KEGG   ORTHOLOGY: K02158Help
Entry
K02158                      KO                                     

Name
BAD
Definition
Bcl-2-antagonist of cell death
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04140  Autophagy - animal
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04370  VEGF signaling pathway
ko04510  Focal adhesion
ko04722  Neurotrophin signaling pathway
ko04910  Insulin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko05010  Alzheimer disease
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05145  Toxoplasmosis
ko05152  Tuberculosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05215  Prostate cancer
ko05218  Melanoma
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05223  Non-small cell lung cancer
ko05225  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
   04012 ErbB signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
   04370 VEGF signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
   04024 cAMP signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
   04022 cGMP - PKG signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
   04151 PI3K-Akt signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K02158  BAD; Bcl-2-antagonist of cell death
  09143 Cell growth and death
   04210 Apoptosis
    K02158  BAD; Bcl-2-antagonist of cell death
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K02158  BAD; Bcl-2-antagonist of cell death
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
   04919 Thyroid hormone signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K02158  BAD; Bcl-2-antagonist of cell death
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K02158  BAD; Bcl-2-antagonist of cell death
   05203 Viral carcinogenesis
    K02158  BAD; Bcl-2-antagonist of cell death
   05210 Colorectal cancer
    K02158  BAD; Bcl-2-antagonist of cell death
   05212 Pancreatic cancer
    K02158  BAD; Bcl-2-antagonist of cell death
   05225 Hepatocellular carcinoma
    K02158  BAD; Bcl-2-antagonist of cell death
   05221 Acute myeloid leukemia
    K02158  BAD; Bcl-2-antagonist of cell death
   05220 Chronic myeloid leukemia
    K02158  BAD; Bcl-2-antagonist of cell death
   05218 Melanoma
    K02158  BAD; Bcl-2-antagonist of cell death
   05211 Renal cell carcinoma
    K02158  BAD; Bcl-2-antagonist of cell death
   05215 Prostate cancer
    K02158  BAD; Bcl-2-antagonist of cell death
   05213 Endometrial cancer
    K02158  BAD; Bcl-2-antagonist of cell death
   05223 Non-small cell lung cancer
    K02158  BAD; Bcl-2-antagonist of cell death
  09163 Neurodegenerative diseases
   05010 Alzheimer disease
    K02158  BAD; Bcl-2-antagonist of cell death
   05014 Amyotrophic lateral sclerosis (ALS)
    K02158  BAD; Bcl-2-antagonist of cell death
  09167 Infectious diseases
   05152 Tuberculosis
    K02158  BAD; Bcl-2-antagonist of cell death
   05161 Hepatitis B
    K02158  BAD; Bcl-2-antagonist of cell death
   05160 Hepatitis C
    K02158  BAD; Bcl-2-antagonist of cell death
   05165 Human papillomavirus infection
    K02158  BAD; Bcl-2-antagonist of cell death
   05145 Toxoplasmosis
    K02158  BAD; Bcl-2-antagonist of cell death
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K02158  BAD; Bcl-2-antagonist of cell death
   01524 Platinum drug resistance
    K02158  BAD; Bcl-2-antagonist of cell death
   01522 Endocrine resistance
    K02158  BAD; Bcl-2-antagonist of cell death
BRITE hierarchy
Genes
HSA: 572(BAD)
PTR: 100615623(BAD)
PPS: 100988665(BAD)
GGO: 101151128(BAD)
PON: 100454097(BAD)
NLE: 101178725(BAD)
MCC: 717740(BAD)
MCF: 102121921(BAD)
CSAB: 103233293(BAD)
RRO: 104673141(BAD)
RBB: 108542734(BAD)
CJC: 100412880(BAD)
SBQ: 101049631(BAD)
MMU: 12015(Bad)
RNO: 64639(Bad)
CGE: 100760426(Bad)
NGI: 103738795(Bad)
HGL: 101726042(Bad)
CCAN: 109683261(Bad)
OCU: 100358587(BAD)
TUP: 102498069(BAD)
CFA: 483763(BAD)
AML: 100473937(BAD)
UMR: 103679423(BAD)
ORO: 101375422(BAD)
FCA: 768269(BAD)
PTG: 102956027(BAD)
AJU: 106981699(BAD)
BTA: 615013(BAD)
BOM: 102275975(BAD)
BIU: 109554386(BAD)
PHD: 102331776(BAD)
CHX: 102189930(BAD)
OAS: 780444(BAD)
SSC: 100521065(BAD)
CFR: 102523295(BAD)
CDK: 105101547(BAD)
BACU: 103005702(BAD)
LVE: 103083608(BAD)
OOR: 101274967(BAD)
ECB: 100055447(BAD)
EPZ: 103542187(BAD)
EAI: 106833626(BAD)
MYB: 102239479(BAD)
MYD: 102771665(BAD)
HAI: 109384256(BAD)
RSS: 109450456(BAD)
PALE: 102877892(BAD)
LAV: 100668387(BAD)
TMU: 101352047
MDO: 100031246(BAD)
SHR: 100923199(BAD)
AMJ: 109282419(BAD)
PSS: 102450183(BAD)
CMY: 102931799(BAD)
CPIC: 101939860(BAD)
PVT: 110083340(BAD)
PBI: 103066611(BAD)
GJA: 107115197(BAD)
XTR: 100487418(bad)
NPR: 108794161(BAD)
DRE: 58100(badb)
IPU: 108267538(P100/11E) 108278747(bad)
TRU: 105418743(bad)
LCO: 104928899(bad)
NCC: 104948201(bad)
MZE: 101483296(bad)
OLA: 101171945(bad)
XMA: 111611010(bad)
PRET: 103480747(bad)
NFU: 107377126(bad)
CSEM: 103384187(bad)
LCF: 108888776(bad)
HCQ: 109516634(bad)
SASA: 106563493(BAD) 106578087 106603152(BAD)
SFM: 108925227(bad)
LCM: 102363793(BAD)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9388232
  Authors
Ottilie S, Diaz JL, Horne W, Chang J, Wang Y, Wilson G, Chang S, Weeks S, Fritz LC, Oltersdorf T
  Title
Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins.
  Journal
J Biol Chem 272:30866-72 (1997)
DOI:10.1074/jbc.272.49.30866
  Sequence
[hsa:572]
Reference
PMID:9372935
  Authors
Kelekar A, Chang BS, Harlan JE, Fesik SW, Thompson CB
  Title
Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.
  Journal
Mol Cell Biol 17:7040-6 (1997)
DOI:10.1128/MCB.17.12.7040
  Sequence
[mmu:12015]

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