KEGG ORTHOLOGY: K01366

ORTHOLOGY: K01366

Entry

K01366                      KO

Symbol

CTSH

Name

cathepsin H [EC:3.4.22.16]

Pathway

map04142

Lysosome

map04210

Apoptosis

Disease

H00408

Type 1 diabetes mellitus

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    K01366  CTSH; cathepsin H
  09143 Cell growth and death
   04210 Apoptosis
    K01366  CTSH; cathepsin H
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01366  CTSH; cathepsin H
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.16  cathepsin H
     K01366  CTSH; cathepsin H
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C1: papain family
   K01366  CTSH; cathepsin H

Genes

HSA:	1512(CTSH)

PTR:	740462(CTSH)

PPS:	100994578(CTSH)

GGO:	101144312(CTSH)

PON:	100460934(CTSH)

NLE:	100584322(CTSH)

HMH:	116482262(CTSH)

MCC:	711437(CTSH)

MCF:	102115935(CTSH)

MTHB:

126960059

MNI:	105493125(CTSH)

CSAB:

103245241(CTSH)

CATY:

105571724(CTSH)

PANU:

101005151(CTSH)

TGE:	112627736(CTSH)

MLEU:

105542261(CTSH)

RRO:	104675185(CTSH)

RBB:	108538647(CTSH)

TFN:	117070311(CTSH)

PTEH:

111527187(CTSH)

CANG:

105509239(CTSH)

CJC:	100413104(CTSH)

SBQ:	101038067(CTSH)

CIMI:

108298612(CTSH)

CSYR:

103266021(CTSH)

MMUR:

105856543(CTSH)

LCAT:

123644767(CTSH)

PCOQ:

105822761(CTSH)

OGA:	100946905(CTSH)

MMU:	13036(Ctsh)

MCAL:

110302403(Ctsh)

MPAH:

110327865(Ctsh)

RNO:	25425(Ctsh)

MCOC:

116072927(Ctsh)

ANU:	117693791(Ctsh)

MUN:	110549493(Ctsh)

CGE:	100756691(Ctsh)

MAUA:

101826391(Ctsh)

PROB:

127238684(Ctsh)

PLEU:

114690943(Ctsh) 114705701

MORG:

121444740(Ctsh)

MFOT:

126510630

AAMP:

119809603(Ctsh)

NGI:	103726016(Ctsh)

HGL:	101700582(Ctsh)

CPOC:

100731416(Ctsh)

CCAN:

109697210(Ctsh)

DORD:

105982452(Ctsh)

DSP:	122123430(Ctsh)

PLOP:

125338662(Ctsh) 125368313

NCAR:

124977509

MMMA:

107137898(Ctsh)

OCU:

100101597

OPI:	101520792(CTSH)

TUP:	102483972(CTSH)

GVR:	103606706(CTSH)

CFA:	479065(CTSH)

CLUD:

112653434(CTSH)

VVP:	112920972(CTSH)

VLG:	121490014(CTSH)

NPO:	129510384(CTSH)

AML:	100481013(CTSH)

UMR:	103660296(CTSH)

UAH:	113263792(CTSH)

UAR:	123796880(CTSH)

ELK:

111152563

LLV:

125103910

MPUF:

101674358(CTSH)

MNP:	131998958(CTSH)

MLK:	131835486(CTSH)

NVS:	122893529(CTSH)

ORO:	101362840(CTSH)

EJU:	114201245(CTSH)

ZCA:	113909565(CTSH)

MLX:	118023131(CTSH)

NSU:	110572404(CTSH)

LWW:	102744465(CTSH)

FCA:	101092687(CTSH)

PYU:	121042262(CTSH)

PCOO:

112855339(CTSH)

PBG:	122468169(CTSH)

PVIV:

125158989(CTSH)

LRUF:

124517256

PTG:	102969753(CTSH)

PPAD:

109273576(CTSH)

PUC:

125910846

AJU:

106988474

HHV:	120249214(CTSH)

BTA:	510524(CTSH)

BOM:	102281958(CTSH)

BIU:	109575407(CTSH)

BBUB:

102413180(CTSH)

BBIS:

104990903(CTSH)

CHX:	102170638(CTSH)

OAS:	101108427(CTSH)

BTAX:

128066659(CTSH)

ODA:	120875562(CTSH)

CCAD:

122454810(CTSH)

MBEZ:

129550345(CTSH)

SSC:	396969(CTSH)

CFR:	102524291(CTSH)

CBAI:

105069140(CTSH)

CDK:	105092231(CTSH)

VPC:	102534271(CTSH)

BACU:

103019787(CTSH)

BMUS:

118890614(CTSH)

LVE:	103084230(CTSH)

OOR:	101287575(CTSH)

DLE:	111164745(CTSH)

PCAD:

102974243(CTSH)

PSIU:

116749231(CTSH)

NASI:

112398272(CTSH)

ECB:	100059835(CTSH) 111775628 111775633

EPZ:	103559011(CTSH)

EAI:	106840814(CTSH)

MYB:	102242799(CTSH)

MYD:	102754763(CTSH)

MMYO:

118679104(CTSH)

PKL:	118718009(CTSH)

EFUS:

103303838(CTSH)

MNA:	107525553(CTSH)

DRO:	112305948(CTSH)

SHON:

118991857(CTSH)

AJM:	119046535 119057245(CTSH)

PDIC:

114488579(CTSH)

PHAS:

123809802(CTSH)

MMF:	118640936(CTSH)

PPAM:

129083088(CTSH)

HAI:	109381379(CTSH)

RFQ:	117018786(CTSH)

PALE:

102897634(CTSH)

PGIG:

120599346(CTSH)

PVP:	105301620(CTSH)

RAY:	107500384(CTSH)

MJV:	108400192(CTSH)

TOD:	119245129(CTSH)

SARA:

101557008(CTSH)

LAV:	100662496(CTSH)

TMU:

101361718

ETF:	101655316(CTSH)

DNM:	101411932(CTSH)

MDO:	100014210(CTSH)

GAS:	123234217(CTSH)

SHR:	100926518(CTSH)

AFZ:

127551417

PCW:	110193663(CTSH)

OAA:	100681064(CTSH)

GGA:	770109(CTSH)

PCOC:

116225511(CTSH)

MGP:	100551376(CTSH)

CJO:	107318952(CTSH)

TPAI:

128075192(CTSH)

LMUT:

125698100(CTSH)

NMEL:

110403678(CTSH)

APLA:

101804912(CTSH)

ACYG:

106048660(CTSH)

CATA:

118259409(CTSH)

AFUL:

116493445(CTSH)

TGU:	115496729(CTSH)

LSR:	110476644(CTSH)

SCAN:

103816275(CTSH)

PMOA:

120509070(CTSH)

OTC:	121343689(CTSH)

PRUF:

121352244(CTSH)

GFR:	102036092(CTSH)

FAB:	101811077(CTSH)

OMA:	130257559(CTSH)

PHI:	102108387(CTSH)

PMAJ:

107209076(CTSH)

CCAE:

111933844

CCW:	104684052(CTSH)

CBRC:

103619701(CTSH)

ETL:	114069603(CTSH)

ZAB:	106629985(CTSH)

ACHL:

103797081(CTSH)

SVG:	106860153(CTSH)

MMEA:

130585606(CTSH)

HRT:	120758984(CTSH)

FPG:	101922144(CTSH)

FCH:	102057998(CTSH)

CLV:	102087477(CTSH)

EGZ:	104122478(CTSH)

NNI:	104017190(CTSH)

PCRI:

104033100(CTSH)

PLET:

104618666(CTSH)

PCAO:

104052832(CTSH)

ACUN:

113483959(CTSH)

TALA:

104363972(CTSH)

PADL:

103914793(CTSH)

AFOR:

103899903(CTSH)

ACHC:

115341996(CTSH)

HALD:

104313835(CTSH)

HLE:	104834643(CTSH)

AGEN:

126044151

GCL:

127020404

CCRI:

104164564(CTSH)

CMAC:

104479155(CTSH)

MUI:	104545144(CTSH)

BREG:

104629162(CTSH)

FGA:	104079240(CTSH)

GSTE:

104255707(CTSH)

LDI:	104347483(CTSH)

NNT:	104405276(CTSH)

SHAB:

115612955(CTSH)

DPUB:

104297403(CTSH)

PGUU:

104464671(CTSH)

ACAR:

104528744

CPEA:

104393357(CTSH)

AVIT:

104276160(CTSH)

CVF:	104283015(CTSH)

RTD:	128915158(CTSH)

CUCA:

104056437(CTSH)

TEO:	104378620(CTSH)

BRHI:

104498362(CTSH)

AAM:	106487037(CTSH)

AROW:

112963599(CTSH)

NPD:	112948249(CTSH)

DNE:	112987928(CTSH)

SCAM:

104151508(CTSH)

ASN:	102384797(CTSH)

AMJ:	102564481(CTSH)

CPOO:

109309243(CTSH)

GGN:	109288388(CTSH)

PSS:	102458148(CTSH)

CMY:	102938471(CTSH)

CCAY:

125643794(CTSH)

DCC:	119862069(CTSH)

CPIC:

101936196(CTSH)

TST:	117884141(CTSH)

CABI:

116833068(CTSH)

MRV:	120373479(CTSH)

ACS:	100561600(ctsh)

ASAO:

132762444(CTSH)

PVT:	110091401(CTSH)

SUND:

121933119(CTSH)

PBI:

103061128

PMUR:

107283909(CTSH)

CTIG:

120316446(CTSH)

PGUT:

117676211(CTSH)

APRI:

131184589(CTSH)

PTEX:

113442050(CTSH)

NSS:	113423342(CTSH)

VKO:	123030736(CTSH)

PMUA:

114584529(CTSH)

PRAF:

128401656(CTSH)

ZVI:	118093178(CTSH)

HCG:	128334904(CTSH)

GJA:	107125357(CTSH)

STOW:

125425625(CTSH)

EMC:	129345664(CTSH)

MUO:	115459969(CTSH)

GSH:	117348571(CTSH)

DRE:	324818(ctsh)

SRX:	107715232(ctsh)

SANH:

107690365 107691125 107691144

SGH:	107551467(ctsh) 107556249

CCAR:

109056799 109076347

CAUA:

113061626 113091663

CGIB:

127933788 127977650

PTET:

122322981(ctsh)

LROH:

127180335(ctsh)

OMC:	131524537(ctsh)

PPRM:

120487745(ctsh)

RKG:	130089331(ctsh)

MAMB:

125254127(ctsh)

CIDE:

127499510

MASI:

127455705

TROS:

130562877(ctsh)

TDW:	130435519(ctsh)

MANU:

129419440(ctsh)

IPU:	100305012(ctsh)

IFU:	128602094(ctsh)

PHYP:

113537355(ctsh)

SMEO:

124378189(ctsh)

TFD:	113663684(ctsh)

TVC:	132839189(ctsh)

AMEX:

103043563(ctsh)

CMAO:

118801415(ctsh)

EEE:	113573981(ctsh)

TRU:	101078766(ctsh)

TFS:	130536688(ctsh)

TNG:	GSTEN00035643G001

LCO:	104917829(ctsh) 104940230

NCC:	104951771 104964027

TBEN:

117471203 117491363(ctsh)

CGOB:

115009720 115025119

PGEO:

117448148(ctsh) 117461038

GACU:

117533014 117557664(ctsh)

EMAC:

134863320 134882397(ctsh)

ELY:	117255654 117262553(ctsh)

EFO:	125888044(ctsh) 125906114

PLEP:

121943753 121950050(ctsh)

SLUC:

116038479(ctsh) 116060462

ECRA:

117943849 117948573(ctsh)

ESP:	116690568 116694176

PFLV:

114560026(ctsh) 114573889

GAT:	120831228(ctsh)

PPUG:

119227596(ctsh)

AFB:	129104763 129107893

CLUM:

117728662(ctsh)

MSAM:

119890554 119894208(ctsh)

SCHU:

122874366(ctsh) 122877551

CUD:	121514231 121515145(ctsh)

ALAT:

119017778 119024705(ctsh)

MZE:	101468200(ctsh) 101475779

ONL:	100702144 100708413(ctsh)

OAU:	116314697 116326248(ctsh)

OLA:	111947539(ctsh)

OML:	112152656(ctsh)

CSAI:

133444247(ctsh)

XMA:	102227764(ctsh)

XCO:	114159939(ctsh)

XHE:	116732858(ctsh)

PRET:

103466621(ctsh)

PFOR:

103147844(ctsh)

PLAI:

106946134(ctsh)

PMEI:

106921434(ctsh)

GAF:	122835462(ctsh)

PPRL:

129359743(ctsh)

CVG:	107099914(ctsh)

CTUL:

119772364(ctsh)

GMU:	124856929(ctsh)

NFU:	107388794(ctsh)

KMR:	108230028(ctsh) 108237393

ALIM:

106514343(ctsh) 106518967

NWH:	119415727(ctsh) 119430108

AOCE:

111580156 111587586

MCEP:

125005757 125014320(ctsH)

CSEM:

103379443(ctsh)

SSEN:

122775464(ctsh)

HHIP:

117754538(ctsh)

HSP:	118108131(ctsh)

SMAU:

118315004(ctsh)

LCF:	108875435(ctsh) 108877025

SDU:	111220923 111228545

SLAL:

111659106 111666932

XGL:	120792665(ctsh)

SBIA:

133497759(ctsh)

PEE:	133415492(ctsh)

PTAO:

133474248(ctsh)

MALB:

109967274(ctsh)

BSPL:

114857358(ctsh)

SJO:	128356599 128358692

SASA:

106561173(CATH) 106562440(CATH)

STRU:

115196734 115203334

OTW:	112218593(ctsh) 112247294 112247472

OMY:	110495904(ctsh) 110506772

OGO:	124035003 124036427(ctsh)

ONE:	115113802 115134231

OKI:	109867538 109881088 109882252

OKE:	118360888 118396737(ctsh)

SALP:

111962429

SNH:	120024924 120066687(ctsh)

CCLU:

121531924(ctsh) 121560399 121577450

ELS:	105025674(ctsh)

SFM:	108931675(ctsh)

PKI:	111843502(ctsh)

AANG:

118215419(ctsh)

LOC:	102699078(ctsh)

PSPA:

121294562 121299342(ctsh)

ARUT:

117427928 117429312

PSEX:

120541458(ctsh)

LCM:	102358878(CTSH)

CMK:	103186362(ctsh)

RTP:	109934550(ctsh)

CPLA:

122540879(ctsh)

HOC:	132834158(ctsh)

LERI:

129712712(ctsh)

BFO:

BBEL:

CIN:

SCLV:

AJC:

SKO:

SOY:

VCD:

MCIX:

PPOT:

PRAP:

ZCE:

PGW:

DCI:	103517125 103518578

DMK:	116919996 116919998 116932915

TCF:	131877454 131891409 131891754 131892094

VDE:

111248979

VJA:

111263297

DFR:	124494675 124496119

AQU:	100636464 100636590

ATH:	AT3G45310 AT5G60360(ALP)

ALY:	9302454 9313468

CRB:	17876993 17887285

CSAT:

104710996 104726627 104737757 104756683 104762144 104790787

EUS:	EUTSA_v10002588mg EUTSA_v10013934mg

BRP:	103837111 103845456 103851512 103856563 103856569

BNA:	106364017 106371600 106385145 106385833 106386886 106401153 106419550 106419694 106431716

BOE:	106319139 106327677 106329729

RSZ:	108818372 108820664 108846542 108846647 130502195 130508428

THJ:

104814838

CPAP:

110817702

CIT:

102578016

CIC:	CICLE_v10008748mg

PVY:	116126364 116132552

MINC:

123194768 123200041

TCC:

18588277

GRA:	105768892 105772929 105782653

GHI:	107893361 107901061 107907097 107951073 107958837 121212573

GAB:	108463952 108465689 108473592

HSYR:

120117644 120147630 120166319 120166320 120169344 120192438

DZI:	111285718 111299188 111303055

EGR:	104436411 104436414 104436415 104439005 120291616 120291617 120291618

GMX:	100170694 100787165 547734

GSJ:	114367678 114387650 114393883

PVU:	PHAVU_003G130600g PHAVU_009G227100g

VRA:	106762644 106769487

VAR:	108330571 108337148

VUN:	114163167 114179052

VUM:	124834179 124843666

CCAJ:

109808138 109815285

APRC:

113846206 113862658

MTR:	120577892 25494167

TPRA:

CAM:

PSAT:

VVO:

LJA:	Lj4g3v2203610.1(Lj4g3v2203610.1)

ADU:	107457839 107479122

AIP:	107630460 107643670

AHF:	112696530 112738342 112790519

LANG:

109347727 109356310

PCIN:

129320296

QSA:	O6P43_002662 O6P43_022494

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103400937 103451125 103453996

MSYL:

126604718 126607040

PXB:	103929718 103950268

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:	110631569 110635086

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:	111993009 112023279

QLO:

115968365

TWL:	119996375 120005633

VVI:

100244107

VRI:

117925012

SLY:	101252200 101252505(Cyp-3)

SPEN:

107024548 107026034

SOT:	102578939 102579266 107059966

SSTN:

125876799 125876800

SDUL:

129893196

CANN:

107877862

LBB:	132616737 132640917

NTA:	107775429 107779938 107784768(NTCP-23) 107818105 107823208(CYS)

NSY:	104224819 104246478

NTO:	104089405 104107336

NAU:	109225599 109225621

INI:

109193112

ITR:	116013982 116020733

SIND:

105161928 105173682

OEU:	111368619 111385176

EGT:	105968067 105971000

SSPL:

121747527 121796246 121799996

SMIL:

130987613

SHIS:

125197334

APAN:

127239644 127263718 127263719

HAN:	110886998 110896208

ECAD:

122594952

LSV:	111892539 111917749

CCAV:

DCR:

CSIN:

RVL:

AEW:	130757540 130789002

BVG:

104883466

SOE:

110805191

CQI:	110682962 110715980

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

Os09t0442300-01(Os09g0442300)

OBR:

OGL:

BDI:

ATS:

TDC:	119301562 119309424

TAES:

100037648 123051968 123111956 123121517

TUA:

125509313

LPER:

127301398

LRD:	124652793 124652893

SBI:

ZMA:

SITA:

SVS:

PVIR:

PHAI:

PDA:	103702035 103704943

EGU:	105036231 105041860

MUS:	103991149 103998167

ZOF:	121971521 121976133

DCT:	110106914 110109127 110110535

PEQ:	110018397 110018399 110026028

AOF:	109844564 109845680

MSIN:

131251718

NCOL:

116259100

ATR:

18439478

SMO:	SELMODRAFT_228454 SELMODRAFT_439207

PPP:

112286849

TET:	TTHERM_00191270 TTHERM_00191280 TTHERM_00911100 TTHERM_01001420 TTHERM_01028740

AAF:	AURANDRAFT_34950 AURANDRAFT_3602

PIF:	PITG_13074

PSOJ:

PHYSODRAFT_361379

SPAR:

SPRG_12173

EHX:	EMIHUDRAFT_458272 EMIHUDRAFT_464692

GTT:	GUITHDRAFT_71985

» show all

Reference

PMID:8335702 (H.sapiens)

Authors

Popovic T, Brzin J, Ritonja A, Svetic B, Turk V

Title

Rapid affinity chromatographic method for the isolation of human cathepsin H.

Journal

J Chromatogr 615:243-9 (1993)
DOI:10.1016/0378-4347(93)80338-5

Reference

PMID:22582844

Authors

Lu WD, Funkelstein L, Toneff T, Reinheckel T, Peters C, Hook V

Title

Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters.

Journal

J Neurochem 122:512-22 (2012)
DOI:10.1111/j.1471-4159.2012.07788.x

Sequence

[mmu:13036]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (7394)   
   KEGG GENES (731)   
   KEGG MGENES (138)   
   RefGene (6516)   
   OC (9)   
Literature (2)   
   PubMed (2)   
All databases (7405)   

Download RDF

DBGET integrated database retrieval system