KEGG   ORTHOLOGY: K04359Help
Entry
K04359                      KO                                     

Name
PDGFA
Definition
platelet-derived growth factor subunit A
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05231  Choline metabolism in cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H00015  Malignant pleural mesothelioma
H00042  Glioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04015 Rap1 signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04010 MAPK signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04630 Jak-STAT signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04072 Phospholipase D signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04151 PI3K-Akt signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04359  PDGFA; platelet-derived growth factor subunit A
   04540 Gap junction
    K04359  PDGFA; platelet-derived growth factor subunit A
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04359  PDGFA; platelet-derived growth factor subunit A
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05231 Choline metabolism in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05202 Transcriptional misregulation in cancers
    K04359  PDGFA; platelet-derived growth factor subunit A
   05206 MicroRNAs in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05214 Glioma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05218 Melanoma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05215 Prostate cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
  09165 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04359  PDGFA; platelet-derived growth factor subunit A
  09167 Infectious diseases
   05166 HTLV-I infection
    K04359  PDGFA; platelet-derived growth factor subunit A
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04359  PDGFA; platelet-derived growth factor subunit A
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K04359  PDGFA; platelet-derived growth factor subunit A
   00536 Glycosaminoglycan binding proteins
    K04359  PDGFA; platelet-derived growth factor subunit A
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K04359  PDGFA; platelet-derived growth factor subunit A
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Growth factors/receptors
   K04359  PDGFA; platelet-derived growth factor subunit A
BRITE hierarchy
Other DBs
GO: 0005161
Genes
HSA: 5154(PDGFA)
PTR: 740202(PDGFA)
PPS: 100991389(PDGFA)
GGO: 101132059(PDGFA)
PON: 100440212(PDGFA)
NLE: 100583683(PDGFA)
MCC: 707725(PDGFA)
MCF: 102126620(PDGFA)
CSAB: 103246906(PDGFA)
RRO: 104664975(PDGFA)
RBB: 108542315(PDGFA)
CJC: 100412906(PDGFA)
SBQ: 101034511(PDGFA)
MMU: 18590(Pdgfa)
RNO: 25266(Pdgfa)
CGE: 100771503(Pdgfa)
NGI: 103748699(Pdgfa)
HGL: 101725739(Pdgfa)
CCAN: 109684500(Pdgfa)
OCU: 100352388(PDGFA)
TUP: 102499235(PDGFA)
CFA: 491597(PDGFA)
AML: 100473486(PDGFA)
UMR: 103670054(PDGFA)
ORO: 101386160(PDGFA)
FCA: 101087287(PDGFA)
BTA: 505908(PDGFA)
BOM: 102271219(PDGFA)
BIU: 109578611(PDGFA)
PHD: 102338084(PDGFA)
CHX: 102174268(PDGFA)
SSC: 100519764(PDGFA)
CFR: 102520052(PDGFA)
CDK: 105102061(PDGFA)
BACU: 103005337(PDGFA)
LVE: 103089216(PDGFA)
OOR: 101287211(PDGFA)
ECB: 100055086(PDGFA)
EPZ: 103555992(PDGFA)
EAI: 106834748(PDGFA)
MYB: 102253551(PDGFA)
MYD: 102762551(PDGFA)
HAI: 109380137(PDGFA)
RSS: 109455731(PDGFA)
PALE: 102893670(PDGFA)
TMU: 101344666
MDO: 100020951(PDGFA)
SHR: 100924985(PDGFA)
OAA: 100081033(PDGFA)
GGA: 374196(PDGFA)
MGP: 100545955(PDGFA)
CJO: 107320713(PDGFA)
APLA: 101803502(PDGFA)
ACYG: 106033384(PDGFA)
TGU: 100222155(PDGFA)
GFR: 102032936(PDGFA)
FAB: 101810376(PDGFA)
PHI: 102099148(PDGFA)
PMAJ: 107211209(PDGFA)
CCW: 104685042(PDGFA)
FPG: 101922505(PDGFA)
FCH: 102059520(PDGFA)
CLV: 102085857(PDGFA)
EGZ: 104128975(PDGFA)
ASN: 102386051(PDGFA)
AMJ: 102568490(PDGFA)
PSS: 102453111(PDGFA)
CMY: 102936738(PDGFA)
CPIC: 101940087(PDGFA)
ACS: 100560004(pdgfa)
PVT: 110090337(PDGFA)
PBI: 103066198(PDGFA)
GJA: 107115509(PDGFA)
XLA: 108701573(pdgfa.L) 397765(pdgfa.S)
XTR: 100038202(pdgfa)
NPR: 108800714(PDGFA)
DRE: 103909601 378480(pdgfaa) 767790(pdgfab) 796490(pdgfbb)
IPU: 108259440
TRU: 101063539 101077475(pdgfa)
LCO: 104925707(pdgfa) 104938193
NCC: 104945697(pdgfa)
OLA: 101156252(pdgfa) 101171139
XMA: 102226782(pdgfa) 102233791
PRET: 103469195(pdgfa) 103476211
NFU: 107373888 107376493(pdgfa)
LCF: 108886167(pdgfa) 108887178
BPEC: 110169079(pdgfa)
SFM: 108928863(pdgfa) 108930223
LCM: 102352946(PDGFA)
CMK: 103175503 103178687(pdgfa)
SOC: 105202236
ZNE: 110830060
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3422746
  Authors
Bonthron DT, Morton CC, Orkin SH, Collins T
  Title
Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.
  Journal
Proc Natl Acad Sci U S A 85:1492-6 (1988)
DOI:10.1073/pnas.85.5.1492
  Sequence
[hsa:5154]
Reference
  Authors
Wu E, Palmer N, Tian Z, Moseman AP, Galdzicki M, Wang X, Berger B, Zhang H, Kohane IS
  Title
Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells.
  Journal
PLoS One 3:e3794 (2008)
DOI:10.1371/journal.pone.0003794
  Sequence
[dre:386856]

DBGET integrated database retrieval system