KEGG   ORTHOLOGY: K04359Help
Entry
K04359                      KO                                     

Name
PDGFA
Definition
platelet-derived growth factor subunit A
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05231  Choline metabolism in cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H00015  Malignant pleural mesothelioma
H00042  Glioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04015 Rap1 signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04010 MAPK signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04630 Jak-STAT signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04072 Phospholipase D signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04151 PI3K-Akt signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04359  PDGFA; platelet-derived growth factor subunit A
   04540 Gap junction
    K04359  PDGFA; platelet-derived growth factor subunit A
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04359  PDGFA; platelet-derived growth factor subunit A
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05231 Choline metabolism in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05202 Transcriptional misregulation in cancers
    K04359  PDGFA; platelet-derived growth factor subunit A
   05206 MicroRNAs in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05214 Glioma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05218 Melanoma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05215 Prostate cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
  09165 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04359  PDGFA; platelet-derived growth factor subunit A
  09167 Infectious diseases
   05166 HTLV-I infection
    K04359  PDGFA; platelet-derived growth factor subunit A
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04359  PDGFA; platelet-derived growth factor subunit A
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K04359  PDGFA; platelet-derived growth factor subunit A
   00536 Glycosaminoglycan binding proteins
    K04359  PDGFA; platelet-derived growth factor subunit A
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K04359  PDGFA; platelet-derived growth factor subunit A
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Growth factors/receptors
   K04359  PDGFA; platelet-derived growth factor subunit A
BRITE hierarchy
Other DBs
GO: 0005161
Genes
HSA: 5154(PDGFA)
PTR: 740202(PDGFA)
PPS: 100991389(PDGFA)
GGO: 101132059(PDGFA)
PON: 100440212(PDGFA)
NLE: 100583683(PDGFA)
MCC: 707725(PDGFA)
MCF: 102126620(PDGFA)
CSAB: 103246906(PDGFA)
RRO: 104664975(PDGFA)
RBB: 108542315(PDGFA)
CJC: 100412906(PDGFA)
SBQ: 101034511(PDGFA)
MMU: 18590(Pdgfa)
RNO: 25266(Pdgfa)
CGE: 100771503(Pdgfa)
NGI: 103748699(Pdgfa)
HGL: 101725739(Pdgfa)
CCAN: 109684500(Pdgfa)
OCU: 100352388(PDGFA)
TUP: 102499235(PDGFA)
CFA: 491597(PDGFA)
AML: 100473486(PDGFA)
UMR: 103670054(PDGFA)
ORO: 101386160(PDGFA)
FCA: 101087287(PDGFA)
BTA: 505908(PDGFA)
BOM: 102271219(PDGFA)
BIU: 109578611(PDGFA)
PHD: 102338084(PDGFA)
CHX: 102174268(PDGFA)
SSC: 100519764(PDGFA)
CFR: 102520052(PDGFA)
CDK: 105102061(PDGFA)
BACU: 103005337(PDGFA)
LVE: 103089216(PDGFA)
OOR: 101287211(PDGFA)
ECB: 100055086(PDGFA)
EPZ: 103555992(PDGFA)
EAI: 106834748(PDGFA)
MYB: 102253551(PDGFA)
MYD: 102762551(PDGFA)
HAI: 109380137(PDGFA)
RSS: 109455731(PDGFA)
PALE: 102893670(PDGFA)
TMU: 101344666
MDO: 100020951(PDGFA)
SHR: 100924985(PDGFA)
OAA: 100081033(PDGFA)
GGA: 374196(PDGFA)
MGP: 100545955(PDGFA)
CJO: 107320713(PDGFA)
APLA: 101803502(PDGFA)
ACYG: 106033384(PDGFA)
TGU: 100222155(PDGFA)
GFR: 102032936(PDGFA)
FAB: 101810376(PDGFA)
PHI: 102099148(PDGFA)
PMAJ: 107211209(PDGFA)
CCW: 104685042(PDGFA)
FPG: 101922505(PDGFA)
FCH: 102059520(PDGFA)
CLV: 102085857(PDGFA)
EGZ: 104128975(PDGFA)
ASN: 102386051(PDGFA)
AMJ: 102568490(PDGFA)
PSS: 102453111(PDGFA)
CMY: 102936738(PDGFA)
CPIC: 101940087(PDGFA)
ACS: 100560004(pdgfa)
PVT: 110090337(PDGFA)
PBI: 103066198(PDGFA)
GJA: 107115509(PDGFA)
XLA: 108701573(pdgfa.L) 397765(pdgfa.S)
XTR: 100038202(pdgfa)
NPR: 108800714(PDGFA)
DRE: 103909601 378480(pdgfaa) 767790(pdgfab) 796490(pdgfbb)
IPU: 108259440
TRU: 101063539 101077475(pdgfa)
LCO: 104925707(pdgfa) 104938193
NCC: 104945697(pdgfa)
OLA: 101156252(pdgfa) 101171139
XMA: 102226782(pdgfa) 102233791
PRET: 103469195(pdgfa) 103476211
NFU: 107373888 107376493(pdgfa)
LCF: 108886167(pdgfa) 108887178
BPEC: 110169079(pdgfa)
SFM: 108928863(pdgfa) 108930223
LCM: 102352946(PDGFA)
CMK: 103175503 103178687(pdgfa)
SOC: 105202236
ZNE: 110830060
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3422746
  Authors
Bonthron DT, Morton CC, Orkin SH, Collins T
  Title
Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.
  Journal
Proc Natl Acad Sci U S A 85:1492-6 (1988)
DOI:10.1073/pnas.85.5.1492
  Sequence
[hsa:5154]
Reference
  Authors
Wu E, Palmer N, Tian Z, Moseman AP, Galdzicki M, Wang X, Berger B, Zhang H, Kohane IS
  Title
Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells.
  Journal
PLoS One 3:e3794 (2008)
DOI:10.1371/journal.pone.0003794
  Sequence
[dre:386856]

KEGG   ORTHOLOGY: K05450Help
Entry
K05450                      KO                                     

Name
PDGFC_D
Definition
platelet derived growth factor C/D
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04810  Regulation of actin cytoskeleton
ko05215  Prostate cancer
ko05218  Melanoma
ko05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04015 Rap1 signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04010 MAPK signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04072 Phospholipase D signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04151 PI3K-Akt signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05450  PDGFC_D; platelet derived growth factor C/D
   04540 Gap junction
    K05450  PDGFC_D; platelet derived growth factor C/D
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05450  PDGFC_D; platelet derived growth factor C/D
 09160 Human Diseases
  09161 Cancers
   05231 Choline metabolism in cancer
    K05450  PDGFC_D; platelet derived growth factor C/D
   05218 Melanoma
    K05450  PDGFC_D; platelet derived growth factor C/D
   05215 Prostate cancer
    K05450  PDGFC_D; platelet derived growth factor C/D
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05450  PDGFC_D; platelet derived growth factor C/D
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05450  PDGFC_D; platelet derived growth factor C/D
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K05450  PDGFC_D; platelet derived growth factor C/D
BRITE hierarchy
Other DBs
GO: 0005161
Genes
HSA: 56034(PDGFC) 80310(PDGFD)
PTR: 466765(PDGFD) 736477(PDGFC)
PPS: 100982459(PDGFC) 100992738(PDGFD)
GGO: 101134877(PDGFD) 101144807(PDGFC)
PON: 100172718(PDGFD) 100437861(PDGFC)
NLE: 100585549(PDGFC) 100586178(PDGFD)
MCC: 700236(PDGFC) 704310(PDGFD)
MCF: 101925936(PDGFD) 102132043(PDGFC)
CSAB: 103236438(PDGFC) 103248362(PDGFD)
RRO: 104655283(PDGFD) 104658109(PDGFC)
RBB: 108529019(PDGFC) 108534757(PDGFD)
CJC: 100393010(PDGFC) 100398033(PDGFD)
SBQ: 101038849(PDGFC) 101049234(PDGFD)
MMU: 54635(Pdgfc) 71785(Pdgfd)
RNO: 66018(Pdgfd) 79429(Pdgfc)
CGE: 100756952(Pdgfd) 100765334(Pdgfc)
NGI: 103731702(Pdgfd) 103751038(Pdgfc)
HGL: 101696768(Pdgfd) 101710927(Pdgfc)
CCAN: 109701575(Pdgfc) 109702404(Pdgfd)
OCU: 100008912(PDGFD) 100350272(PDGFC)
TUP: 102485007(PDGFD) 102487522(PDGFC)
CFA: 479460(PDGFD) 482666(PDGFC)
AML: 100479872(PDGFD) 100481171(PDGFC)
UMR: 103658054(PDGFC) 103662543(PDGFD)
ORO: 101363701(PDGFD) 101378889(PDGFC)
FCA: 101084984(PDGFD) 101088742(PDGFC)
PTG: 102949957(PDGFD) 102970530(PDGFC)
AJU: 106974876(PDGFC) 106976474(PDGFD)
BTA: 525931(PDGFD) 613787(PDGFC)
BOM: 102273267(PDGFD) 102274384(PDGFC)
BIU: 109569805(PDGFD) 109571395(PDGFC)
PHD: 102331529(PDGFC) 102341549(PDGFD)
CHX: 102168651(PDGFD) 102168934(PDGFC)
OAS: 101112600(PDGFC) 101117784(PDGFD)
SSC: 100515267(PDGFC) 100524161(PDGFD)
CFR: 102508964(PDGFC) 102515439(PDGFD)
CDK: 105101177(PDGFC) 105103704(PDGFD)
BACU: 103015925(PDGFD) 103019677(PDGFC)
LVE: 103076387(PDGFC) 103085046(PDGFD)
OOR: 101278539(PDGFC) 101290342(PDGFD)
ECB: 100061488(PDGFD) 100062015(PDGFC)
EPZ: 103547315(PDGFC) 103558709(PDGFD)
EAI: 106833032(PDGFC) 106843123(PDGFD)
MYB: 102240259(PDGFD) 102248385(PDGFC)
MYD: 102766117(PDGFC) 102772727(PDGFD)
HAI: 109372936(PDGFC) 109394938(PDGFD)
RSS: 109437504(PDGFD) 109448190(PDGFC)
PALE: 102890668(PDGFC) 102894123(PDGFD)
LAV: 100661451(PDGFD) 100672750(PDGFC)
MDO: 100011261(PDGFD) 100023701(PDGFC)
SHR: 100916102(PDGFD) 100928148(PDGFC)
OAA: 100078558(PDGFD) 100079757(PDGFC)
GGA: 395469(PDGFC) 418978(PDGFD)
MGP: 100543088(PDGFD) 100547981(PDGFC) 104917613
CJO: 107308377(PDGFD) 107313060(PDGFC)
APLA: 101789650(PDGFC) 101798843(PDGFD)
ACYG: 106032364(PDGFC) 106034125(PDGFD)
TGU: 100217775(PDGFC) 100221512(PDGFD)
GFR: 102035549(PDGFC) 102044886(PDGFD)
FAB: 101806397(PDGFD) 101808607(PDGFC)
PHI: 102106969(PDGFC) 102112153(PDGFD)
PMAJ: 107203600(PDGFC) 107209392(PDGFD)
CCW: 104690110(PDGFD) 104697317(PDGFC)
FPG: 101910328(PDGFD) 101915028(PDGFC)
FCH: 102048020(PDGFC) 102052290(PDGFD)
CLV: 102087107(PDGFC) 102088608(PDGFD)
EGZ: 104124151(PDGFC) 104133608(PDGFD)
AAM: 106491877(PDGFC) 106495523(PDGFD)
ASN: 102378690(PDGFC) 102380973(PDGFD)
AMJ: 102569106(PDGFC) 102572032(PDGFD)
PSS: 102445898(PDGFD) 102452310(PDGFC)
CMY: 102930493(PDGFD) 102939099(PDGFC)
CPIC: 101938348(PDGFD) 101944573(PDGFC)
ACS: 100551866(pdgfd) 100568114(pdgfc)
PVT: 110072781(PDGFC) 110091114(PDGFD)
PBI: 103051428(PDGFC) 103065334(PDGFD)
GJA: 107126145(PDGFD) 107126248(PDGFC)
XLA: 108699243(pdgfc.L) 108706647(pdgfc.S) 108707572 108709984(pdgfd.S)
XTR: 100492060(pdgfd) 100494492(pdgfc)
DRE: 100535718(pdgfd) 560564(pdgfc)
IPU: 108269254(pdgfc) 108277755(pdgfd)
AMEX: 103040737(pdgfc) 103045444(pdgfd)
TRU: 101062634(pdgfc) 101063213(pdgfd)
LCO: 104928604(pdgfc) 104929855(pdgfd) 109137149
NCC: 104952384(pdgfc) 104961516(pdgfd)
MZE: 101466155(pdgfc) 101473381(pdgfd)
OLA: 101159654(pdgfc) 101163754(pdgfd)
XMA: 102217846(pdgfc) 102220475(pdgfd)
PRET: 103471839(pdgfc) 103474493(pdgfd)
NFU: 107379856(pdgfc) 107380445(pdgfd)
CSEM: 103378536(pdgfd) 103390671(pdgfc)
LCF: 108885187(pdgfc) 108886631(pdgfd)
HCQ: 109525495(pdgfd) 109526276(pdgfc)
BPEC: 110153706(pdgfc) 110174393(pdgfd)
ELS: 105024074(pdgfd) 105027646(pdgfc)
SFM: 108924448(pdgfc) 108930808 108932118(pdgfd)
LCM: 102351685(PDGFD) 102356509(PDGFC)
CMK: 103182267(pdgfc) 103185765(pdgfd)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tsai YJ, Lee RK, Lin SP, Chen YH
  Title
Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract.
  Journal
Biochim Biophys Acta 1492:196-202 (2000)
DOI:10.1016/S0167-4781(00)00066-X
  Sequence
[hsa:56034]
Reference
  Authors
Fang L, Yan Y, Komuves LG, Yonkovich S, Sullivan CM, Stringer B, Galbraith S, Lokker NA, Hwang SS, Nurden P, Phillips DR, Giese NA
  Title
PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle.
  Journal
Arterioscler Thromb Vasc Biol 24:787-92 (2004)
DOI:10.1161/01.ATV.0000120785.82268.8b
  Sequence
[mmu:54635]

KEGG   ORTHOLOGY: K04357Help
Entry
K04357                      KO                                     

Name
EGF
Definition
epidermal growth factor
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05160  Hepatitis C
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05226  Gastric cancer
ko05231  Choline metabolism in cancer
Disease
H00020  Colorectal cancer
H01210  Hypomagnesemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04357  EGF; epidermal growth factor
   04015 Rap1 signaling pathway
    K04357  EGF; epidermal growth factor
   04010 MAPK signaling pathway
    K04357  EGF; epidermal growth factor
   04012 ErbB signaling pathway
    K04357  EGF; epidermal growth factor
   04630 Jak-STAT signaling pathway
    K04357  EGF; epidermal growth factor
   04066 HIF-1 signaling pathway
    K04357  EGF; epidermal growth factor
   04068 FoxO signaling pathway
    K04357  EGF; epidermal growth factor
   04072 Phospholipase D signaling pathway
    K04357  EGF; epidermal growth factor
   04151 PI3K-Akt signaling pathway
    K04357  EGF; epidermal growth factor
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04357  EGF; epidermal growth factor
   04540 Gap junction
    K04357  EGF; epidermal growth factor
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04357  EGF; epidermal growth factor
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04357  EGF; epidermal growth factor
   05231 Choline metabolism in cancer
    K04357  EGF; epidermal growth factor
   05210 Colorectal cancer
    K04357  EGF; epidermal growth factor
   05212 Pancreatic cancer
    K04357  EGF; epidermal growth factor
   05226 Gastric cancer
    K04357  EGF; epidermal growth factor
   05214 Glioma
    K04357  EGF; epidermal growth factor
   05218 Melanoma
    K04357  EGF; epidermal growth factor
   05219 Bladder cancer
    K04357  EGF; epidermal growth factor
   05215 Prostate cancer
    K04357  EGF; epidermal growth factor
   05213 Endometrial cancer
    K04357  EGF; epidermal growth factor
   05224 Breast cancer
    K04357  EGF; epidermal growth factor
   05223 Non-small cell lung cancer
    K04357  EGF; epidermal growth factor
  09167 Infectious diseases
   05160 Hepatitis C
    K04357  EGF; epidermal growth factor
   05165 Human papillomavirus infection
    K04357  EGF; epidermal growth factor
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04357  EGF; epidermal growth factor
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K04357  EGF; epidermal growth factor
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K04357  EGF; epidermal growth factor
BRITE hierarchy
Other DBs
GO: 0005155
Genes
HSA: 1950(EGF)
PTR: 461435(EGF)
PPS: 100975632(EGF)
GGO: 101153700(EGF)
PON: 100455021(EGF)
NLE: 100588963(EGF)
MCC: 698619(EGF)
MCF: 102123415(EGF)
CSAB: 103236114(EGF)
RRO: 104682421(EGF)
RBB: 108541026(EGF)
CJC: 100388651(EGF)
SBQ: 101052478(EGF)
MMU: 13645(Egf)
RNO: 25313(Egf)
CGE: 100763146(Egf)
NGI: 103742642(Egf)
HGL: 101704789 106007527(Egf)
CCAN: 109700925(Egf)
OCU: 100008808(EGF)
TUP: 102490423(EGF)
CFA: 403657(EGF)
AML: 100467733(EGF)
UMR: 103661742(EGF)
ORO: 101377629(EGF)
FCA: 493978(EGF)
PTG: 102959656(EGF)
AJU: 106983657(EGF)
BTA: 530315(EGF)
BOM: 102285914(EGF)
BIU: 109559983(EGF)
PHD: 102335984(EGF)
CHX: 106502173(EGF)
OAS: 105614258(EGF)
SSC: 397083(EGF)
CFR: 102523769(EGF) 106728895
CDK: 105089905(EGF)
BACU: 103004366(EGF)
LVE: 103073883(EGF)
OOR: 101283152(EGF)
ECB: 106782874(EGF)
EPZ: 103543333 103567315(EGF)
EAI: 106829795(EGF)
MYB: 102264252(EGF)
MYD: 102758044(EGF)
HAI: 109379436(EGF)
RSS: 109452768(EGF)
PALE: 102891552(EGF)
LAV: 100670137(EGF)
TMU: 101355971
MDO: 100619143(EGF)
SHR: 100933169(EGF)
OAA: 100074960(EGF)
GGA: 408035(EGF)
MGP: 100543460(EGF)
CJO: 107313609(EGF)
APLA: 101795002(EGF)
ACYG: 106038683(EGF)
TGU: 100218747(EGF)
GFR: 102034269(EGF)
FAB: 101819290(EGF)
PHI: 102112980(EGF)
PMAJ: 107203603(EGF)
CCW: 104697130(EGF)
FPG: 101916879(EGF)
FCH: 102049265(EGF)
CLV: 102083886(EGF)
EGZ: 104135535(EGF)
AAM: 106491937(EGF)
ASN: 102388605(EGF)
AMJ: 102560233(EGF)
PSS: 102453328(EGF)
CMY: 102933086(EGF)
CPIC: 101934754(EGF)
ACS: 100562822(egf)
PVT: 110087292(EGF)
PBI: 103061516(EGF)
GJA: 107122699(EGF)
XLA: 108704401 108710179(egf.L)
XTR: 100127663(egf)
NPR: 108798307(EGF)
DRE: 403045(egf)
IPU: 108268549(egf)
AMEX: 103045727(egf)
TRU: 101061284(egf)
LCO: 104917921(egf)
NCC: 104953729(egf)
MZE: 101487082(egf)
OLA: 101167023(egf)
XMA: 102219388(egf)
PRET: 103471828(egf)
NFU: 107374766(egf)
CSEM: 103390644(egf)
LCF: 108885177(egf)
HCQ: 109524192(egf)
BPEC: 110153711(egf)
SASA: 106611584(egf)
ELS: 105027559(egf)
SFM: 108938717(egf)
LCM: 102348800 102356822(EGF)
CMK: 103180890(egf)
SKO: 102807105
ADF: 107331023
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3491360
  Authors
Bell GI, Fong NM, Stempien MM, Wormsted MA, Caput D, Ku LL, Urdea MS, Rall LB, Sanchez-Pescador R
  Title
Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization.
  Journal
Nucleic Acids Res 14:8427-46 (1986)
DOI:10.1093/nar/14.21.8427
  Sequence
[hsa:1950]
Reference
  Authors
Hermann PM, van Kesteren RE, Wildering WC, Painter SD, Reno JM, Smith JS, Kumar SB, Geraerts WP, Ericsson LH, Smit AB, Bulloch AG, Nagle GT
  Title
Neurotrophic actions of a novel molluscan epidermal growth factor.
  Journal
J Neurosci 20:6355-64 (2000)
  Sequence
[mmu:13645]

KEGG   ORTHOLOGY: K05459Help
Entry
K05459                      KO                                     

Name
IGF1
Definition
insulin-like growth factor 1
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04114  Oocyte meiosis
ko04115  p53 signaling pathway
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04510  Focal adhesion
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04730  Long-term depression
ko04750  Inflammatory mediator regulation of TRP channels
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04960  Aldosterone-regulated sodium reabsorption
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05205  Proteoglycans in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05224  Breast cancer
ko05410  Hypertrophic cardiomyopathy (HCM)
ko05414  Dilated cardiomyopathy (DCM)
Disease
H00015  Malignant pleural mesothelioma
H02040  Insulin-like growth factor I deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04015 Rap1 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04010 MAPK signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04066 HIF-1 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04068 FoxO signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04151 PI3K-Akt signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04152 AMPK signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04150 mTOR signaling pathway
    K05459  IGF1; insulin-like growth factor 1
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K05459  IGF1; insulin-like growth factor 1
   04115 p53 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05459  IGF1; insulin-like growth factor 1
   04550 Signaling pathways regulating pluripotency of stem cells
    K05459  IGF1; insulin-like growth factor 1
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian Steroidogenesis
    K05459  IGF1; insulin-like growth factor 1
   04914 Progesterone-mediated oocyte maturation
    K05459  IGF1; insulin-like growth factor 1
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K05459  IGF1; insulin-like growth factor 1
  09156 Nervous system
   04730 Long-term depression
    K05459  IGF1; insulin-like growth factor 1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K05459  IGF1; insulin-like growth factor 1
  09149 Aging
   04211 Longevity regulating pathway - mammal
    K05459  IGF1; insulin-like growth factor 1
   04213 Longevity regulating pathway - multiple species
    K05459  IGF1; insulin-like growth factor 1
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K05459  IGF1; insulin-like growth factor 1
   05202 Transcriptional misregulation in cancers
    K05459  IGF1; insulin-like growth factor 1
   05205 Proteoglycans in cancer
    K05459  IGF1; insulin-like growth factor 1
   05214 Glioma
    K05459  IGF1; insulin-like growth factor 1
   05218 Melanoma
    K05459  IGF1; insulin-like growth factor 1
   05215 Prostate cancer
    K05459  IGF1; insulin-like growth factor 1
   05224 Breast cancer
    K05459  IGF1; insulin-like growth factor 1
  09165 Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K05459  IGF1; insulin-like growth factor 1
   05414 Dilated cardiomyopathy (DCM)
    K05459  IGF1; insulin-like growth factor 1
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05459  IGF1; insulin-like growth factor 1
   01522 Endocrine resistance
    K05459  IGF1; insulin-like growth factor 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05459  IGF1; insulin-like growth factor 1
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K05459  IGF1; insulin-like growth factor 1
BRITE hierarchy
Other DBs
GO: 0005159
Genes
HSA: 3479(IGF1)
PTR: 741055(IGF1)
PPS: 100982978(IGF1)
GGO: 101154397(IGF1)
PON: 100444645(IGF1)
NLE: 100595306(IGF1)
MCC: 698444(IGF1)
MCF: 102128018(IGF1)
CSAB: 103238957(IGF1)
RRO: 104657459(IGF1)
RBB: 108543134(IGF1)
CJC: 100394985(IGF1)
SBQ: 101036963(IGF1)
MMU: 16000(Igf1)
RNO: 24482(Igf1)
CGE: 100751642(Igf1)
NGI: 103733723(Igf1)
HGL: 101707684(Igf1)
CCAN: 109677734 109697466(Igf1)
OCU: 100008668(IGF1)
TUP: 102490248(IGF1)
CFA: 610255(IGF1)
AML: 100473254(IGF1)
UMR: 103676495(IGF1)
ORO: 101386334(IGF1)
FCA: 101101237(IGF1)
PTG: 102962543(IGF1)
AJU: 106971906(IGF1)
BTA: 281239(IGF1)
BOM: 102272009(IGF1)
BIU: 109559448(IGF1)
PHD: 102318534(IGF1)
CHX: 100860838(IGF1)
OAS: 443318(IGF1)
SSC: 397491(IGF1)
CFR: 102506236(IGF1)
CDK: 105097468(IGF1)
BACU: 103014780(IGF1)
LVE: 103078928(IGF1)
OOR: 101269950(IGF1)
ECB: 100034198(IGF1)
EPZ: 103549360(IGF1)
EAI: 106827264(IGF1)
MYB: 102252071(IGF1)
MYD: 102752580(IGF1)
HAI: 109387785(IGF1)
RSS: 109447628(IGF1)
PALE: 102890331(IGF1)
LAV: 100664710(IGF1)
TMU: 101361934
MDO: 100021295(IGF1)
SHR: 100918816(IGF1)
OAA: 100075905(IGF1)
GGA: 418090(IGF1)
MGP: 678666(IGF1)
CJO: 107316281(IGF1)
APLA: 101793597(IGF1)
ACYG: 106035916(IGF1)
TGU: 100226283(IGF1)
GFR: 102032215(IGF1)
FAB: 101808710(IGF1)
PHI: 102112946(IGF1)
PMAJ: 107204610(IGF1)
CCW: 104696228(IGF1)
FPG: 101922655(IGF1)
FCH: 102060062(IGF1)
CLV: 102092089(IGF1)
EGZ: 104135582(IGF1)
AAM: 106488383(IGF1)
ASN: 102372626(IGF1)
AMJ: 102559209(IGF1)
PSS: 102454948(IGF1)
CMY: 102932263(IGF1)
CPIC: 101939474(IGF1)
ACS: 100566682(igf1)
PVT: 110084792(IGF1)
PBI: 103062109(IGF1)
GJA: 107119991(IGF1)
XLA: 108711020(igf1.L) 108712492 378699(igf1.S)
XTR: 100486334(igf1)
NPR: 108789614(IGF1)
DRE: 114433(igf1)
IPU: 100305062(igf1)
AMEX: 103036238(igf1)
TRU: 100462939(igf1)
NCC: 104956990
MZE: 101464291 101476517(igf1)
OLA: 101168167(igf1) 105354483
XMA: 102221578 102222602(igf1)
PRET: 103459389(igf1) 103466958
NFU: 107386743(igf1) 107391385
CSEM: 103382578(igf1) 103384875
LCF: 108897582(igf1) 108900498
HCQ: 109528351 109530129(igf1)
ELS: 105013816 105030158(igf1)
SFM: 108931632(igf1)
LCM: 102361051(IGF1) 102365620
CMK: 103179868(igf1)
CIN: 100170003(ins-l1)
DME: Dmel_CG14049(Ilp6)
DSI: Dsimw501_GD28130(Dsim_GD28130)
MDE: 101896013
AME: 107964907
BIM: 105680848
BTER: 100648980
SOC: 105197201
AEC: 105154102
ACEP: 105617935
HST: 105186969
CFO: 105257619
PGC: 109855579
BMOR: 100147697(Bbx-c2) 100169656(Bbx-b11) 100169718(Bbx-b8) 100169722(Bbx-b3) 100169724(Bbx-b5) 100270769(Igflp)
PRAP: 110996560
API: 107882462
ZNE: 110826827
CRG: 105319754
SHX: MS3_05637
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3002851
  Authors
de Pagter-Holthuizen P, van Schaik FM, Verduijn GM, van Ommen GJ, Bouma BN, Jansen M, Sussenbach JS
  Title
Organization of the human genes for insulin-like growth factors I and II.
  Journal
FEBS Lett 195:179-84 (1986)
DOI:10.1016/0014-5793(86)80156-9
  Sequence
[hsa:3479]
Reference
  Authors
Zoidis E, Ghirlanda-Keller C, Schmid C
  Title
Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I.
  Journal
Mol Cell Biochem 348:33-42 (2011)
DOI:10.1007/s11010-010-0634-z
  Sequence
[hsa:3479]

KEGG   ORTHOLOGY: K05448Help
Entry
K05448                      KO                                     

Name
VEGFA
Definition
vascular endothelial growth factor A
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04066  HIF-1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04370  VEGF signaling pathway
ko04510  Focal adhesion
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05219  Bladder cancer
ko05323  Rheumatoid arthritis
ko05418  Fluid shear stress and atherosclerosis
Disease
H01456  Diabetic nephropathy
H01457  Diabetic retinopathy
H01459  Diabetic neuropathy
H01529  Avascular necrosis of femoral head
H01709  Glucocorticoid-induced osteonecrosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05448  VEGFA; vascular endothelial growth factor A
   04015 Rap1 signaling pathway
    K05448  VEGFA; vascular endothelial growth factor A
   04010 MAPK signaling pathway
    K05448  VEGFA; vascular endothelial growth factor A
   04370 VEGF signaling pathway
    K05448  VEGFA; vascular endothelial growth factor A
   04066 HIF-1 signaling pathway
    K05448  VEGFA; vascular endothelial growth factor A
   04151 PI3K-Akt signaling pathway
    K05448  VEGFA; vascular endothelial growth factor A
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05448  VEGFA; vascular endothelial growth factor A
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K05448  VEGFA; vascular endothelial growth factor A
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K05448  VEGFA; vascular endothelial growth factor A
   05206 MicroRNAs in cancer
    K05448  VEGFA; vascular endothelial growth factor A
   05205 Proteoglycans in cancer
    K05448  VEGFA; vascular endothelial growth factor A
   05212 Pancreatic cancer
    K05448  VEGFA; vascular endothelial growth factor A
   05211 Renal cell carcinoma
    K05448  VEGFA; vascular endothelial growth factor A
   05219 Bladder cancer
    K05448  VEGFA; vascular endothelial growth factor A
  09162 Immune diseases
   05323 Rheumatoid arthritis
    K05448  VEGFA; vascular endothelial growth factor A
  09165 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K05448  VEGFA; vascular endothelial growth factor A
  09166 Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05448  VEGFA; vascular endothelial growth factor A
  09167 Infectious diseases
   05163 Human cytomegalovirus infection
    K05448  VEGFA; vascular endothelial growth factor A
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05448  VEGFA; vascular endothelial growth factor A
   05165 Human papillomavirus infection
    K05448  VEGFA; vascular endothelial growth factor A
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05448  VEGFA; vascular endothelial growth factor A
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05448  VEGFA; vascular endothelial growth factor A
   00536 Glycosaminoglycan binding proteins
    K05448  VEGFA; vascular endothelial growth factor A
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K05448  VEGFA; vascular endothelial growth factor A
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Growth factors/receptors
   K05448  VEGFA; vascular endothelial growth factor A
BRITE hierarchy
Other DBs
GO: 0005172
Genes
HSA: 7422(VEGFA)
PTR: 736875(VEGFA)
PPS: 100970217(VEGFA)
GGO: 101131949(VEGFA)
PON: 100448769(VEGFA)
NLE: 100601396
MCC: 574209(VEGFA)
MCF: 102140241(VEGFA)
CSAB: 103221446(VEGFA)
RRO: 104667362(VEGFA)
RBB: 108533452(VEGFA)
CJC: 100389629(VEGFA)
SBQ: 101032691(VEGFA)
MMU: 22339(Vegfa)
RNO: 83785(Vegfa)
CGE: 100755957(Vegfa)
NGI: 103730772(Vegfa)
HGL: 101702403(Vegfa)
CCAN: 109682127(Vegfa)
OCU: 100008899(VEGFA)
TUP: 102499303(VEGFA)
CFA: 403802(VEGFA)
AML: 100482983(VEGFA)
UMR: 103664148(VEGFA)
ORO: 101363442(VEGFA)
FCA: 493845(VEGFA)
PTG: 102954556(VEGFA)
AJU: 106974016(VEGFA)
BTA: 281572(VEGFA)
BOM: 102270607(VEGFA)
BIU: 109576576(VEGFA)
PHD: 102319777(VEGFA)
CHX: 100860957(VEGFA)
OAS: 443103(VEGFA)
SSC: 397157(VEGFA)
CFR: 102514843(VEGFA)
CDK: 105088633(VEGFA)
BACU: 103008131(VEGFA)
LVE: 103089095(VEGFA)
OOR: 101279969(VEGFA)
ECB: 100033839(VEGFA)
EPZ: 103548136(VEGFA)
EAI: 106828747(VEGFA)
MYB: 102254357(VEGFA)
MYD: 102771975(VEGFA)
HAI: 109382864(VEGFA)
RSS: 109450763(VEGFA)
PALE: 102890394(VEGFA)
LAV: 100661392(VEGFA)
TMU: 101341920
MDO: 100012132(VEGFA)
SHR: 100913423(VEGFA)
OAA: 100077009
GGA: 395909(VEGFA)
MGP: 100539186(VEGFA)
CJO: 107311307(VEGFA)
APLA: 101805258(VEGFA)
ACYG: 106048193(VEGFA)
TGU: 100230266(VEGFA)
GFR: 102038819(VEGFA)
FAB: 101806742(VEGFA)
PHI: 102114381(VEGFA)
PMAJ: 107201252(VEGFA)
CCW: 104684484(VEGFA)
FPG: 101913384(VEGFA)
FCH: 102053577(VEGFA)
CLV: 102087578(VEGFA)
EGZ: 104132722(VEGFA)
AAM: 106485436(VEGFA)
ASN: 102372950(VEGFA)
AMJ: 102576555(VEGFA)
PSS: 102448827(VEGFB) 102456411(VEGFA)
CMY: 102932696 102942789(VEGFA)
CPIC: 101942497(VEGFB) 101951073(VEGFA)
ACS: 100568086(vegfa)
PVT: 110074690(VEGFA)
PBI: 103060055(VEGFA) 103062159(VEGFB)
GJA: 107125774(VEGFA)
XLA: 100037058(vegfa.S) 373589(vegfa.L)
XTR: 100038089(vegfa)
NPR: 108794236(VEGFB) 108800210(VEGFA)
DRE: 30682(vegfaa) 558154(vegfab)
TRU: 101070662 101073237(vegfa) 101077724(vegfb)
LCO: 104925542(vegfb) 104925623(vegfa) 104932871
NCC: 104944845(vegfa) 104948932 104960665(vegfb)
MZE: 101467969(vegfb) 101472090(vegfa)
OLA: 100125510(vegfa) 105354863(vegfb)
XMA: 102234868(vegfa)
PRET: 103457700(vegfa)
NFU: 107377612(vegfb) 107378043(vegfa) 107378093
CSEM: 103380788(vegfa) 103388751 103390839(vegfb)
HCQ: 109511963(vegfb) 109521925 109523530(vegfa)
BPEC: 110154009(vegfa) 110158996(vegfb) 110161092
ELS: 105006584 105017629(vegfa) 105026727(vegfb)
LCM: 102347582(VEGFB) 102367264(VEGFA)
CMK: 103179198(vegfa)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2479986
  Authors
Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N
  Title
Vascular endothelial growth factor is a secreted angiogenic mitogen.
  Journal
Science 246:1306-9 (1989)
DOI:10.1126/science.2479986
  Sequence
[hsa:7422]

KEGG   ORTHOLOGY: K05449Help
Entry
K05449                      KO                                     

Name
VEGFC_D
Definition
vascular endothelial growth factor C/D
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05200  Pathways in cancer
Disease
H00535  Hereditary lymphedema
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05449  VEGFC_D; vascular endothelial growth factor C/D
   04015 Rap1 signaling pathway
    K05449  VEGFC_D; vascular endothelial growth factor C/D
   04010 MAPK signaling pathway
    K05449  VEGFC_D; vascular endothelial growth factor C/D
   04151 PI3K-Akt signaling pathway
    K05449  VEGFC_D; vascular endothelial growth factor C/D
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05449  VEGFC_D; vascular endothelial growth factor C/D
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K05449  VEGFC_D; vascular endothelial growth factor C/D
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K05449  VEGFC_D; vascular endothelial growth factor C/D
  09166 Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05449  VEGFC_D; vascular endothelial growth factor C/D
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05449  VEGFC_D; vascular endothelial growth factor C/D
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K05449  VEGFC_D; vascular endothelial growth factor C/D
BRITE hierarchy
Other DBs
GO: 0005172
Genes
HSA: 2277(VEGFD) 7424(VEGFC)
PTR: 465508(VEGFD) 471358(VEGFC)
PPS: 100969999(VEGFD) 100990660(VEGFC)
GGO: 101140168(VEGFD) 101140874(VEGFC) 109025007
PON: 100433743(VEGFD) 100453191(VEGFC)
NLE: 100595914(VEGFC) 100601827(VEGFD)
MCC: 699502(VEGFC) 712654(VEGFD)
MCF: 102117741(VEGFC) 107126428(VEGFD)
CSAB: 103231636(VEGFD) 103236566(VEGFC)
RRO: 104664532(VEGFD) 104678733(VEGFC)
RBB: 108534048(VEGFC) 108539697(VEGFD)
CJC: 100395294(VEGFC) 100407908(VEGFD)
SBQ: 101044650(FIGF) 101048128(VEGFC)
MMU: 14205(Vegfd) 22341(Vegfc)
RNO: 114111(Vegfc) 360457(Vegfd)
CGE: 100753419(Vegfc) 100773421(Vegfd)
NGI: 103740292(Vegfd) 103745233(Vegfc)
HGL: 101719504(Vegfc) 101726005(Vegfd)
CCAN: 109676954(Vegfc)
OCU: 100338090(VEGFD) 100338211(VEGFC)
TUP: 102486007(VEGFD) 102498502(VEGFC)
CFA: 482932(VEGFC) 491749(VEGFD)
AML: 100482213(VEGFD) 100483046(VEGFC)
UMR: 103668144(VEGFD) 103679375(VEGFC)
ORO: 101372364(FIGF) 101375487(VEGFC)
FCA: 101085368(VEGFC) 493703(VEGFD)
PTG: 102952237(VEGFC) 102965995(VEGFD)
AJU: 106974232(VEGFD) 106976756(VEGFC)
BTA: 282122(VEGFC) 286799(VEGFD)
BOM: 102276010(VEGFD) 102280941(VEGFC)
BIU: 109553526(VEGFC) 109555471(VEGFD)
PHD: 102318845(VEGFD) 102338017(VEGFC)
CHX: 102185645(VEGFD) 102189826(VEGFC)
OAS: 101102873(FIGF) 101105629(VEGFC)
SSC: 100155670(VEGFD) 100525960(VEGFC)
CFR: 102514127(VEGFC) 102522536(VEGFD)
CDK: 105084416(VEGFC) 105100399(VEGFD)
BACU: 103007348(VEGFD) 103014140(VEGFC)
LVE: 103074827(VEGFC) 103087133(VEGFD)
OOR: 101284490(FIGF) 101286312(VEGFC)
ECB: 100050877(VEGFD) 100060890(VEGFC)
EPZ: 103551779(VEGFC) 103564509(VEGFD)
EAI: 106841578(VEGFD) 106843564(VEGFC)
MYB: 102252136(VEGFC) 102260639(VEGFD)
MYD: 102764314(VEGFD) 102770606(VEGFC)
HAI: 109387670(VEGFC) 109395927(VEGFD)
RSS: 109455022(VEGFD) 109456898(VEGFC)
PALE: 102884251(VEGFC) 102889143(VEGFD)
LAV: 100657845(VEGFC) 100665819(VEGFD)
MDO: 100013301(VEGFC) 100031803(VEGFD)
SHR: 100918372(VEGFD) 100928742(VEGFC)
OAA: 100082290(VEGFD) 100087477
GGA: 395255(VEGFD) 422573(VEGFC)
MGP: 100540731(VEGFD) 100550234 104910687(VEGFC)
CJO: 107313491(VEGFC) 107325582(VEGFD)
APLA: 101791715(VEGFD) 101794827(VEGFC)
ACYG: 106037783(FIGF) 106041769(VEGFC)
TGU: 100221203(VEGFC) 100227068(VEGFD)
GFR: 102036850(VEGFC) 102037618(VEGFD)
FAB: 101814975(VEGFD) 101821523(VEGFC)
PHI: 102101573(VEGFC) 102108122(VEGFD)
PMAJ: 107203121(VEGFC) 107212276(VEGFD)
CCW: 104686165(VEGFD) 104690559(VEGFC)
FPG: 101912084(VEGFD) 101912626(VEGFC)
FCH: 102046374(VEGFC) 102060261(VEGFD)
CLV: 102091004(VEGFC) 102094006(VEGFD)
EGZ: 104127304(FIGF) 104129420(VEGFC)
AAM: 106484003(VEGFC) 106491870(VEGFD)
ASN: 102379047(VEGFC)
AMJ: 102569065(VEGFD) 102571219(VEGFC)
PSS: 102452480(VEGFD) 102457900(VEGFC)
CMY: 102937370(VEGFC) 102939169(VEGFD)
CPIC: 101937490(VEGFC) 101951395(VEGFD)
ACS: 100564908(vegfd) 100565904(vegfc)
PVT: 110075463(VEGFD) 110084103(VEGFC)
PBI: 103050857(VEGFC) 103066682(VEGFD)
GJA: 107115841(VEGFD) 107124817(VEGFC)
XLA: 100158352(vegfd.L) 108698878(vegfc.L) 734331(vegfc.S)
XTR: 100144690(vegfd) 100487606(vegfc)
NPR: 108792318(VEGFD) 108792718(VEGFC)
DRE: 403049(vegfc) 678512(vegfd)
IPU: 108259562(vegfd) 108263825(vegfc)
AMEX: 103030522(vegfd) 111191781(vegfc)
TRU: 101065678(vegfd) 101076347 101078181(vegfc)
LCO: 104919793(vegfd) 104936729(vegfc) 104937628
NCC: 104954640
MZE: 101477124(vegfc) 101479861(vegfd) 101486579
OLA: 100125534(vegfc) 101168772
XMA: 102217921(vegfd) 102230333(vegfc) 102234660
PRET: 103462022(figf) 103470697(vegfc) 103474483
NFU: 107380855 107381684(figf) 107382268(vegfc)
CSEM: 103378665(figf) 103383876(vegfc) 103389258
LCF: 108887370(vegfc) 108887950(vegfd) 108892841
HCQ: 109510369 109521746(vegfc) 109525970(vegfd)
BPEC: 110153300 110167607(vegfc) 110173052(vegfd)
ELS: 105019936(vegfd) 105024500(vegfc) 105030013
LCM: 102360711 102361433(VEGFD) 102367077(VEGFC)
CMK: 103177593(vegfd) 103180215(vegfc) 103184142
SPU: 754084
APLC: 110983719
SKO: 100329011(VEGF)
CRG: 105343926
LAK: 106156542
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8617204
  Authors
Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, Saksela O, Kalkkinen N, Alitalo K
  Title
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.
  Journal
EMBO J 15:290-98 (1996)
  Sequence
[hsa:7424]
Reference
  Authors
Li X, Eriksson U.
  Title
Novel VEGF family members: VEGF-B, VEGF-C and VEGF-D.
  Journal
Int J Biochem Cell Biol 33:421-6 (2001)
DOI:10.1016/S1357-2725(01)00027-9

KEGG   ORTHOLOGY: K05460Help
Entry
K05460                      KO                                     

Name
HGF
Definition
hepatocyte growth factor
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko05144  Malaria
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05211  Renal cell carcinoma
ko05218  Melanoma
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00048  Hepatocellular carcinoma
H00605  Deafness, autosomal recessive
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05460  HGF; hepatocyte growth factor
   04015 Rap1 signaling pathway
    K05460  HGF; hepatocyte growth factor
   04010 MAPK signaling pathway
    K05460  HGF; hepatocyte growth factor
   04151 PI3K-Akt signaling pathway
    K05460  HGF; hepatocyte growth factor
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05460  HGF; hepatocyte growth factor
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K05460  HGF; hepatocyte growth factor
   05205 Proteoglycans in cancer
    K05460  HGF; hepatocyte growth factor
   05225 Hepatocellular carcinoma
    K05460  HGF; hepatocyte growth factor
   05226 Gastric cancer
    K05460  HGF; hepatocyte growth factor
   05218 Melanoma
    K05460  HGF; hepatocyte growth factor
   05211 Renal cell carcinoma
    K05460  HGF; hepatocyte growth factor
  09167 Infectious diseases
   05144 Malaria
    K05460  HGF; hepatocyte growth factor
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05460  HGF; hepatocyte growth factor
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05460  HGF; hepatocyte growth factor
   00536 Glycosaminoglycan binding proteins
    K05460  HGF; hepatocyte growth factor
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K05460  HGF; hepatocyte growth factor
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Growth factors/receptors
   K05460  HGF; hepatocyte growth factor
BRITE hierarchy
Other DBs
GO: 0005171
Genes
HSA: 3082(HGF)
PTR: 463503(HGF)
PPS: 100983117(HGF)
GGO: 101127877(HGF)
PON: 100462115(HGF)
NLE: 100586296(HGF)
MCC: 708316(HGF)
MCF: 102133907(HGF)
CSAB: 103226643(HGF)
RRO: 104681576(HGF)
RBB: 108536940(HGF)
CJC: 100385966(HGF)
SBQ: 101045517(HGF)
MMU: 15234(Hgf)
RNO: 24446(Hgf)
CGE: 100764472(Hgf)
NGI: 103730723(Hgf)
HGL: 101707056(Hgf)
OCU: 100316908(HGF)
TUP: 102483689(HGF)
CFA: 403441(HGF)
AML: 100463560(HGF)
UMR: 103658669(HGF)
ORO: 101373766(HGF)
FCA: 493705(HGF)
PTG: 102952318(HGF)
AJU: 106975661(HGF)
BTA: 282879(HGF)
BOM: 102267837(HGF)
BIU: 109557878(HGF)
PHD: 102316675(HGF)
CHX: 102183288(HGF)
OAS: 443075(HGF)
SSC: 100525120(HGF)
CFR: 102515749(HGF)
BACU: 102997605
LVE: 103079072(HGF)
OOR: 101273491(HGF)
ECB: 100049848(HGF)
EPZ: 103563173(HGF)
EAI: 106840178(HGF)
MYB: 102259449(HGF)
MYD: 102765945(HGF)
HAI: 109392334(HGF)
RSS: 109455385(HGF)
PALE: 102884470(HGF)
LAV: 100665493(HGF)
TMU: 101344799
MDO: 100016122(HGF)
SHR: 100915696(HGF)
OAA: 100074892(HGF)
GGA: 395941(HGF)
MGP: 100542153(HGF)
CJO: 107321440(HGF)
APLA: 101793664(HGF)
ACYG: 106035566(HGF)
TGU: 100218784(HGF)
GFR: 102042539(HGF)
FAB: 101810717(HGF)
PHI: 102106058(HGF)
PMAJ: 107205229(HGF)
CCW: 104686934(HGF)
FPG: 101917184(HGF)
FCH: 102052167(HGF)
CLV: 102084988(HGF)
EGZ: 104132389(HGF)
AAM: 106485602(HGF)
ASN: 102385607(HGF)
AMJ: 102564574(HGF)
PSS: 102451409(HGF)
CMY: 102929769(HGF)
CPIC: 101946945(HGF)
ACS: 100566618(hgf)
PVT: 110077194(HGF)
PBI: 103063662
GJA: 107110492(HGF)
XLA: 108711206(hgf.L) 108713062(hgf.S)
XTR: 100495840(hgf)
NPR: 108792728(HGF)
DRE: 100334116 493781(hgfa)
IPU: 108264660(HGF)
TRU: 101064315(hgf) 101078862
NCC: 104952156(hgf) 104958230
MZE: 101470516(hgf) 101486965
OLA: 101156453 101167035(hgf)
XMA: 102226489(hgf) 102232629
PRET: 103459222 103466001(hgf)
NFU: 107385652 107388871(hgf)
CSEM: 103380100(hgf) 103382777
HCQ: 109523797 109526843(hgf)
SFM: 108921145(hgf) 108936428
LCM: 102354206(HGF)
CMK: 103177006(hgf)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2528952
  Authors
Miyazawa K, Tsubouchi H, Naka D, Takahashi K, Okigaki M, Arakaki N, Nakayama H, Hirono S, Sakiyama O, Takahashi K, et al.
  Title
Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor.
  Journal
Biochem Biophys Res Commun 163:967-73 (1989)
DOI:10.1016/0006-291X(89)92316-4
  Sequence
[hsa:3082]

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