KEGG   ORTHOLOGY: K00234Help
Entry
K00234                      KO                                     

Name
SDHA, SDH1
Definition
succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]
Pathway
ko00020  Citrate cycle (TCA cycle)
ko00190  Oxidative phosphorylation
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01130  Biosynthesis of antibiotics
ko01200  Carbon metabolism
ko04714  Thermogenesis
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko05010  Alzheimer disease
ko05012  Parkinson disease
ko05016  Huntington disease
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00148  Succinate dehydrogenase (ubiquinone)
Disease
H00294  Dilated cardiomyopathy (DCM)
H01022  Diseases of the tricarboxylic acid cycle
H01354  Leigh syndrome
H02005  Mitochondrial complex II deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
 09160 Human Diseases
  09163 Neurodegenerative diseases
   05010 Alzheimer disease
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
   05012 Parkinson disease
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
   05016 Huntington disease
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
  09166 Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Central carbohydrate metabolism
    M00009  Citrate cycle (TCA cycle, Krebs cycle)
     K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
    M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
     K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
 Structural complex
  Energy metabolism
   ATP synthesis
    M00148  Succinate dehydrogenase (ubiquinone)
     K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.5  With a quinone or related compound as acceptor
    1.3.5.1  succinate dehydrogenase
     K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit
BRITE hierarchy
Other DBs
RN: R02164
COG: COG1053
GO: 0008177
Genes
HSA: 6389(SDHA)
PTR: 107974583(SDHA)
PPS: 100987473(SDHA)
GGO: 101124208 101141874(SDHA) 101147313
PON: 100173631(SDHA)
NLE: 100580596 100593202(SDHA) 100594023
MCC: 708018(SDHA)
MCF: 102126003
CSAB: 103215231(SDHA) 103215235
RRO: 104659264 104662045 104668708(SDHA)
CJC: 100400483(SDHA)
SBQ: 101049489(SDHA)
MMU: 66945(Sdha)
RNO: 157074(Sdha)
CGE: 100750732(Sdha)
NGI: 103749659(Sdha)
HGL: 101697591(Sdha)
CCAN: 109693457(Sdha)
OCU: 100328584(SDHA)
TUP: 102502720(SDHA)
CFA: 478634(SDHA)
AML: 100483034(SDHA)
UMR: 103679246(SDHA)
ORO: 101382073(SDHA)
FCA: 751619(SDHA)
PTG: 102949810(SDHA)
AJU: 106988566(SDHA)
BTA: 281480(SDHA)
BOM: 102278228(SDHA)
PHD: 102332015(SDHA)
CHX: 102183107(SDHA)
OAS: 100036762(SDHA)
SSC: 780433(SDHA)
CFR: 102523856(SDHA)
CDK: 105102189(SDHA)
BACU: 103005047(SDHA)
LVE: 103090475(SDHA)
OOR: 101271279(SDHA)
ECB: 100034244(SDHA)
EPZ: 103560327(SDHA)
EAI: 106835869(SDHA)
MYB: 102240483(SDHA)
MYD: 102766070(SDHA)
HAI: 109371695(SDHA)
RSS: 109440254 109454181(SDHA)
PALE: 102897292(SDHA)
LAV: 100141371(SDHA)
TMU: 101357812
MDO: 751085(SDHA)
SHR: 100931806(SDHA)
OAA: 100083131(SDHA)
GGA: 395758(SDHA)
MGP: 100546340(SDHA)
CJO: 107309446(SDHA)
APLA: 101792265(SDHA)
ACYG: 106045013(SDHA)
TGU: 100217509 100230079(SDHA)
GFR: 102036351(SDHA)
FAB: 101819469(SDHA)
PHI: 102108670(SDHA)
PMAJ: 107200805(SDHA)
CCW: 104685847(SDHA)
FPG: 101916111(SDHA)
FCH: 102047706(SDHA)
CLV: 102093871(SDHA)
EGZ: 104128506(SDHA)
AAM: 106492875(SDHA)
ASN: 102372796(SDHA)
AMJ: 102561508(SDHA)
PSS: 102455030(SDHA)
CMY: 102943548(SDHA)
CPIC: 101930831(SDHA)
ACS: 100551545(sdha)
PVT: 110090570(SDHA)
GJA: 107118404(SDHA)
XLA: 380463(sdha.S) 398946(sdha.L)
XTR: 548743(sdha)
NPR: 108803812(SDHA)
DRE: 393884(sdha)
IPU: 108272761(sdha)
AMEX: 103022581(sdha)
TRU: 101076572(sdha)
LCO: 104928090(sdha) 109138819
NCC: 104952821(sdha)
MZE: 101470960(sdha)
XMA: 102235474(sdha)
PRET: 103478296(sdha)
NFU: 107378888(sdha)
CSEM: 103388781(sdha)
LCF: 108888123(sdha)
HCQ: 109529672(sdha)
BPEC: 110171397(sdha)
SFM: 108931739(sdha)
LCM: 102348838(SDHA)
CMK: 103181549(sdha)
CIN: 100183000
SPU: 580610
APLC: 110986692
SKO: 100371134
DME: Dmel_CG17246(SdhA) Dmel_CG5718(SdhAL)
DSI: Dsimw501_GD12763(Dsim_GD12763) Dsimw501_GD25325(Dsim_GD25325)
MDE: 101898176
AAG: 5575223
AME: 408734(GB15847) 550667(SdhA)
NVI: 100119074(Sdha) 100119112
NVL: 108560967
API: 100166540
DNX: 107161701
ZNE: 110840631
FCD: 110845478
TUT: 107362728
CEL: CELE_C03G5.1(sdha-1) CELE_C34B2.7(sdha-2)
CBR: CBG12805(Cbr-sdha-2) CBG22795(Cbr-sdha-1)
BMY: Bm1_17330
TSP: Tsp_06974
CRG: 105337089
MYI: 110450908
SHX: MS3_00508
EPA: 110233821
HMG: 100210215
AQU: 100632409
ATH: AT2G18450(SDH1-2) AT5G66760(SDH1-1)
ALY: ARALYDRAFT_480752(SDH1-2) ARALYDRAFT_496924(SDH1-1)
CPAP: 110822288
CIT: 102623970
TCC: 18610944
EGR: 104419754
LJA: Lj4g3v0948900.1(Lj4g3v0948900.1)
ADU: 107487854
AIP: 107642871
FVE: 101303935
PPER: 18769030
PMUM: 103340079
PAVI: 110773605
ZJU: 107424596
CSV: 101211616
CMO: 103494381
MCHA: 111008239
CMAX: 111483154
CMOS: 111435915
CPEP: 111810124
RCU: 8283123
JCU: 105641357
VVI: 100254718
SLY: 101256641
SPEN: 107011073
SOT: 102604123
CANN: 107859955
NSY: 104241425
NTO: 104115838
LSV: 111901866
BVG: 104895015
SOE: 110803652
OSA: 4342350
DOSA: Os07t0134800-01(Os07g0134800)
OBR: 102704350
ATS: 109753010(LOC109753010) 109757946(LOC109757946)
ZMA: 100279930(TIDP3457) 100280324 103636824
DCT: 110098030
ATR: 18445831
CRE: CHLREDRAFT_195972(SDH1)
VCN: VOLCADRAFT_74298(sdh1)
MIS: MICPUN_106467(SDH2)
APRO: F751_1347
SCE: YJL045W YKL148C(SDH1)
ERC: Ecym_8248
KMX: KLMA_20466(SDH1)
NCS: NCAS_0F02320(NCAS0F02320)
NDI: NDAI_0C03810(NDAI0C03810)
TPF: TPHA_0E02930(TPHA0E02930)
TBL: TBLA_0A10080(TBLA0A10080)
TDL: TDEL_0E03730(TDEL0E03730)
KAF: KAFR_0H03590(KAFR0H03590)
PIC: PICST_66251(SDH1)
CAUR: QG37_03344
SLB: AWJ20_4699(SDH1)
NCR: NCU08336(tca-12)
NTE: NEUTE1DRAFT71896(NEUTE1DRAFT_71896)
MGR: MGG_00168
MAW: MAC_01061
MAJ: MAA_05673
CMT: CCM_02366
MBE: MBM_01461
ANI: AN2916.2
ANG: ANI_1_1750024(An02g12770) ANI_1_2706024(An02g07600)
ABE: ARB_06591
TVE: TRV_04812
PNO: SNOG_07395(SNOG_07394) SNOG_16547(SNOG_16546)
SPO: SPAC1556.02c(sdh1)
CNE: CNI03270
CNB: CNBH3130
ABP: AGABI1DRAFT111304(SDH1)
ABV: AGABI2DRAFT190526(SDH1)
SLA: SERLADRAFT_475471(SDH1)
MGL: MGL_3463
DDI: DDB_G0280535(sdhA)
DFA: DFA_01593(sdhA)
PYO: PY17X_0519300(PY05468)
PCB: PCHAS_051830(PC001322.02.0)
TAN: TA03455
TPV: TP03_0230
BBO: BBOV_IV007210(23.m06369)
SMIN: v1.2.013871.t1(symbB.v1.2.013871.t1) v1.2.031094.t1(symbB.v1.2.031094.t1)
PTI: PHATR_41812(SDH1)
FCY: FRACYDRAFT_173934(SDH5)
SPAR: SPRG_13201
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8142412
  Authors
Morris AA, Farnsworth L, Ackrell BA, Turnbull DM, Birch-Machin MA
  Title
The cDNA sequence of the flavoprotein subunit of human heart succinate dehydrogenase.
  Journal
Biochim Biophys Acta 1185:125-8 (1994)
DOI:10.1016/0005-2728(94)90203-8
  Sequence
[hsa:6389]
Reference
  Authors
Renkema GH, Wortmann SB, Smeets RJ, Venselaar H, Antoine M, Visser G, Ben-Omran T, van den Heuvel LP, Timmers HJ, Smeitink JA, Rodenburg RJ
  Title
SDHA mutations causing a multisystem mitochondrial disease: novel mutations and genetic overlap with hereditary tumors.
  Journal
Eur J Hum Genet 23:202-9 (2015)
DOI:10.1038/ejhg.2014.80

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