KEGG   ORTHOLOGY: K04388Help
Entry
K04388                      KO                                     

Name
TGFBR2
Definition
TGF-beta receptor type-2 [EC:2.7.11.30]
Pathway
ko04010  MAPK signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04068  FoxO signaling pathway
ko04144  Endocytosis
ko04218  Cellular senescence
ko04350  TGF-beta signaling pathway
ko04380  Osteoclast differentiation
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04659  Th17 cell differentiation
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05142  Chagas disease (American trypanosomiasis)
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05220  Chronic myeloid leukemia
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Module
M00680  TGF-beta signaling
Disease
H00020  Colorectal cancer
H00048  Hepatocellular carcinoma
H00800  Loeys-Dietz syndrome (LDS)
H00801  Familial thoracic aortic aneurysm and dissection (TAAD)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04350 TGF-beta signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04390 Hippo signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04068 FoxO signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04388  TGFBR2; TGF-beta receptor type-2
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04388  TGFBR2; TGF-beta receptor type-2
  09143 Cell growth and death
   04218 Cellular senescence
    K04388  TGFBR2; TGF-beta receptor type-2
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04388  TGFBR2; TGF-beta receptor type-2
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04388  TGFBR2; TGF-beta receptor type-2
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
  09158 Development
   04380 Osteoclast differentiation
    K04388  TGFBR2; TGF-beta receptor type-2
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05202 Transcriptional misregulation in cancers
    K04388  TGFBR2; TGF-beta receptor type-2
   05210 Colorectal cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05212 Pancreatic cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05225 Hepatocellular carcinoma
    K04388  TGFBR2; TGF-beta receptor type-2
   05226 Gastric cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05220 Chronic myeloid leukemia
    K04388  TGFBR2; TGF-beta receptor type-2
  09166 Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04388  TGFBR2; TGF-beta receptor type-2
  09167 Infectious diseases
   05166 HTLV-I infection
    K04388  TGFBR2; TGF-beta receptor type-2
   05142 Chagas disease (American trypanosomiasis)
    K04388  TGFBR2; TGF-beta receptor type-2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04388  TGFBR2; TGF-beta receptor type-2
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00680  TGF-beta signaling
     K04388  TGFBR2; TGF-beta receptor type-2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04388  TGFBR2; TGF-beta receptor type-2
Protein kinases [BR:ko01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR2 family [OT]
   K04388  TGFBR2; TGF-beta receptor type-2
BRITE hierarchy
Other DBs
GO: 0005026
Genes
HSA: 7048(TGFBR2)
PTR: 460243(TGFBR2)
PPS: 100985497(TGFBR2)
GGO: 101146131(TGFBR2)
PON: 100459236(TGFBR2)
NLE: 100606849(TGFBR2)
MCC: 703088(TGFBR2)
MCF: 102134273(TGFBR2)
CSAB: 103241808(TGFBR2)
RRO: 104655082(TGFBR2)
RBB: 108516558(TGFBR2)
CJC: 100404359(TGFBR2)
SBQ: 101034142(TGFBR2)
MMU: 21813(Tgfbr2)
RNO: 81810(Tgfbr2)
CGE: 100773953(Tgfbr2)
NGI: 103744639(Tgfbr2)
HGL: 101704397(Tgfbr2)
CCAN: 109681522(Tgfbr2)
OCU: 100344335(TGFBR2)
TUP: 102486518(TGFBR2)
CFA: 477039(TGFBR2)
AML: 100482939(TGFBR2)
UMR: 103682015(TGFBR2)
ORO: 101364575(TGFBR2)
FCA: 101091725(TGFBR2)
PTG: 102958413(TGFBR2)
AJU: 106984570(TGFBR2)
BTA: 535376(TGFBR2)
BOM: 102267018(TGFBR2)
BIU: 109576148(TGFBR2)
PHD: 102330019(TGFBR2)
CHX: 100861300(TGFBR2)
OAS: 494191(TGFBR2)
SSC: 100038019(TGFBR2)
CFR: 102509744(TGFBR2)
CDK: 105087202(TGFBR2)
BACU: 103005777(TGFBR2)
LVE: 103077265(TGFBR2)
OOR: 101289351(TGFBR2)
ECB: 100033860(TGFBR2)
EPZ: 103566847 103567708(TGFBR2)
EAI: 106830994(TGFBR2)
MYB: 102248472(TGFBR2)
MYD: 102767756(TGFBR2)
HAI: 109394441(TGFBR2)
RSS: 109454546(TGFBR2)
PALE: 102889618(TGFBR2)
LAV: 100671392(TGFBR2)
TMU: 101354258
MDO: 100031897(TGFBR2)
SHR: 100913352(TGFBR2)
OAA: 100076965(TGFBR2)
GGA: 396399(TGFBR2) 424261(AMHR2)
MGP: 100546861(TGFBR2) 100549829
CJO: 107309296(TGFBR2) 107316805
APLA: 101794795(TGFBR2) 101801641
TGU: 100220619(TGFBR2) 100224677
GFR: 102040558(TGFBR2) 102044945
FAB: 101808986 101811048(TGFBR2)
PHI: 102099204 102112281(TGFBR2)
PMAJ: 107200593(TGFBR2) 107207553
CCW: 104689295(TGFBR2) 104694032
FPG: 101911268(TGFBR2) 101924328
FCH: 102048632 102053489(TGFBR2)
CLV: 102083591(TGFBR2) 102091992
EGZ: 104122957(TGFBR2) 104128099
AAM: 106491249(TGFBR2) 106498480
ASN: 102371879 102380434(TGFBR2)
AMJ: 102567839(TGFBR2) 102573702
PSS: 102444710(TGFBR2) 102457599
CMY: 102947040(TGFBR2)
CPIC: 101930851 101936050(TGFBR2)
ACS: 100552899(tgfbr2) 100556560
PVT: 110086832(TGFBR2) 110090113
PBI: 103057562(TGFBR2) 103063579
XLA: 108702885 108718935(tgfbr2.L) 108719963(tgfbr2.S) 373815(tgfbr2.2.L)
XTR: 100487430(tgfbr2.2) 100488582(tgfbr2)
DRE: 30739(tgfbr2b) 560446(si:dkey-101k6.5)
LCO: 104922506 104923102(tgfbr2)
OLA: 101170689(tgfbr2) 101174785
PRET: 103465886(tgfbr2) 103472661
HCQ: 109516370(tgfbr2) 109530278
SFM: 108918826 108935840(tgfbr2)
LCM: 102346621(TGFBR2) 102356233
CMK: 103176334(tgfbr2) 103188937
CIN: 778778(tgfbr-iib)
SPU: 580712
APLC: 110984215
SKO: 100329004(TGFbRII)
EPA: 110254510
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1310899
  Authors
Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, Lodish HF
  Title
Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase.
  Journal
Cell 68:775-85 (1992)
DOI:10.1016/0092-8674(92)90152-3
  Sequence
[hsa:7048]

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