KEGG   ORTHOLOGY: K03178Help
Entry
K03178                      KO                                     

Name
UBE1, UBA1
Definition
ubiquitin-activating enzyme E1 [EC:6.2.1.45]
Pathway
ko04120  Ubiquitin mediated proteolysis
ko05012  Parkinson disease
Disease
H00455  Spinal muscular atrophy (SMA)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03178  UBE1, UBA1; ubiquitin-activating enzyme E1
 09160 Human Diseases
  09163 Neurodegenerative diseases
   05012 Parkinson disease
    K03178  UBE1, UBA1; ubiquitin-activating enzyme E1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K03178  UBE1, UBA1; ubiquitin-activating enzyme E1
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K03178  UBE1, UBA1; ubiquitin-activating enzyme E1
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.45  E1 ubiquitin-activating enzyme
     K03178  UBE1, UBA1; ubiquitin-activating enzyme E1
Ubiquitin system [BR:ko04121]
 Ubiquitin-activating enzymes (E1)
  Ubiquitin activating enzyme
   K03178  UBE1, UBA1; ubiquitin-activating enzyme E1
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K03178  UBE1, UBA1; ubiquitin-activating enzyme E1
  Exosomal proteins of other body fluids (saliva and urine)
   K03178  UBE1, UBA1; ubiquitin-activating enzyme E1
  Exosomal proteins of colorectal cancer cells
   K03178  UBE1, UBA1; ubiquitin-activating enzyme E1
BRITE hierarchy
Other DBs
COG: COG0476
Genes
HSA: 7317(UBA1)
PTR: 749307(UBA1)
PPS: 100981812(UBA1)
GGO: 101127886(UBA1)
PON: 100461474(UBA1)
NLE: 100600288(UBA1)
MCC: 706324(UBA1)
MCF: 102138253(UBA1)
CSAB: 103231883(UBA1)
RRO: 104664586(UBA1)
RBB: 108523037(UBA1)
SBQ: 101034798(UBA1)
MMU: 22201(Uba1) 22202(Uba1y)
CGE: 100769040(Uba1)
NGI: 103726491(Uba1)
HGL: 101718119(Uba1)
OCU: 100009225(UBA1)
CFA: 480896(UBA1)
AML: 100476711(UBA1)
ORO: 101370294(UBA1) 101374872
FCA: 101093248(UBA1)
PTG: 102964908(UBA1) 102966805
AJU: 106972849(UBA1) 106989093(Ube1y)
BTA: 282869(UBA1)
BOM: 102283600(UBA1)
BIU: 109555087(UBA1) 109555603
PHD: 102322346(UBA1) 102322985
CHX: 102190674(UBA1)
OAS: 101117052(UBA1)
SSC: 100525439(UBA1)
CFR: 102505479(UBA1)
CDK: 105101957(UBA1)
BACU: 103002578(UBA1)
LVE: 103087883(UBA1)
OOR: 101275213(UBA1)
ECB: 100060792(UBA1)
EPZ: 103540469(UBA1) 103542719
EAI: 106827205 106847990(UBA1)
MYB: 102263116(UBA1)
MYD: 102753904(UBA1)
HAI: 109386227(UBA1)
RSS: 109437472(UBA1) 109440005
LAV: 100666571(UBA1)
TMU: 101354928
MDO: 100012835(UBA1)
SHR: 100915722(UBA1) 100920292
OAA: 100079248
MGP: 100546418
CJO: 107307607 107319590(UBA7)
APLA: 101795290
ACYG: 106048774(UBA7)
TGU: 100220159(UBA7)
GFR: 102036001(UBA1) 102041566(UBA7)
FAB: 101811664(UBA7)
PHI: 102100702(UBA1) 102100720(UBA7)
PMAJ: 107199621 107210471(UBA7)
FPG: 101918945(UBA7) 101924506(UBA1)
FCH: 102058401(UBA1) 102058682(UBA7)
CLV: 102097533(UBA7)
EGZ: 104132453
AAM: 106492176(UBA7)
ASN: 102375291(UBA7) 102383493(UBA1)
AMJ: 102567140(UBA7) 106739684(UBA1)
PSS: 102447270(UBA1) 102451656(UBA7)
CMY: 102934586
CPIC: 101932630(UBA7) 101951669(UBA1)
ACS: 100552704(uba1) 100559247(uba7)
PVT: 110077021(UBA7) 110081138(UBA1)
PBI: 103064044(UBA7) 103068061(UBA1)
GJA: 107106087(UBA1) 107107153(UBA7)
XLA: 379877(uba1.S) 398370(uba1.L)
XTR: 100495145
NPR: 108789228(UBA1)
DRE: 100001302(uba7) 406335(uba1)
IPU: 108272095 108276038(uba1)
AMEX: 103025954 103045813(uba1)
TRU: 101070345(uba1) 101071293
NCC: 104956168(uba1) 104965614
MZE: 101470208 101487678(uba1)
OLA: 101158523(uba1) 101175149
XMA: 102220506 102233267(uba1)
NFU: 107385199 107390967(uba1)
HCQ: 109528415(uba1)
BPEC: 110164871(uba1) 110168613
SFM: 108936972 108939436(uba1)
LCM: 102348081(UBA1) 102358077(UBA7)
CMK: 103173873 103176627(uba7)
CIN: 100176463(uba1)
SPU: 590611
APLC: 110973608
SKO: 100369938(Uba1)
DME: Dmel_CG1782(Uba1)
DSI: Dsimw501_GD10057(Dsim_GD10057)
AAG: 5566596
AME: 410958(Uba1)
BIM: 100742264
BTER: 100642600
SOC: 105201083
AEC: 105145830
ACEP: 105618966
PBAR: 105434116
HST: 105191028
CFO: 105258256
LHU: 105679914
PGC: 109861204
NVI: 100116562
TCA: 657621
DPA: 109542938
NVL: 108565788
BMOR: 101739389
PMAC: 106710386
PRAP: 110997175
API: 100165036
DNX: 107173723
ZNE: 110828946
TUT: 107364379
CEL: CELE_C47E12.5(uba-1)
CBR: CBG03440(Cbr-uba-1)
BMY: Bm1_50525
MYI: 110443407
OBI: 106876734
LAK: 106174753
SHX: MS3_08395
EPA: 110249491
ADF: 107348632
HMG: 100215063(uba1)
ATH: AT2G30110(UBA1) AT5G06460(UBA_2)
LJA: Lj0g3v0335099.1(Lj0g3v0335099.1) Lj0g3v0335099.2(Lj0g3v0335099.2) Lj2g3v2315140.1(Lj2g3v2315140.1) Lj2g3v2315140.2(Lj2g3v2315140.2) Lj2g3v2315140.3(Lj2g3v2315140.3)
CSV: 101215209
CMO: 103502928
MCHA: 111017114
NNU: 104597299
DOSA: Os03t0294900-01(Os03g0294900) Os07t0692900-01(Os07g0692900) Os11t0106400-01(Os11g0106400) Os12t0105950-01(Os12g0105950) Os12t0105975-00(Os12g0105975)
ATS: 109736459(LOC109736459) 109748406(LOC109748406) 109756238(LOC109756238) 109769586(LOC109769586) 109773955(LOC109773955)
ATR: 18437136
CRE: CHLREDRAFT_191903(UBA1)
MNG: MNEG_1260
APRO: F751_6092
SCE: YKL210W(UBA1)
ERC: Ecym_3613
KMX: KLMA_30033(UBA1)
NCS: NCAS_0G03530(NCAS0G03530)
NDI: NDAI_0C02530(NDAI0C02530)
TPF: TPHA_0F03610(TPHA0F03610)
TBL: TBLA_0D03620(TBLA0D03620)
TDL: TDEL_0F00330(TDEL0F00330)
KAF: KAFR_0E00220(KAFR0E00220)
CAL: CAALFM_C306500WA(UBA1)
CAUR: QG37_05978
SLB: AWJ20_2192(UBA1)
NCR: NCU04370
NTE: NEUTE1DRAFT79528(NEUTE1DRAFT_79528)
MGR: MGG_01409
MAW: MAC_03978
MAJ: MAA_10762
CMT: CCM_07576
BFU: BCIN_12g01350(Bcuba1)
MBE: MBM_01974
ANI: AN2174.2
ANG: ANI_1_1658134(An15g06020)
CIM: CIMG_10518(CIMG00292)
ABE: ARB_07430
TVE: TRV_02656
PTE: PTT_19992
SPO: SPBC1604.21c(ptr3)
CNE: CNA01230
CNB: CNBA1200
ABP: AGABI1DRAFT113639(AGABI1DRAFT_113639)
ABV: AGABI2DRAFT191711(AGABI2DRAFT_191711)
MGL: MGL_2996
DDI: DDB_G0270272(uae1)
DFA: DFA_05136(uae1) DFA_05538
EHI: EHI_020270(334.t00009)
PYO: PY17X_1443200(PY01879)
PCB: PCHAS_144270(PC001230.02.0)
TAN: TA14590
TPV: TP02_0689
BBO: BBOV_II007710(18.m06639)
CPV: cgd4_2300
SMIN: v1.2.008259.t1(symbB.v1.2.008259.t1) v1.2.017879.t1(symbB.v1.2.017879.t1) v1.2.020866.t1(symbB.v1.2.020866.t1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Jin J, Li X, Gygi SP, Harper JW
  Title
Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.
  Journal
Nature 447:1135-8 (2007)
DOI:10.1038/nature05902
  Sequence
[hsa:7317]
Reference
PMID:9076989
  Authors
Hatfield PM, Gosink MM, Carpenter TB, Vierstra RD
  Title
The ubiquitin-activating enzyme (E1) gene family in Arabidopsis thaliana.
  Journal
Plant J 11:213-26 (1997)
DOI:10.1046/j.1365-313X.1997.11020213.x
  Sequence

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