KEGG   Homo sapiens (human): 9869
Entry
9869              CDS       T01001                                 
Symbol
SETDB1, ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21
Name
(RefSeq) SET domain bifurcated histone lysine methyltransferase 1
  KO
K11421  [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase [EC:2.1.1.366]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00310  Lysine degradation
hsa01100  Metabolic pathways
hsa04550  Signaling pathways regulating pluripotency of stem cells
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    9869 (SETDB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    9869 (SETDB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    9869 (SETDB1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.366  [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
     9869 (SETDB1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     9869 (SETDB1)
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    9869 (SETDB1)
SSDB
Motif
Pfam: DUF5604 Tudor_4 Tudor_5 MBD SET Pre-SET Chromo_MORC2_6th DUF4537 Chromo
Other DBs
NCBI-GeneID: 9869
NCBI-ProteinID: NP_001138887
OMIM: 604396
HGNC: 10761
Ensembl: ENSG00000143379
UniProt: Q15047
Structure
Position
1:150926263..150964737
AA seq 1291 aa
MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL
AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS
ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL
LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL
DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN
TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE
CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD
FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE
SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP
PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME
AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT
SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS
EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF
YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTE
LTWDYNYEVGSVEGKELLCCCGAIECRGRLL
NT seq 3876 nt   +upstreamnt  +downstreamnt
atgtcttcccttcctgggtgcattggtttggatgcagcaacagctacagtggagtctgaa
gagattgcagagctgcaacaggcagtggttgaggaactgggtatctctatggaggaactt
cggcatttcatcgatgaggaactggagaagatggattgtgtacagcaacgcaagaagcag
ctagcagagttagagacatgggtaatacagaaagaatctgaggtggctcacgttgaccaa
ctctttgatgatgcatccagggcagtgactaattgtgagtctttggtgaaggacttctac
tccaagctgggactacaataccgggacagtagctctgaggacgaatcttcccggcctaca
gaaataattgagattcctgatgaagatgatgatgtcctcagtattgattcaggtgatgct
gggagcagaactccaaaagaccagaagctccgtgaagctatggctgccttaagaaagtca
gctcaagatgttcagaagttcatggatgctgtcaacaagaagagcagttcccaggatctg
cataaaggaaccttgagtcagatgtctggagaactaagcaaagatggtgacctgatagtc
agcatgcgaattctgggcaagaagagaactaagacttggcacaaaggcacccttattgcc
atccagacagttgggccagggaagaaatacaaggtgaaatttgacaacaaaggaaagagt
ctactgtcggggaaccatattgcctatgattaccaccctcctgctgacaagctgtatgtg
ggcagtcgggtggtcgccaaatacaaagatgggaatcaggtctggctctatgctggcatt
gtagctgagacaccaaacgtcaaaaacaagctcaggtttctcattttctttgatgatggc
tatgcttcctatgtcacacagtcggaactgtatcccatttgccggccactgaaaaagact
tgggaggacatagaagacatctcctgccgtgacttcatagaggagtatgtcactgcctac
cccaaccgccccatggtactgctcaagagtggccagcttatcaagactgagtgggaaggc
acgtggtggaagtcccgagttgaggaggtggatggcagcctagtcaggatcctcttcctg
gatgacaaaagatgtgagtggatctatcgaggctctacacggctggagcccatgttcagc
atgaaaacatcctcagcctctgcactggagaagaagcaaggacagctcaggacacgtcca
aatatgggtgctgtgaggagcaaaggccctgttgtccagtacacacaggatctgaccggt
actggaacccagttcaagccagtggaacccccacagcctacagctccacctgccccacct
ttcccacctgctccacctctatccccccaagcaggtgacagtgacttggaaagccagctt
gcccagtcacggaagcaggtagccaaaaagagcacgtcctttcgaccaggatctgtgggc
tctggtcattcctcccctacatctcctgcactcagtgaaaatgtctctggtgggaaacct
gggatcaaccagacatatagatcacctttaggctccacagcctctgccccagcaccctca
gcactcccggcccctccagcacccccagtcttccatggcatgctggagcgggccccagca
gagccctcctaccgtgctcccatggagaagcttttctacttacctcatgtctgcagctat
acctgtctgtctcgagtcagacctatgaggaatgagcagtaccggggcaagaaccctctg
ctggtcccgttactatatgacttccggcggatgacagcccggcgtcgagttaaccgcaag
atgggctttcatgttatctataagacaccttgtggtctctgccttcggacaatgcaggag
atagaacgctaccttttcgagactggctgtgacttcctcttcctggagatgttctgtttg
gatccatatgttcttgtggaccgaaagtttcagccctataagcctttttactatattttg
gacatcacttatgggaaggaagatgttcccctatcctgtgtcaatgagattgacacaacc
cctccaccccaggtggcctacagcaaggaacgtatcccgggcaagggtgttttcattaac
acaggccctgaatttctggttggctgtgactgcaaggatgggtgtcgggacaagtccaag
tgtgcctgccatcaactaactatccaggctacagcctgtaccccaggaggccaaatcaac
cctaactctggctaccagtacaagagactagaagagtgtctacccacaggggtatatgag
tgtaacaaacgctgcaaatgtgacccaaacatgtgcacaaaccggttggtgcaacatgga
ctacaagttcggctacagctattcaagacacagaacaagggctggggtatccgctgcttg
gatgacattgccaaaggctcttttgtttgtatttatgcaggcaaaatcctgacagatgac
tttgcagacaaggagggtctggaaatgggtgatgagtactttgcaaatctggaccatatc
gagagcgtggagaacttcaaagaaggatatgagagtgatgccccctgttcctctgacagc
agtggtgtagacttgaaggaccaggaagatggcaacagcggtacagaggaccctgaagag
tccaatgatgatagctcagatgataacttctgtaaggatgaggacttcagcaccagttca
gtgtggcggagctatgctacccggaggcagacccggggccagaaagagaacggactctct
gagacaacttccaaggactcccaccccccagatcttggacccccacatattcctgttcct
ccctcaatccctgtaggtggctgcaatccaccttcctccgaagagacacccaagaacaag
gtggcctcatggttgagctgcaatagtgtcagtgaaggtggttttgctgactctgatagc
cattcatccttcaagactaatgaaggtggggagggccgggctgggggaagccgaatggag
gctgagaaggcctccacctcaggactaggcatcaaggatgagggagacatcaaacaggcc
aagaaagaggacactgacgaccgaaacaagatgtcagtagttactgaaagctctcgaaat
tacggttacaatccttctcctgtgaagcctgaaggacttcgccgcccacctagtaagact
agtatgcatcaaagccgaagactcatggcttctgctcagtccaaccctgatgatgtcctg
acactgtccagcagcacagaaagtgagggggaaagtgggaccagccgaaagcccactgct
ggtcagacttcggctacagcggttgacagtgatgatatccagaccatatcctctggctct
gaaggggatgactttgaggacaagaagaacatgactggtccaatgaagcgtcaagtggca
gtaaaatcaacccgaggctttgctcttaaatcaacccatgggattgcaattaaatcaacc
aacatggcctctgtggacaagggggagagcgcacctgttcgtaagaacacacgccaattc
tatgatggcgaggagtcttgctacatcattgatgccaagcttgaaggcaacctgggccgc
tacctcaaccacagttgcagccccaacctgtttgtccagaatgtcttcgtggatacccat
gatcttcgcttcccctgggtggccttctttgccagcaaaagaatccgggctgggacagaa
cttacttgggactacaactacgaggtgggcagtgtggaaggcaaggagctactctgttgc
tgtggggccattgaatgcagaggacgtcttctttag

  All links  
Disease (1)   
   OMIM (1)   
Gene (26)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (28)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (26)   
DNA sequence (45)   
   RefSeq(nuc) (27)   
   GenBank (9)   
   EMBL (9)   
3D Structure (26)   
   PDB (26)   
Protein domain (9)   
   Pfam (9)   
All databases (135)   

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