KEGG   ORTHOLOGY: K03879Help
Entry
K03879                      KO                                     

Name
ND2
Definition
NADH-ubiquinone oxidoreductase chain 2 [EC:1.6.5.3]
Pathway
ko00190  Oxidative phosphorylation
ko01100  Metabolic pathways
ko04714  Thermogenesis
ko04723  Retrograde endocannabinoid signaling
ko05012  Parkinson's disease
Module
M00142  NADH:ubiquinone oxidoreductase, mitochondria
Disease
H00068  Leber hereditary optic atrophy (LHON)
H00473  Mitochondrial complex I deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Energy metabolism
   00190 Oxidative phosphorylation
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
 Organismal Systems
  Nervous system
   04723 Retrograde endocannabinoid signaling
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
  Environmental adaptation
   04714 Thermogenesis
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
 Human Diseases
  Neurodegenerative diseases
   05012 Parkinson's disease
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
KEGG modules [BR:ko00002]
 Structural complex
  Energy metabolism
   ATP synthesis
    M00142  NADH:ubiquinone oxidoreductase, mitochondria
     K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.6  Acting on NADH or NADPH
   1.6.5  With a quinone or similar compound as acceptor
    1.6.5.3  NADH:ubiquinone reductase (H+-translocating)
     K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Mitochondrial respiratory chain complex I
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
BRITE hierarchy
Other DBs
RN: R11945
GO: 0008137
TC: 3.D.1.6
Genes
HSA: 4536(ND2)
PTR: 807865(ND2)
PPS: 807883(ND2)
GGO: 6742677(ND2)
PON: 808478(ND2)
NLE: 16545240(ND2)
MCC: 2846626(ND2)
MCF: 7857750(ND2)
CSAB: 4097489(ND2)
RRO: 4171535(ND2)
RBB: 10549368(ND2)
CJC: 22203901(ND2)
SBQ: 13228912(ND2)
MMU: 17717(ND2)
RNO: 26194(ND2)
CGE: 3979184(ND2)
NGI: 15088424(ND2)
HGL: 10201215(ND2)
CCAN: 31082897(ND2)
OCU: 808230(ND2)
CFA: 804477(ND2)
AML: 5179725(ND2)
UMR: 804862(ND2)
FCA: 807935(ND2)
AJU: 2654019(ND2)
BTA: 3283878(ND2)
BOM: 22161767(ND2)
BIU: 2885976(ND2)
PHD: 3703623(ND2)
CHX: 1485857(ND2)
OAS: 808250(ND2)
SSC: 808502(ND2)
CFR: 5326218(ND2)
CDK: 5618961(ND2)
LVE: 3802093(ND2)
OOR: 18982981(ND2)
ECB: 807844(ND2)
EPZ: 19019453(ND2)
EAI: 808059(ND2)
MYB: 20964693(ND2)
MYD: 22203929(ND2)
HAI: 13539866(ND2)
PALE: 17963485(ND2)
LAV: 808792(ND2)
MDO: 3074668(ND2)
SHR: 13826439(ND2)
OAA: 808700(ND2)
GGA: 807645(ND2)
MGP: 5848009(ND2)
CJO: 804667(ND2)
APLA: 5405821(ND2)
TGU: 3950791(ND2)
FAB: 16027866(ND2)
PHI: 9480993(ND2)
PMAJ: 22974844(ND2)
CCW: 20160628(ND2)
FPG: 808588(ND2)
FCH: 23808610(ND2)
CLV: 8889996(ND2)
EGZ: 18985248(ND2)
ASN: 806141(ND2)
AMJ: 808246(ND2)
PSS: 2943118(ND2)
CMY: 808652(ND2)
CPIC: 18982995(ND2)
ACS: 6385980(ND2)
PVT: 3338343(ND2)
GJA: 26044422(ND2)
XLA: 2642087(ND2)
XTR: 3283493(ND2)
NPR: 24020212(ND2)
DRE: 140532(ND2)
SRX: 24419155(ND2)
SANH: 24419945(ND2)
SGH: 8382163(ND2)
CCAR: 807766(ND2)
IPU: 804883(ND2)
TRU: 805217(ND2)
TNG: BAE79218(ND2)
LCO: 7095382(ND2)
NCC: 10752023(ND2)
MZE: 26037637(APK84_gp12)
OLA: 805440(ND2)
XMA: 6986209(ND2)
PRET: 19590714(ND2)
NFU: 7256389(ND2)
CSEM: 7996492(ND2)
LCF: 3703588(ND2)
HCQ: 14658011(ND2)
SASA: 808316(ND2)
ELS: 806646(ND2)
SFM: 3416105(ND2)
LCM: 808084(ND2)
CMK: 9385345(ND2)
BFO: ND2
CIN: 806123(ND2)
SPU: 2652717(ND2)
APLC: 3907680(ND2)
SKO: 3703612(ND2)
DME: ND2
DSE: ND2
DSI: ND2
DYA: ND2
MDE: 20358592(ND2)
AGA: ND2
AAG: 33307554(ND2)
CQU: ND2
SOC: 9977801(ND2)
LHU: 26408701(ND2)
TCA: 803823(ND2)
BMOR: 809265(ND2)
DPL: AGL76298(ND2)
PMAC: 13080340(ND2)
PRAP: 11030477(ND2)
PXY: 20834458(ND2)
API: 7055887(ND2)
DNX: 17428421(ND2)
ZNE: 20004831(ND2)
DPX: AAD33230(ND2)
CEL: ND2
CBR: ND2
BMY: ND2
LOA: ND2
TSP: ND2
CRG: 808826(ND2)
MYI: 4910448(ND2)
OBI: 106869121 27205956(ND2)
LAK: C2G87_mgp12(ND2)
SMM: ND2
ADF: 17674589(ND2)
HMG: 6904228(ND2)
TAD: TradoM_p10(ND2)
AQU: 4794351(ND2)
ATH: AT2G07689 ArthMp026(nad2)
BNA: 106360840 4237887(nad2)
GRA: 105796873 27429583(nad2)
GHI: 107893137
GMX: 15308633(nad2)
VAR: 15382820(nad2)
MTR: A0S16_gp17(nad2)
ADU: 107472565
LJA: Ljmtg3v0000140.1(Ljmitog3v0000140.1)
PMUM: 107881883
MDM: 13630220(nad2)
ZJU: 27215290(nad2)
CSV: 11123895(nad2)
RCU: 10221400(nad2)
JCU: 105650393
HBR: 110654472
VVI: 104878429 7498551(nad2)
SOT: 102603210
NTA: 3205197(nad2) 3205259(orf214)
INI: 29082055(nad2)
SIND: 105155298
BVG: 809516(orf300) 809520(nad2)
SOE: 33876625(nad2)
NNU: 28482668(nad2)
OSA: 6450140(nad2)
SBI: 4306038(nad2)
PDA: 11542591(nad2)
MUS: 103973027
CRE: ChrepMp05(nad2)
OTA: OstapMp34(nad2)
BPG: BathyMg00060(nad2)
MIS: MicpuN_mit23(nad2)
CSL: CospCoM_p24(nad2)
CVR: OJ20_p17(nad2)
APRO: ChprMp016(nad2)
CCP: ChcroMp15(nad2)
DHA: ND2
CAL: CaalfMp09(NAD2)
YLI: YalifMp28(nd2)
NCR: NCU16006
SMP: SMAC_12648(nad2)
PAN: PoanfMp04(nad2)
FGR: GizefMp03(nad2)
ANG: Asnifp16(nad2)
PNO: SNOGp13(nad2)
DDI: DidioMp03(nad2)
TET: TepyoMp11(nad2)
PSOJ: PhsooMp17(nad2)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9475751
  Authors
Wise CA, Sraml M, Easteal S
  Title
Departure from neutrality at the mitochondrial NADH dehydrogenase subunit 2 gene in humans, but not in chimpanzees.
  Journal
Genetics 148:409-21 (1998)
  Sequence
[hsa:4536]

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