KEGG   ORTHOLOGY: K04363Help
Entry
K04363                      KO                                     

Name
PDGFRA, CD140A
Definition
platelet-derived growth factor receptor alpha [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04072  Phospholipase D signaling pathway
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05163  Human cytomegalovirus infection
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
Disease
H00042  Glioma
H01590  Chronic eosinophilic leukemia
H01591  Gastrotintestinal stromal tumor
H01599  Hypereosinophilic syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04015 Rap1 signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04010 MAPK signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04630 Jak-STAT signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04020 Calcium signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04072 Phospholipase D signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04151 PI3K-Akt signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04540 Gap junction
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05230 Central carbon metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05231 Choline metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05206 MicroRNAs in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05214 Glioma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05218 Melanoma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05215 Prostate cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09167 Infectious diseases
   05166 HTLV-I infection
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05163 Human cytomegalovirus infection
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09183 Protein families: signaling and cellular processes
   04090 CD Molecules
    K04363  CD140a, PDGFRA; platelet-derived growth factor receptor, alpha polypeptide
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
CD molecules [BR:ko04090]
 Proteins
  K04363  CD140a, PDGFRA; platelet-derived growth factor receptor, alpha polypeptide
BRITE hierarchy
Other DBs
GO: 0005018
Genes
HSA: 5156(PDGFRA)
PTR: 461318(PDGFRA)
PPS: 100982337(PDGFRA)
GGO: 101124928(PDGFRA)
PON: 100431735(PDGFRA)
NLE: 100603207(PDGFRA)
MCC: 697002(PDGFRA)
MCF: 102138392(PDGFRA)
CSAB: 103235675(PDGFRA)
RRO: 104658857(PDGFRA)
RBB: 108533750(PDGFRA)
CJC: 100412331(PDGFRA)
SBQ: 101040156(PDGFRA)
MMU: 18595(Pdgfra)
RNO: 25267(Pdgfra)
CGE: 100760258(Pdgfra)
NGI: 103734393(Pdgfra)
HGL: 101697360(Pdgfra)
CCAN: 109685094(Pdgfra) 109702274
OCU: 100343006(PDGFRA)
TUP: 102488187(PDGFRA)
CFA: 442860(PDGFRA)
AML: 100464991(PDGFRA)
UMR: 103672737(PDGFRA)
ORO: 101372359(PDGFRA)
FCA: 101090765(PDGFRA)
PTG: 102955481(PDGFRA)
AJU: 106983998(PDGFRA)
BTA: 282301(PDGFRA)
BOM: 102282598(PDGFRA)
BIU: 109560475(PDGFRA)
PHD: 102329243(PDGFRA)
CHX: 102174007(PDGFRA)
OAS: 101106012(PDGFRA)
SSC: 100627123(PDGFRA)
CFR: 102512589(PDGFRA)
CDK: 105103397(PDGFRA)
BACU: 102998016(PDGFRA)
LVE: 103071473(PDGFRA)
OOR: 101269459(PDGFRA)
ECB: 100059815(PDGFRA)
EPZ: 103552305(PDGFRA)
EAI: 106839051(PDGFRA)
MYB: 102255326(PDGFRA)
MYD: 102761943(PDGFRA)
HAI: 109381815(PDGFRA)
RSS: 109451713(PDGFRA)
PALE: 102895362(PDGFRA)
LAV: 100670735(PDGFRA)
TMU: 101348884
MDO: 100013088(PDGFRA)
SHR: 100925116(PDGFRA)
OAA: 100084432(PDGFRA)
GGA: 395509(PDGFRA)
MGP: 100542010(PDGFRA)
CJO: 107313741(PDGFRA)
APLA: 101797285(PDGFRA)
ACYG: 106030788(PDGFRA)
TGU: 100218386(PDGFRA)
GFR: 102044274(PDGFRA)
FAB: 101820996(PDGFRA)
PHI: 102113476(PDGFRA)
PMAJ: 107203533(PDGFRA)
CCW: 104690630(PDGFRA)
FPG: 101913531(PDGFRA)
FCH: 102054310(PDGFRA)
CLV: 102087625(PDGFRA)
EGZ: 104129386(PDGFRA)
AAM: 106490172(PDGFRA)
ASN: 102378120(PDGFRA)
AMJ: 102575338(PDGFRA)
PSS: 102443708(PDGFRA)
CMY: 102935642(PDGFRA)
CPIC: 101935558(PDGFRA)
ACS: 100565834(pdgfra) 103278978
PVT: 110078407(PDGFRA)
PBI: 103067713(PDGFRA)
GJA: 107106036(PDGFRA)
XLA: 108706592(pdgfra.S) 380245(pdgfra.L)
XTR: 100124862(pdgfra)
NPR: 108804111(PDGFRA)
DRE: 386856(pdgfra)
CCAR: 109112741
IPU: 108258040(pdgfra)
AMEX: 103044267(pdgfra)
TRU: 101073543(pdgfra)
LCO: 104919088(pdgfra) 109142841
NCC: 104947073(pdgfra)
MZE: 101471693(pdgfra)
OLA: 100049280(pdgfra)
XMA: 102219876(pdgfra)
PRET: 103463840(pdgfra)
NFU: 107393382(pdgfra)
CSEM: 103376707(pdgfra)
LCF: 108879100(pdgfra)
HCQ: 109532287(pdgfra)
BPEC: 110154688(pdgfra)
SASA: 106560269 106584117(pdgfra)
ELS: 105011836(pdgfra)
SFM: 108922803(pdgfra)
LCM: 102353753(PDGFRA)
CMK: 103178167(pdgfra)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2544881
  Authors
Claesson-Welsh L, Eriksson A, Westermark B, Heldin CH
  Title
cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.
  Journal
Proc Natl Acad Sci U S A 86:4917-21 (1989)
DOI:10.1073/pnas.86.13.4917
  Sequence
[hsa:5156]
Reference
PMID:8188664
  Authors
Vassbotn FS, Havnen OK, Heldin CH, Holmsen H
  Title
Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor.
  Journal
J Biol Chem 269:13874-9 (1994)
  Sequence
[hsa:5156]

KEGG   ORTHOLOGY: K05089Help
Entry
K05089                      KO                                     

Name
PDGFRB, CD140B
Definition
platelet-derived growth factor receptor beta [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
Disease
H00042  Glioma
H01574  Familial idiopathic basal ganglia calcification
H01910  Infantile myofibromatosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04015 Rap1 signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04010 MAPK signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04630 Jak-STAT signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04020 Calcium signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04072 Phospholipase D signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04151 PI3K-Akt signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04540 Gap junction
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05230 Central carbon metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05231 Choline metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05206 MicroRNAs in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05214 Glioma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05218 Melanoma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05215 Prostate cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09167 Infectious diseases
   05166 HTLV-I infection
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05165 Human papillomavirus infection
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09183 Protein families: signaling and cellular processes
   04090 CD Molecules
    K05089  CD140b, PDGFRB; platelet-derived growth factor receptor, beta polypeptide
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
CD molecules [BR:ko04090]
 Proteins
  K05089  CD140b, PDGFRB; platelet-derived growth factor receptor, beta polypeptide
BRITE hierarchy
Other DBs
GO: 0004992
Genes
HSA: 5159(PDGFRB)
PTR: 462188(PDGFRB)
PPS: 100975853(PDGFRB)
GGO: 101150577(PDGFRB)
PON: 100460001(PDGFRB)
NLE: 100597894(PDGFRB)
MCC: 711353(PDGFRB)
MCF: 101867161(PDGFRB)
CSAB: 103244790(PDGFRB)
RRO: 104670408(PDGFRB)
RBB: 108532047(PDGFRB)
CJC: 100389852(PDGFRB)
SBQ: 101040158(PDGFRB)
MMU: 18596(Pdgfrb)
RNO: 24629(Pdgfrb)
CGE: 100764374(Pdgfrb)
NGI: 103747076(Pdgfrb)
HGL: 101721151(Pdgfrb)
CCAN: 109685664(Pdgfrb) 109685672
OCU: 100342872(PDGFRB)
TUP: 102492413(PDGFRB)
CFA: 442985(PDGFRB)
AML: 100472005(PDGFRB)
UMR: 103664600(PDGFRB)
ORO: 101374793(PDGFRB)
FCA: 101084600(PDGFRB)
PTG: 102954207(PDGFRB)
AJU: 106985388(PDGFRB)
BTA: 527165(PDGFRB)
BOM: 102270608(PDGFRB)
BIU: 109562197(PDGFRB)
PHD: 102333941(PDGFRB)
CHX: 102184426(PDGFRB)
OAS: 101122783(PDGFRB)
SSC: 102166564(PDGFRB)
CFR: 102512951(PDGFRB)
CDK: 105098486(PDGFRB)
BACU: 103019883(PDGFRB)
LVE: 103082363(PDGFRB)
OOR: 101272795(PDGFRB)
ECB: 100071665(PDGFRB)
EPZ: 103549125(PDGFRB)
EAI: 106838493(PDGFRB)
MYB: 102241145(PDGFRB)
MYD: 102764172(PDGFRB)
HAI: 109375002(PDGFRB)
RSS: 109448748(PDGFRB)
PALE: 102887643(PDGFRB)
LAV: 100671240(PDGFRB)
TMU: 101360003
MDO: 100028943(PDGFRB)
SHR: 100917212(PDGFRB)
OAA: 100079459(PDGFRB)
GGA: 770488(PDGFRB)
MGP: 100550611(PDGFRB)
CJO: 107320191(PDGFRB)
APLA: 101799587(PDGFRB)
ACYG: 106032823(PDGFRB)
TGU: 100223375(PDGFRB)
GFR: 102045343(PDGFRB)
FAB: 101809926(PDGFRB)
PHI: 102111524(PDGFRB)
PMAJ: 107210844(PDGFRB)
CCW: 104689579(PDGFRB)
FPG: 101918438(PDGFRB)
FCH: 102052718(PDGFRB)
CLV: 102096790(PDGFRB)
EGZ: 104123312(PDGFRB)
AAM: 106493441(PDGFRB)
ASN: 102372962(PDGFRB)
AMJ: 102566175(PDGFRB)
PSS: 102460895(PDGFRB)
CMY: 102944650(PDGFRB)
CPIC: 101940553(PDGFRB)
ACS: 100555784(pdgfrb)
PVT: 110086089(PDGFRB)
PBI: 103051588(PDGFRB)
GJA: 107116322(PDGFRB) 107123329
XLA: 108712643(pdgfrb.S)
XTR: 100487523(pdgfrb)
NPR: 108785807(PDGFRB)
DRE: 559529(pdgfrb)
IPU: 108274697(pdgfrb)
AMEX: 103036483
TRU: 101061130 101074724(PDGFR-beta)
LCO: 104919444 104927056(pdgfrb)
NCC: 104965701(pdgfrb)
MZE: 101466822 101484671(pdgfrb)
OLA: 101155039(pdgfrb) 101156428
XMA: 102229755 102233464(pdgfrb)
PRET: 103459902 103471279(pdgfrb)
NFU: 107375657(pdgfrb)
CSEM: 103391002(pdgfrb) 103392104
LCF: 108873646 108899186(pdgfrb)
HCQ: 109518748(pdgfrb) 109528881
SFM: 108936824(pdgfrb)
LCM: 102361386(PDGFRB)
CMK: 103188232(pdgfrb)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Jones AV, Cross NC
  Title
Oncogenic derivatives of platelet-derived growth factor receptors.
  Journal
Cell Mol Life Sci 61:2912-23 (2004)
DOI:10.1007/s00018-004-4272-z
Reference
PMID:2835772
  Authors
Gronwald RG, Grant FJ, Haldeman BA, Hart CE, O'Hara PJ, Hagen FS, Ross R, Bowen-Pope DF, Murray MJ
  Title
Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.
  Journal
Proc Natl Acad Sci U S A 85:3435-9 (1988)
DOI:10.1073/pnas.85.10.3435
  Sequence
[hsa:5159]

KEGG   ORTHOLOGY: K04361Help
Entry
K04361                      KO                                     

Name
EGFR, ERBB1
Definition
epidermal growth factor receptor [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04072  Phospholipase D signaling pathway
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04214  Apoptosis - fly
ko04320  Dorso-ventral axis formation
ko04510  Focal adhesion
ko04520  Adherens junction
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04921  Oxytocin signaling pathway
ko04926  Relaxin signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05160  Hepatitis C
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
Disease
H00014  Non-small cell lung cancer
H00016  Oral cancer
H00017  Esophageal cancer
H00022  Bladder cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00031  Breast cancer
H00042  Glioma
H00055  Laryngeal cancer
H01508  Salivary gland cancer
H01559  Oropharyngeal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04015 Rap1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04010 MAPK signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04013 MAPK signaling pathway - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04012 ErbB signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04630 Jak-STAT signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04066 HIF-1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04068 FoxO signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04020 Calcium signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04072 Phospholipase D signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04151 PI3K-Akt signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09143 Cell growth and death
   04214 Apoptosis - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04520 Adherens junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04540 Gap junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04915 Estrogen signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04921 Oxytocin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04926 Relaxin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04928 Parathyroid hormone synthesis, secretion and action
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09158 Development
   04320 Dorso-ventral axis formation
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05230 Central carbon metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05231 Choline metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05206 MicroRNAs in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05205 Proteoglycans in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05210 Colorectal cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05212 Pancreatic cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05225 Hepatocellular carcinoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05226 Gastric cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05214 Glioma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05218 Melanoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05219 Bladder cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05215 Prostate cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05213 Endometrial cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05224 Breast cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05223 Non-small cell lung cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09167 Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05160 Hepatitis C
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05163 Human cytomegalovirus infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05165 Human papillomavirus infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   01522 Endocrine resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04361  EGFR, ERBB1; epidermal growth factor receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04361  EGFR, ERBB1; epidermal growth factor receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of pancreatic cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of bladder cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
BRITE hierarchy
Other DBs
GO: 0005006
Genes
HSA: 1956(EGFR)
PTR: 463415(EGFR)
PPS: 100974885(EGFR)
GGO: 101126190(EGFR)
PON: 100459280(EGFR)
NLE: 100597255(EGFR)
MCC: 613027(EGFR)
MCF: 102138724(EGFR)
CSAB: 103226055(EGFR)
RRO: 104675886(EGFR)
RBB: 108522039(EGFR)
CJC: 100412158(EGFR)
SBQ: 101047461(EGFR)
MMU: 13649(Egfr)
RNO: 24329(Egfr)
CGE: 100774580(Egfr)
NGI: 103748852
HGL: 101723771(Egfr)
CCAN: 109693753(Egfr)
OCU: 100008806(EGFR)
TUP: 102485304(EGFR)
CFA: 404306(EGFR)
UMR: 103674660(EGFR)
ORO: 101386858(EGFR)
FCA: 100510799(EGFR)
PTG: 102967370(EGFR)
AJU: 106976977(EGFR)
BTA: 407217(EGFR)
BOM: 102269868
BIU: 109576048(EGFR)
PHD: 102337306(EGFR)
CHX: 102172767(EGFR)
OAS: 780479(EGFR)
SSC: 397070(EGFR)
CFR: 102504272(EGFR)
CDK: 105105749
BACU: 103017029(EGFR)
LVE: 103071962(EGFR)
OOR: 101275398(EGFR)
ECB: 100067755(EGFR)
EPZ: 103560128(EGFR)
EAI: 106824133(EGFR)
MYB: 102257758(EGFR)
MYD: 102775204(EGFR)
HAI: 109388365(EGFR)
RSS: 109444752(EGFR)
PALE: 102893495(EGFR)
LAV: 100659125(EGFR)
TMU: 101356822
MDO: 100029625(EGFR)
SHR: 100914017(EGFR)
OAA: 100075894(EGFR)
GGA: 396494(EGFR)
MGP: 100543252(EGFR)
CJO: 107309802(EGFR)
APLA: 101797830(EGFR)
ACYG: 106046417(EGFR)
TGU: 100221035(EGFR)
GFR: 102045482(EGFR)
FAB: 101818290(EGFR)
PHI: 102101445(EGFR)
PMAJ: 107200328(EGFR)
CCW: 104689262(EGFR)
FPG: 101910521(EGFR)
FCH: 102058683(EGFR)
CLV: 102097879(EGFR)
EGZ: 104131586(EGFR)
AAM: 106495273(EGFR)
ASN: 102378285(EGFR)
AMJ: 102565209(EGFR)
PSS: 102443405(EGFR)
CMY: 102933326(EGFR)
CPIC: 101952725(EGFR)
ACS: 100562231(egfr)
PVT: 110081594(EGFR)
PBI: 103050691(EGFR)
GJA: 107119225(EGFR)
XLA: 108719997(egfr.S) 724072(egfr.L)
XTR: 100492965(egfr)
DRE: 378478(egfra) 571431
IPU: 108280575(egfr)
TRU: 101069322(egfr) 101073748
OLA: 101159776(egfr) 101169984
PRET: 103456976 103479868(egfr)
NFU: 107383161 107383833(egfr)
CSEM: 103377298 103396351(egfr)
LCF: 108883329(egfr) 108894667
HCQ: 109521299(egfr) 109530291
SFM: 108937670(egfr)
CMK: 103181270(egfr)
SPU: 586488
SKO: 100372961
DME: Dmel_CG10079(Egfr)
DSI: Dsimw501_GD11601(Dsim_GD11601)
MDE: 101887261
AGA: AgaP_AGAP008819(EGFR)
AAG: 5564544
AME: 100577393(Egfr)
BIM: 100740344
BTER: 100645521
AEC: 105144059
ACEP: 105627284
PBAR: 105427056
HST: 105191569
CFO: 105257833
LHU: 105676042
PGC: 109852274
NVI: 100118970(Egfr)
TCA: 660037(DER)
DPA: 109536124
NVL: 108556379
BMOR: 101741679
PMAC: 106717252
PRAP: 110998172
PXY: 105385471
API: 100168353
DNX: 107162454
ZNE: 110832144
FCD: 110842323
TUT: 107359081
CEL: CELE_ZK1067.1(let-23)
CBR: CBG00911(Cbr-let-23)
BMY: Bm1_48745
CRG: 105330118(Egfr) 105339116
LAK: 106153603
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Shao H, Cheng HY, Cook RG, Tweardy DJ
  Title
Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor.
  Journal
Cancer Res 63:3923-30 (2003)
  Sequence
[hsa:1956]
Reference
  Authors
Habib AA, Chatterjee S, Park SK, Ratan RR, Lefebvre S, Vartanian T
  Title
The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome.
  Journal
J Biol Chem 276:8865-74 (2001)
DOI:10.1074/jbc.M008458200
  Sequence
[hsa:1956]
Reference
PMID:6328312
  Authors
Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tam AW, Lee J, Yarden Y, Libermann TA, Schlessinger J, et al.
  Title
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.
  Journal
Nature 309:418-25 (1984)
  Sequence
[hsa:1956]

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