KEGG   ORTHOLOGY: K02161Help
Entry
K02161                      KO                                     

Name
BCL2
Definition
apoptosis regulator Bcl-2
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04064  NF-kappa B signaling pathway
ko04066  HIF-1 signaling pathway
ko04071  Sphingolipid signaling pathway
ko04115  p53 signaling pathway
ko04140  Autophagy - animal
ko04141  Protein processing in endoplasmic reticulum
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04215  Apoptosis - multiple species
ko04217  Necroptosis
ko04261  Adrenergic signaling in cardiomyocytes
ko04340  Hedgehog signaling pathway
ko04510  Focal adhesion
ko04621  NOD-like receptor signaling pathway
ko04630  JAK-STAT signaling pathway
ko04722  Neurotrophin signaling pathway
ko04725  Cholinergic synapse
ko04915  Estrogen signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05145  Toxoplasmosis
ko05152  Tuberculosis
ko05161  Hepatitis B
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05215  Prostate cancer
ko05222  Small cell lung cancer
ko05226  Gastric cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H00005  Chronic lymphocytic leukemia (CLL)
H00013  Small cell lung cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00041  Kaposi sarcoma
H00054  Nasopharyngeal cancer
H01613  Follicular lymphoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K02161  BCL2; apoptosis regulator Bcl-2
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04630 Jak-STAT signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04064 NF-kappa B signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04066 HIF-1 signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04071 Sphingolipid signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04151 PI3K-Akt signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K02161  BCL2; apoptosis regulator Bcl-2
  09143 Cell growth and death
   04210 Apoptosis
    K02161  BCL2; apoptosis regulator Bcl-2
   04215 Apoptosis - multiple species
    K02161  BCL2; apoptosis regulator Bcl-2
   04217 Necroptosis
    K02161  BCL2; apoptosis regulator Bcl-2
   04115 p53 signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K02161  BCL2; apoptosis regulator Bcl-2
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04928 Parathyroid hormone synthesis, secretion and action
    K02161  BCL2; apoptosis regulator Bcl-2
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K02161  BCL2; apoptosis regulator Bcl-2
  09156 Nervous system
   04725 Cholinergic synapse
    K02161  BCL2; apoptosis regulator Bcl-2
   04722 Neurotrophin signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05206 MicroRNAs in cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05210 Colorectal cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05226 Gastric cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05215 Prostate cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05222 Small cell lung cancer
    K02161  BCL2; apoptosis regulator Bcl-2
  09163 Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K02161  BCL2; apoptosis regulator Bcl-2
  09165 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K02161  BCL2; apoptosis regulator Bcl-2
  09166 Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02161  BCL2; apoptosis regulator Bcl-2
  09167 Infectious diseases
   05152 Tuberculosis
    K02161  BCL2; apoptosis regulator Bcl-2
   05161 Hepatitis B
    K02161  BCL2; apoptosis regulator Bcl-2
   05169 Epstein-Barr virus infection
    K02161  BCL2; apoptosis regulator Bcl-2
   05145 Toxoplasmosis
    K02161  BCL2; apoptosis regulator Bcl-2
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K02161  BCL2; apoptosis regulator Bcl-2
   01524 Platinum drug resistance
    K02161  BCL2; apoptosis regulator Bcl-2
   01522 Endocrine resistance
    K02161  BCL2; apoptosis regulator Bcl-2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatase and associated proteins
    K02161  BCL2; apoptosis regulator Bcl-2
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K02161  BCL2; apoptosis regulator Bcl-2
BRITE hierarchy
Genes
HSA: 596(BCL2)
PTR: 738409(BCL2)
PPS: 100992951(BCL2)
GGO: 101136123(BCL2)
PON: 100938429(BCL2)
NLE: 100599011(BCL2)
MCC: 707407(BCL2)
MCF: 102138212(BCL2)
CSAB: 103244166(BCL2)
RRO: 104682248(BCL2)
RBB: 108526412(BCL2)
CJC: 100408947(BCL2)
SBQ: 101051366(BCL2)
MMU: 12043(Bcl2)
RNO: 24224(Bcl2)
CGE: 100774873(Bcl2)
NGI: 103740099(Bcl2)
HGL: 101701667(Bcl2)
CCAN: 109693757(Bcl2)
OCU: 103349397(BCL2)
TUP: 102474592(BCL2)
CFA: 403416(BCL2)
AML: 100484344(BCL2)
UMR: 103676164(BCL2)
ORO: 101372267(BCL2)
FCA: 493934(BCL2)
PTG: 102953487(BCL2)
AJU: 106985187(BCL2)
BTA: 281020(BCL2)
BOM: 102268592(BCL2)
BIU: 109577782(BCL2)
PHD: 102336438(BCL2)
CHX: 100861254(BCL2)
OAS: 101119602(BCL2)
SSC: 100049703(BCL2)
CFR: 102523830(BCL2)
CDK: 105088999(BCL2)
BACU: 103015542(BCL2)
LVE: 103077294(BCL2)
OOR: 101276750(BCL2)
ECB: 100050934(BCL2)
EPZ: 103550767(BCL2)
EAI: 106832883(BCL2)
MYB: 102248597(BCL2)
MYD: 102769473(BCL2)
HAI: 109390784(BCL2)
RSS: 109446183(BCL2)
PALE: 102896443(BCL2)
LAV: 100675268(BCL2)
TMU: 101347007
MDO: 100016570(BCL2)
SHR: 100934666(BCL2)
GGA: 396282(BCL2)
MGP: 100545008(BCL2)
CJO: 107309650(BCL2)
APLA: 101791240(BCL2)
ACYG: 106039908(BCL2)
TGU: 100224888(BCL2)
GFR: 102032008(BCL2)
FAB: 101818228(BCL2)
PHI: 102113262(BCL2)
PMAJ: 107200701(BCL2)
CCW: 104698161(BCL2)
FPG: 101921728(BCL2)
FCH: 102056589(BCL2)
CLV: 102092853(BCL2)
AAM: 106482986(BCL2)
ASN: 102370035(BCL2)
AMJ: 102564752(BCL2)
PSS: 102444136(BCL2)
CMY: 102941395(BCL2)
CPIC: 101937209(BCL2)
ACS: 100564886(bcl2)
PVT: 110075422(BCL2)
PBI: 103059077(BCL2)
GJA: 107108130
XLA: 100271914(bcl2.S) 108719105
XTR: 100485267(bcl2)
NPR: 108793666(BCL2)
DRE: 100007048(bcl2b) 570772(bcl2a)
CCAR: 109049771 109050096(bcl2)
IPU: 108256596(bcl2) 108267470(BCL2)
TRU: 101071405(bcl2)
LCO: 104918293(bcl2) 104939569
NCC: 104957668
MZE: 101466853(bcl2) 101477921
OLA: 101163032(bcl2)
XMA: 102223266(bcl2)
PRET: 103479578(bcl2)
NFU: 107383942(bcl2)
CSEM: 103396176(bcl2)
LCF: 108883441(bcl2) 108890128
HCQ: 109521170
BPEC: 110157967(bcl2)
CMK: 103183201(bcl2)
SKO: 100374347
MYI: 110449714
EPA: 110231689
AQU: 100635395
VG: 26836919(vBcl-2)
 » show all
TaxonomyVtaxonomyKoalaUniProt
Reference
PMID:3523487
  Authors
Tsujimoto Y, Croce CM
  Title
Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.
  Journal
Proc Natl Acad Sci U S A 83:5214-8 (1986)
DOI:10.1073/pnas.83.14.5214
  Sequence
[hsa:596]
Reference
  Authors
Wei Y, Pattingre S, Sinha S, Bassik M, Levine B
  Title
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy.
  Journal
Mol Cell 30:678-88 (2008)
DOI:10.1016/j.molcel.2008.06.001
  Sequence
[hsa:596]

DBGET integrated database retrieval system