KEGG   Homo sapiens (human): 9700
Entry
9700              CDS       T01001                                 
Symbol
ESPL1, ESP1, SEPA
Name
(RefSeq) extra spindle pole bodies like 1, separase
  KO
K02365  separase [EC:3.4.22.49]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa05166  Human T-cell leukemia virus 1 infection
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06230  Cell cycle (cancer)
nt06512  Chromosome cohesion and segregation
  Element
N00221  HTLV-1 Tax to spindle assembly checkpoint signaling
N00493  Spindle assembly checkpoint signaling
N01486  Cohesin dissociation in anaphase
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    9700 (ESPL1)
   04114 Oocyte meiosis
    9700 (ESPL1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    9700 (ESPL1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    9700 (ESPL1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    9700 (ESPL1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.49  separase
     9700 (ESPL1)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C50: separase family
   9700 (ESPL1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Sister chromatid separation proteins
   Separase
    9700 (ESPL1)
SSDB
Motif
Pfam: Peptidase_C50
Other DBs
NCBI-GeneID: 9700
NCBI-ProteinID: NP_036423
OMIM: 604143
HGNC: 16856
Ensembl: ENSG00000135476
UniProt: Q14674
Structure
Position
12:53268299..53293638
AA seq 2120 aa
MRSFKRVNFGTLLSSQKEAEELLPALKEFLSNPPAGFPSSRSDAERRQACDAILRACNQQ
LTAKLACPRHLGSLLELAELACDGYLVSTPQRPPLYLERILFVLLRNAAAQGSPEATLRL
AQPLHACLVQCSREAAPQDYEAVARGSFSLLWKGAEALLERRAAFAARLKALSFLVLLED
ESTPCEVPHFASPTACRAVAAHQLFDASGHGLNEADADFLDDLLSRHVIRALVGERGSSS
GLLSPQRALCLLELTLEHCRRFCWSRHHDKAISAVEKAHSYLRNTNLAPSLQLCQLGVKL
LQVGEEGPQAVAKLLIKASAVLSKSMEAPSPPLRALYESCQFFLSGLERGTKRRYRLDAI
LSLFAFLGGYCSLLQQLRDDGVYGGSSKQQQSFLQMYFQGLHLYTVVVYDFAQGCQIVDL
ADLTQLVDSCKSTVVWMLEALEGLSGQELTDHMGMTASYTSNLAYSFYSHKLYAEACAIS
EPLCQHLGLVKPGTYPEVPPEKLHRCFRLQVESLKKLGKQAQGCKMVILWLAALQPCSPE
HMAEPVTFWVRVKMDAARAGDKELQLKTLRDSLSGWDPETLALLLREELQAYKAVRADTG
QERFNIICDLLELSPEETPAGAWARATHLVELAQVLCYHDFTQQTNCSALDAIREALQLL
DSVRPEAQARDQLLDDKAQALLWLYICTLEAKMQEGIERDRRAQAPGNLEEFEVNDLNYE
DKLQEDRFLYSNIAFNLAADAAQSKCLDQALALWKELLTKGQAPAVRCLQQTAASLQILA
ALYQLVAKPMQALEVLLLLRIVSERLKDHSKAAGSSCHITQLLLTLGCPSYAQLHLEEAA
SSLKHLDQTTDTYLLLSLTCDLLRSQLYWTHQKVTKGVSLLLSVLRDPALQKSSKAWYLL
RVQVLQLVAAYLSLPSNNLSHSLWEQLCAQGWQTPEIALIDSHKLLRSIILLLMGSDILS
TQKAAVETSFLDYGENLVQKWQVLSEVLSCSEKLVCHLGRLGSVSEAKAFCLEALKLTTK
LQIPRQCALFLVLKGELELARNDIDLCQSDLQQVLFLLESCTEFGGVTQHLDSVKKVHLQ
KGKQQAQVPCPPQLPEEELFLRGPALELVATVAKEPGPIAPSTNSSPVLKTKPQPIPNFL
SHSPTCDCSLCASPVLTAVCLRWVLVTAGVRLAMGHQAQGLDLLQVVLKGCPEAAERLTQ
ALQASLNHKTPPSLVPSLLDEILAQAYTLLALEGLNQPSNESLQKVLQSGLKFVAARIPH
LEPWRASLLLIWALTKLGGLSCCTTQLFASSWGWQPPLIKSVPGSEPSKTQGQKRSGRGR
QKLASAPLRLNNTSQKGLEGRGLPCTPKPPDRIRQAGPHVPFTVFEEVCPTESKPEVPQA
PRVQQRVQTRLKVNFSDDSDLEDPVSAEAWLAEEPKRRGTASRGRGRARKGLSLKTDAVV
APGSAPGNPGLNGRSRRAKKVASRHCEERRPQRASDQARPGPEIMRTIPEEELTDNWRKM
SFEILRGSDGEDSASGGKTPAPGPEAASGEWELLRLDSSKKKLPSPCPDKESDKDLGPRL
RLPSAPVATGLSTLDSICDSLSVAFRGISHCPPSGLYAHLCRFLALCLGHRDPYATAFLV
TESVSITCRHQLLTHLHRQLSKAQKHRGSLEIADQLQGLSLQEMPGDVPLARIQRLFSFR
ALESGHFPQPEKESFQERLALIPSGVTVCVLALATLQPGTVGNTLLLTRLEKDSPPVSVQ
IPTGQNKLHLRSVLNEFDAIQKAQKENSSCTDKREWWTGRLALDHRMEVLIASLEKSVLG
CWKGLLLPSSEEPGPAQEASRLQELLQDCGWKYPDRTLLKIMLSGAGALTPQDIQALAYG
LCPTQPERAQELLNEAVGRLQGLTVPSNSHLVLVLDKDLQKLPWESMPSLQALPVTRLPS
FRFLLSYSIIKEYGASPVLSQGVDPRSTFYVLNPHNNLSSTEEQFRANFSSEAGWRGVVG
EVPRPEQVQEALTKHDLYIYAGHGAGARFLDGQAVLRLSCRAVALLFGCSSAALAVRGNL
EGAGIVLKYIMAGCPLFLGNLWDVTDRDIDRYTEALLQGWLGAGPGAPLLYYVNQARQAP
RLKYLIGAAPIAYGLPVSLR
NT seq 6363 nt   +upstreamnt  +downstreamnt
atgaggagcttcaaaagagtcaactttgggactctgctaagcagccagaaggaggctgaa
gagttgctgcccgccttgaaggagttcctgtccaaccctccagctggttttcccagcagc
cgatctgatgctgagaggagacaagcttgtgatgccatcctgagggcttgcaaccagcag
ctgactgctaagctagcttgccctaggcatctggggagcctgctggagctggcagagctg
gcctgtgatggctacttagtgtctaccccacagcgtcctcccctctacctggaacgaatt
ctctttgtcttactgcggaatgctgctgcacaaggaagcccagaggccacactccgcctt
gctcagcccctccatgcctgcttggtgcagtgctctcgcgaggctgctccccaggactat
gaggccgtggctcggggcagcttttctctgctttggaagggggcagaagccctgttggaa
cggcgagctgcatttgcagctcggctgaaggccttgagcttcctagtactcttggaggat
gaaagtaccccttgtgaggttcctcactttgcttctccaacagcctgtcgagcggtagct
gcccatcagctatttgatgccagtggccatggtctaaatgaagcagatgctgatttccta
gatgacctgctctccaggcacgtgatcagagccttggtgggtgagagagggagctcttct
gggcttctttctccccagagggccctctgcctcttggagctcaccttggaacactgccgt
cgcttttgctggagccgccaccatgacaaagccatcagcgcagtggagaaggctcacagt
tacctaaggaacaccaatctagcccctagccttcagctatgtcagctgggggttaagctg
ctgcaggttggggaggaaggacctcaggcagtggccaagcttctgatcaaggcatcagct
gtcctgagcaagagtatggaggcaccatcacccccacttcgggcattgtatgagagctgc
cagttcttcctttcaggcctggaacgaggcaccaagaggcgctatagacttgatgccatt
ctgagcctctttgcttttcttggagggtactgctctcttctgcagcagctgcgggatgat
ggtgtgtatgggggctcctccaagcaacagcagtcttttcttcagatgtactttcaggga
cttcacctctacactgtggtggtttatgactttgcccaaggctgtcagatagttgatttg
gctgacctgacccaactagtggacagttgtaaatctaccgttgtctggatgctggaggcc
ttagagggcctgtcgggccaagagctgacggaccacatggggatgaccgcttcttacacc
agtaatttggcctacagcttctatagtcacaagctctatgccgaggcctgtgccatctct
gagccgctctgtcagcacctgggtttggtgaagccaggcacttatcccgaggtgcctcct
gagaagttgcacaggtgcttccggctacaagtagagagtttgaagaaactgggtaaacag
gcccagggctgcaagatggtgattttgtggctggcagccctgcaaccctgtagccctgaa
cacatggctgagccagtcactttctgggttcgggtcaagatggatgcggccagggctgga
gacaaggagctacagctaaagactctgcgagacagcctcagtggctgggacccggagacc
ctggccctcctgctgagggaggagctgcaggcctacaaggcggtgcgggccgacactgga
caggaacgcttcaacatcatctgtgacctcctggagctgagccccgaggagacaccagcc
ggggcctgggcacgagccacccacctggtagaactggctcaggtgctctgctaccacgac
tttacgcagcagaccaactgctctgctctggatgctatccgggaagccctgcagcttctg
gactctgtgaggcctgaggcccaggccagagatcagcttctggacgataaagcacaggcc
ttgctgtggctttacatctgtactctggaagccaaaatgcaggaaggtatcgagcgggat
cggagagcccaggcccctggtaacttggaggaatttgaagtcaatgacctgaactatgaa
gataaactccaggaagatcgtttcctatacagtaacattgccttcaacctggctgcagat
gctgctcagtccaaatgcctggaccaagccctggccctgtggaaggagctgcttacaaag
gggcaggccccagctgtacggtgtctccagcagacagcagcctcactgcagatcctagca
gccctctaccagctggtggcaaagcccatgcaggctctggaggtcctcctgctgctacgg
attgtctctgagagactgaaggaccactcgaaggcagctggctcctcctgccacatcacc
cagctcctcctgaccctcggctgtcccagctatgcccagttacacctggaagaggcagca
tcgagcctgaagcatctcgatcagactactgacacatacctgctcctttccctgacctgt
gatctgcttcgaagtcaactctactggactcaccagaaggtgaccaagggtgtctctctg
ctgctgtctgtgcttcgggatcctgccctccagaagtcctccaaggcttggtacttgctg
cgtgtccaggtcctgcagctggtggcagcttaccttagcctcccgtcaaacaacctctca
cactccctgtgggagcagctctgtgcccaaggctggcagacacctgagatagctctcata
gactcccataagctcctccgaagcatcatcctcctgctgatgggcagtgacattctctca
actcagaaagcagctgtggagacatcgtttttggactatggtgaaaatctggtacaaaaa
tggcaggttctttcagaggtgctgagctgctcagagaagctggtctgccacctgggccgc
ctgggtagtgtgagtgaagccaaggccttttgcttggaggccctaaaacttacaacaaag
ctgcagataccacgccagtgtgccctgttcctggtgctgaagggcgagctggagctggcc
cgcaatgacattgatctctgtcagtcggacctgcagcaggttctgttcttgcttgagtct
tgcacagagtttggtggggtgactcagcacctggactctgtgaagaaggtccacctgcag
aaggggaagcagcaggcccaggtcccctgtcctccacagctcccagaggaggagctcttc
ctaagaggccctgctctagagctggtggccactgtggccaaggagcctggccccatagca
ccttctacaaactcctccccagtcttgaaaaccaagccccagcccatacccaacttcctg
tcccattcacccacctgtgactgctcgctctgcgccagccctgtcctcacagcagtctgt
ctgcgctgggtattggtcacggcaggggtgaggctggccatgggccaccaagcccagggt
ctggatctgctgcaggtcgtgctgaagggctgtcctgaagccgctgagcgcctcacccaa
gctctccaagcttccctgaatcataaaacacccccctccttggttccaagcctcttggat
gagatcttggctcaagcatacacactgttggcactggagggcctgaaccagccatcaaac
gagagcctgcagaaggttctacagtcagggctgaagtttgtagcagcacggataccccac
ctagagccctggcgagccagcctgctcttgatttgggccctcacaaaactaggtggcctc
agctgctgtactacccaactttttgcaagctcctggggctggcagccaccattaataaaa
agtgtccctggctcagagccctctaagactcagggccaaaaacgttctggacgagggcgc
caaaagttagcctctgctcccctgcgcctcaataatacctctcagaaaggtctggaaggt
agaggactgccctgcacacctaaacccccagaccggatcaggcaagctggccctcatgtc
cccttcacggtgtttgaggaagtctgccctacagagagcaagcctgaagtaccccaggcc
cccagggtacaacagagagtccagacgcgcctcaaggtgaacttcagtgatgacagtgac
ttggaagaccctgtctcagctgaggcctggctggcagaggagcctaagagacggggcact
gcttcccggggccgggggcgagcaaggaagggcctgagcctaaagacggatgccgtggtt
gccccaggtagtgcccctgggaaccctggcctgaatggcaggagccggagggccaagaag
gtggcatcaagacattgtgaggagcggcgtccccagagggccagtgaccaggccaggcct
ggccctgagatcatgaggaccatccctgaggaagaactgactgacaactggagaaaaatg
agctttgagatcctcaggggctctgacggggaagactcagcctcaggtgggaagactcca
gctccgggccctgaggcagcttctggagaatgggagctgctgaggctggattccagcaag
aagaagctgcccagcccatgcccagacaaggagagtgacaaggaccttggtcctcggctc
cggctcccctcagcccccgtagccactggtctttctaccctggactccatctgtgactcc
ctgagtgttgctttccggggcattagtcactgtcctcctagtgggctctatgcccacctc
tgccgcttcctggccttgtgcctgggccaccgggatccttatgccactgctttccttgtc
accgagtctgtctccatcacctgtcgccaccagctgctcacccacctccacagacagctc
agcaaggcccagaagcaccgaggatcacttgaaatagcagaccagctgcaggggctgagc
cttcaggagatgcctggagatgtccccctggcccgcatccagcgcctcttttccttcagg
gctttggaatctggccacttcccccagcctgaaaaggagagtttccaggagcgcctggct
ctgatccccagtggggtgactgtgtgtgtgttggccctggccaccctccagcccggaacc
gtgggcaacaccctcctgctgacccggctggaaaaggacagtcccccagtcagtgtgcag
attcccactggccagaacaagcttcatctgcgttcagtcctgaatgagtttgatgccatc
cagaaggcacagaaagagaacagcagctgtactgacaagcgagaatggtggacagggcgg
ctggcactggaccacaggatggaggttctcatcgcttccctagagaagtctgtgctgggc
tgctggaaggggctgctgctgccgtccagtgaggagcccggccctgcccaggaggcctcc
cgcctacaggagctgctacaggactgtggctggaaatatcctgaccgcactctgctgaaa
atcatgctcagtggtgccggtgccctcacccctcaggacattcaggccctggcctacggg
ctgtgcccaacccagccagagcgagcccaggagctcctgaatgaggcagtaggacgtcta
cagggcctgacagtaccaagcaatagccaccttgtcttggtcctagacaaggacttgcag
aagctgccgtgggaaagcatgcccagcctccaagcactgcctgtcacccggctgccctcc
ttccgcttcctactcagctactccatcatcaaagagtatggggcctcgccagtgctgagt
caaggggtggatccacgaagtaccttctatgtcctgaaccctcacaataacctgtcaagc
acagaggagcaatttcgagccaatttcagcagtgaagctggctggagaggagtggttggg
gaggtgccaagacctgaacaggtgcaggaagccctgacaaagcatgatttgtatatctat
gcagggcatggggctggtgcccgcttccttgatgggcaggctgtcctgcggctgagctgt
cgggcagtggccctgctgtttggctgtagcagtgcggccctggctgtgcgtggaaacctg
gagggggctggcatcgtgctcaagtacatcatggctggttgccccttgtttctgggtaat
ctctgggatgtgactgaccgcgacattgaccgctacacggaagctctgctgcaaggctgg
cttggagcaggcccaggggccccccttctctactatgtaaaccaggcccgccaagctccc
cgactcaagtatcttattggggctgcacctatagcctatggcttgcctgtctctctgcgg
taa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (6)   
   KEGG NETWORK (6)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (33)   
   KEGG ORTHOLOGY (1)   
   RefGene (26)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (29)   
   RefSeq(nuc) (9)   
   GenBank (10)   
   EMBL (10)   
3D Structure (2)   
   PDB (2)   
Protein domain (1)   
   Pfam (1)   
All databases (92)   

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