KEGG   ORTHOLOGY: K02187Help
Entry
K02187                      KO                                     

Name
CASP3
Definition
caspase 3 [EC:3.4.22.56]
Pathway
ko01524  Platinum drug resistance
ko04010  MAPK signaling pathway
ko04115  p53 signaling pathway
ko04210  Apoptosis
ko04215  Apoptosis - multiple species
ko04650  Natural killer cell mediated cytotoxicity
ko04657  IL-17 signaling pathway
ko04668  TNF signaling pathway
ko04726  Serotonergic synapse
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05010  Alzheimer disease
ko05012  Parkinson disease
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05016  Huntington disease
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05133  Pertussis
ko05134  Legionellosis
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05152  Tuberculosis
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05222  Small cell lung cancer
ko05416  Viral myocarditis
Module
M00685  Apoptotic machinery
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K02187  CASP3; caspase 3
   04668 TNF signaling pathway
    K02187  CASP3; caspase 3
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K02187  CASP3; caspase 3
   04215 Apoptosis - multiple species
    K02187  CASP3; caspase 3
   04115 p53 signaling pathway
    K02187  CASP3; caspase 3
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K02187  CASP3; caspase 3
   04657 IL-17 signaling pathway
    K02187  CASP3; caspase 3
  09156 Nervous system
   04726 Serotonergic synapse
    K02187  CASP3; caspase 3
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K02187  CASP3; caspase 3
   05206 MicroRNAs in cancer
    K02187  CASP3; caspase 3
   05205 Proteoglycans in cancer
    K02187  CASP3; caspase 3
   05203 Viral carcinogenesis
    K02187  CASP3; caspase 3
   05210 Colorectal cancer
    K02187  CASP3; caspase 3
   05222 Small cell lung cancer
    K02187  CASP3; caspase 3
  09163 Neurodegenerative diseases
   05010 Alzheimer disease
    K02187  CASP3; caspase 3
   05012 Parkinson disease
    K02187  CASP3; caspase 3
   05014 Amyotrophic lateral sclerosis (ALS)
    K02187  CASP3; caspase 3
   05016 Huntington disease
    K02187  CASP3; caspase 3
  09165 Cardiovascular diseases
   05416 Viral myocarditis
    K02187  CASP3; caspase 3
  09166 Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K02187  CASP3; caspase 3
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02187  CASP3; caspase 3
  09167 Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K02187  CASP3; caspase 3
   05133 Pertussis
    K02187  CASP3; caspase 3
   05134 Legionellosis
    K02187  CASP3; caspase 3
   05152 Tuberculosis
    K02187  CASP3; caspase 3
   05161 Hepatitis B
    K02187  CASP3; caspase 3
   05168 Herpes simplex infection
    K02187  CASP3; caspase 3
   05163 Human cytomegalovirus infection
    K02187  CASP3; caspase 3
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02187  CASP3; caspase 3
   05165 Human papillomavirus infection
    K02187  CASP3; caspase 3
   05146 Amoebiasis
    K02187  CASP3; caspase 3
   05145 Toxoplasmosis
    K02187  CASP3; caspase 3
  09168 Drug resistance
   01524 Platinum drug resistance
    K02187  CASP3; caspase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases
    K02187  CASP3; caspase 3
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00685  Apoptotic machinery
     K02187  CASP3; caspase 3
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.56  caspase-3
     K02187  CASP3; caspase 3
Peptidases [BR:ko01002]
 Cysteine Peptidases
  Family C14: caspase family
   K02187  CASP3; caspase 3
BRITE hierarchy
Other DBs
GO: 0097200
Genes
HSA: 836(CASP3)
PTR: 461669(CASP3)
PPS: 100974934(CASP3)
GGO: 101126742(CASP3)
PON: 100435491(CASP3)
NLE: 100585064(CASP3)
MCC: 694473(CASP3)
MCF: 102144182(CASP3)
CSAB: 103236614(CASP3)
RRO: 104666783 104673791(CASP3)
RBB: 108512689
CJC: 100387570(CASP3)
SBQ: 101029697(CASP3)
MMU: 12367(Casp3)
RNO: 25402(Casp3)
CGE: 100689061(Casp3)
NGI: 103744668 103750475(Casp3)
OCU: 100008840(CASP3)
TUP: 102472926(CASP3) 102487119
CFA: 403567(CASP3)
AML: 100469056(CASP3)
UMR: 103680991(CASP3)
ORO: 101371336(CASP3)
FCA: 493932(CASP3)
PTG: 102954729(CASP3)
AJU: 106979326(CASP3)
BTA: 408016(CASP3)
BOM: 102287348(CASP3)
BIU: 109553316(CASP3)
PHD: 102334771(CASP3)
CHX: 102177031(CASP3)
OAS: 443031(CASP3)
SSC: 397244(CASP3)
CFR: 102520133(CASP3)
CDK: 105084433(CASP3)
BACU: 103019939(CASP3)
LVE: 103073819(CASP3)
OOR: 101289847(CASP3)
ECB: 100034083(CASP3)
EPZ: 103549132(CASP3)
EAI: 106830081(CASP3)
MYB: 102258599(CASP3)
MYD: 102760961(CASP3)
HAI: 109395706(CASP3)
RSS: 109449637(CASP3)
PALE: 102897289(CASP3)
LAV: 100672256(CASP3)
TMU: 101354307
MDO: 654273(CASP3) 654275
SHR: 100922500(CASP3) 100922757
OAA: 100087105(CASP3)
GGA: 395476(CASP3)
MGP: 100548182(CASP3)
CJO: 107313280(CASP3)
APLA: 101805296(CASP3)
ACYG: 106035172(CASP3)
TGU: 100230799
GFR: 102035830(CASP3)
FAB: 101808212(CASP3)
PHI: 102104322(CASP3)
PMAJ: 107203069(CASP3)
CCW: 104690575(CASP3)
FPG: 101913355(CASP3)
FCH: 102056397(CASP3)
CLV: 102089427(CASP3)
EGZ: 104129473(CASP3)
AAM: 106484082(CASP3)
ASN: 102383553(CASP3)
AMJ: 102572621(CASP3) 102576234(CASP14)
PSS: 102463828(CASP3)
CMY: 102942062(CASP3)
CPIC: 101948246(CASP3)
ACS: 100563931(casp3)
PVT: 110083865(CASP3)
PBI: 103049711(CASP3)
GJA: 107115654(CASP3)
XLA: 100036910(casp3.L) 397720(casp3.S)
XTR: 100151728(casp3)
DRE: 140621(casp3a) 566604(casp3b)
IPU: 100528811(casp3) 108260860
TRU: 446083(casp3)
LCO: 104928227 104936945(caspase-3)
NCC: 104959742 104967108(casp3)
OLA: 100049215(casp3) 100049265
NFU: 107390752(casp3) 107397381
CSEM: 103383467 103391460(casp3)
SASA: 100194892(casp3) 106602722(CASP3) 106612018
ELS: 105006735(casp3) 105029385(casp3)
SFM: 108924572(casp3)
LCM: 106705928(CASP3)
CMK: 103187405(casp3)
SKO: 102802674
CRG: 105326608
MYI: 110452312
SHX: MS3_07622
EPA: 110247107
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7983002
  Authors
Fernandes-Alnemri T, Litwack G, Alnemri ES
  Title
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
  Journal
J Biol Chem 269:30761-4 (1994)
  Sequence
[hsa:836]
Reference
  Authors
Brentnall M, Rodriguez-Menocal L, De Guevara RL, Cepero E, Boise LH
  Title
Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis.
  Journal
BMC Cell Biol 14:32 (2013)
DOI:10.1186/1471-2121-14-32
  Sequence
[mmu:12367]

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