KEGG   ORTHOLOGY: K02085Help
Entry
K02085                      KO                                     

Name
APC
Definition
adenomatosis polyposis coli protein
Pathway
ko04310  Wnt signaling pathway
ko04390  Hippo signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04810  Regulation of actin cytoskeleton
ko04934  Cushing syndrome
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05213  Endometrial cancer
ko05217  Basal cell carcinoma
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00017  Esophageal cancer
H00018  Gastric cancer
H00020  Colorectal cancer
H00044  Cancer of the anal canal
H00047  Gallbladder cancer
H01025  Familial adenomatous polyposis
H01431  Cushing syndrome
H01667  Medulloblastoma
H02049  Bilateral macronodular adrenal hyperplasia (BMAH)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K02085  APC; adenomatosis polyposis coli protein
   04390 Hippo signaling pathway
    K02085  APC; adenomatosis polyposis coli protein
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K02085  APC; adenomatosis polyposis coli protein
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K02085  APC; adenomatosis polyposis coli protein
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K02085  APC; adenomatosis polyposis coli protein
   05206 MicroRNAs in cancer
    K02085  APC; adenomatosis polyposis coli protein
   05210 Colorectal cancer
    K02085  APC; adenomatosis polyposis coli protein
   05225 Hepatocellular carcinoma
    K02085  APC; adenomatosis polyposis coli protein
   05226 Gastric cancer
    K02085  APC; adenomatosis polyposis coli protein
   05217 Basal cell carcinoma
    K02085  APC; adenomatosis polyposis coli protein
   05213 Endometrial cancer
    K02085  APC; adenomatosis polyposis coli protein
   05224 Breast cancer
    K02085  APC; adenomatosis polyposis coli protein
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K02085  APC; adenomatosis polyposis coli protein
  09167 Infectious diseases
   05166 HTLV-I infection
    K02085  APC; adenomatosis polyposis coli protein
   05165 Human papillomavirus infection
    K02085  APC; adenomatosis polyposis coli protein
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatase and associated proteins
    K02085  APC; adenomatosis polyposis coli protein
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K02085  APC; adenomatosis polyposis coli protein
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K02085  APC; adenomatosis polyposis coli protein
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K02085  APC; adenomatosis polyposis coli protein
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Other centriole associated proteins
    K02085  APC; adenomatosis polyposis coli protein
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    EB / APC
     K02085  APC; adenomatosis polyposis coli protein
BRITE hierarchy
Genes
HSA: 10297(APC2) 324(APC)
PTR: 455551(APC2) 461999(APC)
PPS: 100977146(APC2) 100992823(APC)
GGO: 101130129(APC2) 101137098(APC)
PON: 100431482(APC) 100435472(APC2)
NLE: 100585467(APC) 100602025(APC2)
MCC: 693443(APC) 707345(APC2)
MCF: 102123489(APC2) 102126553(APC)
CSAB: 103234321(APC2) 103244338(APC)
RRO: 104669245(APC) 104671452(APC2)
RBB: 108530233(APC2) 108540305(APC)
CJC: 100385653(APC) 100397972(APC2)
SBQ: 101034942(APC2) 101049516
MMU: 11789(Apc) 23805(Apc2)
RNO: 24205(Apc) 299611(Apc2)
CGE: 100750563(Apc) 100767273(Apc2)
NGI: 103735168(Apc) 103737324(Apc2)
HGL: 101699189(Apc2) 101704055(Apc)
CCAN: 109691007(Apc2) 109699342(Apc)
OCU: 100353976(APC) 103346018
TUP: 102470052(APC2) 102484859(APC)
CFA: 479139(APC) 485084(APC2)
AML: 100465768(APC2) 100472257(APC)
UMR: 103675797(APC) 103681784(APC2)
ORO: 101371790(APC) 101372249(APC2)
FCA: 101096138(APC) 101097211(APC2)
PTG: 102948725(APC) 102969111
AJU: 106973163(APC)
BTA: 526572(APC2) 533233(APC)
BOM: 102272116(APC) 102282143(APC2)
BIU: 109561990(APC2) 109564604(APC)
PHD: 102316874(APC) 102326036(APC2)
CHX: 102177435(APC2) 102184724(APC)
OAS: 101104664(APC) 101115458(APC2)
SSC: 100517932(APC) 100579172(APC2)
CFR: 102521446(APC2) 102522612(APC) 106731103
CDK: 105095381(APC) 105104128(APC2) 105106540
BACU: 103001169(APC) 103014178(APC2)
LVE: 103083467(APC) 103084983(APC2)
OOR: 101275920(APC) 101276919(APC2)
ECB: 100064431(APC) 100147102(APC2)
EPZ: 103544756 103561228(APC)
EAI: 106832251(APC) 106834222(APC2)
MYB: 102243742(APC2) 102246124(APC)
MYD: 102751934(APC) 102768246(APC2)
HAI: 109390647(APC2) 109391522(APC)
RSS: 109445415(APC) 109453963(APC2)
PALE: 102880260(APC) 102891886(APC2)
LAV: 100659017(APC)
MDO: 100013592(APC) 100020785(APC2)
OAA: 100082114(APC)
GGA: 415607(APC) 429363(APC2)
MGP: 100544685(APC2) 104915165(APC)
CJO: 107306337(APC) 107325420(APC2)
APLA: 101793979(APC2) 101795988(APC)
ACYG: 106042343(APC) 106048197(APC2)
TGU: 100217575(APC2) 100231767(APC)
GFR: 102038857(APC2) 102041365(APC)
FAB: 101819406(APC) 101820774(APC2)
PHI: 102099173(APC) 102111044(APC2)
PMAJ: 107215377(APC2) 107216177(APC)
CCW: 104684175(APC) 104697069(APC2)
FPG: 101912417(APC2) 101913625(APC)
FCH: 102051031(APC) 102052505(APC2)
CLV: 102093207(APC) 102094189(APC2)
EGZ: 104128291 104135069(APC)
AAM: 106486559(APC2) 106495024
ASN: 102376341(APC2) 102377654(APC)
AMJ: 102567239(APC) 102570878(APC2)
PSS: 102462387(APC) 102463006(APC2)
CMY: 102943104(APC) 102947058(APC2)
CPIC: 101935001(APC2) 101952269(APC)
ACS: 100559625(apc2) 100561377(apc)
PVT: 110072031(APC) 110072522(APC2)
PBI: 103062549(APC) 103068257(APC2)
GJA: 107116347(APC2) 107116684(APC)
XLA: 108704666 108707215(apc.S) 108712468(apc2.L) 399455(apc.L)
XTR: 100487473(apc2) 779466(apc)
NPR: 108791892(APC) 108793493(APC2)
DRE: 386762(apc) 565771(apc2)
IPU: 108270570(apc2) 108277162(apc)
AMEX: 103031611(apc) 103040193(apc2)
TRU: 101062949 101079661(apc)
LCO: 104935740(apc2) 104937427(apc)
NCC: 104945360 104953209(apc)
MZE: 101476338(apc) 101485384(apc2)
OLA: 101162682(apc) 101169683(apc2)
XMA: 102216614(apc) 102228122(apc2)
PRET: 103460454(apc) 103463143(apc2)
NFU: 107374978(apc) 107392633(apc2)
CSEM: 103390350(apc) 103398463(apc2)
HCQ: 109506820(apc2) 109527897
BPEC: 110166035(apc) 110166729(apc2)
ELS: 105011386(apc2) 105029631(apc)
SFM: 108925092(apc) 108930605(apc2) 108938110
LCM: 102356342(APC) 102356576 102364375(APC2)
CMK: 103181147(apc) 103182088(apc2)
CIN: 778909(apc)
SPU: 578083
APLC: 110987304
SKO: 100371477(apc)
DME: Dmel_CG1451(Apc) Dmel_CG6193(Apc2)
DSI: Dsimw501_GD18013(Dsim_GD18013) Dsimw501_GD21072(Dsim_GD21072)
MDE: 101895218
AAG: 110674862
BIM: 100744104
ACEP: 105620768
PBAR: 105433821
HST: 105181272
CFO: 105251334
LHU: 105675015
PGC: 109851743
NVI: 100118980
TCA: 661294
BMOR: 101745327
PMAC: 106711851
PRAP: 110992028
API: 100166146
DNX: 107163228
ZNE: 110840108
FCD: 110849042
BMY: Bm1_48830
TSP: Tsp_08011
CRG: 105323165
MYI: 110447351
OBI: 106883440
LAK: 106157029
EPA: 110239175
ADF: 107345376
HMG: 100203938
AQU: 100616085(Apc)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kaplan KB, Burds AA, Swedlow JR, Bekir SS, Sorger PK, Nathke IS
  Title
A role for the Adenomatous Polyposis Coli protein in chromosome segregation.
  Journal
Nat Cell Biol 3:429-32 (2001)
DOI:10.1038/35070123
Reference
  Authors
van Es JH, Kirkpatrick C, van de Wetering M, Molenaar M, Miles A, Kuipers J, Destree O, Peifer M, Clevers H
  Title
Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor.
  Journal
Curr Biol 9:105-8 (1999)
DOI:10.1016/S0960-9822(99)80024-4
  Sequence
[hsa:10297]
Reference
PMID:1678319
  Authors
Joslyn G, Carlson M, Thliveris A, Albertsen H, Gelbert L, Samowitz W, Groden J, Stevens J, Spirio L, Robertson M, et al.
  Title
Identification of deletion mutations and three new genes at the familial polyposis locus.
  Journal
Cell 66:601-13 (1991)
DOI:10.1016/0092-8674(81)90022-2
  Sequence
[hsa:324]

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