KEGG   ORTHOLOGY: K02367Help
Entry
K02367                      KO                                     

Name
EXT2
Definition
glucuronyl/N-acetylglucosaminyl transferase EXT2 [EC:2.4.1.224 2.4.1.225]
Pathway
ko00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
ko01100  Metabolic pathways
Module
M00059  Glycosaminoglycan biosynthesis, heparan sulfate backbone
Disease
H00122  Multiple exostoses
H00493  Heparan sulfate proteoglycan gene defects
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Glycan biosynthesis and metabolism
   00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
    K02367  EXT2; glucuronyl/N-acetylglucosaminyl transferase EXT2
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Glycosaminoglycan metabolism
    M00059  Glycosaminoglycan biosynthesis, heparan sulfate backbone
     K02367  EXT2; glucuronyl/N-acetylglucosaminyl transferase EXT2
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.224  glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
     K02367  EXT2; glucuronyl/N-acetylglucosaminyl transferase EXT2
    2.4.1.225  N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase
     K02367  EXT2; glucuronyl/N-acetylglucosaminyl transferase EXT2
Glycosyltransferases [BR:ko01003]
 Glycan extension
  O-Glycan
   K02367  EXT2; glucuronyl/N-acetylglucosaminyl transferase EXT2
BRITE hierarchy
Other DBs
RN: R05935 R10138 R10139
GO: 0050508 0050509
CAZy: GT47 GT64
Genes
HSA: 2132(EXT2)
PTR: 451140(EXT2)
PPS: 100975712(EXT2)
GGO: 101130563(EXT2)
PON: 100436160(EXT2)
NLE: 100604250(EXT2)
MCC: 715975(EXT2)
MCF: 102136104(EXT2)
CSAB: 103236980
RRO: 104673882(EXT2)
RBB: 108519255(EXT2)
CJC: 100400679(EXT2)
SBQ: 101039408(EXT2)
MMU: 14043(Ext2)
RNO: 311215(Ext2)
CGE: 100751585(Ext2)
NGI: 103751554(Ext2)
HGL: 101715817(Ext2)
OCU: 100343697(EXT2)
TUP: 102487057(EXT2)
CFA: 475989(EXT2)
AML: 100476265 105242037(EXT2)
UMR: 103672344(EXT2)
ORO: 101366478(EXT2)
FCA: 101083620(EXT2)
PTG: 102964333(EXT2)
AJU: 106978049(EXT2)
BTA: 281151(EXT2)
BOM: 102275740(EXT2)
BIU: 109569634(EXT2)
PHD: 102315584(EXT2)
CHX: 102182243(EXT2)
OAS: 101110867(EXT2)
SSC: 100522362(EXT2)
CFR: 102514645(EXT2)
CDK: 105106838(EXT2)
BACU: 102999728(EXT2)
LVE: 103091009(EXT2)
OOR: 101280958(EXT2)
ECB: 100055879(EXT2)
EPZ: 103556459(EXT2)
EAI: 106843971(EXT2)
MYB: 102238781(EXT2)
MYD: 102767712(EXT2)
HAI: 109391972(EXT2)
RSS: 109455105(EXT2)
PALE: 102890634(EXT2)
LAV: 100656016(EXT2)
TMU: 101361975
MDO: 100010947(EXT2)
SHR: 105750949(EXT2)
OAA: 100079286(EXT2) 100079547
GGA: 425859(EXT2)
MGP: 100545109(EXT2)
CJO: 107314816(EXT2)
APLA: 101790687(EXT2) 101792797
ACYG: 106044125(EXT2)
TGU: 100231605(EXT2)
GFR: 102040196(EXT2)
FAB: 101814666(EXT2)
PHI: 102107359(EXT2)
PMAJ: 107205846(EXT2)
CCW: 104695274(EXT2)
FPG: 101923547(EXT2)
FCH: 102054426(EXT2)
CLV: 102085197(EXT2)
EGZ: 104134053(EXT2)
AAM: 106498294(EXT2)
ASN: 102379048(EXT2)
AMJ: 102562202(EXT2)
PSS: 102446763(EXT2)
CMY: 102938478(EXT2)
CPIC: 101949276(EXT2)
ACS: 100555771(ext2)
PVT: 110081549(EXT2)
PBI: 103053410 103062807(EXT2)
GJA: 107122615(EXT2)
XLA: 380140(ext2.L) 398750(ext2.S)
XTR: 100151709(ext2)
NPR: 108786158(EXT2)
DRE: 493780(ext2)
CCAR: 109072430 109074535(ext2)
IPU: 108271344(ext2)
AMEX: 103046596(ext2)
TRU: 101066048(ext2)
LCO: 104919199(ext2)
NCC: 104963025(ext2)
MZE: 101473582(ext2)
OLA: 101163398(ext2)
XMA: 102234444(ext2)
PRET: 103462432(ext2)
NFU: 107381443(ext2)
CSEM: 103378751(ext2)
LCF: 108889668(ext2)
HCQ: 109514394(ext2)
BPEC: 110172856(ext2)
SASA: 100380322(ext2)
ELS: 105022258(ext2)
SFM: 108934682(ext2)
LCM: 102363354(EXT2)
CMK: 103174976(ext2)
CIN: 100176235
SPU: 100893938
APLC: 110981069
DME: Dmel_CG8433(Ext2)
DSI: Dsimw501_GD25567(Dsim_GD25567)
MDE: 101901385
AAG: 5566768
AME: 726216(Ext2)
BIM: 100744382
BTER: 100643223
SOC: 105198634
AEC: 105150811
ACEP: 105627211
PBAR: 105427034
HST: 105181013
CFO: 105253243
LHU: 105673709
PGC: 109854839
TCA: 659287
NVL: 108557086
PMAC: 106709701
PRAP: 110993283
API: 100164685
DNX: 107174001
ZNE: 110831848
FCD: 110859221
TUT: 107361403
BMY: Bm1_15685
CRG: 105324710
MYI: 110451580
OBI: 106868410
SHX: MS3_06951
EPA: 110240280
HMG: 100212044
AQU: 100636774
TCC: 18585918
DZI: 111310141
EGR: 104454377
GMX: 100781217
VRA: 106765199
VAR: 108338303
LJA: Lj2g3v2714440.1(Lj2g3v2714440.1)
LANG: 109357010
FVE: 101294521
PPER: 18786692
PMUM: 103333289
PAVI: 110767776
MDM: 103455113
PXB: 103936450
ZJU: 107413784
SIND: 105160544
LSV: 111901324
PDA: 103718232
AOF: 109851605
CRE: CHLREDRAFT_144608(ELG2)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9756849
  Authors
Lind T, Tufaro F, McCormick C, Lindahl U, Lidholt K
  Title
The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate.
  Journal
J Biol Chem 273:26265-8 (1998)
DOI:10.1074/jbc.273.41.26265
  Sequence
[bta:281151]

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