KEGG   ORTHOLOGY: K04368Help
Entry
K04368                      KO                                     

Name
MAP2K1, MEK1
Definition
mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04114  Oocyte meiosis
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04218  Cellular senescence
ko04270  Vascular smooth muscle contraction
ko04320  Dorso-ventral axis formation
ko04370  VEGF signaling pathway
ko04371  Apelin signaling pathway
ko04380  Osteoclast differentiation
ko04510  Focal adhesion
ko04540  Gap junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04620  Toll-like receptor signaling pathway
ko04626  Plant-pathogen interaction
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04668  TNF signaling pathway
ko04720  Long-term potentiation
ko04722  Neurotrophin signaling pathway
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04912  GnRH signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04917  Prolactin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04921  Oxytocin signaling pathway
ko04926  Relaxin signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko05020  Prion diseases
ko05034  Alcoholism
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
Module
M00687  MAPK (ERK1/2) signaling
Disease
H00523  Noonan syndrome and related disorders
H01512  Langerhans cell histiocytosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04015 Rap1 signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04010 MAPK signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04013 MAPK signaling pathway - fly
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04012 ErbB signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04370 VEGF signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04371 Apelin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04668 TNF signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04066 HIF-1 signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04068 FoxO signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04072 Phospholipase D signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04071 Sphingolipid signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04024 cAMP signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04022 cGMP - PKG signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04151 PI3K-Akt signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04150 mTOR signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09143 Cell growth and death
   04114 Oocyte meiosis
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04210 Apoptosis
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04218 Cellular senescence
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04540 Gap junction
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04550 Signaling pathways regulating pluripotency of stem cells
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04650 Natural killer cell mediated cytotoxicity
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04660 T cell receptor signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04662 B cell receptor signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04664 Fc epsilon RI signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04666 Fc gamma R-mediated phagocytosis
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04062 Chemokine signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04912 GnRH signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04915 Estrogen signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04914 Progesterone-mediated oocyte maturation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04917 Prolactin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04921 Oxytocin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04926 Relaxin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04919 Thyroid hormone signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04928 Parathyroid hormone synthesis, secretion and action
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04916 Melanogenesis
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09156 Nervous system
   04725 Cholinergic synapse
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04726 Serotonergic synapse
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04720 Long-term potentiation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04730 Long-term depression
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04722 Neurotrophin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09158 Development
   04320 Dorso-ventral axis formation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04380 Osteoclast differentiation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09159 Environmental adaptation
   04626 Plant-pathogen interaction
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05230 Central carbon metabolism in cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05231 Choline metabolism in cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05206 MicroRNAs in cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05205 Proteoglycans in cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05210 Colorectal cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05212 Pancreatic cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05225 Hepatocellular carcinoma
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05226 Gastric cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05214 Glioma
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05216 Thyroid cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05221 Acute myeloid leukemia
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05220 Chronic myeloid leukemia
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05218 Melanoma
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05211 Renal cell carcinoma
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05219 Bladder cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05215 Prostate cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05213 Endometrial cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05224 Breast cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05223 Non-small cell lung cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09163 Neurodegenerative diseases
   05020 Prion diseases
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09164 Substance dependence
   05034 Alcoholism
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09167 Infectious diseases
   05164 Influenza A
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05161 Hepatitis B
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05163 Human cytomegalovirus infection
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05165 Human papillomavirus infection
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   01522 Endocrine resistance
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00687  MAPK (ERK1/2) signaling
     K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE7 family
   K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
BRITE hierarchy
Other DBs
GO: 0004708
Genes
HSA: 5604(MAP2K1)
PTR: 450188(MAP2K1)
PPS: 100988422(MAP2K1)
GGO: 101132391(MAP2K1)
PON: 100446021(MAP2K1)
NLE: 100579506(MAP2K1)
MCC: 710415(MAP2K1)
MCF: 102141214(MAP2K1)
CSAB: 103245451(MAP2K1)
RRO: 104662575(MAP2K1)
RBB: 108514672(MAP2K1)
CJC: 100387394(MAP2K1)
SBQ: 101040361(MAP2K1)
MMU: 26395(Map2k1)
RNO: 170851(Map2k1)
CGE: 100689403(Map2k1)
NGI: 103736801(Map2k1)
HGL: 101715628(Map2k1)
CCAN: 109687824(Map2k1)
OCU: 100009316(MAP2K1)
TUP: 102476496(MAP2K1)
CFA: 478347(MAP2K1)
AML: 100478039(MAP2K1)
UMR: 103679064(MAP2K1)
ORO: 101365373(MAP2K1)
FCA: 101081387(MAP2K1)
PTG: 102969757(MAP2K1)
AJU: 106980282(MAP2K1)
BTA: 533199(MAP2K1)
BOM: 102280670(MAP2K1)
BIU: 109564697(MAP2K1)
CHX: 102190520(MAP2K1)
OAS: 101123635(MAP2K1)
SSC: 100233191(MAP2K1)
CFR: 102515937(MAP2K1)
CDK: 105093267(MAP2K1)
BACU: 103017381(MAP2K1)
LVE: 103082805(MAP2K1)
OOR: 101286388(MAP2K1)
ECB: 100065996(MAP2K1)
EPZ: 103549630(MAP2K1)
EAI: 106840602(MAP2K1)
MYB: 102240696(MAP2K1)
MYD: 102763997(MAP2K1)
HAI: 109385252(MAP2K1)
RSS: 109444309(MAP2K1)
PALE: 102897122(MAP2K1)
LAV: 100667623(MAP2K1)
TMU: 101343332
MDO: 100018410(MAP2K1)
SHR: 100921899(MAP2K1) 100934929
OAA: 100080362(MAP2K1)
GGA: 415549(MAP2K1)
MGP: 100543421(MAP2K1)
CJO: 107318921(MAP2K1)
APLA: 101791037(MAP2K1)
ACYG: 106043651(MAP2K1)
TGU: 100226448(MAP2K1)
GFR: 102031727(MAP2K1)
FAB: 101816905(MAP2K1)
PHI: 102110075(MAP2K1)
PMAJ: 107209483(MAP2K1)
CCW: 104683880(MAP2K1)
FPG: 101924998(MAP2K1)
FCH: 102053397(MAP2K1)
CLV: 102096091(MAP2K1)
EGZ: 104133527(MAP2K1)
AAM: 106487663(MAP2K1)
ASN: 102373880(MAP2K1)
AMJ: 102563228(MAP2K1)
PSS: 102443595(MAP2K1)
CMY: 102945547(MAP2K1)
CPIC: 101949355(MAP2K1)
ACS: 100558982
PVT: 110085468(MAP2K1)
PBI: 103051071(MAP2K1)
GJA: 107121194(MAP2K1)
XLA: 108712802(map2k1.S) 379991(map2k1.L)
XTR: 493420(map2k1)
NPR: 108784101(MAP2K1)
DRE: 406728(map2k1)
SRX: 107718304 107738719(map2k1)
IPU: 108264753(map2k1)
AMEX: 103028644(map2k1)
TRU: 101063584(map2k1)
LCO: 104922316(map2k1)
NCC: 104967860(map2k1)
MZE: 101465184(map2k1)
OLA: 101162677(map2k1)
XMA: 102217036(map2k1)
PRET: 103466546(map2k1)
NFU: 107388720(map2k1)
CSEM: 103380238(map2k1)
LCF: 108886445(map2k1)
HCQ: 109519419(map2k1)
BPEC: 110160811(map2k1)
SASA: 106584829(map2k1) 106592363
ELS: 105006978(map2k1)
SFM: 108926724(map2k1)
LCM: 102358560(MAP2K1)
CMK: 103186399(map2k1)
CIN: 778923(mapkk1/2)
SPU: 576066
APLC: 110982925
SKO: 100370801
DME: Dmel_CG15793(Dsor1)
DAN: Dana_GF19085(Dana_Dsor1)
DSI: Dsimw501_GD16945(Dsim_Dsor1)
MDE: 101901485
AAG: 5576696
AME: 409925(Dsor1)
BIM: 100742289
BTER: 100649968
SOC: 105204688
AEC: 105151971
ACEP: 105625005
PBAR: 105423551
HST: 105189689
CFO: 105255739
LHU: 105668080
PGC: 109856723
NVI: 103318128
TCA: 661995
DPA: 109540984
BMOR: 692467(Mek)
PMAC: 106716354
PRAP: 111004260
API: 100159396
DNX: 107171279
ZNE: 110829818
FCD: 110856140
TUT: 107366172
CEL: CELE_Y54E10BL.6(mek-2)
CBR: CBG04190(Cbr-mek-2)
BMY: Bm1_48560
TSP: Tsp_10801
CRG: 105339480
MYI: 110462626
OBI: 106880850
LAK: 106152593
ADF: 107334270
AQU: 100638124
ATH: AT5G56580(MKK6)
CRB: 17875895
BRP: 103856810
CPAP: 110812440
CIT: 102625904
TCC: 18588491
EGR: 104438209
VRA: 106763728
VAR: 108344747
CCAJ: 109816106
CAM: 101494029
LJA: Lj2g3v0890200.1(Lj2g3v0890200.1)
ADU: 107479175
LANG: 109342960
FVE: 101299988
PPER: 18771831
PMUM: 103340802
PAVI: 110751155
PXB: 103943916
ZJU: 107432800
CSV: 101218848
CMO: 103498246
MCHA: 111021852
RCU: 8265133
JCU: 105637830
POP: 18107672
VVI: 100252603
SLY: 543947(MKK3)
SPEN: 107012802
SOT: 102594623(MKK6)
CANN: 107865874
NTA: 107806359 107818136(mek1)
NSY: 104246534
NTO: 104092097
INI: 109193026
SIND: 105173561
LSV: 111888070
DCR: 108213025
BVG: 104902319
SOE: 110791517
NNU: 104592034
OSA: 4324023
DOSA: Os01t0510100-01(Os01g0510100)
OBR: 102711840
BDI: 100826178(MKK6.1)
ATS: 109783679(LOC109783679)
SBI: 8059201
ZMA: 542356(mek1)
MUS: 103996546
AOF: 109829965
ATR: 18443463
DDI: DDB_G0269152(mekA)
SMIN: v1.2.018514.t1(symbB.v1.2.018514.t1)
TCR: 511075.60
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1281467
  Authors
Seger R, Seger D, Lozeman FJ, Ahn NG, Graves LM, Campbell JS, Ericsson L, Harrylock M, Jensen AM, Krebs EG
  Title
Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases.
  Journal
J Biol Chem 267:25628-31 (1992)
  Sequence
[hsa:5604]

KEGG   ORTHOLOGY: K04369Help
Entry
K04369                      KO                                     

Name
MAP2K2, MEK2
Definition
mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04218  Cellular senescence
ko04270  Vascular smooth muscle contraction
ko04370  VEGF signaling pathway
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04620  Toll-like receptor signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04720  Long-term potentiation
ko04722  Neurotrophin signaling pathway
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04917  Prolactin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04921  Oxytocin signaling pathway
ko04926  Relaxin signaling pathway
ko04934  Cushing syndrome
ko05020  Prion diseases
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
Module
M00687  MAPK (ERK1/2) signaling
Disease
H00523  Noonan syndrome and related disorders
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04015 Rap1 signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04010 MAPK signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04012 ErbB signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04370 VEGF signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04371 Apelin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04066 HIF-1 signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04068 FoxO signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04072 Phospholipase D signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04071 Sphingolipid signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04024 cAMP signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04022 cGMP - PKG signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04151 PI3K-Akt signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04150 mTOR signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09143 Cell growth and death
   04210 Apoptosis
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04218 Cellular senescence
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04550 Signaling pathways regulating pluripotency of stem cells
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04650 Natural killer cell mediated cytotoxicity
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04660 T cell receptor signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04662 B cell receptor signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04664 Fc epsilon RI signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04912 GnRH signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04915 Estrogen signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04917 Prolactin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04921 Oxytocin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04926 Relaxin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04919 Thyroid hormone signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04916 Melanogenesis
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09156 Nervous system
   04720 Long-term potentiation
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04730 Long-term depression
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04722 Neurotrophin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05230 Central carbon metabolism in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05231 Choline metabolism in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05206 MicroRNAs in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05205 Proteoglycans in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05210 Colorectal cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05225 Hepatocellular carcinoma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05226 Gastric cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05214 Glioma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05216 Thyroid cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05221 Acute myeloid leukemia
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05220 Chronic myeloid leukemia
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05218 Melanoma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05211 Renal cell carcinoma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05219 Bladder cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05215 Prostate cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05213 Endometrial cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05224 Breast cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05223 Non-small cell lung cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09163 Neurodegenerative diseases
   05020 Prion diseases
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09167 Infectious diseases
   05164 Influenza A
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05161 Hepatitis B
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05163 Human cytomegalovirus infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05165 Human papillomavirus infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   01522 Endocrine resistance
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00687  MAPK (ERK1/2) signaling
     K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE7 family
   K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
BRITE hierarchy
Other DBs
GO: 0004708
Genes
HSA: 5605(MAP2K2)
PTR: 456390(MAP2K2)
PPS: 100977025(MAP2K2)
GGO: 101126885(MAP2K2)
PON: 100450988(MAP2K2)
NLE: 100591827(MAP2K2)
MCC: 721821(MAP2K2)
MCF: 102140855(MAP2K2)
CSAB: 103233717(MAP2K2)
RRO: 104665487(MAP2K2)
RBB: 108512087(MAP2K2)
CJC: 100393991(MAP2K2)
SBQ: 101036151(MAP2K2)
MMU: 26396(Map2k2)
RNO: 58960(Map2k2)
CGE: 100774204(Map2k2)
NGI: 103737276(Map2k2)
HGL: 101707562(Map2k2)
CCAN: 109687808(Map2k2)
TUP: 102483700(MAP2K2)
CFA: 611939(MAP2K2)
AML: 100465700(MAP2K2)
UMR: 103681834(MAP2K2)
ORO: 101376586(MAP2K2)
FCA: 101100281(MAP2K2)
PTG: 102956808(MAP2K2)
AJU: 106975474(MAP2K2)
BTA: 510434(MAP2K2)
BOM: 102271710(MAP2K2)
BIU: 109561751(MAP2K2)
PHD: 102325860(MAP2K2)
CHX: 102175285(MAP2K2)
OAS: 101113846(MAP2K2)
SSC: 100525505(MAP2K2)
CFR: 102511209(MAP2K2)
CDK: 105105302(MAP2K2)
BACU: 103018627(MAP2K2)
LVE: 103090769(MAP2K2)
OOR: 101287162(MAP2K2)
ECB: 100063190(MAP2K2)
EPZ: 103543290
EAI: 106832322(MAP2K2)
MYB: 102245571(MAP2K2)
MYD: 102757282(MAP2K2)
HAI: 109388626(MAP2K2)
RSS: 109453977(MAP2K2)
PALE: 102879034(MAP2K2)
LAV: 100657587(MAP2K2)
TMU: 101341078
MDO: 100018044(MAP2K2)
SHR: 100917396(MAP2K2)
OAA: 100087942
GGA: 396349(MAP2K2)
MGP: 100551337(MAP2K2)
CJO: 107325595(MAP2K2)
APLA: 101793398(MAP2K2)
ACYG: 106044951(MAP2K2)
TGU: 100225195(MAP2K2)
GFR: 102041148(MAP2K2)
FAB: 101820507(MAP2K2)
PHI: 102102285(MAP2K2)
PMAJ: 107215477(MAP2K2)
CCW: 104697410(MAP2K2)
FPG: 101924296(MAP2K2)
FCH: 102049695(MAP2K2)
CLV: 102097053(MAP2K2)
EGZ: 104124397(MAP2K2)
AAM: 106492199(MAP2K2)
ASN: 102375508(MAP2K2)
AMJ: 106736997(MAP2K2)
PSS: 102457075(MAP2K2)
CMY: 102931357(MAP2K2)
CPIC: 101938330(MAP2K2)
ACS: 100567176(map2k2)
PVT: 110072466(MAP2K2)
PBI: 103067786(MAP2K2)
GJA: 107118240(MAP2K2)
DRE: 100002225(map2k2b) 563181(map2k2a)
IPU: 100528123(mp2k2) 108271291
AMEX: 103030512(map2k2)
TRU: 101070236(map2k2)
NCC: 104963431(map2k2) 104965132
OLA: 101173453(map2k2)
XMA: 102225775(map2k2)
PRET: 103463649(map2k2)
NFU: 107393294(map2k2)
CSEM: 103376625(map2k2)
HCQ: 109532301
BPEC: 110173999(map2k2)
SFM: 108919814 108921692(map2k2)
LCM: 102350370(MAP2K2)
CMK: 103183530(map2k2)
EPA: 110245894
HMG: 100213114
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8297798
  Authors
Brott BK, Alessandrini A, Largaespada DA, Copeland NG, Jenkins NA, Crews CM, Erikson RL
  Title
MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues.
  Journal
Cell Growth Differ 4:921-9 (1993)
  Sequence
[mmu:26396]

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