KEGG   ORTHOLOGY: K00922Help
Entry
K00922                      KO                                     

Name
PIK3CA_B_D
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Pathway
ko00562  Inositol phosphate metabolism
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04210  Apoptosis
ko04211  Longevity regulating pathway
ko04212  Longevity regulating pathway - worm
ko04213  Longevity regulating pathway - multiple species
ko04218  Cellular senescence
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04380  Osteoclast differentiation
ko04510  Focal adhesion
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04611  Platelet activation
ko04620  Toll-like receptor signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04630  JAK-STAT signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04668  TNF signaling pathway
ko04670  Leukocyte transendothelial migration
ko04722  Neurotrophin signaling pathway
ko04725  Cholinergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04917  Prolactin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04926  Relaxin signaling pathway
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04960  Aldosterone-regulated sodium reabsorption
ko04973  Carbohydrate digestion and absorption
ko05100  Bacterial invasion of epithelial cells
ko05142  Chagas disease (American trypanosomiasis)
ko05146  Amoebiasis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
ko05418  Fluid shear stress and atherosclerosis
Module
M00676  PI3K-Akt signaling
Disease
H00027  Ovarian cancer
H00031  Breast cancer
H00048  Hepatocellular carcinoma
H01102  Pituitary adenomas
H01222  Cowden syndrome
H01387  Activated PI3K-delta syndrome (APDS)
H01431  Cushing syndrome
H01912  Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi
H01985  Desmoplastic small round cell tumor
H02153  Megalencephaly-capillary malformation syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04015 Rap1 signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04012 ErbB signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04370 VEGF signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04630 Jak-STAT signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04668 TNF signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04066 HIF-1 signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04068 FoxO signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04070 Phosphatidylinositol signaling system
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04072 Phospholipase D signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04071 Sphingolipid signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04024 cAMP signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04151 PI3K-Akt signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04152 AMPK signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04150 mTOR signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09143 Cell growth and death
   04210 Apoptosis
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04218 Cellular senescence
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04550 Signaling pathways regulating pluripotency of stem cells
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04620 Toll-like receptor signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04625 C-type lectin receptor signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04650 Natural killer cell mediated cytotoxicity
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04660 T cell receptor signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04662 B cell receptor signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04664 Fc epsilon RI signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04666 Fc gamma R-mediated phagocytosis
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04670 Leukocyte transendothelial migration
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04062 Chemokine signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09152 Endocrine system
   04910 Insulin signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04923 Regulation of lipolysis in adipocyte
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04915 Estrogen signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04914 Progesterone-mediated oocyte maturation
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04917 Prolactin signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04926 Relaxin signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04919 Thyroid hormone signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09156 Nervous system
   04725 Cholinergic synapse
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04722 Neurotrophin signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09158 Development
   04360 Axon guidance
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04380 Osteoclast differentiation
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09149 Aging
   04211 Longevity regulating pathway - mammal
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04212 Longevity regulating pathway - worm
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04213 Longevity regulating pathway - multiple species
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05230 Central carbon metabolism in cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05231 Choline metabolism in cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05205 Proteoglycans in cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05203 Viral carcinogenesis
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05210 Colorectal cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05212 Pancreatic cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05225 Hepatocellular carcinoma
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05226 Gastric cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05214 Glioma
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05221 Acute myeloid leukemia
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05220 Chronic myeloid leukemia
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05218 Melanoma
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05211 Renal cell carcinoma
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05215 Prostate cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05213 Endometrial cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05224 Breast cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05222 Small cell lung cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05223 Non-small cell lung cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09165 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09166 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04931 Insulin resistance
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04933 AGE-RAGE signaling pathway in diabetic complications
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09167 Infectious diseases
   05100 Bacterial invasion of epithelial cells
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05166 HTLV-I infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05162 Measles
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05164 Influenza A
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05161 Hepatitis B
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05160 Hepatitis C
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05163 Human cytomegalovirus infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05167 Kaposi sarcoma-associated herpesvirus infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05169 Epstein-Barr virus infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05165 Human papillomavirus infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05146 Amoebiasis
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05142 Chagas disease (American trypanosomiasis)
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   01524 Platinum drug resistance
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   01522 Endocrine resistance
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00676  PI3K-Akt signaling
     K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
BRITE hierarchy
Other DBs
RN: R04545
GO: 0046934
Genes
HSA: 5290(PIK3CA) 5291(PIK3CB) 5293(PIK3CD)
PTR: 457922(PIK3CD) 460858(PIK3CA) 471079(PIK3CB)
PPS: 100989732(PIK3CD) 100990108(PIK3CB) 100990828(PIK3CA)
GGO: 101143811(PIK3CA) 101146434(PIK3CD) 101152123(PIK3CB)
PON: 100432846(PIK3CB) 100453779(PIK3CA) 103889133(PIK3CD)
NLE: 100580872(PIK3CD) 100584384(PIK3CB) 100588218(PIK3CA)
MCC: 709959(PIK3CA) 710552(PIK3CD) 716098(PIK3CB)
MCF: 102122725(PIK3CA) 102142026(PIK3CB) 102143464(PIK3CD)
CSAB: 103221212(PIK3CA) 103225637(PIK3CD) 103241599(PIK3CB)
RRO: 104663050(PIK3CD) 104665061(PIK3CB) 104670605(PIK3CA)
RBB: 108532960(PIK3CA) 108539355(PIK3CD) 108544591(PIK3CB)
CJC: 100391655(PIK3CB) 100398849(PIK3CD) 100403494(PIK3CA)
SBQ: 101027982(PIK3CB) 101029768(PIK3CA) 101052779(PIK3CD)
MMU: 18706(Pik3ca) 18707(Pik3cd) 74769(Pik3cb)
RNO: 170911(Pik3ca) 366508(Pik3cd) 85243(Pik3cb)
CGE: 100689251(Pik3ca) 100689252(Pik3cb) 100769225(Pik3cd)
NGI: 103733121(Pik3cd) 103738596(Pik3ca) 103742946(Pik3cb)
HGL: 101711934(Pik3ca) 101712941(Pik3cd) 101715249(Pik3cb)
CCAN: 109681900(Pik3cd) 109689664(Pik3ca)
OCU: 100337822(PIK3CA) 100345181(PIK3CB) 100348663(PIK3CD)
TUP: 102483329(PIK3CA) 102500530(PIK3CD) 102502163(PIK3CB) 106736453
CFA: 477085(PIK3CB) 488084(PIK3CA) 489644(PIK3CD)
AML: 100463775(PIK3CB) 100479294(PIK3CA) 100479580(PIK3CD)
UMR: 103666874(PIK3CD) 103676125(PIK3CA) 103678592(PIK3CB)
ORO: 101370689(PIK3CA) 101385241(PIK3CB) 101385267(PIK3CD)
FCA: 101091892(PIK3CB) 101094274(PIK3CD) 101097413(PIK3CA)
PTG: 102953082(PIK3CD) 102965070(PIK3CA) 102972487(PIK3CB)
AJU: 106973880(PIK3CA) 106984265(PIK3CB) 106984896(PIK3CD)
BTA: 282306(PIK3CA) 504531(PIK3CD) 517948(PIK3CB)
BOM: 102274461(PIK3CD) 102274553(PIK3CA) 102277548(PIK3CB)
BIU: 109557823(PIK3CA) 109559805(PIK3CB) 109564614 109570415(PIK3CD)
PHD: 102320516(PIK3CB) 102321231(PIK3CA) 102333324(PIK3CD)
CHX: 102168391(PIK3CA) 102177551(PIK3CD) 102185042(PIK3CB)
OAS: 101109759(PIK3CB) 101110015(PIK3CA) 101117348(PIK3CD)
SSC: 100518131(PIK3CD) 100621789(PIK3CA) 100622559(PIK3CB)
CFR: 102518643(PIK3CD) 102519994(PIK3CB) 102523502(PIK3CA)
CDK: 105085928(PIK3CA) 105086305(PIK3CB) 105107003(PIK3CD)
BACU: 103012691(PIK3CA) 103012931(PIK3CB) 103014043(PIK3CD)
LVE: 103085303(PIK3CA) 103088756(PIK3CB) 103089257(PIK3CD)
OOR: 101278075(PIK3CA) 101278974(PIK3CD) 101283011(PIK3CB)
ECB: 100051623(PIK3CD) 100051753(PIK3CB) 100058141(PIK3CA)
EPZ: 103549076(PIK3CD) 103550588(PIK3CB) 103552150(PIK3CA) 103554655
EAI: 106829313(PIK3CA) 106836695(PIK3CD) 106838100(PIK3CB)
MYB: 102239669(PIK3CA) 102252921(PIK3CD) 102260487(PIK3CB)
MYD: 102758951(PIK3CA) 102764343(PIK3CB) 102766356(PIK3CD)
HAI: 109372681(PIK3CA) 109381238(PIK3CD) 109394108(PIK3CB)
RSS: 109455259(PIK3CD) 109455777(PIK3CB) 109458390(PIK3CA)
PALE: 102880320(PIK3CB) 102889227(PIK3CA) 102889576(PIK3CD)
LAV: 100657948(PIK3CA) 100658340(PIK3CB) 100666266(PIK3CD)
MDO: 100010412(PIK3CA) 100017332(PIK3CB) 100024769(PIK3CD)
SHR: 100929811(PIK3CB) 100932099(PIK3CA) 105749979(PIK3CD)
OAA: 100073788(PIK3CA) 100074273(PIK3CD) 100086270(PIK3CB)
GGA: 419444(PIK3CD) 424826(PIK3CB) 424971(PIK3CA)
MGP: 100543492(PIK3CD) 100546867(PIK3CA)
CJO: 107317945(PIK3CB) 107318114(PIK3CA) 107323497(PIK3CD)
APLA: 101796183(PIK3CA) 101800900(PIK3CB) 101802796(PIK3CD)
ACYG: 106032026(PIK3CA) 106040311(PIK3CB) 106044285(PIK3CD)
TGU: 100219602(PIK3CB) 100224188(PIK3CD) 100229768(PIK3CA)
GFR: 102040845(PIK3CB) 102040853(PIK3CD) 102042284(PIK3CA)
FAB: 101811931(PIK3CD) 101814811(PIK3CA) 101821801(PIK3CB)
PHI: 102099156(PIK3CA) 102103635(PIK3CD) 102106643(PIK3CB)
PMAJ: 107208827(PIK3CA) 107208852(PIK3CB) 107213667(PIK3CD)
CCW: 104688020(PIK3CA) 104693039(PIK3CB) 104693336(PIK3CD)
FPG: 101911441(PIK3CA) 101919202(PIK3CD) 101923805(PIK3CB)
FCH: 102049197(PIK3CA) 102049812(PIK3CD) 102057414(PIK3CB)
CLV: 102083735(PIK3CB) 102084293(PIK3CA) 102095297(PIK3CD)
EGZ: 104129991(PIK3CA) 104133065(PIK3CD) 104135481(PIK3CB)
AAM: 106482245(PIK3CA) 106496183(PIK3CB) 106499152(PIK3CD)
ASN: 102372482(PIK3CB) 102387818(PIK3CA) 102388304(PIK3CD)
AMJ: 102564312(PIK3CD) 102571877(PIK3CB) 106737094(PIK3CA)
PSS: 102448624(PIK3CA) 102459577(PIK3CD) 102461096(PIK3CB) 102462482
CMY: 102929971(PIK3CA) 102932183(PIK3CD) 102936956(PIK3CB)
CPIC: 101934126(PIK3CD) 101935421(PIK3CA) 101940315(PIK3CB) 101943751 101952320
ACS: 100562345(pik3ca) 100567254(pik3cb) 100567364 100568252(pik3cd)
PVT: 110071696 110073252(PIK3CD) 110078719(PIK3CB) 110081909(PIK3CA) 110082359
PBI: 103049546(PIK3CB) 103050043(PIK3CA) 103061550(PIK3CD) 103063682
GJA: 107107376(PIK3CD) 107110507(PIK3CB) 107110982(PIK3CA) 107118085
XLA: 108717120(pik3cb.L) 108718090 108718190(pik3cb.S) 373752(pik3ca.L)
XTR: 100144924(pik3ca) 780390(pik3cb)
NPR: 108785765(PIK3CA) 108796670(PIK3CB) 108798423(PIK3CD)
DRE: 100002263(pik3cb) 394174(pik3cd) 561737(pik3ca)
IPU: 108271155(pik3ca) 108275608 108276156(pik3cd) 108280664(pik3cb)
AMEX: 103022173(pik3cb) 103032909 103041606(pik3ca) 103045036(pik3cd)
LCO: 104919391(pik3cb) 104921281 104927097(pik3cd) 104933269(pik3ca) 104934900
OLA: 101161626(pik3ca) 101161887(pik3cd) 101165660(pik3cb) 101168152
PRET: 103463230(pik3ca) 103467210(pik3cd) 103474947(pik3cb) 103475907 103479066
CSEM: 103378227(pik3cb) 103385041(pik3cd) 103396148 103396566(pik3ca) 107988201
LCM: 102350948(PIK3CA) 102351332 102351622(PIK3CD) 102359335(PIK3CB)
CMK: 103175241(pik3cb) 103175843(pik3ca) 103184230(pik3cd)
DME: Dmel_CG4141(Pi3K92E)
DSI: Dsimw501_GD20048(Dsim_GD20048)
MDE: 101900071
AAG: 5576468
AME: 551500
BIM: 100748255
BTER: 100646352
SOC: 105205485
AEC: 105149725
ACEP: 105620083
PBAR: 105432118
HST: 105189236
CFO: 105253109
LHU: 105678402
PGC: 109855345
NVI: 100115810(Pik3cb)
TCA: 657286
DPA: 109538758
NVL: 108565087
BMOR: 101741278
PMAC: 106718395
PRAP: 110995586
PXY: 105394660
API: 100160001
DNX: 107164340
ZNE: 110828562
FCD: 110846541
CEL: CELE_B0334.8(age-1)
CBR: CBG02868(Cbr-age-1)
BMY: Bm1_55680
SHX: MS3_06635
ADF: 107327044
MBR: MONBRDRAFT_18656(PI3K-CA_alpha)
DDI: DDB_G0268548(pikF) DDB_G0275011(pikC) DDB_G0278727(pikA) DDB_G0282625(pikG) DDB_G0283081(pikB)
DFA: DFA_00682 DFA_02787(pikB) DFA_06196(pikC) DFA_10225(pikF) DFA_11886(pikA)
EHI: EHI_006130(83.t00026) EHI_095130(269.t00003) EHI_188970(67.t00015)
EHX: EMIHUDRAFT_632222(PI3K1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7713498
  Authors
Volinia S, Hiles I, Ormondroyd E, Nizetic D, Antonacci R, Rocchi M, Waterfield MD
  Title
Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene.
  Journal
Genomics 24:472-7 (1994)
DOI:10.1006/geno.1994.1655
  Sequence
[hsa:5290]
Reference
PMID:8246984
  Authors
Hu P, Mondino A, Skolnik EY, Schlessinger J
  Title
Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.
  Journal
Mol Cell Biol 13:7677-88 (1993)
DOI:10.1128/MCB.13.12.7677
  Sequence
[hsa:5291]
Reference
PMID:9113989
  Authors
Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD
  Title
P110delta, a novel phosphoinositide 3-kinase in leukocytes.
  Journal
Proc Natl Acad Sci U S A 94:4330-5 (1997)
DOI:10.1073/pnas.94.9.4330
  Sequence
[hsa:5293]

KEGG   ORTHOLOGY: K02649Help
Entry
K02649                      KO                                     

Name
PIK3R1_2_3
Definition
phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04210  Apoptosis
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04218  Cellular senescence
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04380  Osteoclast differentiation
ko04510  Focal adhesion
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04611  Platelet activation
ko04620  Toll-like receptor signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04630  JAK-STAT signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04668  TNF signaling pathway
ko04670  Leukocyte transendothelial migration
ko04722  Neurotrophin signaling pathway
ko04725  Cholinergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04917  Prolactin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04926  Relaxin signaling pathway
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04960  Aldosterone-regulated sodium reabsorption
ko04973  Carbohydrate digestion and absorption
ko05100  Bacterial invasion of epithelial cells
ko05142  Chagas disease (American trypanosomiasis)
ko05146  Amoebiasis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
ko05418  Fluid shear stress and atherosclerosis
Module
M00676  PI3K-Akt signaling
Disease
H01370  SHORT syndrome
H01885  Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04015 Rap1 signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04012 ErbB signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04370 VEGF signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04630 Jak-STAT signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04668 TNF signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04066 HIF-1 signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04068 FoxO signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04070 Phosphatidylinositol signaling system
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04072 Phospholipase D signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04071 Sphingolipid signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04024 cAMP signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04151 PI3K-Akt signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04152 AMPK signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04150 mTOR signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09143 Cell growth and death
   04210 Apoptosis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04218 Cellular senescence
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04550 Signaling pathways regulating pluripotency of stem cells
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04620 Toll-like receptor signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04625 C-type lectin receptor signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04650 Natural killer cell mediated cytotoxicity
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04660 T cell receptor signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04662 B cell receptor signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04664 Fc epsilon RI signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04666 Fc gamma R-mediated phagocytosis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04670 Leukocyte transendothelial migration
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04062 Chemokine signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09152 Endocrine system
   04910 Insulin signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04923 Regulation of lipolysis in adipocyte
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04915 Estrogen signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04914 Progesterone-mediated oocyte maturation
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04917 Prolactin signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04926 Relaxin signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04919 Thyroid hormone signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09156 Nervous system
   04725 Cholinergic synapse
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04722 Neurotrophin signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09158 Development
   04360 Axon guidance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04380 Osteoclast differentiation
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09149 Aging
   04211 Longevity regulating pathway - mammal
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04213 Longevity regulating pathway - multiple species
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05230 Central carbon metabolism in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05231 Choline metabolism in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05205 Proteoglycans in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05203 Viral carcinogenesis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05210 Colorectal cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05212 Pancreatic cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05225 Hepatocellular carcinoma
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05226 Gastric cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05214 Glioma
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05221 Acute myeloid leukemia
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05220 Chronic myeloid leukemia
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05218 Melanoma
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05211 Renal cell carcinoma
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05215 Prostate cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05213 Endometrial cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05224 Breast cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05222 Small cell lung cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05223 Non-small cell lung cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09165 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09166 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04931 Insulin resistance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09167 Infectious diseases
   05100 Bacterial invasion of epithelial cells
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05166 HTLV-I infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05162 Measles
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05164 Influenza A
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05161 Hepatitis B
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05160 Hepatitis C
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05163 Human cytomegalovirus infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05169 Epstein-Barr virus infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05165 Human papillomavirus infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05146 Amoebiasis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05142 Chagas disease (American trypanosomiasis)
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   01524 Platinum drug resistance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   01522 Endocrine resistance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00676  PI3K-Akt signaling
     K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
BRITE hierarchy
Other DBs
RN: R03362 R04545 R05795
Genes
HSA: 5295(PIK3R1) 5296(PIK3R2) 8503(PIK3R3)
PTR: 455855(PIK3R2) 456565(PIK3R3) 461836(PIK3R1)
PPS: 100969981(PIK3R2) 100986080(PIK3R3) 100994315(PIK3R1)
GGO: 101129336(PIK3R3) 101130978(PIK3R1) 101135298(PIK3R2)
PON: 100173589(PIK3R1) 100174298(PIK3R3) 100437617(PIK3R2)
NLE: 100591270(PIK3R3) 100599301(PIK3R2) 100605788(PIK3R1)
MCC: 698996(PIK3R1) 707310(PIK3R3) 719367(PIK3R2)
MCF: 101866246(PIK3R1) 102124804(PIK3R2) 102137291(PIK3R3)
CSAB: 103222594(PIK3R1) 103224900(PIK3R3) 103234391(PIK3R2)
RRO: 104662124(PIK3R3) 104675620(PIK3R1) 104680672(PIK3R2)
RBB: 108534276(PIK3R2) 108535636(PIK3R3) 108541175(PIK3R1)
CJC: 100392639(PIK3R1) 100406689(PIK3R2) 100414659(PIK3R3)
SBQ: 101032496(PIK3R1) 101033359(PIK3R2) 101050592(PIK3R3)
MMU: 18708(Pik3r1) 18709(Pik3r2) 18710(Pik3r3)
RNO: 25513(Pik3r1) 29741(Pik3r2) 60664(Pik3r3)
CGE: 100750761(Pik3r1) 100771181(Pik3r2) 100774067(Pik3r3)
NGI: 103726879(Pik3r2) 103730305(Pik3r3) 103738715(Pik3r1)
HGL: 101703691(Pik3r1) 101717096(Pik3r3) 101718815(Pik3r2)
OCU: 100345250(PIK3R3) 100357841(PIK3R1)
TUP: 102469401(PIK3R2) 102484444(PIK3R3) 102484500(PIK3R1)
CFA: 100856339(PIK3R3) 487235(PIK3R1) 609956(PIK3R2)
AML: 100467916(PIK3R3) 100475291(PIK3R2) 100483828(PIK3R1)
UMR: 103663617(PIK3R1) 103670766(PIK3R3) 103675162(PIK3R2)
ORO: 101370100(PIK3R1) 101371800(PIK3R2) 101374787(PIK3R3)
FCA: 100271864(PIK3R1) 101093286(PIK3R3) 101093586(PIK3R2)
PTG: 102949853(PIK3R3) 102952993(PIK3R1) 102967709(PIK3R2)
AJU: 106969150(PIK3R2) 106973297(PIK3R3) 106976917(PIK3R1)
BTA: 282307(PIK3R1) 282308(PIK3R2) 286865(PIK3R3)
BOM: 102266922(PIK3R1) 102280296(PIK3R3) 102286868(PIK3R2)
BIU: 109556345 109561418(PIK3R2) 109574805(PIK3R1)
PHD: 102332168(PIK3R1) 102332759(PIK3R2) 102333565(PIK3R3)
CHX: 102170135(PIK3R2) 102179343(PIK3R3) 102188710(PIK3R1)
OAS: 101111546(PIK3R2) 101121455(PIK3R1) 101123247(PIK3R3)
SSC: 100511937 100623707(PIK3R1) 100739510(PIK3R2)
CFR: 102505690(PIK3R3) 102513205(PIK3R2) 102520923(PIK3R1)
CDK: 105084758(PIK3R1) 105092913(PIK3R3) 105101867(PIK3R2)
BACU: 103007464(PIK3R1) 103008077(PIK3R3) 103009307(PIK3R2)
LVE: 103070370(PIK3R1) 103078725(PIK3R3) 103083960(PIK3R2)
OOR: 101277568(PIK3R3) 101281352(PIK3R2) 101285437(PIK3R1)
ECB: 100050227(PIK3R1) 100052122 100146348(PIK3R2)
EPZ: 103548220(PIK3R1) 103551868(PIK3R3) 103561550(PIK3R2)
EAI: 106822593(PIK3R3) 106824993(PIK3R2) 106840141(PIK3R1)
MYB: 102242302(PIK3R1) 102253405(PIK3R2) 102258430(PIK3R3)
MYD: 102753036(PIK3R1) 102760468(PIK3R3) 102763670(PIK3R2)
HAI: 109373811(PIK3R3) 109382484(PIK3R2) 109395865(PIK3R1)
RSS: 109450001(PIK3R2) 109454893(PIK3R1) 109456862(PIK3R3)
PALE: 102879163(PIK3R1) 102879453(PIK3R2) 102891637
LAV: 100653731(PIK3R1) 100665045(PIK3R2) 100675496(PIK3R3)
MDO: 100019317(PIK3R1) 100032726(PIK3R2)
SHR: 100924976(PIK3R1) 100926892(PIK3R2) 100935230(PIK3R3)
OAA: 100080187(PIK3R2) 100082075(PIK3R3) 100084726
GGA: 427171(PIK3R1) 429096(PIK3R3) 771142(PIK3R2)
MGP: 100548237(PIK3R1) 100549239(PIK3R2) 100549888(PIK3R3)
CJO: 107305909(PIK3R1) 107317608(PIK3R3) 107325533(PIK3R2)
APLA: 101795759(PIK3R3) 101799717(PIK3R1) 101803461(PIK3R2)
ACYG: 106033049(PIK3R3) 106042106(PIK3R1) 106045000(PIK3R2)
TGU: 100221185(PIK3R3) 100223949(PIK3R1) 100226234(PIK3R2)
GFR: 102032353(PIK3R1) 102035891(PIK3R2) 102039817(PIK3R3)
FAB: 101811808(PIK3R2) 101812251(PIK3R3) 101820843(PIK3R1)
PHI: 102106897(PIK3R2) 102112482(PIK3R3) 102114750(PIK3R1)
PMAJ: 107208273(PIK3R3) 107215603(PIK3R2) 107216262(PIK3R1)
CCW: 104686712(PIK3R1) 104695234(PIK3R3) 104696977(PIK3R2)
FPG: 101913266(PIK3R3) 101915242(PIK3R2) 101924523(PIK3R1)
FCH: 102056135(PIK3R1) 102057083(PIK3R2) 102059517(PIK3R3)
CLV: 102084272(PIK3R3) 102084904(PIK3R2) 102092838(PIK3R1)
EGZ: 104124880(PIK3R1) 104126253(PIK3R3) 104135641(PIK3R2)
AAM: 106485939(PIK3R3) 106495610(PIK3R2) 106499441(PIK3R1)
ASN: 102377899(PIK3R2) 102380057(PIK3R3) 102382060(PIK3R1)
AMJ: 102567863(PIK3R2) 102570922(PIK3R1) 106737141(PIK3R3)
PSS: 102449585(PIK3R1) 102457516(PIK3R3)
CMY: 102933845(PIK3R2) 102941819(PIK3R3) 102945631(PIK3R1)
CPIC: 101945673(PIK3R2) 101947423(PIK3R3) 101953817(PIK3R1)
ACS: 100554618(pik3r3) 100555182(pik3r2) 100556883(pik3r1)
PVT: 110072561(PIK3R2) 110073778(PIK3R3) 110073951(PIK3R1)
PBI: 103055280(PIK3R2) 103065132 103065975(PIK3R1)
GJA: 107108905(PIK3R1) 107119473(PIK3R3) 107121678(PIK3R2)
XLA: 108706884 108713027 399202(pik3r1.L) 443964(pik3r1.S) 446786(pik3r2) 447594(pik3r3.L)
XTR: 100486835(pik3r1) 100497001(pik3r2) 549983(pik3r3)
NPR: 108789013(PIK3R2) 108797628(PIK3R1) 108802963
DRE: 100000252(pik3r3b) 404211(pik3r2) 557176(pik3r1)
IPU: 108260231(pik3r1) 108272037(pik3r3)
AMEX: 103029972(pik3r3) 103035767 103046618(pik3r1) 111190801
PRET: 103463201(pik3r3) 103463319 103470780 103473324(pik3r1) 103478998 103479173(pik3r2)
LCM: 102348007(PIK3R3) 102353218(PIK3R1)
CMK: 103177781(pik3r1) 103182064(pik3r2) 103182762(pik3r3)
CIN: 100184893
SPU: 588766
APLC: 110977729
SKO: 100372481
DME: Dmel_CG2699(Pi3K21B)
DSI: Dsimw501_GD23016(Dsim_GD23016)
MDE: 101896300
AME: 408577
BIM: 100743083
BTER: 100643962
SOC: 105195470
AEC: 105151922
ACEP: 105620878
PBAR: 105430848
HST: 105192434
CFO: 105255336
LHU: 105667777
PGC: 109854747
NVI: 100122747
TCA: 100141888
DPA: 109540864
NVL: 108559788
BMOR: 100158253(Pi3k60)
PMAC: 106714800
PRAP: 110992252
PXY: 105388447
FCD: 110845224
CEL: CELE_Y110A7A.10(aap-1)
CBR: CBG10815(Cbr-aap-1)
BMY: Bm1_37505
TSP: Tsp_02388
CRG: 105321629
OBI: 106879157
SHX: MS3_06277
ADF: 107335159
HMG: 100197475
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1849461
  Authors
Skolnik EY, Margolis B, Mohammadi M, Lowenstein E, Fischer R, Drepps A, Ullrich A, Schlessinger J
  Title
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.
  Journal
Cell 65:83-90 (1991)
DOI:10.1016/0092-8674(91)90410-Z
  Sequence
[hsa:5295]
Reference
PMID:9582025
  Authors
Janssen JW, Schleithoff L, Bartram CR, Schulz AS
  Title
An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme.
  Journal
Oncogene 16:1767-72 (1998)
DOI:10.1038/sj.onc.1201695
  Sequence
[hsa:5296]
Reference
PMID:9524259
  Authors
Dey BR, Furlanetto RW, Nissley SP
  Title
Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor.
  Journal
Gene 209:175-83 (1998)
DOI:10.1016/S0378-1119(98)00045-6
  Sequence
[hsa:8503]

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