KEGG   ORTHOLOGY: K02620Help
Entry
K02620                      KO                                     

Name
TCF7
Definition
transcription factor 7
Pathway
ko04310  Wnt signaling pathway
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04916  Melanogenesis
ko04934  Cushing's syndrome
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05213  Endometrial cancer
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05217  Basal cell carcinoma
ko05221  Acute myeloid leukemia
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Module
M00677  Wnt signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K02620  TCF7; transcription factor 7
   04390 Hippo signaling pathway
    K02620  TCF7; transcription factor 7
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    K02620  TCF7; transcription factor 7
 Organismal Systems
  Endocrine system
   04916 Melanogenesis
    K02620  TCF7; transcription factor 7
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K02620  TCF7; transcription factor 7
   05210 Colorectal cancer
    K02620  TCF7; transcription factor 7
   05225 Hepatocellular carcinoma
    K02620  TCF7; transcription factor 7
   05226 Gastric cancer
    K02620  TCF7; transcription factor 7
   05216 Thyroid cancer
    K02620  TCF7; transcription factor 7
   05221 Acute myeloid leukemia
    K02620  TCF7; transcription factor 7
   05217 Basal cell carcinoma
    K02620  TCF7; transcription factor 7
   05215 Prostate cancer
    K02620  TCF7; transcription factor 7
   05213 Endometrial cancer
    K02620  TCF7; transcription factor 7
   05224 Breast cancer
    K02620  TCF7; transcription factor 7
  Cardiovascular diseases
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K02620  TCF7; transcription factor 7
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    K02620  TCF7; transcription factor 7
  Infectious diseases
   05165 Human papillomavirus infection
    K02620  TCF7; transcription factor 7
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00677  Wnt signaling
     K02620  TCF7; transcription factor 7
Transcription factors [BR:ko03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K02620  TCF7; transcription factor 7
BRITE hierarchy
Genes
HSA: 6932(TCF7)
PTR: 745839(TCF7)
PPS: 100980839(TCF7)
GGO: 101149731(TCF7)
PON: 100461234(TCF7)
NLE: 100595737(TCF7)
MCC: 710234(TCF7)
MCF: 102142248(TCF7)
CSAB: 103244543(TCF7)
RRO: 104659811(TCF7)
RBB: 108529562(TCF7)
CJC: 100399154(TCF7)
SBQ: 101029076(TCF7)
MMU: 21414(Tcf7)
RNO: 363595(Tcf7)
CGE: 100757390(Tcf7)
NGI: 103729786(Tcf7)
HGL: 101707882(Tcf7)
CCAN: 109689465(Tcf7)
OCU: 100339216(TCF7)
TUP: 102484318(TCF7)
CFA: 481506(TCF7)
AML: 100476528(TCF7)
UMR: 103663815(TCF7)
ORO: 101376237(TCF7)
FCA: 101098768(TCF7)
PTG: 102957988(TCF7)
AJU: 106984911(TCF7)
BTA: 782690(TCF7)
BOM: 102266633(TCF7)
BIU: 109562015(TCF7)
PHD: 102338430(TCF7)
CHX: 102173736(TCF7)
OAS: 101101980(TCF7)
SSC: 100512951(TCF7)
CFR: 102519063(TCF7)
CDK: 105090254(TCF7)
BACU: 103018264(TCF7)
LVE: 103074150(TCF7)
OOR: 101289599(TCF7)
ECB: 100072786(TCF7)
EPZ: 103543120(TCF7)
EAI: 106834657(TCF7)
MYB: 102250528(TCF7)
MYD: 102757003(TCF7)
HAI: 109382635(TCF7)
RSS: 109451821(TCF7)
PALE: 102885788(TCF7)
LAV: 100663559(TCF7)
TMU: 101350837
MDO: 100017589(TCF7)
SHR: 100930141(TCF7)
OAA: 100082332(TCF7)
GGA: 395229(TCF7)
MGP: 100544924(TCF7)
CJO: 107320225(TCF7)
APLA: 101803610(TCF7)
ACYG: 106032766(TCF7)
TGU: 100221008(TCF7)
GFR: 102036749(TCF7)
FAB: 101820491(TCF7)
PHI: 102110510(TCF7)
PMAJ: 107210639(TCF7)
CCW: 104683724(TCF7)
FPG: 101919678(TCF7)
FCH: 102058554(TCF7)
CLV: 102094656(TCF7)
EGZ: 104133478(TCF7)
AAM: 106487174(TCF7)
ASN: 102383175(TCF7)
AMJ: 102576120(TCF7)
PSS: 102446665(TCF7)
CMY: 102943166
CPIC: 101937399(TCF7)
ACS: 100554608(tcf7)
PVT: 110079405(TCF7)
PBI: 103067042(TCF7)
GJA: 107125983(TCF7)
XLA: 398658(tcf7.S)
XTR: 395061(tcf7)
NPR: 108792126(TCF7)
SRX: 107735101 107742437(tcf7)
SANH: 107661683(tcf7)
SGH: 107603263
AMEX: 103045826
NCC: 104960861(tcf7)
XMA: 111610761
PRET: 103480959
NFU: 107386837(tcf7)
HCQ: 109531063
LCM: 102350321(TCF7)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1569101
  Authors
van de Wetering M, Oosterwegel M, Holstege F, Dooyes D, Suijkerbuijk R, Geurts van Kessel A, Clevers H
  Title
The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.
  Journal
J Biol Chem 267:8530-6 (1992)
  Sequence
[hsa:6932]
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056
Reference
  Authors
Ioannidis V, Beermann F, Clevers H, Held W
  Title
The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival.
  Journal
Nat Immunol 2:691-7 (2001)
DOI:10.1038/90623
  Sequence
[mmu:21414]

KEGG   ORTHOLOGY: K04490Help
Entry
K04490                      KO                                     

Name
TCF7L1
Definition
transcription factor 7-like 1
Pathway
ko04310  Wnt signaling pathway
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04916  Melanogenesis
ko04934  Cushing's syndrome
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05213  Endometrial cancer
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05217  Basal cell carcinoma
ko05221  Acute myeloid leukemia
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Module
M00677  Wnt signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K04490  TCF7L1; transcription factor 7-like 1
   04390 Hippo signaling pathway
    K04490  TCF7L1; transcription factor 7-like 1
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    K04490  TCF7L1; transcription factor 7-like 1
 Organismal Systems
  Endocrine system
   04916 Melanogenesis
    K04490  TCF7L1; transcription factor 7-like 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05210 Colorectal cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05225 Hepatocellular carcinoma
    K04490  TCF7L1; transcription factor 7-like 1
   05226 Gastric cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05216 Thyroid cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05221 Acute myeloid leukemia
    K04490  TCF7L1; transcription factor 7-like 1
   05217 Basal cell carcinoma
    K04490  TCF7L1; transcription factor 7-like 1
   05215 Prostate cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05213 Endometrial cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05224 Breast cancer
    K04490  TCF7L1; transcription factor 7-like 1
  Cardiovascular diseases
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K04490  TCF7L1; transcription factor 7-like 1
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    K04490  TCF7L1; transcription factor 7-like 1
  Infectious diseases
   05165 Human papillomavirus infection
    K04490  TCF7L1; transcription factor 7-like 1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00677  Wnt signaling
     K04490  TCF7L1; transcription factor 7-like 1
Transcription factors [BR:ko03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04490  TCF7L1; transcription factor 7-like 1
BRITE hierarchy
Genes
HSA: 83439(TCF7L1)
PTR: 744526(TCF7L1)
PPS: 100968002(TCF7L1)
GGO: 101151621(TCF7L1)
PON: 100436197(TCF7L1)
NLE: 100601518(TCF7L1)
MCC: 694560(TCF7L1)
MCF: 102125513(TCF7L1)
CSAB: 103219950(TCF7L1)
RRO: 104659731(TCF7L1)
RBB: 108542809(TCF7L1)
SBQ: 101033762(TCF7L1)
MMU: 21415(Tcf7l1)
RNO: 312451(Tcf7l1)
CGE: 100753225(Tcf7l1)
NGI: 103739783(Tcf7l1)
HGL: 101699909(Tcf7l1)
CCAN: 109686184(Tcf7l1)
OCU: 100340471(TCF7L1)
TUP: 102481394(TCF7L1)
CFA: 612070(TCF7L1)
AML: 100480690(TCF7L1)
UMR: 103671448(TCF7L1)
ORO: 101382778(TCF7L1)
FCA: 101089850(TCF7L1)
PTG: 102958078(TCF7L1)
AJU: 106978197(TCF7L1)
BTA: 515303(TCF7L1)
BOM: 102281039(TCF7L1)
BIU: 109565564(TCF7L1)
PHD: 102325013(TCF7L1)
CHX: 102187776(TCF7L1)
OAS: 100913162(TCF7L1)
SSC: 100523899(TCF7L1)
CFR: 102516787(TCF7L1)
CDK: 105104146(TCF7L1)
BACU: 103010166(TCF7L1)
LVE: 103069353(TCF7L1)
OOR: 101287223(TCF7L1)
ECB: 100067427(TCF7L1)
EPZ: 103548276(TCF7L1)
EAI: 106838609(TCF7L1)
MYB: 102240393(TCF7L1)
MYD: 102768915(TCF7L1)
HAI: 109371340(TCF7L1)
RSS: 109436180(TCF7L1)
PALE: 102886093(TCF7L1)
TMU: 101341696
MDO: 100030368(TCF7L1)
SHR: 100922609(TCF7L1)
GGA: 395230(TCF7L1)
MGP: 104917108(TCF7L1)
CJO: 107323707(TCF7L1)
APLA: 101801135(TCF7L1)
ACYG: 106048886(TCF7L1)
GFR: 102039905(TCF7L1)
FAB: 101817952(TCF7L1)
PHI: 102105833(TCF7L1)
PMAJ: 107213891(TCF7L1)
CCW: 104683181(TCF7L1)
FPG: 101922879(TCF7L1)
FCH: 102051021(TCF7L1)
CLV: 102084814(TCF7L1)
EGZ: 104121757(TCF7L1)
AAM: 106497459
ASN: 102382172(TCF7L1)
AMJ: 102559656(TCF7L1)
PSS: 102456229(TCF7L1)
CMY: 102947844(TCF7L1)
CPIC: 101943923(TCF7L1)
ACS: 100553130(tcf7l1)
PVT: 110084320(TCF7L1)
PBI: 103066724(TCF7L1)
GJA: 107117396(TCF7L1)
XLA: 100329123(tcf7l1-d) 394281(tcf7l1.S) 397863(tcf7l1.L) 397969(tcf7l1-c)
XTR: 448107(tcf7l1)
NPR: 108792469
DRE: 30523(tcf7l1a)
IPU: 108265410
AMEX: 103022374
TRU: 101063163(tcf7l1) 101074632
LCO: 104935330(tcf7l1) 104937897
NCC: 104946533(tcf7l1)
MZE: 101466461 101481605(tcf7l1)
OLA: 100820729(tcf7l1) 111948314
NFU: 107393717(tcf7l1) 107395259
LCM: 102364488(TCF7L1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056
Reference
PMID:1741298
  Authors
Castrop J, van Norren K, Clevers H
  Title
A gene family of HMG-box transcription factors with homology to TCF-1.
  Journal
Nucleic Acids Res 20:611 (1992)
DOI:10.1093/nar/20.3.611
  Sequence
[hsa:83439]

KEGG   ORTHOLOGY: K04491Help
Entry
K04491                      KO                                     

Name
TCF7L2
Definition
transcription factor 7-like 2
Pathway
ko04310  Wnt signaling pathway
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04916  Melanogenesis
ko04934  Cushing's syndrome
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05213  Endometrial cancer
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05217  Basal cell carcinoma
ko05221  Acute myeloid leukemia
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Module
M00677  Wnt signaling
Disease
H00409  Type II diabetes mellitus
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K04491  TCF7L2; transcription factor 7-like 2
   04390 Hippo signaling pathway
    K04491  TCF7L2; transcription factor 7-like 2
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    K04491  TCF7L2; transcription factor 7-like 2
 Organismal Systems
  Endocrine system
   04916 Melanogenesis
    K04491  TCF7L2; transcription factor 7-like 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05210 Colorectal cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05225 Hepatocellular carcinoma
    K04491  TCF7L2; transcription factor 7-like 2
   05226 Gastric cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05216 Thyroid cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05221 Acute myeloid leukemia
    K04491  TCF7L2; transcription factor 7-like 2
   05217 Basal cell carcinoma
    K04491  TCF7L2; transcription factor 7-like 2
   05215 Prostate cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05213 Endometrial cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05224 Breast cancer
    K04491  TCF7L2; transcription factor 7-like 2
  Cardiovascular diseases
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K04491  TCF7L2; transcription factor 7-like 2
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    K04491  TCF7L2; transcription factor 7-like 2
  Infectious diseases
   05165 Human papillomavirus infection
    K04491  TCF7L2; transcription factor 7-like 2
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00677  Wnt signaling
     K04491  TCF7L2; transcription factor 7-like 2
Transcription factors [BR:ko03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04491  TCF7L2; transcription factor 7-like 2
BRITE hierarchy
Genes
HSA: 6934(TCF7L2)
PTR: 450743(TCF7L2)
PPS: 100978424(TCF7L2)
GGO: 109025238 109028637(TCF7L2)
PON: 100434811(TCF7L2)
NLE: 100605701(TCF7L2)
MCC: 701759(TCF7L2)
MCF: 102116470(TCF7L2)
CSAB: 103216817(TCF7L2)
RRO: 104664436(TCF7L2)
RBB: 108542456(TCF7L2)
CJC: 100406757(TCF7L2)
SBQ: 101037011(TCF7L2)
MMU: 21416(Tcf7l2)
RNO: 679869(Tcf7l2)
CGE: 100758400(Tcf7l2)
NGI: 103731749(Tcf7l2)
HGL: 101710380(Tcf7l2)
CCAN: 109688561(Tcf7l2)
OCU: 100358378(TCF7L2)
TUP: 102472810(TCF7L2)
CFA: 486894(TCF7L2)
AML: 100467719(TCF7L2)
UMR: 103657263(TCF7L2)
ORO: 101385846(TCF7L2)
FCA: 101095618(TCF7L2)
PTG: 102961321(TCF7L2)
AJU: 106974119(TCF7L2)
BTA: 540481(TCF7L2)
BOM: 102272230(TCF7L2)
BIU: 109553057(TCF7L2)
PHD: 102322359(TCF7L2)
CHX: 102180102(TCF7L2)
OAS: 101118068(TCF7L2)
SSC: 100153922(TCF7L2)
CFR: 102510763(TCF7L2)
CDK: 105091689(TCF7L2)
BACU: 103010923(TCF7L2)
LVE: 103068781(TCF7L2)
OOR: 101288107(TCF7L2)
ECB: 100059146(TCF7L2)
EPZ: 103564289(TCF7L2)
EAI: 106848101(TCF7L2)
MYB: 102245737(TCF7L2)
MYD: 102767014(TCF7L2)
HAI: 109384898(TCF7L2)
RSS: 109444072(TCF7L2)
PALE: 102880370(TCF7L2)
LAV: 100656106(TCF7L2)
TMU: 101345532
MDO: 100021451(TCF7L2)
SHR: 100922675(TCF7L2)
OAA: 100080633(TCF7L2)
GGA: 395508(TCF7L2)
MGP: 100545943(TCF7L2)
CJO: 107316122(TCF7L2)
APLA: 101790790(TCF7L2)
ACYG: 106031894(TCF7L2)
TGU: 100229459(TCF7L2)
GFR: 102035103(TCF7L2)
FAB: 101808150(TCF7L2)
PHI: 102110960(TCF7L2)
PMAJ: 107206579(TCF7L2)
CCW: 104695213(TCF7L2)
FPG: 101911463(TCF7L2)
FCH: 102053252(TCF7L2)
CLV: 102092542(TCF7L2)
EGZ: 104130428(TCF7L2)
AAM: 106483723(TCF7L2)
ASN: 102373887(TCF7L2)
AMJ: 102558653(TCF7L2)
PSS: 102459521(TCF7L2)
CMY: 102935138(TCF7L2)
CPIC: 101938831(TCF7L2)
ACS: 100561311(tcf7l2) 100563899
PVT: 110071969(TCF7L2)
PBI: 103067231(TCF7L2)
GJA: 107121002(TCF7L2)
XLA: 108697306 399164(tcf7l2.L)
XTR: 100101719(tcf7l2)
NPR: 108793512(TCF7L2)
DRE: 30510(tcf7l2)
IPU: 108274114(tcf7l2)
AMEX: 103031257(tcf7l2)
TRU: 101067664(tcf7l2) 105417996
LCO: 104932553(tcf7l2)
NCC: 104943463(tcf7l2)
MZE: 101472434 101473558(tcf7l2)
OLA: 101169492(tcf7l2) 101174687
XMA: 102216716(tcf7l2)
PRET: 103473336 103481429(tcf7l2)
NFU: 107387573(tcf7l2) 107396480
CSEM: 103381486(tcf7l2) 103385014
LCF: 108874537 108901696(tcf7l2)
HCQ: 109513392(tcf7l2)
BPEC: 110154410(tcf7l2)
ELS: 105007703(tcf7l2)
SFM: 108932732 108940446(tcf7l2)
LCM: 102346208(TCF7L2)
CMK: 103186546(tcf7l2)
CIN: 778773(tcf/lef)
SPU: 373203(Tcf/Lef)
APLC: 110984316
SKO: 100303556(tcf7l)
DME: Dmel_CG34403(pan)
DSI: Dsimw501_GD17850(Dsim_pan)
AAG: 5565423
AME: 726671(Tcf)
BIM: 100745788
BTER: 100643645
SOC: 105198489
AEC: 105151104
ACEP: 105619854
PBAR: 105424403
HST: 105186992
CFO: 105253941
LHU: 105675787
PGC: 109859232
NVI: 100120687
TCA: 641465(Pan)
DPA: 109535398
NVL: 108564096
BMOR: 101742450
PMAC: 106719867
PRAP: 110998995
PXY: 105381194
API: 100161896
DNX: 107171946
ZNE: 110830984
FCD: 110843907
CEL: CELE_W10C8.2(pop-1)
CBR: CBG04236(Cbr-pop-1)
BMY: Bm1_47615
TSP: Tsp_02818
CRG: 105329818
OBI: 106876393
LAK: 106155607
EPA: 110242253
ADF: 107340855
HMG: 100199257
AQU: 100641322(Tcf)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Prokunina-Olsson L, Welch C, Hansson O, Adhikari N, Scott LJ, Usher N, Tong M, Sprau A, Swift A, Bonnycastle LL, Erdos MR, He Z, Saxena R, Harmon B, Kotova O, Hoffman EP, Altshuler D, Groop L, Boehnke M, Collins FS, Hall JL
  Title
Tissue-specific alternative splicing of TCF7L2.
  Journal
Hum Mol Genet 18:3795-804 (2009)
DOI:10.1093/hmg/ddp321
  Sequence
[hsa:6934]
Reference
PMID:9065401
  Authors
Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B, Clevers H
  Title
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
  Journal
Science 275:1784-7 (1997)
DOI:10.1126/science.275.5307.1784
  Sequence
[hsa:6934]

KEGG   ORTHOLOGY: K04492Help
Entry
K04492                      KO                                     

Name
LEF1
Definition
lymphoid enhancer-binding factor 1
Pathway
ko04310  Wnt signaling pathway
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04916  Melanogenesis
ko04934  Cushing's syndrome
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05213  Endometrial cancer
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05217  Basal cell carcinoma
ko05221  Acute myeloid leukemia
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Module
M00677  Wnt signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K04492  LEF1; lymphoid enhancer-binding factor 1
   04390 Hippo signaling pathway
    K04492  LEF1; lymphoid enhancer-binding factor 1
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    K04492  LEF1; lymphoid enhancer-binding factor 1
 Organismal Systems
  Endocrine system
   04916 Melanogenesis
    K04492  LEF1; lymphoid enhancer-binding factor 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05210 Colorectal cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05225 Hepatocellular carcinoma
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05226 Gastric cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05216 Thyroid cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05221 Acute myeloid leukemia
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05217 Basal cell carcinoma
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05215 Prostate cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05213 Endometrial cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05224 Breast cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
  Cardiovascular diseases
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K04492  LEF1; lymphoid enhancer-binding factor 1
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    K04492  LEF1; lymphoid enhancer-binding factor 1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00677  Wnt signaling
     K04492  LEF1; lymphoid enhancer-binding factor 1
Transcription factors [BR:ko03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04492  LEF1; lymphoid enhancer-binding factor 1
BRITE hierarchy
Genes
HSA: 51176(LEF1)
PTR: 461425(LEF1)
PPS: 100995847(LEF1)
GGO: 101140253(LEF1)
PON: 100447785(LEF1)
NLE: 100593051(LEF1)
MCC: 695776(LEF1)
MCF: 101925349(LEF1)
CSAB: 103236088(LEF1)
RRO: 104670045(LEF1)
RBB: 108515891(LEF1)
CJC: 100399759(LEF1)
SBQ: 101047688(LEF1)
MMU: 16842(Lef1)
RNO: 161452(Lef1)
CGE: 100761200(Lef1)
NGI: 103742515(Lef1)
HGL: 101711023(Lef1)
OCU: 100352691(LEF1)
TUP: 102474621(LEF1)
CFA: 478507(LEF1)
AML: 100465982(LEF1)
UMR: 103661728(LEF1)
ORO: 101372325(LEF1)
FCA: 101088077(LEF1)
PTG: 102970026(LEF1)
AJU: 106983664(LEF1)
BTA: 535399(LEF1)
BOM: 102266946(LEF1)
BIU: 109560266(LEF1)
PHD: 102341699(LEF1)
CHX: 100860901(LEF1)
OAS: 780521(LEF1)
SSC: 100170126(LEF1)
CFR: 102510619(LEF1)
CDK: 105105289(LEF1)
BACU: 103020844(LEF1)
LVE: 103068879(LEF1)
OOR: 101287631(LEF1)
ECB: 100072938(LEF1)
EPZ: 103557035(LEF1)
EAI: 106829814(LEF1)
MYB: 102255910(LEF1)
MYD: 102767379(LEF1)
HAI: 109379461(LEF1)
RSS: 109452751(LEF1)
PALE: 102886933(LEF1)
LAV: 100658960(LEF1)
TMU: 101345125
MDO: 100011783(LEF1)
OAA: 100079818
GGA: 395865(LEF1)
MGP: 100542839(LEF1)
CJO: 107313267(LEF1)
APLA: 101792052(LEF1)
ACYG: 106038656(LEF1)
TGU: 100228376(LEF1)
GFR: 102034937(LEF1)
FAB: 101821185(LEF1)
PHI: 102109576(LEF1)
PMAJ: 107203557(LEF1)
CCW: 104697293(LEF1)
FPG: 101917929(LEF1)
FCH: 102050307(LEF1)
CLV: 102084626(LEF1)
EGZ: 104135527(LEF1)
AAM: 106491833(LEF1)
ASN: 102385539(LEF1)
AMJ: 102560337(LEF1)
PSS: 102456780(LEF1)
CMY: 102930185(LEF1)
CPIC: 101953582(LEF1)
ACS: 100556215(lef1)
PVT: 110080460(LEF1)
PBI: 103064656(LEF1)
GJA: 107123114(LEF1)
XLA: 100337575(lef-1) 398238(lef1.L) 779101(lef1)
XTR: 100493178(lef1)
NPR: 108785415(LEF1)
DRE: 30701(lef1)
SGH: 107583218(lef1) 107594427
IPU: 108262963(lef1)
AMEX: 103033630(lef1)
TRU: 101064872(lef1)
LCO: 104927262(lef1)
MZE: 101464688(lef1)
OLA: 101167344(lef1)
XMA: 102226301(lef1) 111609564
PRET: 103472749(lef1)
NFU: 107375038(lef1)
LCF: 108888246(lef1)
BPEC: 110165341(lef1)
SASA: 106602294 106610340(lef1)
ELS: 105020989(lef1)
LCM: 102354030(LEF1) 106706489
CMK: 103182161
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Hovanes K, Li TW, Waterman ML
  Title
The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing.
  Journal
Nucleic Acids Res 28:1994-2003 (2000)
DOI:10.1093/nar/28.9.1994
  Sequence
[hsa:51176]
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056

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