KEGG   ORTHOLOGY: K04402Help
Entry
K04402                      KO                                     

Name
GADD45
Definition
growth arrest and DNA-damage-inducible protein
Pathway
ko04010  MAPK signaling pathway
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04115  p53 signaling pathway
ko04210  Apoptosis
ko04218  Cellular senescence
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05216  Thyroid cancer
ko05217  Basal cell carcinoma
ko05218  Melanoma
ko05220  Chronic myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   04068 FoxO signaling pathway
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   04210 Apoptosis
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   04115 p53 signaling pathway
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   04218 Cellular senescence
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05202 Transcriptional misregulation in cancers
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05210 Colorectal cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05212 Pancreatic cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05225 Hepatocellular carcinoma
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05226 Gastric cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05214 Glioma
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05216 Thyroid cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05220 Chronic myeloid leukemia
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05217 Basal cell carcinoma
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05218 Melanoma
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05213 Endometrial cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05224 Breast cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05222 Small cell lung cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05223 Non-small cell lung cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Centrosome duplication proteins
    Other centrosome duplication proteins
     K04402  GADD45; growth arrest and DNA-damage-inducible protein
  Sister chromatid separation proteins
   Aurora kinases
    Regulators of Aurora kinases
     K04402  GADD45; growth arrest and DNA-damage-inducible protein
BRITE hierarchy
Genes
HSA: 10912(GADD45G) 1647(GADD45A) 4616(GADD45B)
PTR: 456929(GADD45A) 464585(GADD45G) 744311(GADD45B)
PPS: 100982764(GADD45B) 100990548(GADD45A) 100992917(GADD45G)
GGO: 101131508(GADD45G) 101140270(GADD45B) 101146783(GADD45A)
PON: 100436665(GADD45G) 100452809(GADD45B) 100456437(GADD45A)
NLE: 100583800 100593432(GADD45G)
MCC: 697835(GADD45G) 701054(GADD45A) 711257(GADD45B)
MCF: 102115080(GADD45B) 102128083(GADD45A) 102135480(GADD45G)
CSAB: 103219731(GADD45G) 103224652(GADD45A) 103233650(GADD45B)
RRO: 104656307(GADD45G) 104657306(GADD45A) 104671382(GADD45B)
RBB: 108531451(GADD45B) 108532870(GADD45A) 108538612(GADD45G)
CJC: 100394399(GADD45A) 100405303(GADD45G) 100412572(GADD45B)
SBQ: 101030208(GADD45B) 101039106(GADD45G) 101047513(GADD45A)
MMU: 13197(Gadd45a) 17873(Gadd45b) 23882(Gadd45g)
RNO: 25112(Gadd45a) 291005(Gadd45g) 299626(Gadd45b)
CGE: 100759228(Gadd45g) 100766127(Gadd45b) 103159266
NGI: 103737285(Gadd45b) 103743354(Gadd45a) 103751225(Gadd45g)
HGL: 101710909(Gadd45b) 101711314(Gadd45g) 101725746(Gadd45a)
CCAN: 109691045(Gadd45b) 109696612(Gadd45g) 109698312(Gadd45a)
OCU: 100353284(GADD45A) 100353742(GADD45G)
TUP: 102476523(GADD45B) 102496861(GADD45G) 102502813(GADD45A)
CFA: 100855728(GADD45A) 484198(GADD45G) 485069(GADD45B)
AML: 100470600(GADD45G) 100477654(GADD45A) 100482871(GADD45B)
UMR: 103663135(GADD45A) 103663314(GADD45G) 103681651(GADD45B)
ORO: 101363875(GADD45B) 101374334(GADD45G) 101374376(GADD45A)
FCA: 101086509(GADD45G) 101087971(GADD45B)
PTG: 102951885(GADD45A) 102964763(GADD45B)
AJU: 106985200(GADD45A) 106989693(GADD45B)
BTA: 504939(GADD45G) 505463(GADD45A) 618405(GADD45B)
BOM: 102266978(GADD45B) 102276116(GADD45G) 102288000(GADD45A)
BIU: 109556176(GADD45A) 109561788(GADD45B) 109563283(GADD45G)
PHD: 102324661(GADD45B) 102341257(GADD45A) 102343412(GADD45G)
CHX: 102179904(GADD45A) 102183684(GADD45B) 102188317(GADD45G)
OAS: 100885762(GADD45G) 101115240(GADD45A) 101120573(GADD45B)
SSC: 100152997(GADD45G) 100621090(GADD45B) 733669(GADD45A)
CFR: 102508482(GADD45A) 102516207(GADD45B)
CDK: 105086406(GADD45G) 105096626(GADD45A) 105103609(GADD45B)
BACU: 103012188(GADD45G) 103016967(GADD45B) 103020367(GADD45A)
LVE: 103079241(GADD45G) 103080866(GADD45A) 103089793(GADD45B)
OOR: 101281489(GADD45G) 101281934(GADD45A) 101285919(GADD45B)
ECB: 100054996(GADD45G) 100059768(GADD45B) 100630299(GADD45A)
EPZ: 103543986(GADD45B) 103552106(GADD45G) 103564848
EAI: 106825069(GADD45A) 106825118(GADD45G) 106834158(GADD45B)
MYB: 102239140(GADD45B) 102242156(GADD45A) 102246302(GADD45G)
MYD: 102751752(GADD45B) 102752386(GADD45A) 102771581(GADD45G)
HAI: 109374090(GADD45G) 109384926(GADD45A) 109390584(GADD45B)
RSS: 109435719(GADD45G) 109447680(GADD45A) 109453894(GADD45B)
PALE: 102878191(GADD45G) 102885790(GADD45B) 102886440(GADD45A)
LAV: 100653562(GADD45A) 100655692(GADD45B) 100658253(GADD45G)
MDO: 100010225(GADD45G) 100014651(GADD45B) 100016952(GADD45A)
SHR: 100920439(GADD45B) 100926902(GADD45G) 111719849
OAA: 100081893(GADD45A) 100090762(GADD45B)
GGA: 100859853(GADD45B) 429929(GADD45G) 693255(GADD45A)
MGP: 100540601(GADD45A) 104915137(GADD45G)
CJO: 107306297(GADD45G) 107317806(GADD45A) 107325480(GADD45B)
APLA: 101792274(GADD45A) 101793631(GADD45B)
ACYG: 106045084(GADD45G) 106048205(GADD45B)
TGU: 100190269(GADD45B) 100223813(GADD45G)
FAB: 101821221(GADD45G)
PHI: 102102492(GADD45A) 102109500(GADD45G) 102109553(GADD45B)
PMAJ: 107198526(GADD45G) 107208453(GADD45A) 107215503(GADD45B)
FPG: 101915163(GADD45G) 101916621(GADD45B)
FCH: 102057224(GADD45G) 102057932(GADD45B)
CLV: 102087532(GADD45B) 102090065(GADD45G)
EGZ: 104126926(GADD45G)
ASN: 102372381(GADD45G) 102374172(GADD45A) 102374205(GADD45B)
AMJ: 102560377(GADD45G) 102570271(GADD45B) 102575022(GADD45A)
PSS: 102447859(GADD45G) 102457123(GADD45A) 102460773
CMY: 102935322(GADD45A) 102943336(GADD45G) 102945688(GADD45B)
CPIC: 101933443(GADD45A) 101945211(GADD45B) 101945778(GADD45G)
ACS: 100554443(gadd45a) 100567812(gadd45g)
PVT: 110072507(GADD45B) 110079870(GADD45A) 110080579(GADD45G)
PBI: 103059109(GADD45A) 103063697 103064821(GADD45G)
GJA: 107108632(GADD45G) 107114354(GADD45A) 107120631(GADD45B)
XLA: 101027271(gadd45b.S) 108712402(gadd45b.L) 108714209 379224(gadd45a.L) 379285(gadd45g.S) 399196(gadd45g.L)
XTR: 100487013(gadd45b) 448442(gadd45g) 548905(gadd45a)
NPR: 108795520(GADD45G) 108795947(GADD45A) 108798643(GADD45B)
DRE: 393548(gadd45aa) 402991(gadd45ga) 406304(gadd45ba) 431763(gadd45ab) 497646(gadd45bb)
AMEX: 103029638 103036194 103036359(gadd45g) 103038163(gadd45a) 103039224 103042551(gadd45b)
XMA: 102219106(gadd45g) 102228350 102234824 102236617(gadd45b) 102237948(gadd45a)
PRET: 103458442 103463150(gadd45b) 103463991 103470135(gadd45g) 103474023 103479130(gadd45a)
ELS: 105011357(gadd45b) 105011762 105015059 105015060 105024086(gadd45a) 105030709(gadd45g)
LCM: 102349018(GADD45A) 102353479(GADD45G) 102361538(GADD45B)
CMK: 103181960(gadd45b) 103182857(gadd45g) 103189132(gadd45a)
SPU: 100893493
APLC: 110985835
SKO: 100303593(gadd45a-like)
DME: Dmel_CG11086(Gadd45)
DSI: Dsimw501_GD15338(Dsim_GD15338)
MDE: 101897064
TCA: 664422
DPA: 109534077
NVL: 108569187
BMOR: 101742570
PMAC: 106710523
PRAP: 110993798
ZNE: 110832383
OBI: 106874428
EPA: 110236571
ADF: 107338326
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wang X, Wang RH, Li W, Xu X, Hollander MC, Fornace AJ Jr, Deng CX
  Title
Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure.
  Journal
J Biol Chem 279:29606-14 (2004)
DOI:10.1074/jbc.M312279200
  Sequence
[mmu:13197]
Reference
  Authors
Shao S, Wang Y, Jin S, Song Y, Wang X, Fan W, Zhao Z, Fu M, Tong T, Dong L, Fan F, Xu N, Zhan Q
  Title
Gadd45a interacts with aurora-A and inhibits its kinase activity.
  Journal
J Biol Chem 281:28943-50 (2006)
DOI:10.1074/jbc.M600235200
  Sequence
[hsa:1647] [mmu:13197]
Reference
  Authors
Ying J, Srivastava G, Hsieh WS, Gao Z, Murray P, Liao SK, Ambinder R, Tao Q
  Title
The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors.
  Journal
Clin Cancer Res 11:6442-9 (2005)
DOI:10.1158/1078-0432.CCR-05-0267
  Sequence
[hsa:10912]
Reference
PMID:8226988
  Authors
Hollander MC, Alamo I, Jackman J, Wang MG, McBride OW, Fornace AJ Jr
  Title
Analysis of the mammalian gadd45 gene and its response to DNA damage.
  Journal
J Biol Chem 268:24385-93 (1993)
  Sequence
[hsa:1647]
Reference
PMID:1990262
  Authors
Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, Alamo I Jr, Barrett SF, Hickson ID, Fornace AJ Jr
  Title
Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C.
  Journal
Mol Cell Biol 11:1009-16 (1991)
  Sequence
[hsa:1647]

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