KEGG ORTHOLOGY: K00543

ORTHOLOGY: K00543

Entry

K00543                      KO

Symbol

ASMT

Name

acetylserotonin O-methyltransferase [EC:2.1.1.4]

Pathway

map00380

Tryptophan metabolism

map01100

Metabolic pathways

Module

M00037

Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin

Reaction

R03130

S-adenosyl-L-homocysteine:N-acetylserotonin O-methyltransferase

R04905

S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K00543  ASMT; acetylserotonin O-methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.4  acetylserotonin O-methyltransferase
     K00543  ASMT; acetylserotonin O-methyltransferase

Other DBs

GO:

0017096

Genes

HSA:

438(ASMT)

PTR:	107971195(ASMT)

PPS:	100968232(ASMT)

PON:	100457801(ASMT)

NLE:	100594711(ASMT)

MCC:	574350(ASMT)

MCF:	102123281(ASMT)

MTHB:

126946854 126947141

MNI:	105478259(ASMT)

CSAB:

103232876(ASMT)

CATY:

105574778(ASMT)

PANU:

101016694(ASMT)

TGE:	112615123(ASMT)

MLEU:

105537122(ASMT)

RBB:	108516657(ASMT)

TFN:	117076215(ASMT)

CANG:

105516176(ASMT)

CJC:

100406578

CIMI:

108296371(ASMT)

MMUR:

105870820(ASMT)

LCAT:

123628068(ASMT)

PCOQ:

105820335(ASMT)

OGA:	100946414(ASMT)

MMU:	107626(Asmt)

MCAL:

110288766(Asmt)

MPAH:

110315745(Asmt)

RNO:	246281(Asmt)

ANU:	117695741(Asmt)

MUN:	110542401(Asmt)

CGE:

113838540

MAUA:

101839364(Asmt)

PROB:

127214765 127217575

MORG:

121443725 121444542 121445347

MFOT:

126495523

AAMP:

119826834

NGI:	103750116(Asmt)

HGL:	101697837(Asmt)

DORD:

106000184(Asmt)

DSP:	122102637 122102762

PLOP:

125345394(Asmt)

NCAR:

124972173

OPI:	101532831(ASMT)

TUP:	102472243(ASMT)

GVR:	103586843(ASMT)

CFA:	100683688(ASMT)

CLUD:

112651992(ASMT)

VVP:	112908965(ASMT)

VLG:	121483444(ASMT)

NPO:	129518656(ASMT)

AML:	100466738(ASMT)

UMR:	103666293(ASMT)

UAH:	113240809(ASMT)

UAR:	123802762(ASMT)

ELK:

111157193

LLV:

125092380

MPUF:

101694091(ASMT)

MNP:	132007414(ASMT)

MLK:	131821369(ASMT)

NVS:	122896952(ASMT)

ORO:	101380092(ASMT)

EJU:	114218018(ASMT)

ZCA:	113931316(ASMT)

MLX:	118026672(ASMT)

NSU:	110570022(ASMT)

LWW:	102749404(ASMT)

FCA:	101101365(ASMT)

PYU:	121020204(ASMT) 121024201

PBG:	122477503(ASMT)

PVIV:

125159259(ASMT)

LRUF:

124509606

PTG:	102965330(ASMT)

PPAD:

109256144(ASMT)

PUC:

125931445

AJU:

106982046

HHV:	120240552(ASMT)

BTA:	281013(ASMT)

BOM:	102278615(ASMT)

BBUB:

102402187(ASMT)

BBIS:

104996841(ASMT)

CHX:	100861249(ASMT)

OAS:	101114754(ASMT)

BTAX:

128069818(ASMT)

ODA:	120882418(ASMT)

CCAD:

122434360(ASMT)

MBEZ:

129535155(ASMT)

SSC:

110258194

CFR:	102511012(ASMT)

CBAI:

105079530(ASMT)

CDK:	105103096(ASMT)

VPC:	102538364(ASMT)

BACU:

103008325(ASMT)

BMUS:

118889129(ASMT)

LVE:	103086659(ASMT)

OOR:	101269606(ASMT)

DLE:	111168289(ASMT)

PCAD:

102992951(ASMT)

PSIU:

116747745(ASMT)

NASI:

112415229(ASMT)

ECB:	100146729(ASMT)

EPZ:	103544951(ASMT)

EAI:	106821899(ASMT)

MYB:	102248110(ASMT)

MYD:	102766854(ASMT)

MMYO:

118657291(ASMT)

EFUS:

129150051(ASMT)

MNA:	107542463(ASMT)

DRO:	112313231(ASMT)

SHON:

118974337(ASMT)

AJM:	119045533(ASMT)

PDIC:

114489900(ASMT)

PHAS:

123830129(ASMT)

MMF:	118635966(ASMT)

PPAM:

129079761(ASMT)

HAI:	109375564(ASMT)

RFQ:	117025862(ASMT)

PALE:

102895851(ASMT)

PGIG:

120619045(ASMT)

PVP:	105309071(ASMT)

RAY:	107509923(ASMT) 107510818

TOD:	119246796(ASMT)

SARA:

101542906(ASMT)

SETR:

126000584(ASMT)

LAV:	100656176(ASMT)

TMU:

101351625

MDO:	100010602(ASMT)

GAS:	123239704(ASMT)

SHR:	100931838(ASMT)

AFZ:

127553690

PCW:	110212828(ASMT)

GGA:	396286(ASMT)

PCOC:

116230784(ASMT)

MGP:

100547251

CJO:	107305906(ASMT)

TPAI:

128071719(ASMT)

LMUT:

125688412(ASMT)

NMEL:

110405835(ASMT)

ACYG:

106035745(ASMT)

CATA:

118245767(ASMT)

AFUL:

116502250(ASMT)

TGU:	100223806(ASMT)

LSR:	110479371(ASMT)

SCAN:

103812316(ASMT)

PMOA:

120510174(ASMT)

OTC:	121345337(ASMT)

PRUF:

121354077 121354122(ASMT)

GFR:	102034059(ASMT)

FAB:	101816146(ASMT)

OMA:	130252078(ASMT)

PHI:	102106159(ASMT)

PMAJ:

107211015(ASMT)

CCAE:

111945698(ASMT)

CCW:	104686012(ASMT)

CBRC:

103611766(ASMT)

ETL:	114067000(ASMT)

ZAB:	102068772(ASMT)

ACHL:

103807790(ASMT)

SVG:	106862585(ASMT)

MMEA:

130577912(ASMT)

HRT:	120749052(ASMT)

FPG:	101921940(ASMT)

FCH:	102059795(ASMT)

CLV:	102093193(ASMT)

EGZ:	104125159(ASMT)

NNI:	104009836(ASMT)

PCRI:

104032563(ASMT)

PLET:

104622691(ASMT)

EHS:	104517355(ASMT)

PCAO:

104053078(ASMT)

ACUN:

113481640(ASMT)

TALA:

104365399(ASMT)

PADL:

103923027(ASMT)

AFOR:

103900642(ASMT)

ACHC:

115334543(ASMT)

HALD:

104325372(ASMT)

HLE:	104839869(ASMT)

AGEN:

126053045

GCL:

127024923

CCRI:

104154486(ASMT)

CMAC:

104486309(ASMT)

MUI:	104541176(ASMT)

BREG:

104635287(ASMT)

FGA:	104069105(ASMT)

GSTE:

104250290(ASMT)

LDI:	104342081(ASMT)

MNB:	103780791(ASMT)

OHA:	104326404(ASMT)

NNT:	104399038(ASMT)

SHAB:

115604005(ASMT)

DPUB:

104302145(ASMT)

PGUU:

104471253(ASMT)

ACAR:

104529150(ASMT)

CPEA:

104391828(ASMT)

AVIT:

104276945(ASMT)

CVF:	104290351(ASMT)

RTD:	128911416(ASMT)

CUCA:

104063724(ASMT)

TEO:	104373904(ASMT)

BRHI:

104497662(ASMT)

AAM:	106490940(ASMT)

AROW:

112968865(ASMT)

NPD:	112944022(ASMT)

TGT:	104570661(ASMT)

DNE:

112996763

SCAM:

104138696(ASMT)

ASN:	102386765(ASMT)

AMJ:	102575782(ASMT)

CPOO:

109306007(ASMT)

GGN:	109302482(ASMT)

PSS:	102457160(ASMT) 102457574

CMY:	102941645 102941873

CCAY:

125640798 125640803

DCC:	119844621(ASMT)

CPIC:

101936567(ASMT) 101938338

CABI:

116816321 116816338

MRV:	120383012 120395792 120395794 120395795

ACS:	100553393 100554348(asmt) 100557477 100557672 100561592 100562136 100562579 100562776 100567799 100567994 103277504 103279712

ASAO:

132766454 132766455 132769980 132769981 132769982 132769983 132769984 132771638(ASMT)

PVT:	110070785 110070786 110075585 110085416 110085441 110085442 110085443 110090148 110090150

SUND:

121924699 121924700 121924701 121924702 121925830 121925832 121925834 121926228 121926262 121926614 121926871(ASMT)

PBI:	103059937(ASMT)

PMUR:

107286536 107286538 107294461

CTIG:

120313672 120313676 120313678 120313679

TSR:	106540010 106549727 106554057(ASMT)

PGUT:

117658084 117658471 117659087 117659298 117659424 117659969 117660121 117666934 117673715 117673798(ASMT)

APRI:

131199692 131199693 131199695 131199723 131199962 131199963 131199964 131200088 131200125(ASMT)

PTEX:

113440784 113440785 113440786 113440787 113440842 113440843 113440845(ASMT) 113440846

NSS:	113411578 113411579 113411580 113411729 113411743(ASMT)

VKO:	123025348 123033223(ASMT)

PMUA:

114595348(ASMT) 114595351 114595352 114595353 114596398 114596399

PRAF:

128411790 128411791 128411792 128412402 128413244(ASMT)

ZVI:	118085464(ASMT) 118085691 118085693 118085694 118085697 118085698 118085744

HCG:	128350417 128351472(ASMT)

GJA:	107120387(ASMT)

STOW:

125431336(ASMT)

EMC:	129326071 129326177 129326459 129326477 129326550(ASMT)

XLA:	108709071(asmt.S)

XTR:	496888(asmt)

NPR:	108793182(ASMT)

RTEM:

120927478(ASMT) 120927479

BBUF:

120993281 120993678 120994863 120994864 120994865 120994867

BGAR:

122931737 122932660 122932695 122932900 122933182 122935343 122935721

MUO:	115468122 115468123

GSH:	117362958(ASMT)

DRE:	100141344(asmt) 568256(asmt2)

SRX:	107711955 107721495 107749230(asmt)

SANH:

107654826 107668509 107697797(asmt)

SGH:	107566579(asmt) 107590930

CCAR:

109108087

CAUA:

113109204(asmt) 113117525 113117572

CGIB:

127964935 127976092

PTET:

122333026(asmt) 122361757(asmt2)

LROH:

127170535(asmt) 127180181(asmt2)

OMC:	131522811(asmt2) 131547291(asmt)

PPRM:

120487322(asmt2)

RKG:	130073466(asmt2) 130105369(asmt)

MAMB:

125269153(asmt2) 125269539(asmt)

CIDE:

127499151 127519140

MASI:

127411555 127448275

TROS:

130555408(asmt) 130560378(asmt2)

TDW:	130427303(asmt) 130436585(asmt2)

MANU:

129417127(asmt2) 129451554(asmt)

IPU:	108266217(asmt) 108270049(asmt2)

IFU:	128609318(asmt) 128612855(asmt2)

PHYP:

113524340(asmt) 113545123

SMEO:

124379824(asmt)

TFD:	113640490(asmt2) 113642110(asmt)

TVC:	132850570(asmt) 132852046(asmt2)

AMEX:

103034755 103044675(asmt)

CMAO:

118809593(asmt) 118823888(asmt2)

EEE:	113586732(asmt)

CHAR:

105898096(asmt) 122131781(asmt2)

TRU:	101072678(asmt) 101079954

TFS:	130513144(asmt2) 130525867(asmt)

TNG:	GSTEN00023328G001 GSTEN00030451G001

LCO:	104923845(asmt) 104937665

NCC:	104942862(asmt)

TBEN:

117480060(asmt2) 117485872(asmt)

CGOB:

115026565(asmt) 115027136

PGEO:

117467071(asmt) 117467670(asmt2)

GACU:

117558940(asmt2) 117560131(asmt)

EMAC:

134867526(asmt) 134881548(asmt2)

ELY:	117251693(asmt) 117267285(asmt2)

EFO:	125899464(asmt) 125900651(asmt2)

PLEP:

121949552(asmt) 121953800(asmt2) 121963288

SLUC:

116036795(asmt2) 116037745(asmt)

ECRA:

117936141(asmt2) 117953240(asmt)

ESP:	116695950 116697565(asmt)

PFLV:

114546790 114564545(asmt)

GAT:	120833317(asmt2) 120833566(asmt)

PPUG:

119227820(asmt2) 119228336(asmt)

AFB:	129103815(asmt2) 129105003(asmt)

CLUM:

117750757(asmt) 117751204(asmt2)

PSWI:

130208809(asmt)

MSAM:

119904581(asmt) 119910192(asmt2)

SCHU:

122861388(asmt2) 122886038(asmt)

CUD:	121522973(asmt) 121526411(asmt2)

ALAT:

119025887(asmt) 119034306(asmt2)

MZE:	101473716 101482331(asmt)

ONL:	100692897 100697334(asmt)

OAU:	116311951(asmt) 116329033(asmt2)

OLA:	101155734 101166758(asmt)

OML:	112148334(asmt2) 112155348(asmt)

CSAI:

133446478(asmt) 133462244(asmt2)

XMA:	102225007(asmt) 102236297

XCO:	114134515 114147679(asmt)

XHE:	116709187 116722617(asmt)

PRET:

103461453(asmt)

PFOR:

103129115 103141459(asmt) 103149431

PLAI:

106940144 106949064(asmt) 106952479

PMEI:

106918884(asmt) 106921139 106922542

GAF:	122839351(asmt) 122846142(asmt2)

PPRL:

129361268(asmt) 129377283(asmt2)

CVG:	107087107 107104193(asmt)

CTUL:

119775138(asmt) 119796203(asmt2)

GMU:	124856065(asmt2) 124871029(asmt)

NFU:	107390146(asmt) 107391898

KMR:	108240421(asmt) 108249919(asmt2)

ALIM:

106519738(asmt) 106519950

NWH:	119419074(asmt) 119427098(asmt2)

AOCE:

111584885(asmt) 111585950

MCEP:

125017288(asmT) 125023759(asmt2)

CSEM:

103392244(asmt)

POV:	109631129(asmt) 109647786 109647889

SSEN:

122765204(asmt)

HHIP:

117755464(asmt) 117756740(asmt2)

HSP:	118115901(asmt2) 118119671(asmt)

SMAU:

118286016(asmt2) 118320526(asmt)

LCF:	108892755 108902203(asmt2)

SDU:	111218208(asmt) 111225582

SLAL:

111659875 111662718(asmt)

XGL:	120795101(asmt2) 120801723(asmt)

HCQ:	109521119 109531283(asmt)

SSCV:

125973678 125980628

SBIA:

133512419(asmt) 133513087(asmt2)

PEE:	133410747(asmt) 133412521

PTAO:

133486847(asmt) 133488324(asmt2)

BPEC:

110156077 110159972

MALB:

109962406 109964371(asmt)

BSPL:

114847552(asmt) 114848561(asmt2)

SJO:	128367464(asmt) 128375667(asmt2)

SASA:

106582195 106586510(asmt) 106611414 106611424

STRU:

115161042(asmt) 115161806

OTW:	112224519(asmt2) 112239807

OMY:	110502086 110506012(asmt2) 110520357

OGO:	124044057(asmt) 124045376(asmt2)

ONE:	115111702(asmt) 115121856

OKI:	109880781 109902910(asmt)

OKE:

118366840

SALP:

111978003(asmt) 112072454

SNH:	120036611(asmt2) 120058059 120063973

CCLU:

121536310 121555335(asmt2)

ELS:	105015875 105016360(asmt)

SFM:	108920780 108929286(asmt)

PKI:	111844195 111846849(asmt)

AANG:

118214462(asmt)

LOC:	102683240 102688117(asmt)

PSPA:

121320676 121325361(asmt2)

ARUT:

117406496(asmt) 117420733(asmt2)

PSEX:

120522848(asmt) 120527831(asmt2)

LCM:	102347098(ASMT)

CMK:

103177093

RTP:	109913070(asmt)

CPLA:

122550919(asmt)

HOC:	132816876(asmt)

LERI:

129716262 129716283

PMRN:

116942897(ASMT) 116951550

LRJ:	133340963 133342924

BFO:	118406542 118407243

BBEL:

109477119

SKO:	100366472 100376491 102802951

HRO:	HELRODRAFT_175003 HELRODRAFT_192339

LGI:	LOTGIDRAFT_173251

PVUL:

PCAN:

GAE:

HRF:

CRG:

CVN:

MYI:

PMAX:

OBI:

OSN:

NVE:	5498266 5506515 5506520 5514889 5519567 5520388

EPA:	110231916 110249440

ATEN:

116291505 116307473

DGT:	114520633 114533355 114533363

XEN:	124453238 124455459 124455460 124455637 124455638 124455640

» show all

Reference

PMID:22775292

Authors

Botros HG, Legrand P, Pagan C, Bondet V, Weber P, Ben-Abdallah M, Lemiere N, Huguet G, Bellalou J, Maronde E, Beguin P, Haouz A, Shepard W, Bourgeron T

Title

Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway.

Journal

J Pineal Res 54:46-57 (2013)
DOI:10.1111/j.1600-079X.2012.01020.x

Sequence

[hsa:438]

All links

Ontology (3)   
   KEGG BRITE (2)   
   GO (1)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (809)   
   KEGG GENES (646)   
   KEGG MGENES (105)   
   RefGene (53)   
   OC (5)   
Literature (1)   
   PubMed (1)   
All databases (823)   

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