KEGG   ORTHOLOGY: K03880Help
Entry
K03880                      KO                                     

Name
ND3
Definition
NADH-ubiquinone oxidoreductase chain 3 [EC:1.6.5.3]
Pathway
ko00190  Oxidative phosphorylation
ko01100  Metabolic pathways
ko04714  Thermogenesis
ko04723  Retrograde endocannabinoid signaling
ko05012  Parkinson disease
Module
M00142  NADH:ubiquinone oxidoreductase, mitochondria
Disease
H00473  Mitochondrial complex I deficiency
H01355  Kearns-Sayre syndrome
H01365  Leber hereditary optic neuropathy and dystonia (LDYT)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    K03880  ND3; NADH-ubiquinone oxidoreductase chain 3
 09150 Organismal Systems
  09156 Nervous system
   04723 Retrograde endocannabinoid signaling
    K03880  ND3; NADH-ubiquinone oxidoreductase chain 3
  09159 Environmental adaptation
   04714 Thermogenesis
    K03880  ND3; NADH-ubiquinone oxidoreductase chain 3
 09160 Human Diseases
  09163 Neurodegenerative diseases
   05012 Parkinson disease
    K03880  ND3; NADH-ubiquinone oxidoreductase chain 3
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K03880  ND3; NADH-ubiquinone oxidoreductase chain 3
KEGG modules [BR:ko00002]
 Structural complex
  Energy metabolism
   ATP synthesis
    M00142  NADH:ubiquinone oxidoreductase, mitochondria
     K03880  ND3; NADH-ubiquinone oxidoreductase chain 3
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.6  Acting on NADH or NADPH
   1.6.5  With a quinone or similar compound as acceptor
    1.6.5.3  NADH:ubiquinone reductase (H+-translocating)
     K03880  ND3; NADH-ubiquinone oxidoreductase chain 3
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Mitochondrial respiratory chain complex I
    K03880  ND3; NADH-ubiquinone oxidoreductase chain 3
BRITE hierarchy
Other DBs
RN: R11945
GO: 0008137
TC: 3.D.1.6
Genes
HSA: 4537(ND3)
PTR: 807870(ND3)
PPS: 807879(ND3)
GGO: 6742686(ND3)
PON: 808479(ND3)
NLE: 16545229(ND3)
MCC: 2846622(ND3)
MCF: 7857744(ND3)
CSAB: 4097495(ND3)
RRO: 4171541(ND3)
RBB: 10549374(ND3)
CJC: 22203907(ND3)
SBQ: 13228918(ND3)
MMU: 17718(ND3)
RNO: 26199(ND3)
CGE: 3979190(ND3)
NGI: 15088430(ND3)
HGL: 10201214(ND3)
CCAN: 31082912(ND3)
OCU: 808221(ND3)
CFA: 804481(ND3)
AML: 5179736(ND3)
UMR: 804863(ND3)
FCA: 807938(ND3)
AJU: 2654022(ND3)
BTA: 3283884(ND3)
BOM: 22161773(ND3)
BIU: 2885978(ND3)
PHD: 3703624(ND3)
CHX: 1485863(ND3)
OAS: 808255(ND3)
SSC: 808508(ND3)
CFR: 5326226(ND3)
CDK: 5618962(ND3)
LVE: 3802099(ND3)
OOR: 18982987(ND3)
ECB: 807855(ND3)
EPZ: 19019452(ND3)
EAI: 808060(ND3)
MYB: 20964699(ND3)
MYD: 22203921(ND3)
HAI: 13539872(ND3)
PALE: 17963500(ND3)
LAV: 808786(ND3)
MDO: 3074658(ND3)
SHR: 13826438(ND3)
OAA: 808710(ND3)
GGA: 807638(ND3)
MGP: 5848008(ND3)
CJO: 804659(ND3)
APLA: 5405822(ND3)
TGU: 3950797(ND3)
FAB: 16027881(ND3)
PHI: 9480999(ND3)
PMAJ: 22974850(ND3)
CCW: 20160633(ND3)
FPG: 808587(ND3)
FCH: 23808604(ND3)
CLV: 8890003(ND3)
EGZ: 18985254(ND3)
ASN: 806131(ND3)
AMJ: 808236(ND3)
PSS: 2943125(ND3)
CMY: 808647(ND3)
CPIC: 18983001(ND3)
ACS: 6385979(ND3)
PVT: 3338374(ND3)
GJA: 26044431(ND3)
XLA: 2642085(ND3)
XTR: 3283499(ND3)
NPR: 24020219(ND3)
DRE: 140533(ND3)
SRX: 24419171(ND3)
SANH: 24419970(ND3)
SGH: 8382169(ND3)
CCAR: 807771(ND3)
IPU: 804878(ND3)
TRU: 805224(ND3)
TNG: BAE79224(ND3)
LCO: 7095388(ND3)
NCC: 10752029(ND3)
MZE: 26037646(APK84_gp06)
OLA: 805439(ND3)
XMA: 6986208(ND3)
PRET: 19590708(ND3)
NFU: 7256397(ND3)
CSEM: 7996486(ND3)
LCF: 3703594(ND3)
HCQ: 14658017(ND3)
SASA: 808308(ND3)
ELS: 806654(ND3)
SFM: 3416098(ND3)
LCM: 808090(ND3)
CMK: 9385351(ND3)
BFO: ND3
CIN: 806124(ND3)
SPU: 2652723(ND3)
APLC: 3907681(ND3)
SKO: 3703606(ND3)
DME: ND3
DSE: ND3
DSI: ND3
DYA: ND3
MDE: 20358595(ND3)
AGA: ND3
AAG: 33307561(ND3)
CQU: ND3
SOC: 9977794(ND3)
LHU: 26408683(ND3)
TCA: 803821(ND3)
BMOR: 809257(ND3)
DPL: AGL76304(ND3)
PMAC: 13080346(ND3)
PRAP: 11030483(ND3)
PXY: 20834451(ND3)
API: 7055880(ND3)
DNX: 17428414(ND3)
TUT: 6164205(ND3)
CEL: ND3
CBR: ND3
NAI: 804824(ND3)
BMY: ND3
LOA: ND3
TSP: ND3
CRG: 808834(ND3)
OBI: 27205954(ND3)
LAK: C2G87_mgp05(ND3)
SMM: ND3
ADF: 17674596(ND3)
HMG: 6904242(ND3)
TAD: TradoM_p20(ND3)
AQU: 4794358(ND3)
BNA: 4237970(nad3)
GMX: 15308563(nad3)
CAM: 101509836
MDM: 13630211(nad3)
CSV: 11123864(nad3)
RCU: 10221422(nad3)
VVI: 7498617(nad3)
BVG: 809522(nad3)
DOSA: Os12t0423142-00(Os12g0423142)
SBI: 4306053(nad3)
PDA: 11542580(nad3)
MUS: 103973020
CRE: CHLREDRAFT_24195(NUO3)
VCN: VOLCADRAFT_82032(nuo3)
OTA: OstapMp16(nad3)
BPG: BathyMg00155(nad3)
MIS: MicpuN_mit79(nad3)
CSL: CospCoM_p13(nad3)
CVR: OJ20_p21(nad3)
CCP: ChcroMp13(nad3)
DHA: ND3
CAL: CaalfMp10(NAD3)
YLI: YalifMp29(nd3)
CLUS: 16792611(nad3)
NCR: NCU16007
SMP: SMAC_12651(nad3)
PAN: PoanfMp05(nad3)
FGR: GizefMp04(nad3)
ANG: Asnifp12(nad3)
PNO: SNOGp12(nad3)
DDI: DidioMp13(nad3)
DFA: Difao_mp22(nad3)
TET: TepyoMp26(nad3)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Sarzi E, Brown MD, Lebon S, Chretien D, Munnich A, Rotig A, Procaccio V
  Title
A novel recurrent mitochondrial DNA mutation in ND3 gene is associated with isolated complex I deficiency causing Leigh syndrome and dystonia.
  Journal
Am J Med Genet A 143A:33-41 (2007)
DOI:10.1002/ajmg.a.31565
  Sequence
[hsa:4537]

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