KEGG   ORTHOLOGY: K01110Help
Entry
K01110                      KO                                     

Name
PTEN
Definition
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Pathway
ko00562  Inositol phosphate metabolism
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04068  FoxO signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04071  Sphingolipid signaling pathway
ko04115  p53 signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04212  Longevity regulating pathway - worm
ko04218  Cellular senescence
ko04510  Focal adhesion
ko04931  Insulin resistance
ko05161  Hepatitis B
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05222  Small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05230  Central carbon metabolism in cancer
Disease
H00013  Small cell lung cancer
H00024  Prostate cancer
H00026  Endometrial cancer
H00029  Vulvar cancer
H00031  Breast cancer
H00038  Melanoma
H00042  Glioma
H00048  Hepatocellular carcinoma
H00539  PTEN hamartoma tumor syndrome (PHTS)
H01195  VACTERL/VATER association
H01222  Cowden syndrome
H01463  Mycosis fungoides
H01556  Meningioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04070 Phosphatidylinositol signaling system
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04071 Sphingolipid signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04151 PI3K-Akt signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04150 mTOR signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09143 Cell growth and death
   04115 p53 signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04218 Cellular senescence
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 09150 Organismal Systems
  09149 Aging
   04212 Longevity regulating pathway - worm
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05230 Central carbon metabolism in cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05206 MicroRNAs in cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05225 Hepatocellular carcinoma
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05214 Glioma
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05218 Melanoma
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05215 Prostate cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05213 Endometrial cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05224 Breast cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05222 Small cell lung cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09166 Endocrine and metabolic diseases
   04931 Insulin resistance
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09167 Infectious diseases
   05161 Hepatitis B
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05165 Human papillomavirus infection
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatase and associated proteins
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    3.1.3.48  protein-tyrosine-phosphatase
     K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
BRITE hierarchy
Other DBs
RN: R03363 R04513
GO: 0004722 0004725 0008138 0016314 0051800
Genes
HSA: 5728(PTEN)
PTR: 466142(PTEN)
PPS: 100983152(PTEN)
GGO: 101147526(PTEN)
PON: 100171828(PTEN)
NLE: 100605147(PTEN)
MCC: 705121(PTEN)
MCF: 101867036(PTEN)
CSAB: 103216211(PTEN)
RRO: 104675158(PTEN)
RBB: 108527540(PTEN)
CJC: 100393460(PTEN)
SBQ: 101039215(PTEN)
MMU: 19211(Pten)
RNO: 50557(Pten)
CGE: 100764294(Pten)
NGI: 103738044(Pten)
HGL: 101714930(Pten)
CCAN: 109689440(Pten)
OCU: 100358716(PTEN)
TUP: 102489114(PTEN) 106734783
CFA: 403832(PTEN)
AML: 100469483(PTEN)
UMR: 103661921(PTEN)
ORO: 101367385(PTEN)
FCA: 101091813(PTEN)
PTG: 102972446(PTEN)
AJU: 106980972(PTEN)
BTA: 540786(PTEN)
BOM: 102268478(PTEN)
BIU: 109552991(PTEN)
PHD: 102337473(PTEN)
CHX: 102185891(PTEN)
OAS: 101119351(PTEN)
SSC: 100156264(PTEN)
CFR: 102515104(PTEN)
CDK: 105088956(PTEN)
BACU: 102998704(PTEN)
LVE: 103074298(PTEN)
OOR: 101289838(PTEN)
ECB: 100062388(PTEN)
EPZ: 103561454(PTEN)
EAI: 106845897(PTEN)
MYB: 102257838(PTEN)
MYD: 102755323(PTEN)
HAI: 109387530(PTEN)
RSS: 109441546 109450993(PTEN)
PALE: 102881949(PTEN)
LAV: 100660561(PTEN)
TMU: 101355243
MDO: 100013036(PTEN)
SHR: 100927199(PTEN)
OAA: 100074365(PTEN)
GGA: 423675(PTEN)
MGP: 100541251(PTEN)
CJO: 107315619(PTEN)
APLA: 101798136(PTEN)
ACYG: 106030781(PTEN)
TGU: 100224148(PTEN)
GFR: 102039901(PTEN)
FAB: 101815785(PTEN)
PHI: 102106703(PTEN)
PMAJ: 107206954(PTEN)
CCW: 104695072(PTEN)
FPG: 101912177(PTEN)
FCH: 102050194(PTEN)
CLV: 102094724(PTEN)
EGZ: 104125131(PTEN)
AAM: 106495308(PTEN)
ASN: 106721809(PTEN)
AMJ: 102558284(PTEN)
PSS: 102443573(PTEN)
CMY: 102941367(PTEN)
CPIC: 101934509(PTEN)
ACS: 100552870(pten)
PVT: 110083120(PTEN)
GJA: 107120016(PTEN) 107121111
XLA: 100505440(pten.S) 399142(pten.L)
XTR: 100144716(pten)
NPR: 108788861(PTEN)
DRE: 368415(ptenb) 794088(ptena)
IPU: 108269686 108273661(pten)
AMEX: 103025186(pten) 103046962
TRU: 101079654(pten)
LCO: 104929647 104936542(pten)
OLA: 101171856(pten) 101173689
XMA: 102226067(pten) 102236680
PRET: 103476793 103482129(pten)
NFU: 107376033 107387492(pten)
CSEM: 103382250(pten) 103387686
ELS: 105006284(pten) 105010650
SFM: 108932873 108939683(pten)
LCM: 102348548(PTEN)
CMK: 103180851(pten)
CIN: 100182434
SPU: 590938
SKO: 100313711(Pten)
DME: Dmel_CG5671(Pten)
DSI: Dsimw501_GD22287(Dsim_GD22287)
MDE: 101892103
AME: 411859(Pten)
BIM: 100743534
BTER: 100643227
SOC: 105195960
AEC: 105148783
ACEP: 105619919
PBAR: 105426787
HST: 105192370
CFO: 105253074
LHU: 105670175
PGC: 109856638
NVI: 100117148(Pten)
TCA: 663870
DPA: 109542185
NVL: 108566279
BMOR: 101745952
PMAC: 106718558
PRAP: 110993954
API: 100163194(Pten)
DNX: 107172228
ZNE: 110831106
FCD: 110842984
TUT: 107359492
CEL: CELE_T07A9.6(daf-18)
CBR: CBG13540(Cbr-daf-18)
BMY: Bm1_36650
TSP: Tsp_07635
CRG: 105331286
MYI: 110464227
OBI: 106873013
LAK: 106162681
SHX: MS3_07298
EPA: 110254143
ADF: 107346271
HMG: 101239852
AQU: 100640061
ATH: AT3G19420(PEN2) AT3G50110(PEN3) AT5G39400(PTEN1)
LJA: Lj1g3v2995580.1(Lj1g3v2995580.1) Lj1g3v2995580.2(Lj1g3v2995580.2) Lj2g3v1904480.1(Lj2g3v1904480.1) Lj5g3v2133750.1(Lj5g3v2133750.1)
OSA: 4352052
DOSA: Os12t0407500-01(Os12g0407500)
OBR: 102704853
BDI: 100846535
ATS: 109747383(LOC109747383)
SBI: 8054522
ZMA: 103648286
SITA: 101758319
CRE: CHLREDRAFT_195975(PTN1)
SPO: SPBC609.02(ptn1)
ABP: AGABI1DRAFT123067(AGABI1DRAFT_123067)
ABV: AGABI2DRAFT187375(AGABI2DRAFT_187375)
DFA: DFA_00730 DFA_06571(pten)
EHI: EHI_197010(92.t00018)
SMIN: v1.2.038026.t1(symbB.v1.2.038026.t1)
SPAR: SPRG_05142
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9072974
  Authors
Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R
  Title
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.
  Journal
Science 275:1943-7 (1997)
DOI:10.1126/science.275.5308.1943
  Sequence
[hsa:5728]
Reference
PMID:9593664
  Authors
Maehama T, Dixon JE
  Title
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.
  Journal
J Biol Chem 273:13375-8 (1998)
DOI:10.1074/jbc.273.22.13375
  Sequence
[hsa:5728]

DBGET integrated database retrieval system