KEGG   Homo sapiens (human): 9639
Entry
9639              CDS       T01001                                 
Symbol
ARHGEF10, GEF10, SNCV
Name
(RefSeq) Rho guanine nucleotide exchange factor 10
  KO
K16727  Rho guanine nucleotide exchange factor 10
Organism
hsa  Homo sapiens (human)
Disease
H02649  Autosomal dominant slowed nerve conduction velocity
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    9639 (ARHGEF10)
   03036 Chromosome and associated proteins [BR:hsa03036]
    9639 (ARHGEF10)
Membrane trafficking [BR:hsa04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    9639 (ARHGEF10)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Other centrosome duplication proteins
     9639 (ARHGEF10)
SSDB
Motif
Pfam: WD40_2 PH_19 RhoGEF Beta-prop_LRRK2 WD40_CDC20-Fz DUF6059
Other DBs
NCBI-GeneID: 9639
NCBI-ProteinID: NP_001295082
OMIM: 608136
HGNC: 14103
Ensembl: ENSG00000104728
UniProt: O15013
Position
8:1823300..1958641
AA seq 1344 aa
MDQREPLPPAPAENEMKYDTNNNEEEEGEQFDFDSGDEIPEADRQAPSAPETGGAGASEA
PAPTGGEDGAGAETTPVAEPTKLVLPMKVNPYSVIDITPFQEDQPPTPVPSAEEENVGLH
VPCGYLVPVPCGYAVPSNLPLLLPAYSSPVIICATSLDEEAETPEVTEDRQPNSLSSEEP
PTSEDQVGREDSALARWAADPANTAWMENPEEAIYDDVPRENSDSEPDEMIYDDVENGDE
GGNSSLEYGWSSSEFESYEEQSDSECKNGIPRSFLRSNHKKQLSHDLTRLKEHYEKKMRD
LMASTVGVVEIQQLRQKHELKMQKLVKAAKDGTKDGLERTRAAVKRGRSFIRTKSLIAQD
HRSSLEEEQNLFIDVDCKHPEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRIL
EQYEKPLSEMEPKVLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVA
SFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKEQEASPDRTTLYSLMMKPIQ
RFPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAI
NERYLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHD
SRVMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMG
PGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRA
ADCCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENHMGWFCV
EDDGNHIKKEKHPLLVGHMPVMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTAHGFLWI
GSCTHQMGQIAIVSFQNSTPKVIECFNVESRILCMLYVPVEEKRREPGAPPDPETPAVRA
SDVPTICVGTEEGSISIYKSSQGSKKVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVA
SYARAPDGSWDSEPQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAH
QEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQRLSVT
SLLVCHGLLMVGTSLGVLVALPVPRLQGIPKVTGRGMVSYHAHNSPVKFIVLATALHEKD
KDKSRDSLAPGPEPQDEDQKDALPSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSDLSSSS
GSLSLSHGSSSLEHRSEDSTIYDLLKDPVSLRSKARRAKKAKASSALVVCGGQGHRRVHR
KARQPHQEELAPTVMVWQIPLLNI
NT seq 4035 nt   +upstreamnt  +downstreamnt
atggaccagcgagagcccctgcctcccgctcctgcagaaaatgaaatgaaatatgatacc
aataataatgaagaggaagagggagaacagttcgattttgacagtggagatgaaatccca
gaagcggacagacaggccccatccgcccctgagacaggaggtgctggagccagtgaagcc
cctgcacccacaggaggtgaggatggagctggagcagaaaccaccccagtggcagagcct
actaagctggtgctcccgatgaaagtcaacccatattctgtcatcgacatcacgccattc
caggaggaccagccgcccacccccgtgcccagcgctgaggaggagaatgtgggtctccat
gtgccctgcgggtacttggtgcctgtaccctgcggctatgcggtgccctccaacctgccc
ctcctgctgcccgcctactccagcccggtcatcatctgcgccacgtccctggacgaagaa
gcagaaacaccagaagtcacagaagatcgccagcccaattctctgagttccgaggagcct
ccaaccagtgaagatcaagtcggtcgagaggacagcgcacttgcccgctgggccgcagac
ccggccaacacagcctggatggagaatccagaggaagcaatttacgatgacgttccaagg
gaaaactcagactctgaaccagatgaaatgatttatgatgatgttgagaatggggatgaa
ggtggaaacagctccttggaatacggatggagttcgagtgaatttgaaagttacgaagag
cagagtgactcggagtgcaagaatgggattcccaggtccttcctgcgcagcaaccacaaa
aagcaactttctcatgacctaacccgtttaaaggagcactatgagaaaaagatgagagat
ttgatggcaagcacggtgggcgtggtggagattcagcagctcaggcagaagcatgaactg
aagatgcagaagctcgtgaaggccgcgaaggacggcaccaaggacgggctggagaggacc
agggcagccgtgaagaggggccgctccttcatcaggaccaagtctctcatcgcacaggat
cacagatcttctcttgaggaagaacagaatttgttcattgatgttgactgcaagcacccg
gaagccatcttgaccccgatgcccgagggtttatctcagcagcaggttgtaagaagatat
atactgggttcagttgtcgacagtgaaaagaactacgtagatgctcttaagaggattttg
gagcaatatgagaagccgctgtctgagatggagccaaaggttctgagtgagaggaagctg
aagacggtgttctaccgagtcaaagagatcctgcagtgccactcgctatttcagatcgcg
ctggccagccgcgtttccgagtgggactccgtggaaatgataggcgatgtcttcgtggct
tcgttttctaagtccatggtgctggatgcatacagtgaatatgtgaacaatttcagcaca
gccgtggcagtcctcaagaaaacatgtgccacaaagcccgcttttcttgaatttttaaag
gaacaggaggccagccccgatcgaaccacgctctacagcctgatgatgaagcccatccag
aggttcccacagttcatcctcctgctccaggacatgctgaagaacacctccaaaggccac
cccgacaggctgcctcttcagatggccctgacagagctcgaaacactagcagagaagtta
aatgaaagaaagagagatgctgatcaacgctgtgaagtgaagcaaatagccaaagccata
aacgaaagatacctgaacaagcttctcagcagtggaagccgatacctcattcgatcagat
gatatgatagaaacagtttacaacgacagaggagagattgttaaaaccaaagaacgccga
gtcttcatgttaaatgatgtgttaatgtgtgccaccgtcagctcacgcccctctcatgac
agccgtgtgatgagcagccagaggtacttgctgaagtggagcgttccactgggacatgtg
gacgccatcgagtatggcagcagcgcaggcacgggcgagcacagcaggcaccttgccgtt
cacccgccggagagcctggccgtggttgctaacgcgaaaccaaacaaagtttacatgggg
ccaggacaactgtatcaagatttacaaaacttgttgcatgacttaaatgtaattggccaa
atcactcagctgataggaaaccttaaaggaaactatcagaacttaaaccagtcagtagcc
catgactggacatcaggtttacaaaggcttattttgaagaaagaagatgaaatcagagct
gcggactgctgcagaattcagttacagcttcccgggaagcaggacaaatctgggcgaccg
acgttctttacagctgtgttcaatacgttcacccctgccatcaaggagtcctgggtcaac
agcttacagatggccaagctcgccctagaagaggagaaccacatgggctggttctgtgtg
gaagacgatgggaatcacattaaaaaggagaagcatcctctcctcgtcggacacatgccc
gtgatggtggccaagcagcaggagttcaagattgaatgtgctgcttataaccctgaacct
tacctaaataatgaaagccagccagattcattttccacggcacatggtttcctgtggatc
ggaagttgcacccatcaaatgggtcagattgccatcgtctcgtttcaaaattccactccc
aaagtcattgagtgcttcaacgtggaatctcgcatcctgtgcatgctgtacgttcccgtc
gaggagaagcgcagagagcctggggcacccccggaccccgagaccccggccgtgagagct
tctgatgtccccacgatctgtgtagggacggaggagggaagcatttccatttataaaagc
agtcaaggctccaagaaagtgagacttcagcactttttcactcctgagaagtccacagtc
atgagcctggcttgcacgtctcagagcctgtacgctggcctggtcaacggggcagtcgcc
agctacgccagagccccagatggatcctgggattcagaacctcaaaaagtgatcaagtta
ggcgtcctaccagttagaagtctactcatgatggaagacacgttgtgggcggcttccgga
ggtcaagtcttcatcatcagtgtggagactcatgctgtagagggtcagctggaggcccac
caggaggaaggcatggtgatctcccacatggccgtgtccggcgtcgggatctggattgcc
ttcacctcagggtccacgctccgcctttttcacacggaaactctcaagcacctgcaggac
atcaacatcgccacccctgttcacaacatgctgccagggcaccagcggctgtcggtgacg
agcctgctcgtctgccacggattgctgatggtcggcaccagcctgggagtcctcgtggcc
ctgccggtcccacgtctgcaagggattcccaaagtgaccggaagaggcatggtctcctac
catgcacacaacagtcctgtcaaattcatcgtcctggccacggctctgcacgagaaagac
aaggacaaatccagggacagcctggctcctggccccgagcctcaggacgaagaccagaag
gacgcacttccgagtggaggagctggttcatctctgagccagggtgaccctgacgcagcc
atctggttgggagattcgctgggatcgatgactcagaaaagcgacctgtcctcctcatct
gggtccctgagcttgtctcacggctccagctctctagagcacagatcagaggacagcacc
atctatgatctcctgaaggatcctgtctcgctgagaagcaaagcacgccgggccaagaaa
gccaaggccagctcggcgctggtggtctgtggagggcagggccaccgccgggtgcacagg
aaggcccggcagccccaccaggaagagctggcgccgaccgtcatggtctggcagatccct
ctgctgaatatataa

  All links  
Disease (2)   
   OMIM (2)   
Gene (30)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (16)   
   OC (1)   
Protein sequence (66)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (64)   
DNA sequence (89)   
   RefSeq(nuc) (65)   
   GenBank (12)   
   EMBL (12)   
Protein domain (6)   
   Pfam (6)   
All databases (193)   

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