KEGG   ORTHOLOGY: K02157Help
Entry
K02157                      KO                                     

Name
AXIN1
Definition
axin 1
Pathway
ko04310  Wnt signaling pathway
ko04390  Hippo signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04934  Cushing syndrome
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05213  Endometrial cancer
ko05217  Basal cell carcinoma
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00048  Hepatocellular carcinoma
H00934  Caudal duplication anomaly
H01667  Medulloblastoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K02157  AXIN1; axin 1
   04390 Hippo signaling pathway
    K02157  AXIN1; axin 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K02157  AXIN1; axin 1
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K02157  AXIN1; axin 1
   05210 Colorectal cancer
    K02157  AXIN1; axin 1
   05225 Hepatocellular carcinoma
    K02157  AXIN1; axin 1
   05226 Gastric cancer
    K02157  AXIN1; axin 1
   05217 Basal cell carcinoma
    K02157  AXIN1; axin 1
   05213 Endometrial cancer
    K02157  AXIN1; axin 1
   05224 Breast cancer
    K02157  AXIN1; axin 1
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K02157  AXIN1; axin 1
  09167 Infectious diseases
   05165 Human papillomavirus infection
    K02157  AXIN1; axin 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatase and associated proteins
    K02157  AXIN1; axin 1
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K02157  AXIN1; axin 1
BRITE hierarchy
Genes
HSA: 8312(AXIN1)
PTR: 453789(AXIN1)
PPS: 100986279(AXIN1)
GGO: 101150555(AXIN1)
PON: 100434225(AXIN1)
NLE: 101179424(AXIN1)
MCC: 100424087(AXIN1)
MCF: 102142970(AXIN1)
CSAB: 103225216(AXIN1)
RRO: 104676962(AXIN1)
RBB: 108521119(AXIN1)
CJC: 100392475(AXIN1)
SBQ: 101035780(AXIN1)
MMU: 12005(Axin1)
RNO: 79257(Axin1)
CGE: 100758169(Axin1)
NGI: 103748223(Axin1)
HGL: 101700795(Axin1)
CCAN: 109694685(Axin1)
OCU: 100348127(AXIN1) 100358325
TUP: 102469399(AXIN1)
CFA: 490099(AXIN1)
AML: 100473018(AXIN1)
UMR: 103668450(AXIN1)
ORO: 101375084(AXIN1)
FCA: 101088804(AXIN1)
PTG: 102951323(AXIN1)
AJU: 106977359(AXIN1)
BTA: 504357(AXIN1)
BOM: 102267637(AXIN1)
BIU: 109578518(AXIN1)
PHD: 102327430(AXIN1)
CHX: 102170375(AXIN1)
OAS: 101122656(AXIN1)
SSC: 100523725(AXIN1)
CFR: 102508916(AXIN1)
CDK: 105098424(AXIN1)
BACU: 103006014(AXIN1)
LVE: 103085333(AXIN1)
OOR: 101272348(AXIN1)
ECB: 100065116(AXIN1)
EPZ: 103564115(AXIN1)
EAI: 106836161(AXIN1)
MYB: 102248340(AXIN1)
MYD: 102759594(AXIN1)
HAI: 109385980(AXIN1)
RSS: 109460642(AXIN1)
PALE: 102878657(AXIN1)
LAV: 100655765(AXIN1)
TMU: 101346985
MDO: 100016298(AXIN1)
SHR: 100923576(AXIN1)
OAA: 100093343 100093450(AXIN1)
GGA: 395786(AXIN1)
MGP: 100539162(AXIN1)
CJO: 107320950(AXIN1)
APLA: 101800899(AXIN1)
ACYG: 106033419(AXIN1)
TGU: 100226467(AXIN1)
GFR: 102034015(AXIN1)
FAB: 101812314(AXIN1)
PHI: 102108019(AXIN1)
PMAJ: 107211202(AXIN1)
CCW: 104684681(AXIN1)
FPG: 101924311(AXIN1)
FCH: 102054847(AXIN1)
CLV: 102091034(AXIN1)
EGZ: 104135741(AXIN1)
AAM: 106482339(AXIN1)
ASN: 102383198(AXIN1)
AMJ: 102566966(AXIN1)
PSS: 102453080 106732117(AXIN1)
CMY: 102945350(AXIN1)
CPIC: 101932057(AXIN1)
ACS: 100561864(axin1)
PBI: 103053070(AXIN1)
GJA: 107109315(AXIN1)
XLA: 398097(axin1.L) 734298(axin1.S)
XTR: 100498631(axin1)
NPR: 108796271(AXIN1)
DRE: 57931(axin1)
IPU: 108257243(axin1) 108258814
AMEX: 103030717 103045152(axin1)
TRU: 101065196(axin1) 101075840
LCO: 104918719(axin1) 104921153
MZE: 101472703 101487168(axin1)
OLA: 101155494 101155852(axin1)
XMA: 102228925 102232266(axin1)
PRET: 103456513 103468679(axin1)
NFU: 107378411(axin1) 107395828
CSEM: 103383461 103392632(axin1)
LCF: 108901170 108903015(axin1)
HCQ: 109511398 109513801(axin1)
ELS: 105013228(axin1) 105030252
LCM: 102351869(AXIN1)
CMK: 103188268(axin1)
CIN: 778548(axin)
SPU: 576611
APLC: 110976115
SKO: 100303567(axin1)
DME: Dmel_CG7926(Axn)
DSI: Dsimw501_GD21494(Dsim_Axn)
MDE: 101894228
AAG: 5577995
AME: 724501(Axin)
BIM: 100745962
BTER: 100642412
SOC: 105204827
AEC: 105150595
ACEP: 105620205
PBAR: 105423342
HST: 105190922
CFO: 105259438
LHU: 105674899
PGC: 109856767
NVI: 100120010
TCA: 655873(Axn)
NVL: 108558537
BMOR: 101739893
PMAC: 106713369
PRAP: 111000147
API: 100167569
DNX: 107166081
ZNE: 110835724
FCD: 110848502
CEL: CELE_C37A5.9(pry-1)
CBR: CBG18802(Cbr-pry-1)
BMY: Bm1_56035
TSP: Tsp_05616
CRG: 105334024
MYI: 110455658
OBI: 106867786
LAK: 106168343
SHX: MS3_08351
EPA: 110239987
ADF: 107345943
HMG: 100206389
AQU: 109580476
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9230313
  Authors
Zeng L, Fagotto F, Zhang T, Hsu W, Vasicek TJ, Perry WL 3rd, Lee JJ, Tilghman SM, Gumbiner BM, Costantini F
  Title
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.
  Journal
Cell 90:181-92 (1997)
DOI:10.1016/S0092-8674(00)80324-4
  Sequence
[hsa:8312]
Reference
  Authors
Luo W, Lin SC
  Title
Axin: a master scaffold for multiple signaling pathways.
  Journal
Neurosignals 13:99-113 (2004)
DOI:10.1159/000076563
Reference
  Authors
Willert K, Logan CY, Arora A, Fish M, Nusse R
  Title
A Drosophila Axin homolog, Daxin, inhibits Wnt signaling.
  Journal
Development 126:4165-73 (1999)
  Sequence

KEGG   ORTHOLOGY: K04385Help
Entry
K04385                      KO                                     

Name
AXIN2
Definition
axin 2
Pathway
ko04310  Wnt signaling pathway
ko04390  Hippo signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04934  Cushing syndrome
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05213  Endometrial cancer
ko05217  Basal cell carcinoma
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00857  Oligodontia-colorectal cancer syndrome
H01667  Medulloblastoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04385  AXIN2; axin 2
   04390 Hippo signaling pathway
    K04385  AXIN2; axin 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04385  AXIN2; axin 2
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04385  AXIN2; axin 2
   05210 Colorectal cancer
    K04385  AXIN2; axin 2
   05225 Hepatocellular carcinoma
    K04385  AXIN2; axin 2
   05226 Gastric cancer
    K04385  AXIN2; axin 2
   05217 Basal cell carcinoma
    K04385  AXIN2; axin 2
   05213 Endometrial cancer
    K04385  AXIN2; axin 2
   05224 Breast cancer
    K04385  AXIN2; axin 2
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K04385  AXIN2; axin 2
  09167 Infectious diseases
   05165 Human papillomavirus infection
    K04385  AXIN2; axin 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K04385  AXIN2; axin 2
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Other centriole associated proteins
    K04385  AXIN2; axin 2
BRITE hierarchy
Genes
HSA: 8313(AXIN2)
PTR: 468301(AXIN2)
PPS: 100990800(AXIN2)
GGO: 101154299(AXIN2)
PON: 100431721(AXIN2)
NLE: 100589482(AXIN2)
MCC: 718566(AXIN2)
MCF: 102129656(AXIN2)
CSAB: 103243176(AXIN2)
RRO: 104675432(AXIN2)
RBB: 108517751(AXIN2)
CJC: 100400518(AXIN2)
SBQ: 101036328(AXIN2)
MMU: 12006(Axin2)
RNO: 29134(Axin2)
CGE: 100750382(Axin2)
NGI: 103742203(Axin2)
HGL: 101716964(Axin2)
CCAN: 109681311(Axin2)
OCU: 100339765(AXIN2)
TUP: 102493766(AXIN2)
CFA: 490903(AXIN2)
AML: 100477069(AXIN2)
UMR: 103665908(AXIN2)
ORO: 101362548(AXIN2)
FCA: 101093061(AXIN2)
PTG: 102967280(AXIN2)
AJU: 106975307(AXIN2)
BTA: 511619(AXIN2)
BOM: 102278168(AXIN2)
PHD: 102330442(AXIN2)
CHX: 102180348(AXIN2)
OAS: 101109815(AXIN2)
SSC: 100739604(AXIN2)
CFR: 102508329(AXIN2)
CDK: 105085712(AXIN2)
BACU: 103006133(AXIN2)
LVE: 103072027(AXIN2)
OOR: 101277024(AXIN2)
ECB: 100630049(AXIN2)
EPZ: 103553492(AXIN2)
EAI: 106835348(AXIN2)
MYB: 102260435(AXIN2)
MYD: 102760211(AXIN2)
HAI: 109380327(AXIN2)
RSS: 109448049(AXIN2)
PALE: 102885831(AXIN2)
LAV: 100663921(AXIN2)
TMU: 101347495
MDO: 100024610(AXIN2)
SHR: 100933740(AXIN2)
OAA: 100077932(AXIN2)
GGA: 395152(AXIN2)
MGP: 100541268(AXIN2)
CJO: 107322239(AXIN2)
APLA: 101799849(AXIN2)
ACYG: 106034604(AXIN2)
TGU: 100230658(AXIN2)
GFR: 102040633(AXIN2)
FAB: 101818199(AXIN2)
PHI: 102099770(AXIN2)
PMAJ: 107212583(AXIN2)
CCW: 104696031(AXIN2)
FPG: 101923006(AXIN2)
FCH: 102052896(AXIN2)
CLV: 102087539(AXIN2)
EGZ: 104129411(AXIN2)
AAM: 106493090(AXIN2)
ASN: 102376921(AXIN2)
AMJ: 102568792(AXIN2)
PSS: 102451218(AXIN2)
CMY: 102940811(AXIN2)
CPIC: 101951915(AXIN2)
ACS: 100553926(axin2)
PVT: 110085879(AXIN2)
PBI: 103049867(AXIN2)
GJA: 107105953(AXIN2)
XLA: 108701205 108702158 373619(axin2.L) 447702(axin2.S)
NPR: 108801719(AXIN2) 108804668
DRE: 58080(axin2)
SANH: 107664537(axin2) 107701905
IPU: 108255292 108273124(axin2)
AMEX: 103042974 103044632(axin2)
LCO: 104918811(axin2) 104935090(Axin-2)
OLA: 101156143(axin2) 101159441
XMA: 102216583(axin2)
NFU: 107376523 107390091(axin2)
ELS: 105021564(axin2) 105026129
SFM: 108936851 108940092(axin2)
LCM: 102346005 102365123(AXIN2)
CMK: 103175739(axin2)
AQU: 100616092
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Mai M, Qian C, Yokomizo A, Smith DI, Liu W
  Title
Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24.
  Journal
Genomics 55:341-4 (1999)
DOI:10.1006/geno.1998.5650
  Sequence
[hsa:8313]
Reference
  Authors
Hadjihannas MV, Bruckner M, Behrens J
  Title
Conductin/axin2 and Wnt signalling regulates centrosome cohesion.
  Journal
EMBO Rep 11:317-24 (2010)
DOI:10.1038/embor.2010.23

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