KEGG   ORTHOLOGY: K04365Help
Entry
K04365                      KO                                     

Name
BRAF
Definition
B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04015  Rap1 signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04068  FoxO signaling pathway
ko04150  mTOR signaling pathway
ko04214  Apoptosis - fly
ko04270  Vascular smooth muscle contraction
ko04320  Dorso-ventral axis formation
ko04510  Focal adhesion
ko04650  Natural killer cell mediated cytotoxicity
ko04720  Long-term potentiation
ko04722  Neurotrophin signaling pathway
ko04726  Serotonergic synapse
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko05034  Alcoholism
ko05160  Hepatitis C
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Module
M00687  MAPK (ERK1/2) signaling
Disease
H00032  Thyroid cancer
H00038  Melanoma
H00523  Noonan syndrome and related disorders
H01512  Langerhans cell histiocytosis
H01738  Noonan syndrome
H01984  Leopard syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04010 MAPK signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04013 MAPK signaling pathway - fly
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04024 cAMP signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04150 mTOR signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 09140 Cellular Processes
  09143 Cell growth and death
   04214 Apoptosis - fly
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04062 Chemokine signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04928 Parathyroid hormone synthesis, secretion and action
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09156 Nervous system
   04726 Serotonergic synapse
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04720 Long-term potentiation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04730 Long-term depression
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04722 Neurotrophin signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09158 Development
   04320 Dorso-ventral axis formation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05210 Colorectal cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05212 Pancreatic cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05225 Hepatocellular carcinoma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05226 Gastric cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05214 Glioma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05216 Thyroid cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05218 Melanoma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05219 Bladder cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05215 Prostate cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05213 Endometrial cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05224 Breast cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09164 Substance dependence
   05034 Alcoholism
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09167 Infectious diseases
   05160 Hepatitis C
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   01522 Endocrine resistance
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00687  MAPK (ERK1/2) signaling
     K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
BRITE hierarchy
Genes
HSA: 673(BRAF)
PTR: 463781(BRAF)
PPS: 100971666(BRAF)
GGO: 101145098(BRAF)
PON: 100442288(BRAF)
NLE: 100582848(BRAF)
MCC: 693554(BRAF)
MCF: 101866436(BRAF)
CSAB: 103227022(BRAF)
RRO: 104659700(BRAF)
RBB: 108541537(BRAF)
CJC: 100403091(BRAF)
SBQ: 101052142(BRAF)
MMU: 109880(Braf)
RNO: 114486(Braf)
CGE: 100771486(Braf)
NGI: 103726107(Braf)
HGL: 101702762(Braf)
OCU: 100351964(BRAF)
TUP: 102477389(BRAF)
CFA: 475526(BRAF)
AML: 100469346(BRAF)
UMR: 103669103(BRAF)
ORO: 101377465(BRAF)
FCA: 101092346(BRAF)
PTG: 102951082(BRAF)
AJU: 106970441(BRAF)
BTA: 536051(BRAF)
BOM: 102278631(BRAF)
BIU: 109557698(BRAF)
PHD: 102329974(BRAF)
CHX: 102174360(BRAF)
OAS: 101107438(BRAF)
SSC: 100514612(BRAF)
CFR: 102524100(BRAF)
CDK: 105091663(BRAF)
BACU: 103002372(BRAF)
LVE: 103079256(BRAF)
OOR: 101277195(BRAF)
ECB: 100065760(BRAF)
EPZ: 103555338(BRAF)
EAI: 106842618(BRAF)
MYB: 102260644(BRAF)
MYD: 102760422(BRAF)
HAI: 109395605(BRAF)
RSS: 109457172(BRAF)
PALE: 102878393(BRAF)
LAV: 100664119(BRAF)
TMU: 101353421
MDO: 100024057(BRAF)
SHR: 100934801(BRAF)
OAA: 100086380(BRAF)
GGA: 396239(BRAF)
MGP: 100550268(BRAF)
CJO: 107315883(BRAF)
APLA: 101794380(BRAF)
ACYG: 106030997(BRAF)
TGU: 100219601(BRAF)
GFR: 102032961(BRAF)
FAB: 101806469(BRAF)
PHI: 102104959(BRAF)
PMAJ: 107204658(BRAF)
CCW: 104696191(BRAF)
FPG: 101919653(BRAF)
FCH: 102056938(BRAF)
CLV: 102088487(BRAF)
EGZ: 104135588(BRAF)
AAM: 106488842(BRAF)
ASN: 102380007(BRAF)
AMJ: 106737102(BRAF)
PSS: 102448997(BRAF)
CMY: 102938595(BRAF)
CPIC: 101945568(BRAF)
ACS: 100556317(braf)
PVT: 110082693(BRAF)
PBI: 103054585(BRAF)
GJA: 107108795(BRAF)
XLA: 398973(braf.S) 447268(braf.L)
XTR: 779570(braf)
NPR: 108793029(BRAF)
DRE: 403065(braf)
SANH: 107655608 107694295(braf)
SGH: 107560707 107594271(braf)
IPU: 108279928(braf)
AMEX: 103036930(braf)
TRU: 653021(braf)
LCO: 104938610(braf) 109142428
NCC: 104967463(braf)
MZE: 101476445(braf)
OLA: 101155814(braf)
XMA: 102231368(braf)
PRET: 103459555(braf)
NFU: 107381355(braf)
CSEM: 103383021(braf)
LCF: 108897545(braf)
HCQ: 109513640(braf)
BPEC: 110162539(braf)
ELS: 105006078(braf)
SFM: 108936526(braf)
LCM: 102365161(BRAF) 102366102
CMK: 103181856(braf)
CIN: 778741(raf1)
SPU: 575613(braf)
APLC: 110986911
SKO: 100370381
DME: Dmel_CG2845(Raf)
DSI: Dsimw501_GD16607(Dsim_phl)
MDE: 101891362
AAG: 5579530
AME: 413448(Raf1)
BIM: 100741263
BTER: 100645437
SOC: 105202082
AEC: 105146178
ACEP: 105623044
HST: 105192683
CFO: 105253402
LHU: 105678021
PGC: 109860595
NVI: 100121496
TCA: 655334(raf)
NVL: 108559414
BMOR: 100529216(raf)
PRAP: 110991813
PXY: 105394443
API: 100169206
DNX: 107170145
ZNE: 110836363
FCD: 110858255
CEL: CELE_Y73B6A.5(lin-45)
CBR: CBG05382(Cbr-lin-45)
BMY: Bm1_40290
TSP: Tsp_05804
OBI: 106874195
LAK: 106171322
SHX: MS3_01526
EPA: 110238451
ADF: 107343857
HMG: 100201878
PMUM: 103334870
MDM: 103419723
MNG: MNEG_0685
SMIN: v1.2.012701.t1(symbB.v1.2.012701.t1) v1.2.019335.t1(symbB.v1.2.019335.t1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2284096
  Authors
Sithanandam G, Kolch W, Duh FM, Rapp UR
  Title
Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies.
  Journal
Oncogene 5:1775-80 (1990)
  Sequence
[hsa:673]
Reference
  Authors
Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D
  Title
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.
  Journal
Nature 472:366-9 (2011)
DOI:10.1038/nature09860
  Sequence
[hsa:673]

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