaattcttctagaaccctataaatacttactt
cagttaccaggtaaacaagtgagaaccaaactttcacaggcatttaatcattggctgaaa
gttccagaggacaagctacagattattattgaagtgacagaaatgttgcataatgccagt
ttactcatcgatgatattgaagacaactcaaaactccgacgtggctttccagtggcccac
agcatctatggaatcccatctgtcatcaattctgccaattacgtgtatttccttggcttg
gagaaagtcttaacccttgatcacccagatgcagtgaagctttttacccgccagcttttg
gaactccatcagggacaaggcctagatatttactggagggataattacacttgtcccact
gaagaagaatataaagctatggtgctgcagaaaacaggtggactgtttggattagcagta
ggtctcatgcagttgttctctgattacaaagaagatttaaaaccgctacttaatacactt
gggctctttttccaaattagggatgattatgctaatctacactccaaagaatatagtgaa
aacaaaagtttttgtgaagatctgacagagggaaagttctcatttcctactattcatgct
atttggtcaaggcctgaaagcacccaggtgcagaatatcttgcgccagagaacagaaaac
atagatataaaaaaatactgtgtacattatcttgaggatgtaggttcttttgaatacact
cgtaatacccttaaagagcttgaagctaaagcctataaacagattgatgcacgtggtggg
aaccctgagctagtagccttagtaaaacacttaagtaagatgttcaaagaagaaaatgaa
taa

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