KEGG   ORTHOLOGY: K02206Help
Entry
K02206                      KO                                     

Name
CDK2
Definition
cyclin-dependent kinase 2 [EC:2.7.11.22]
Pathway
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04114  Oocyte meiosis
ko04115  p53 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04218  Cellular senescence
ko04914  Progesterone-mediated oocyte maturation
ko04934  Cushing syndrome
ko05161  Hepatitis B
ko05162  Measles
ko05165  Human papillomavirus infection
ko05168  Herpes simplex infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05215  Prostate cancer
ko05222  Small cell lung cancer
ko05226  Gastric cancer
Module
M00692  Cell cycle - G1/S transition
M00693  Cell cycle - G2/M transition
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K02206  CDK2; cyclin-dependent kinase 2
   04151 PI3K-Akt signaling pathway
    K02206  CDK2; cyclin-dependent kinase 2
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K02206  CDK2; cyclin-dependent kinase 2
   04114 Oocyte meiosis
    K02206  CDK2; cyclin-dependent kinase 2
   04115 p53 signaling pathway
    K02206  CDK2; cyclin-dependent kinase 2
   04218 Cellular senescence
    K02206  CDK2; cyclin-dependent kinase 2
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    K02206  CDK2; cyclin-dependent kinase 2
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K02206  CDK2; cyclin-dependent kinase 2
   05203 Viral carcinogenesis
    K02206  CDK2; cyclin-dependent kinase 2
   05226 Gastric cancer
    K02206  CDK2; cyclin-dependent kinase 2
   05215 Prostate cancer
    K02206  CDK2; cyclin-dependent kinase 2
   05222 Small cell lung cancer
    K02206  CDK2; cyclin-dependent kinase 2
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K02206  CDK2; cyclin-dependent kinase 2
  09167 Infectious diseases
   05162 Measles
    K02206  CDK2; cyclin-dependent kinase 2
   05161 Hepatitis B
    K02206  CDK2; cyclin-dependent kinase 2
   05168 Herpes simplex infection
    K02206  CDK2; cyclin-dependent kinase 2
   05169 Epstein-Barr virus infection
    K02206  CDK2; cyclin-dependent kinase 2
   05165 Human papillomavirus infection
    K02206  CDK2; cyclin-dependent kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K02206  CDK2; cyclin-dependent kinase 2
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K02206  CDK2; cyclin-dependent kinase 2
   03036 Chromosome and associated proteins
    K02206  CDK2; cyclin-dependent kinase 2
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00692  Cell cycle - G1/S transition
     K02206  CDK2; cyclin-dependent kinase 2
    M00693  Cell cycle - G2/M transition
     K02206  CDK2; cyclin-dependent kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     K02206  CDK2; cyclin-dependent kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CMGC group
  CDK family
   K02206  CDK2; cyclin-dependent kinase 2
DNA replication proteins [BR:ko03032]
 Eukaryotic Type
  DNA Replication Initiation Factors
   CDK (cyclin dependent kinase)
    K02206  CDK2; cyclin-dependent kinase 2
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    K02206  CDK2; cyclin-dependent kinase 2
BRITE hierarchy
Other DBs
COG: COG0515
GO: 0004693
Genes
HSA: 1017(CDK2)
PTR: 467032(CDK2)
PPS: 100981695(CDK2)
GGO: 101134769(CDK2)
PON: 100446748(CDK2)
NLE: 100592796(CDK2)
MCC: 711002(CDK2)
MCF: 102139233(CDK2)
CSAB: 103238495(CDK2)
RRO: 104673700(CDK2)
RBB: 108516053(CDK2)
CJC: 100398703(CDK2)
SBQ: 101053477(CDK2)
MMU: 12566(Cdk2)
RNO: 362817(Cdk2)
CGE: 100689039(Cdk2)
NGI: 103746495(Cdk2)
HGL: 101725353(Cdk2)
CCAN: 109698572(Cdk2)
OCU: 100134865(CDK2)
TUP: 102500015(CDK2)
CFA: 100855704(CDK2)
AML: 100468314(CDK2)
UMR: 103682503(CDK2)
ORO: 101383299(CDK2)
FCA: 101093368(CDK2)
PTG: 102959572(CDK2)
AJU: 106986916(CDK2)
BTA: 519217(CDK2)
BOM: 102277344(CDK2)
BIU: 109559386(CDK2)
PHD: 102344511(CDK2)
CHX: 100860751(CDK2)
OAS: 100216433(CDK2)
SSC: 100154715(CDK2)
CFR: 102504649(CDK2)
CDK: 105086385(CDK2)
BACU: 103012976(CDK2)
LVE: 103089138(CDK2)
OOR: 101289729(CDK2)
ECB: 100051790(CDK2)
EPZ: 103560212(CDK2)
EAI: 106841302(CDK2)
MYB: 102256122(CDK2)
MYD: 102756838(CDK2)
HAI: 109396882(CDK2)
RSS: 109442483 109452975(CDK2)
PALE: 102893397(CDK2)
LAV: 100668134(CDK2)
TMU: 101355616
SHR: 100925631(CDK2)
GGA: 100529062(CDK2)
MGP: 100542044(CDK2)
CJO: 107325763(CDK2)
FAB: 101808120
PHI: 102108666 106628853(CDK2)
AAM: 106482119(CDK2)
ASN: 102376317(CDK2)
AMJ: 102570724(CDK2)
PSS: 102459974(CDK2)
CMY: 102929928(CDK2)
CPIC: 101933939(CDK2)
ACS: 100555545(cdk2)
PVT: 110073535(CDK2)
PBI: 103054413(CDK2)
GJA: 107105847(CDK2)
XLA: 399314(cdk2.S) 432036(cdk2.L)
XTR: 493498(cdk2)
NPR: 108790510(CDK2)
DRE: 406715(cdk2)
IPU: 108255265(cdk2)
AMEX: 103028318(cdk2)
TRU: 101062041(cdk2)
NCC: 104951204 104956742(cdk2)
MZE: 101479025(cdk2) 112431130
OLA: 101161880(cdk2)
XMA: 102233595(cdk2)
PRET: 103465316(cdk2)
NFU: 107385661(cdk2)
CSEM: 103386039(cdk2)
LCF: 108886434 108898963(cdk2)
HCQ: 109522438(cdk2)
BPEC: 110171255(cdk2)
SASA: 100196712(cdk2) 106565437
ELS: 105016957(cdk2)
SFM: 108918171(cdk2)
LCM: 102366560(CDK2) 102367189
CMK: 103182904 103189561(cdk2)
CIN: 100182544
SPU: 585950
APLC: 110975774
SKO: 100367943
DME: Dmel_CG10498(Cdk2)
DSI: Dsimw501_GD19371(Dsim_GD19371)
DYA: Dyak_GE25682(Dyak_cdc2c)
MDE: 101895014
AME: 409959(cdc2c)
BIM: 100744168
BTER: 100643829
SOC: 105201449
AEC: 105145907
ACEP: 105622080
PBAR: 105429084
HST: 105182056
CFO: 105253817
LHU: 105671693
PGC: 109863842
NVI: 100117828(Cdk2)
TCA: 103313355 103314472(cdc2)
DPA: 109538506
BMOR: 101738936(CDK2)
PMAC: 106709693
PRAP: 110999496
API: 100162479
DNX: 107166377
ZNE: 110831693
FCD: 110856503
TUT: 107361131
CRG: 105325500
MYI: 110446820
OBI: 106876684
LAK: 106173442
EPA: 110238330
ADF: 107351566
HMG: 100212745
AQU: 100641341
ATH: AT3G48750(CDC2)
CRB: 17886903
CPAP: 110815056
TCC: 18587577
LJA: Lj0g3v0192439.1(Lj0g3v0192439.1) Lj4g3v0334720.1(Lj4g3v0334720.1) Lj6g3v1589780.1(Lj6g3v1589780.1)
AIP: 107638937
FVE: 101303270
PPER: 18787950
PMUM: 103331150
PAVI: 110764980
CSV: 101217311
CMO: 103489404
MCHA: 111018643
JCU: 105628962
VVI: 100262312
SLY: 101248452 544139(SICDKA1) 544140(cdc2A-2)
HAN: 110921605
SOE: 110795436
DOSA: Os02t0123100-01(Os02g0123100) Os03t0118400-01(Os03g0118400)
ATS: 109738027(LOC109738027) 109755114(LOC109755114)
ZMA: 100273306(gpm167a) 100284730(pco133105a) 103628436 109942257 542270(cdc2)
DCT: 110103529
MIS: MICPUN_55646(CDKA)
MPP: MICPUCDRAFT_69828(CDKA)
APRO: F751_4573
DDI: DDB_G0272813(cdk1)
DFA: DFA_00840(cdk1)
EHI: EHI_065280(119.t00008) EHI_152430(6.t00087) EHI_153140(13.t00001)
PYO: PY17X_1356000(PY04971)
PCB: PCHAS_135550(PC000342.01.0)
CPV: cgd1_60
SMIN: v1.2.029202.t1(symbB.v1.2.029202.t1)
AAF: AURANDRAFT_37561(CDK1)
SPAR: SPRG_02555
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1714386
  Authors
Elledge SJ, Spottswood MR
  Title
A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.
  Journal
EMBO J 10:2653-9 (1991)
  Sequence
[hsa:1017]
Reference
  Authors
Zhao H, Chen X, Gurian-West M, Roberts JM
  Title
Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication.
  Journal
Mol Cell Biol 32:1421-32 (2012)
DOI:10.1128/MCB.06721-11

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