KEGG   ORTHOLOGY: K04399Help
Entry
K04399                      KO                                     

Name
CASP9
Definition
caspase 9 [EC:3.4.22.62]
Pathway
ko01524  Platinum drug resistance
ko04115  p53 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04215  Apoptosis - multiple species
ko04370  VEGF signaling pathway
ko04919  Thyroid hormone signaling pathway
ko05010  Alzheimer disease
ko05012  Parkinson disease
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05016  Huntington disease
ko05134  Legionellosis
ko05145  Toxoplasmosis
ko05152  Tuberculosis
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05215  Prostate cancer
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05416  Viral myocarditis
Module
M00685  Apoptotic machinery
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04370 VEGF signaling pathway
    K04399  CASP9; caspase 9
   04151 PI3K-Akt signaling pathway
    K04399  CASP9; caspase 9
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04399  CASP9; caspase 9
   04215 Apoptosis - multiple species
    K04399  CASP9; caspase 9
   04115 p53 signaling pathway
    K04399  CASP9; caspase 9
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K04399  CASP9; caspase 9
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04399  CASP9; caspase 9
   05210 Colorectal cancer
    K04399  CASP9; caspase 9
   05212 Pancreatic cancer
    K04399  CASP9; caspase 9
   05215 Prostate cancer
    K04399  CASP9; caspase 9
   05213 Endometrial cancer
    K04399  CASP9; caspase 9
   05222 Small cell lung cancer
    K04399  CASP9; caspase 9
   05223 Non-small cell lung cancer
    K04399  CASP9; caspase 9
  09163 Neurodegenerative diseases
   05010 Alzheimer disease
    K04399  CASP9; caspase 9
   05012 Parkinson disease
    K04399  CASP9; caspase 9
   05014 Amyotrophic lateral sclerosis (ALS)
    K04399  CASP9; caspase 9
   05016 Huntington disease
    K04399  CASP9; caspase 9
  09165 Cardiovascular diseases
   05416 Viral myocarditis
    K04399  CASP9; caspase 9
  09167 Infectious diseases
   05134 Legionellosis
    K04399  CASP9; caspase 9
   05152 Tuberculosis
    K04399  CASP9; caspase 9
   05164 Influenza A
    K04399  CASP9; caspase 9
   05161 Hepatitis B
    K04399  CASP9; caspase 9
   05163 Human cytomegalovirus infection
    K04399  CASP9; caspase 9
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04399  CASP9; caspase 9
   05145 Toxoplasmosis
    K04399  CASP9; caspase 9
  09168 Drug resistance
   01524 Platinum drug resistance
    K04399  CASP9; caspase 9
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatase and associated proteins
    K04399  CASP9; caspase 9
   01002 Peptidases
    K04399  CASP9; caspase 9
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00685  Apoptotic machinery
     K04399  CASP9; caspase 9
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.62  caspase-9
     K04399  CASP9; caspase 9
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04399  CASP9; caspase 9
Peptidases [BR:ko01002]
 Cysteine Peptidases
  Family C14: caspase family
   K04399  CASP9; caspase 9
BRITE hierarchy
Genes
HSA: 842(CASP9)
PTR: 456457(CASP9)
PPS: 100992567(CASP9)
GGO: 101130414(CASP9)
PON: 100460459(CASP9)
NLE: 100597173(CASP9)
MCC: 694544(CASP9)
MCF: 102126830(CASP9)
CSAB: 103225550(CASP9)
RRO: 104677696(CASP9)
RBB: 108524269(CASP9)
CJC: 100409028(CASP9)
SBQ: 101051525(CASP9)
MMU: 12371(Casp9)
RNO: 58918(Casp9)
NGI: 103725336(Casp9)
HGL: 101702898(Casp9)
CCAN: 109692548(Casp9)
OCU: 100101592(CASP9)
TUP: 102470940(CASP9)
CFA: 487432(CASP9)
AML: 100483760(CASP9)
UMR: 103666628(CASP9)
ORO: 101362812(CASP9)
FCA: 768260(CASP9)
PTG: 102967404(CASP9)
AJU: 106975594(CASP9)
BTA: 100140945(CASP9)
BOM: 102268660(CASP9)
BIU: 109570433(CASP9)
PHD: 102336217(CASP9)
CHX: 102174681(CASP9)
OAS: 101110953(CASP9)
SSC: 100518913(CASP9)
CFR: 102519816(CASP9)
CDK: 105107056(CASP9)
BACU: 103010071(CASP9)
LVE: 103086745(CASP9)
OOR: 101271677(CASP9)
ECB: 100054331(CASP9)
EPZ: 103565016(CASP9)
EAI: 106828005(CASP9)
MYB: 102254877(CASP9)
MYD: 102759481(CASP9)
HAI: 109381302(CASP9)
RSS: 109459000(CASP9)
PALE: 102878565(CASP9)
LAV: 100656597(CASP9)
TMU: 101355103
MDO: 100027338(CASP9)
SHR: 100931481(CASP9)
OAA: 100092345(CASP9)
GGA: 426970(CASP9)
MGP: 100550410(CASP9)
CJO: 107323418(CASP9)
APLA: 101795386(CASP9)
ACYG: 106040238(CASP9)
TGU: 100227981(CASP9)
GFR: 102039030(CASP9)
FAB: 101808292(CASP9)
PHI: 102108950(CASP9)
PMAJ: 107213687(CASP9)
CCW: 104697549(CASP9)
FPG: 101914844(CASP9)
FCH: 102054465(CASP9)
CLV: 102093506(CASP9)
EGZ: 104133155(CASP9)
AAM: 106493414(CASP9)
ASN: 102384999(CASP9)
AMJ: 102573968(CASP9)
PSS: 102443524(CASP9)
CMY: 102939753(CASP9)
CPIC: 101944555(CASP9)
ACS: 100560103(casp9)
PVT: 110072690(CASP9)
PBI: 103063403(CASP9)
GJA: 107124463(CASP9)
XLA: 373560(casp9.S)
XTR: 100144708(casp9)
NPR: 108797190(CASP9)
DRE: 492763(casp9)
IPU: 108276164(casp9)
AMEX: 103034324
TRU: 101075121(casp9)
LCO: 104939007(casp9)
NCC: 104954971
MZE: 101487562(casp9)
OLA: 101157857(casp9)
XMA: 102226741(casp9)
PRET: 103467149(casp9)
CSEM: 103385017(casp9)
LCF: 108882570(casp9)
HCQ: 109511699(casp9)
BPEC: 110167143(casp9)
SASA: 106567147 106572551(casp9)
ELS: 105028691(casp9)
SFM: 108939364(casp9)
LCM: 102362720(CASP9)
CMK: 103187647(casp9)
SKO: 100376094
CRG: 105325340
EPA: 110241763
ADF: 107343798
HMG: 101235218
AQU: 100633941
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Srinivasula SM, Ahmad M, Guo Y, Zhan Y, Lazebnik Y, Fernandes-Alnemri T, Alnemri ES
  Title
Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis.
  Journal
Cancer Res 59:999-1002 (1999)
  Sequence
[hsa:842]
Reference
PMID:8663294
  Authors
Duan H, Orth K, Chinnaiyan AM, Poirier GG, Froelich CJ, He WW, Dixit VM
  Title
ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
  Journal
J Biol Chem 271:16720-4 (1996)
DOI:10.1074/jbc.271.28.16720
Reference
  Authors
Raina D, Pandey P, Ahmad R, Bharti A, Ren J, Kharbanda S, Weichselbaum R, Kufe D
  Title
c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage.
  Journal
J Biol Chem 280:11147-51 (2005)
DOI:10.1074/jbc.M413787200
  Sequence
[hsa:842]

DBGET integrated database retrieval system