KEGG ORTHOLOGY: K02261

ORTHOLOGY: K02261

Entry

K02261                      KO

Symbol

COX2

Name

cytochrome c oxidase subunit 2

Pathway

map00190

Oxidative phosphorylation

map01100

Metabolic pathways

map04260

Cardiac muscle contraction

map04714

Thermogenesis

map04932

Non-alcoholic fatty liver disease

map05010

Alzheimer disease

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05208

Chemical carcinogenesis - reactive oxygen species

map05415

Diabetic cardiomyopathy

Module

M00154

Cytochrome c oxidase

Disease

H01368

Cytochrome c oxidase (COX) deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    K02261  COX2; cytochrome c oxidase subunit 2
09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K02261  COX2; cytochrome c oxidase subunit 2
  09159 Environmental adaptation
   04714 Thermogenesis
    K02261  COX2; cytochrome c oxidase subunit 2
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K02261  COX2; cytochrome c oxidase subunit 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02261  COX2; cytochrome c oxidase subunit 2
   05012 Parkinson disease
    K02261  COX2; cytochrome c oxidase subunit 2
   05014 Amyotrophic lateral sclerosis
    K02261  COX2; cytochrome c oxidase subunit 2
   05016 Huntington disease
    K02261  COX2; cytochrome c oxidase subunit 2
   05020 Prion disease
    K02261  COX2; cytochrome c oxidase subunit 2
   05022 Pathways of neurodegeneration - multiple diseases
    K02261  COX2; cytochrome c oxidase subunit 2
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K02261  COX2; cytochrome c oxidase subunit 2
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K02261  COX2; cytochrome c oxidase subunit 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K02261  COX2; cytochrome c oxidase subunit 2
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Cytochrome c oxidase
    K02261  COX2; cytochrome c oxidase subunit 2

Other DBs

COG:

COG1622

TC:	3.D.4.11 3.D.4.7 3.D.4.8

Genes

HSA:	4513(COX2)

PTR:	807864(COX2)

PPS:	807874(COX2)

GGO:	6742682(COX2)

PON:	808475(COX2)

NLE:	16545238(COX2)

MCC:	2846628(COX2)

MCF:	7857740(COX2)

CSAB:

4097491(COX2)

CATY:

26408635(COX2)

PANU:

14444632(COX2)

TGE:	14216784(COX2)

RRO:	4171537(COX2)

RBB:	10549370(COX2)

TFN:	18985075(COX2)

CJC:	22203903(COX2)

SBQ:	13228914(COX2)

CSYR:

7944469(COX2)

MMUR:

26823976(COX2)

LCAT:

68929184(COX2)

PCOQ:

6458115(COX2)

MMU:	17709(COX2)

MCAL:

20832245(COX2)

MPAH:

36165343(COX2)

RNO:	26198(COX2)

MCOC:

34683002(COX2)

MUN:	18129807(COX2)

CGE:	3979186(COX2)

MAUA:

8457926(COX2)

PROB:

30213873(BOP69_gp10)

PLEU:

36275554(COX2)

NGI:	15088426(COX2)

HGL:	10201212(COX2)

CPOC:

808635(COX2)

CCAN:

31082906(COX2)

DSP:

122102258

PLOP:

125345647

OCU:	808233(COX2)

OPI:	2717276(COX2)

GVR:	804969(COX2)

CFA:	804479(COX2)

VVP:	4355754(COX2)

VLG:	23629749(COX2)

NPO:	8690243(COX2)

AML:	5179728(COX2)

UMR:	804870(COX2)

UAR:	804844(COX2)

LLV:	71922415(COX2)

MNP:	20466141(COX2)

NVS:	14841842(COX2)

EJU:	805022(COX2)

ZCA:	4355791(COX2)

MLX:	4355867(COX2)

LWW:	4355829(COX2)

FCA:	807936(COX2)

PYU:	26129874(COX2)

PCOO:

11473381(COX2)

PBG:	26129494(COX2)

PPAD:

6262377(COX2)

PUC:	6262410(COX2)

AJU:	2654015(COX2)

HHV:	14842158(COX2)

BTA:	3283880(COX2)

BOM:	22161769(COX2)

BIU:	2885980(COX2)

BBUB:

56055856(COX2)

CHX:	1485859(COX2)

OAS:	808252(COX2)

BTAX:

8250963(COX2)

ODA:	11452041(COX2)

CCAD:

59433139(COX2)

MBEZ:

7872545(COX2)

SSC:	808504(COX2)

CFR:	5326224(COX2)

CBAI:

5309940(COX2)

CDK:	5618959(COX2)

VPC:	809428(COX2)

LVE:	3802095(COX2)

OOR:	72909420(COX2)

DLE:	31412987(COX2)

PCAD:

809416(COX2)

ECB:	807845(COX2)

EPZ:	19019450(COX2)

EAI:	808064(COX2)

MYB:	20964695(COX2)

MYD:	22203917(COX2)

MMYO:

26889527(COX2)

MLF:	27214819(COX2)

DRO:	17046633(COX2)

AJM:	808333(COX2)

HAI:	13539868(COX2)

PALE:

17963494(COX2)

RAY:	3666154(COX2)

MJV:	24019672(COX2)

TOD:	38289020(D9W85_mgp10)

LAV:	808790(COX2)

ETF:	802328(COX2)

DNM:	808136(COX2)

MDO:	3074663(COX2)

GAS:	63652837(COX2)

SHR:	13826435(COX2)

AFZ:	65342081(COX2)

PCW:	4108297(COX2)

OAA:	808709(COX2)

GGA:	39116936(COX2)

PCOC:

10609898(COX2)

MGP:	5848004(COX2)

CJO:	804666(COX2)

LMUT:

31079467(COX2)

NMEL:

32282791(COX2)

APLA:

5405812(COX2)

CATA:

7996700(COX2)

AFUL:

19909398(COX2)

TGU:	3950793(COX2)

SCAN:

37275782(COX2)

PMOA:

20355699(COX2)

OTC:	22548461(COX2)

PRUF:

17674378(COX2)

FAB:	16027875(COX2)

PHI:	9480995(COX2)

PMAJ:

39089585(COX2)

CCW:	71712383(COX2)

MMEA:

20357135(COX2)

FPG:	808592(COX2)

FCH:	23808612(COX2)

CLV:	8889998(COX2)

EGZ:	18985250(COX2)

NNI:	4108695(COX2)

PADL:

26737700(COX2)

AGEN:

7256434(COX2)

GSTE:

3416063(COX2)

RTD:	84348656(COX2)

AROW:

62676598(COX2)

NPD:	62676487(COX2)

DNE:	803265(COX2)

ASN:	806139(COX2)

AMJ:	808245(COX2)

CPOO:

4108087(COX2)

GGN:	4178385(COX2)

PSS:	2943122(COX2)

CMY:	808646(COX2)

CCAY:

11747786(COX2)

CPIC:

18982997(COX2)

CABI:

60253689(COX2)

ACS:	6385975(COX2)

PVT:	3338350(CO2)

PBI:	YP_008083602

PMUR:

107301994 15822633(COX2)

APRI:

131187388

PMUA:

7056463(COX2)

ZVI:	118075331 24146102(YC27_gp10)

GJA:	26044429(COX2)

STOW:

125434155

EMC:	30861819(COX2)

XLA:	2642081(COX2)

XTR:	3283495(COX2)

NPR:	24020214(COX2)

BGAR:

4356057(COX2)

MUO:	18490096(COX2)

GSH:	14469872(COX2)

DRE:	140540(COX2)

SRX:	24419178(COX2)

SANH:

24419954(COX2)

SGH:	8382165(COX2)

CCAR:

807772(COX2)

CGIB:

9222067(COX2)

PTET:

5787378(COX2)

LROH:

12079593(COX2)

OMC:	18668120(COX2)

PPRM:

26048344(COX2)

RKG:	130077635 130077636 130077639 130077641

MAMB:

5912295(COX2)

CIDE:

5857710(COX2)

MASI:

3131136(COX2)

TROS:

14048438(COX2)

TDW:	36952192(COX2)

MANU:

6879712(COX2)

IPU:	804875(COX2)

IFU:	26118487(COX2)

PHYP:

16216570(COX2)

SMEO:

10079900(COX2)

TVC:	10079789(COX2)

CHAR:

5228440(COX2)

TRU:	805219(COX2)

TFS:	19524534(COX2)

TNG:	BAE79220(COII)

LCO:	7095384(COX2)

NCC:	10752025(COX2)

PGEO:

67284259(COX2)

EMAC:

30862040(COX2)

ELY:	7095519(COX2)

EFO:	14412330(COX2)

PLEP:

4363285(COX2)

SLUC:

23629805(COX2)

ESP:	40141436(COX2)

PFLV:

14048219(COX2)

PPUG:

119199130 7042820(COX2)

AFB:	13230431(COX2)

PSWI:

72130141(COX2)

MSAM:

4100028(COX2)

SCHU:

10965113(COX2)

CUD:	8774886(COX2)

MZE:	26037644(APK84_gp10)

ONL:	8677314(COX2)

OAU:	8745942(COX2)

OLA:	805431(COX2)

OML:	13540110(COX2)

CSAI:

804092(COX2)

XMA:	6986206(COX2)

XCO:	26048192(COX2)

XHE:	8302509(COX2)

PRET:

19590712(COX2)

GAF:	805448(COX2)

CVG:	26048382(COX2)

CTUL:

26129152(COX2)

NFU:	7256399(COX2)

KMR:	804466(COX2)

AOCE:

4850669(COX2)

CSEM:

7996482(COX2)

POV:	808848(COX2)

SSEN:

4266842(COX2)

HHIP:

5405727(COX2)

HSP:	5405783(COX2)

SMAU:

8382075(COX2)

LCF:	3703590(COX2)

SDU:	11669689(COX2)

XGL:	7871597(COX2)

HCQ:	14658013(COX2)

SSCV:

125966266 125966267

SBIA:

35996588(COX2)

PTAO:

74193753(COX2)

BPEC:

YP_004935134.1

MALB:

803940(COX2)

BSPL:

23631935(COX2)

SJO:	8703816(COX2)

SASA:

808315(COX2)

STRU:

19099178(COX2)

OTW:	KEF73_p10(COX2)

OMY:	807980(COX2)

OGO:	6383209(COX2)

ONE:	4555710(COX2)

OKI:	4955090(COX2)

OKE:	12486862(COX2)

SALP:

808546(COX2)

SNH:	35115221(COX2)

CCLU:

14842634(COX2)

ELS:	806650(COX2)

SFM:	3416107(COX2)

AANG:

3190268(COX2)

LOC:	807196(COX2)

PSPA:

805412(COX2)

ARUT:

17097821(COX2)

LCM:	808086(COX2)

CMK:	9385347(COX2)

RTP:	18267179(COX2)

CPLA:

7768745(COX2)

LERI:

11452181(COX2)

PMRN:

807803(COX2)

LRJ:	9385084(COX2)

BFO:	808727(COX2)

BBEL:

806244(COX2)

SCLV:

36165621(COX2)

SPU:	2652720(COX2)

APLC:

3907676(COX2)

SKO:	3703602(COX2)

DME:	Dmel_CG34069(COX2)

DSE:	116800960 2760949(COX2)

DSI:

COX2

DYA:

COX2

DAN:	116655089 26514691

DMN:	117194305 117194311

DGR:

116806152

CCAT:

808517(COX2)

BOD:	2717267(COX2)

BDR:	4657574(COX2)

AOQ:	79023077(COX2)

TDA:

119664760

MDE:	20358596(COX2)

LSQ:	5469264(COX2)

ECOE:

35199149(COX2)

HIS:	33350929(COX2)

ACOZ:

26121321(COX2)

AARA:

26121207(COX2)

AMER:

26121511(COX2)

AFUN:

76054171(COX2)

AMOU:

73620845(COX2)

AALI:

118463013

AAG:	33307558(COX2)

AALB:

3260126(COX2)

CQU:

COX2

BCOO:

119084558

ACER:

9385639(COX2)

ALAB:

34829161(COX2)

AFLR:

15822484(COX2)

BAFF:

126926943

BPAS:

132915722

OBB:	114881506 114882498

OLG:

117611528

SOC:	9977790(COX2)

VEM:	27912175(COX2)

LHU:	42265443(COX2)

TPRE:

111693314

LHT:

122510120

CGLO:

123274420 123274744

AGIF:

63649819(COX2)

CCIN:

107274034 7872292(COX2)

DSM:

124415517

NPT:	124224121 124224122 124224123

NFB:	124187554 124187555 124187563

NVG:

124306994

TCA:	803826(COX2)

SOY:	28481402(COX2)

ATD:	34926357(COX2)

CSET:

123314001

AGB:	108912903 4171598(COX2)

APLN:

28479672(COX2)

OTU:	111422026 111425647

BMOR:

119631134 809267(COX2)

BMAN:

804645(COX2)

MSEX:

5848748(COX2)

DPL:	AGL76300(COX2)

BANY:

128199777 128199780

PMAC:

13080342(COX2)

PPOT:

20159555(COX2)

PXU:	26836885(COX2)

PRAP:

11030479(COX2)

PBX:

123718330

PNAP:

125062967 125062968 60241344(COX2)

LSIN:

126973514

HAW:	9977713(COX2)

HZE:	124645585 71203127(COX2)

TNL:	44149127(COX2)

SLIU:

17427395(COX2)

PXY:	20834447(COX2)

PGW:	73956679(COX2)

API:	7055876(COX2)

DNX:	17428410(COX2)

AGS:	19909101(COX2)

BTAB:

3077222(COX2)

DCI:	108252528 27914404(COX2)

CLEC:

27787574(COX2)

HHAL:

8457883(COX2)

NLU:	16216527(COX2)

HVI:	3332284(COX2)

MQU:	32891620(COX2)

FOC:	YP_006576372

TPAL:

38092109(COX2)

ZNE:	110840503 20004829(COX2)

SGRE:

73491794(COX2)

DPX:	AAD33232(COII)

DMK:	24147206(COX2)

PVM:	5333214(COX2)

PJA:	3416043(COX2)

PCHN:

5333403(COX2)

PMOO:

808978(COX2)

HAME:

10743673(COX2)

PCLA:

11763611(COX2)

CQD:	17728511(COX2)

PTRU:

1482825(COX2)

ESN:	3355548(COX2)

HAZT:

38169114(COX2)

EAF:	54124856(COX2)

TCF:	4788291(COX2)

DSV:	23630418(COX2)

RSAN:

808373(COX2)

RMP:	18250936(COX2)

VDE:	806166(COX2)

TUT:	6164216(COX2)

DPTE:

7564645(COX2)

CSCU:

111621898

LPOL:

106457924 106462804 803786(COX2)

CEL:	KEF34_p03(COX2)

CBR:

COX2

NAI:	804828(COX2)

BMY:	KEF88_p03(COX2)

LOA:

COX2

TSP:

COX2

PCAN:

19909179(COX2)

BGT:	106050650 2746317(COX2)

HRF:	35985148(COX2)

HRJ:	2846695(COX2)

CRG:	808828(COX2)

CANU:

7865909(COX2)

MMER:

55289785(COX2)

OBI:	27205958(COX2)

OSN:	62676620(COX2)

LAK:	C2G87_mgp13(COX2)

SMM:

COX2

SHX:	4097442(COX2)

EGL:	41697839(cox2)

ATEN:

41854791(COX2)

ADF:	17674594(COX2)

PDAM:

5580397(COX2)

SPIS:

6798782(COX2)

DGT:	8656279(COX2)

XEN:	124455310 124455318

HMG:	6904233(COX2)

TAD:	TradoM_p11(COX2)

AQU:	4794355(COX2)

ATH:	DA397_mgp01(cox2)

CRB:	40490686(cox2)

EUS:	EUTSA_v10023011mg

BRP:	56141033(cox2-1)

BNA:	4237883(cox2-1) 4237884(cox2-2)

RSZ:	13630169(cox2)

CPAP:

110820367 7441425(cox2)

CIT:	36487036(cox2)

GRA:	27429599(cox2)

GHI:	24679512(cox2)

GAB:	33134367(cox2)

HSYR:

120126119 120183016

EGR:	38466595(cox2)

GMX:	100782702(COX2) 15308623(cox2)

GSJ:	114367624 38334506(cox2)

PVU:	PHAVU_009G252600g

VRA:

VAR:

VUN:

VUM:

CCAJ:

TPRA:

55290705(cox2)

CAM:

101496649

PSAT:

127107515

VVO:

131637796

LJA:	Lj0g3v0062549.1(Lj0g3v0062549.1) Lj0g3v0175899.1(Lj0g3v0175899.1) Ljmtg3v0000870.1(Ljmitog3v0000870.1)

ADU:	107472421 107492039 127746502

AIP:

107619623

AHF:	112742270 112770905 114926177 114926187 114927242 114927342

PCIN:

129294843 129294848 129294890 129295608

MDM:	13630207(cox2)

MSYL:

126634178 73938921(cox2)

PXB:

103935049

ZJU:	27215258(cox2)

MNT:	39338986(cox2)

CSAV:

27215472(cox2)

CSV:	11123901(cox2)

CMO:	107990889 127147454 127148059 127150340

BHJ:

120079271

MCHA:

111018435

CPEP:

111810906

RCU:	10221420(cox2)

JCU:

119369480

HBR:

110639978

MESC:

42317494(cox2)

PEU:

105138839

PALZ:

39331206(cox2)

VVI:	132254509 7498556(cox2)

SLY:

101264997

SPEN:

107030119 34926004(cox2)

SOT:

107063149

SSTN:

125873763

CANN:

107855101 124898705 19989172(cox2)

NTA:	3205306(cox2)

NSY:	104227400 27214855(cox2)

NTO:

104091428

NAU:	109208361 109241468 35198919(cox2)

INI:	29082029(cox2)

ITR:

SIND:

EGT:

SSPL:

SMIL:

18126272(cox2)

HAN:

110942618

LSV:	40498720(cox2)

DCR:	108214800 12598549(cox2)

CSIN:

114304736 40867536(cox2)

BVG:	809487(cox2) 809574(orf317)

SOE:	130460645 33876581(cox2)

CQI:	39331948(cox2)

ATRI:

130827079

NNU:	28482653(cox2)

MING:

122081641

TSS:	122647080 122647081

OSA:	6450161(cox2)

DOSA:

Os04t0343050-00(Os04g0343050)

OGL:	127757119 127762850 127762851

TDC:	119281849 119283495 119299775 119302095 119315160 119320154 119325920 119328180 119332451 119361882 119363924

TAES:

123052508 123055615 123060679 123071716 123074751 123102879 123121942 123130606 123137017 123137270 34688777(cox2)

TUA:	125528888 125535802 125537455 125546035 125552321

LPER:

127321049

LRD:

124687851

SBI:	4306043(cox2)

SITA:

111256055

SVS:	117863734 117865664

PVIR:

120693817 120693836

PDA:	11542569(cox2)

MUS:

103974065

MSIN:

131258351

NCOL:

36487337(cox2)

ATR:

110006799

PPP:	3989052(cox2)

CRE:	CHLRE_01g049500v5

VCN:	VOLCADRAFT_80299(cox2B)

CSL:	CospCoM_p09(cox2)

CVR:	OJ20_p06(cox2)

APRO:

ChprMp035(cox2)

OTA:	OstapMp32(Cox2)

BPG:	BathyMg00040(cox2)

MIS:	MicpuN_mit21(cox2)

GSL:	JL72_p04(cox2)

CCP:	ChcroMp04(cox2)

SCE:	Q0250(COX2)

SPAO:

A560_p01(cox2)

AGO:	AGOS_AMI001W

KLA:	KllafMp06(COX2)

KMX:	CRD48_mgp11(COX2)

VPO:	VapofMp05(cox2)

CGR:	CaglfMp11(cox2)

DHA:

cox2

CAL:	CaalfMp01(COX2)

YLI:	YalifMp18(cox2)

CLUS:

16792604(cox2)

NCR:

NCU16028

SMP:	SMAC_12689(cox2)

PAN:	PoanfMp43(cox2)

CTHR:

CTHT_m000310

SSCK:

SPSK_11049

FGR:	GizefMp06(cox2)

PTKZ:

MRV25_mgp12(cox2)

VAL:	VDBG_17011

CLUP:

AYB75_mgp09(cox2)

SSL:	SS1G_20045

ANI:	ANID_20019

ANG:	Asnifp13(cox2)

ALUC:

EJ508_mgp05(cox2)

TML:	GSTUM_00001112001

SPO:	ScpofMp10(cox2)

SOM:	PWB26_mgp08(cox2)

MRT:	D9L16_mgp11(cox2)

PSTR:

EFH26_mgp05(cox2)

PFA:	PF3D7_1430900

PFD:	PFDG_00559

PFH:	PFHG_00500

PREI:

PRSY57_1430200

PGAB:

PGSY75_1430900

PYO:	PY17X_1015300

PCB:	PCHAS_1014600

PBE:	PBANKA_1013800

PVV:	PVVCY_1001860

PKN:	PKNH_1327800

PVX:	PVX_084995

PCY:	PCYB_132780

PMAL:

PREL:

TAN:

TPV:

TOT:	TOT_010000664

BEQ:	BEWA_037790

BBO:	BBOV_IV010440

BMIC:

BMR1_03g03415

BBIG:

BBBOND_0108140

TGO:	TGME49_310470

SMIN:

v1.2.011481.t1(symbB.v1.2.011481.t1)

PSOJ:

PhsooMp05(cox2)

» show all

Reference

PMID:10486321

Authors

Rahman S, Taanman JW, Cooper JM, Nelson I, Hargreaves I, Meunier B, Hanna MG, Garcia JJ, Capaldi RA, Lake BD, Leonard JV, Schapira AH

Title

A missense mutation of cytochrome oxidase subunit II causes defective assembly and myopathy.

Journal

Am J Hum Genet 65:1030-9 (1999)
DOI:10.1086/302590

Sequence

[hsa:4513]

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Ontology (6)   
   KEGG BRITE (2)   
   TC (3)   
   COG (1)   
Pathway (27)   
   KEGG PATHWAY (26)   
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Disease (1)   
   KEGG DISEASE (1)   
Gene (2660)   
   KEGG GENES (645)   
   KEGG MGENES (1263)   
   RefGene (732)   
   OC (20)   
Literature (1)   
   PubMed (1)   
All databases (2695)   

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