KEGG   VARIANT: 3845v1Help
Entry
3845v1                      Variant                                

Name
KRAS mutation
Gene
KRAS  KRAS proto-oncogene, GTPase [KO:K07827]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
mutation G12D
ClinVar: 12582
dbSNP: rs121913529
COSM: 521
Variation
mutation G12V
ClinVar: 12583
dbSNP: rs121913529
COSM: 520
Variation
mutation G13D
ClinVar: 12580
dbSNP: rs112445441
COSM: 532
Variation
mutation G12C
ClinVar: 12578
dbSNP: rs121913530
COSM: 516
Network
nt06210  ERK signaling
nt06213  Other RAS signaling
nt06214  PI3K signaling
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06266  Non-small cell lung cancer
nt06268  Melanoma
nt06271  Endometrial cancer
nt06274  Thyroid cancer
nt06275  Acute myeloid leukemia
  Element
N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00104  Mutation-activated KRAS to RalGDS signaling pathway
Reference
  Authors
Prior IA, Lewis PD, Mattos C
  Title
A comprehensive survey of Ras mutations in cancer.
  Journal
Cancer Res 72:2457-67 (2012)
DOI:10.1158/0008-5472.CAN-11-2612
Reference
  Authors
Bowen DT, Frew ME, Hills R, Gale RE, Wheatley K, Groves MJ, Langabeer SE, Kottaridis PD, Moorman AV, Burnett AK, Linch DC
  Title
RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years.
  Journal
Blood 106:2113-9 (2005)
DOI:10.1182/blood-2005-03-0867

KEGG   VARIANT: 4893v1Help
Entry
4893v1                      Variant                                

Name
NRAS mutation
Gene
NRAS  NRAS proto-oncogene, GTPase [KO:K07828]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
mutation G13V
ClinVar: 375876
dbSNP: rs121434596
COSM: 574
Variation
mutation G13D
ClinVar: 13901
dbSNP: rs121434596
COSM: 573
Variation
mutation Q61R
ClinVar: 13900 375873 376220
dbSNP: rs11554290 rs1057519695 rs1057519834
COSM: 584
Variation
mutation Q61H
ClinVar: 375871 373003
dbSNP: rs12193255 rs12193255
Variation
mutation G12D
ClinVar: 39648
dbSNP: rs12193237
COSM:564
Variation
mutation Q61K
ClinVar: 73058
dbSNP: rs121913254
COSM:580
Variation
mutation Q61L
ClinVar: 375872 375874
dbSNP: rs1057519695 rs11554290
Variation
mutation G12S
ClinVar: 177778
dbSNP: rs121913250
COSM: 563
Variation
mutation G13S
ClinVar: 376221
dbSNP: rs121434595
COSM: 571
Network
nt06210  ERK signaling
nt06214  PI3K signaling
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06266  Non-small cell lung cancer
nt06268  Melanoma
nt06271  Endometrial cancer
nt06274  Thyroid cancer
nt06275  Acute myeloid leukemia
  Element
N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
Reference
PMID:3103719
  Authors
Bos JL, Verlaan-de Vries M, van der Eb AJ, Janssen JW, Delwel R, Lowenberg B, Colly LP
  Title
Mutations in N-ras predominate in acute myeloid leukemia.
  Journal
Blood 69:1237-41 (1987)
Reference
PMID:2674680
  Authors
van 't Veer LJ, Burgering BM, Versteeg R, Boot AJ, Ruiter DJ, Osanto S, Schrier PI, Bos JL
  Title
N-ras mutations in human cutaneous melanoma from sun-exposed body sites.
  Journal
Mol Cell Biol 9:3114-6 (1989)
DOI:10.1128/MCB.9.7.3114
Reference
  Authors
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J.
  Title
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
  Journal
Clin Cancer Res 9:6483-8 (2003)
Reference
  Authors
Takahashi N, Yamada Y, Taniguchi H, Fukahori M, Sasaki Y, Shoji H, Honma Y, Iwasa S, Takashima A, Kato K, Hamaguchi T, Shimada Y
  Title
Clinicopathological features and prognostic roles of KRAS, BRAF, PIK3CA and NRAS mutations in advanced gastric cancer.
  Journal
BMC Res Notes 7:271 (2014)
DOI:10.1186/1756-0500-7-271

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