KEGG   Homo sapiens (human): 952
Entry
952               CDS       T01001                                 
Symbol
CD38, ADPRC 1, ADPRC1, cADPR1
Name
(RefSeq) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
  KO
K01242  ADP-ribosyl cyclase 1 [EC:3.2.2.6 2.4.99.20]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00760  Nicotinate and nicotinamide metabolism
hsa01100  Metabolic pathways
hsa04020  Calcium signaling pathway
hsa04640  Hematopoietic cell lineage
hsa04921  Oxytocin signaling pathway
hsa04970  Salivary secretion
hsa04972  Pancreatic secretion
Drug target
Ciltacabtagene autoleucel: D12315<US>
Daratumumab: D10777<JP/US>
Isatuximab: D11050<JP/US>
Mezagitamab: D11945
Noraramtide: D12862
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    952 (CD38)
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    952 (CD38)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    952 (CD38)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    952 (CD38)
  09154 Digestive system
   04970 Salivary secretion
    952 (CD38)
   04972 Pancreatic secretion
    952 (CD38)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    952 (CD38)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    952 (CD38)
Enzymes [BR:hsa01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.99  Transferring other glycosyl groups
    2.4.99.20  2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
     952 (CD38)
 3. Hydrolases
  3.2  Glycosylases
   3.2.2  Hydrolysing N-glycosyl compounds
    3.2.2.6  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
     952 (CD38)
CD molecules [BR:hsa04090]
 Proteins
  952 (CD38)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Hyaluronan
  Cell surface receptors
   952 (CD38)
SSDB
Motif
Pfam: Rib_hydrolayse
Other DBs
NCBI-GeneID: 952
NCBI-ProteinID: NP_001766
OMIM: 107270
HGNC: 1667
Ensembl: ENSP00000226279.2
UniProt: P28907 B4E006
Structure
Position
4:15778328..15853232
AA seq 300 aa
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFP
ETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCN
KILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDC
SNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEA
WVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
NT seq 903 nt   +upstreamnt  +downstreamnt
atggccaactgcgagttcagcccggtgtccggggacaaaccctgctgccggctctctagg
agagcccaactctgtcttggcgtcagtatcctggtcctgatcctcgtcgtggtgctcgcg
gtggtcgtcccgaggtggcgccagcagtggagcggtccgggcaccaccaagcgctttccc
gagaccgtcctggcgcgatgcgtcaagtacactgaaattcatcctgagatgagacatgta
gactgccaaagtgtatgggatgctttcaagggtgcatttatttcaaaacatccttgcaac
attactgaagaagactatcagccactaatgaagttgggaactcagaccgtaccttgcaac
aagattcttctttggagcagaataaaagatctggcccatcagttcacacaggtccagcgg
gacatgttcaccctggaggacacgctgctaggctaccttgctgatgacctcacatggtgt
ggtgaattcaacacttccaaaataaactatcaatcttgcccagactggagaaaggactgc
agcaacaaccctgtttcagtattctggaaaacggtttcccgcaggtttgcagaagctgcc
tgtgatgtggtccatgtgatgctcaatggatcccgcagtaaaatctttgacaaaaacagc
acttttgggagtgtggaagtccataatttgcaaccagagaaggttcagacactagaggcc
tgggtgatacatggtggaagagaagattccagagacttatgccaggatcccaccataaaa
gagctggaatcgattataagcaaaaggaatattcaattttcctgcaagaatatctacaga
cctgacaagtttcttcagtgtgtgaaaaatcctgaggattcatcttgcacatctgagatc
tga

  All links  
Disease (1)   
   OMIM (1)   
Gene (15)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (20)   
   RefSeq(nuc) (2)   
   GenBank (9)   
   EMBL (9)   
3D Structure (53)   
   PDB (53)   
Protein domain (1)   
   Pfam (1)   
All databases (94)   

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