KEGG   ORTHOLOGY: K04389Help
Entry
K04389                      KO                                     

Name
TNFSF6, FASL, CD178
Definition
tumor necrosis factor ligand superfamily member 6
Pathway
ko01524  Platinum drug resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04068  FoxO signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04217  Necroptosis
ko04650  Natural killer cell mediated cytotoxicity
ko04722  Neurotrophin signaling pathway
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04940  Type I diabetes mellitus
ko05142  Chagas disease (American trypanosomiasis)
ko05143  African trypanosomiasis
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05168  Herpes simplex infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05320  Autoimmune thyroid disease
ko05330  Allograft rejection
ko05332  Graft-versus-host disease
Disease
H00108  Autoimmune lymphoproliferative syndromes (ALPS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04010 MAPK signaling pathway
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04068 FoxO signaling pathway
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04151 PI3K-Akt signaling pathway
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04217 Necroptosis
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05205 Proteoglycans in cancer
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09162 Immune diseases
   05320 Autoimmune thyroid disease
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05330 Allograft rejection
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05332 Graft-versus-host disease
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09166 Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09167 Infectious diseases
   05162 Measles
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05164 Influenza A
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05161 Hepatitis B
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05168 Herpes simplex infection
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05163 Human cytomegalovirus infection
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05165 Human papillomavirus infection
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05142 Chagas disease (American trypanosomiasis)
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05143 African trypanosomiasis
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09168 Drug resistance
   01524 Platinum drug resistance
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04052 Cytokines and growth factors
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04090 CD Molecules
    K04389  CD178, FASLG; tumor necrosis factor (ligand) superfamily, member 6
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Tumor necrosis fators
   K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
CD molecules [BR:ko04090]
 Proteins
  K04389  CD178, FASLG; tumor necrosis factor (ligand) superfamily, member 6
BRITE hierarchy
Other DBs
GO: 0005164
Genes
HSA: 356(FASLG)
PTR: 469584(FASLG)
PPS: 100970360(FASLG)
GGO: 101137781(FASLG)
PON: 100461418(FASLG)
NLE: 100597719(FASLG)
MCC: 574159(FASLG)
MCF: 102139406(FASLG)
CSAB: 103230577(FASLG)
RRO: 104669600(FASLG)
RBB: 108526259(FASLG)
CJC: 100404850(FASLG)
SBQ: 101035660(FASLG)
MMU: 14103(Fasl)
RNO: 25385(Faslg)
CGE: 100773293(Faslg)
NGI: 103740694(Faslg)
HGL: 101698642(Faslg)
CCAN: 109689125(Faslg)
OCU: 100344073(FASLG)
TUP: 102502878(FASLG)
CFA: 442968(FASLG)
AML: 100468235(FASLG)
UMR: 103668115(FASLG)
ORO: 101381319(FASLG)
FCA: 493945(FASLG)
PTG: 102953222(FASLG)
AJU: 106979842(FASLG)
BTA: 407111(FASLG)
BOM: 102281889(FASLG)
BIU: 109570480 109570785(FASLG)
PHD: 102318480(FASLG)
CHX: 102178753(FASLG)
OAS: 100135696(FASLG)
SSC: 396726(FASLG)
CFR: 102503604(FASLG)
CDK: 105092770(FASLG)
BACU: 102999836(FASLG)
LVE: 103073066(FASLG)
OOR: 101272436(FASLG)
ECB: 100052326(FASLG)
EPZ: 103554252(FASLG)
EAI: 106838669(FASLG)
MYB: 102262076(FASLG)
MYD: 102759597(FASLG)
HAI: 109385146(FASLG)
RSS: 109446237(FASLG)
PALE: 102883204(FASLG)
LAV: 100662586(FASLG)
TMU: 101344408
SHR: 100919776(FASLG)
OAA: 100081646(FASLG)
GGA: 429064(FASLG)
MGP: 100551315(FASLG)
CJO: 107317262(FASLG)
APLA: 101801884(FASLG)
ACYG: 106041569(FASLG)
TGU: 100230435(FASLG)
GFR: 102045588(FASLG)
FAB: 101820749(FASLG)
PHI: 102107854(FASLG)
PMAJ: 107207877(FASLG)
CCW: 104695445(FASLG)
FPG: 101922036(FASLG)
FCH: 102046752(FASLG)
CLV: 102097854(FASLG)
EGZ: 104132069(FASLG)
AAM: 106499698(FASLG)
ASN: 102385618(FASLG)
AMJ: 102564044(FASLG)
PSS: 102460695(FASLG)
CMY: 102937724(FASLG)
CPIC: 101951265(FASLG)
ACS: 100554702(faslg)
PVT: 110089831(FASLG)
PBI: 103051809
GJA: 107115985
XLA: 100192357(faslg.L) 108715004(faslg.S)
XTR: 100124789(faslg)
NPR: 108795559(FASLG)
DRE: 735295(faslg)
IPU: 108257517(faslg)
TRU: 101074300
NCC: 104964064(faslg)
XMA: 102222747
PRET: 103463758
NFU: 107396466
LCF: 108879004
BPEC: 110154839(faslg) 110158999
ELS: 105011736(faslg) 105014159
SFM: 108923469
LCM: 102361141 102366280(FASLG)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7528780
  Authors
Alderson MR, Tough TW, Davis-Smith T, Braddy S, Falk B, Schooley KA, Goodwin RG, Smith CA, Ramsdell F, Lynch DH
  Title
Fas ligand mediates activation-induced cell death in human T lymphocytes.
  Journal
J Exp Med 181:71-7 (1995)
DOI:10.1084/jem.181.1.71
  Sequence
[hsa:356]
Reference
  Authors
Kirkin V, Cahuzac N, Guardiola-Serrano F, Huault S, Luckerath K, Friedmann E, Novac N, Wels WS, Martoglio B, Hueber AO, Zornig M
  Title
The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells.
  Journal
Cell Death Differ 14:1678-87 (2007)
DOI:10.1038/sj.cdd.4402175
  Sequence
[hsa:356]

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