KEGG   Homo sapiens (human): 9984
Entry
9984              CDS       T01001                                 
Symbol
THOC1, DFNA86, HPR1, P84, P84N5
Name
(RefSeq) THO complex subunit 1
  KO
K12878  THO complex subunit 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03013  Nucleocytoplasmic transport
hsa03040  Spliceosome
Disease
H00604  Deafness, autosomal dominant
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03040 Spliceosome
    9984 (THOC1)
  09122 Translation
   03013 Nucleocytoplasmic transport
    9984 (THOC1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    9984 (THOC1)
   03041 Spliceosome [BR:hsa03041]
    9984 (THOC1)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    TREX complex
     9984 (THOC1)
Spliceosome [BR:hsa03041]
 Complex C
  Other components
   EJC/TREX
    9984 (THOC1)
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   TREX complex
    9984 (THOC1)
SSDB
Motif
Pfam: efThoc1 Death
Other DBs
NCBI-GeneID: 9984
NCBI-ProteinID: NP_005122
OMIM: 606930
HGNC: 19070
Ensembl: ENSG00000079134
Pharos: Q96FV9(Tbio)
UniProt: Q96FV9
Structure
Position
18:complement(214520..268047)
AA seq 657 aa
MSPTPPLFSLPEARTRFTKSTREALNNKNIKPLLSTFSQVPGSENEKKCTLDQAFRGILE
EEIINHSSCENVLAIISLAIGGVTEGICTASTPFVLLGDVLDCLPLDQCDTIFTFVEKNV
ATWKSNTFYSAGKNYLLRMCNDLLRRLSKSQNTVFCGRIQLFLARLFPLSEKSGLNLQSQ
FNLENVTVFNTNEQESTLGQKHTEDREEGMDVEEGEMGDEEAPTTCSIPIDYNLYRKFWS
LQDYFRNPVQCYEKISWKTFLKYSEEVLAVFKSYKLDDTQASRKKMEELKTGGEHVYFAK
FLTSEKLMDLQLSDSNFRRHILLQYLILFQYLKGQVKFKSSNYVLTDEQSLWIEDTTKSV
YQLLSENPPDGERFSKMVEHILNTEENWNSWKNEGCPSFVKERTSDTKPTRIIRKRTAPE
DFLGKGPTKKILMGNEELTRLWNLCPDNMEACKSETREHMPTLEEFFEEAIEQADPENMV
ENEYKAVNNSNYGWRALRLLARRSPHFFQPTNQQFKSLPEYLENMVIKLAKELPPPSEEI
KTGEDEDEEDNDALLKENESPDVRRDKPVTGEQIEVFANKLGEQWKILAPYLEMKDSEIR
QIECDSEDMKMRAKQLLVAWQDQEGVHATPENLINALNKSGLSDLAESLTNDNETNS
NT seq 1974 nt   +upstreamnt  +downstreamnt
atgtctccgacgccgccgctcttcagtttgcccgaagcgcggacgcggtttacgaagtct
accagagaggccttgaacaacaaaaacatcaagccattgttaagtaccttcagccaggta
cctggcagtgaaaatgaaaaaaaatgtacccttgaccaagctttcagaggtattctagaa
gaagaaattataaatcattcatcatgtgaaaacgttttagctattatttctcttgctatt
gggggagtaactgaaggtatttgtaccgcatctacaccttttgtattgttgggagatgtt
ttggattgtcttcctttggatcagtgtgacacaatattcacttttgtggaaaaaaatgtt
gctacttggaaatcaaatacattctattctgctgggaaaaattacttactacgtatgtgc
aatgatctcctaagaagattgtctaaatcccagaatacagtcttctgtggacggattcag
ctctttttggccaggcttttccctctgtctgagaaatcaggtcttaacttgcagagtcag
tttaatctggaaaatgtcactgttttcaatacaaatgagcaggaaagcaccctgggtcag
aagcacactgaagatagagaagaaggaatggatgtagaagaaggcgaaatgggagacgag
gaagctccaacaacgtgctctattccaattgattacaacctgtatcgaaaattctggtca
cttcaggattacttcaggaaccctgtgcaatgctatgagaagatttcatggaaaactttt
ctcaagtattctgaagaagttttagctgtttttaagagttataaattagatgatactcag
gcctcaagaaaaaagatggaagaattgaaaacaggaggagaacatgtatattttgcaaaa
tttttaacaagtgaaaagctgatggatttacaactgagtgacagtaactttcgtcgacac
atcctgttgcagtatctcattttattccaatatctcaaggggcaggtcaaattcaaaagt
tcaaactatgttttaactgatgagcaatcactttggattgaagatactacaaaatcagtt
tatcaactactatctgaaaacccccccgatggagaaagattttcaaagatggtagagcat
atattaaacactgaagaaaactggaactcgtggaaaaatgaaggttgcccaagttttgtg
aaagaaagaacatcagataccaaacctacgagaataattcggaagagaacagcacccgag
gacttcctagggaaaggacccaccaaaaaaattctgatgggaaatgaggagttaacaagg
ctttggaatctttgccctgataatatggaagcctgtaaatcagagacaagggaacacatg
cccactttggaggaattctttgaagaagccattgaacaggcagaccctgaaaatatggtg
gaaaatgaatataaggctgtgaacaattcaaattatggttggagagccctgagactatta
gcacggagaagccctcacttcttccagccaaccaaccagcagtttaaaagtttaccagaa
tatcttgaaaatatggtaataaagctagccaaggaattaccgcctccttctgaagaaata
aaaacaggtgaggatgaagatgaggaagataatgatgctctactgaaggaaaatgaaagt
cctgatgttcggcgagacaaacctgtaacaggagaacaaatagaggtatttgccaacaag
ctgggtgaacaatggaagattctggctccctacttggaaatgaaagactcagaaattagg
cagattgagtgtgacagtgaagacatgaagatgagagctaagcagctcctggttgcctgg
caagatcaagagggagttcatgcaacacctgagaatctgattaatgcactgaataagtct
ggattaagtgaccttgcagaaagtctaactaatgacaatgagacaaatagttag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
   PHAROS (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (29)   
   RefSeq(nuc) (9)   
   GenBank (10)   
   EMBL (10)   
3D Structure (2)   
   PDB (2)   
Protein domain (2)   
   Pfam (2)   
All databases (77)   

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