KEGG   ORTHOLOGY: K04409Help
Entry
K04409                      KO                                     

Name
PAK1
Definition
p21-activated kinase 1 [EC:2.7.11.1]
Pathway
ko04010  MAPK signaling pathway
ko04011  MAPK signaling pathway - yeast
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04360  Axon guidance
ko04392  Hippo signaling pathway - multiple species
ko04510  Focal adhesion
ko04625  C-type lectin receptor signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04810  Regulation of actin cytoskeleton
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05170  Human immunodeficiency virus 1 infection
ko05205  Proteoglycans in cancer
ko05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04409  PAK1; p21-activated kinase 1
   04010 MAPK signaling pathway
    K04409  PAK1; p21-activated kinase 1
   04011 MAPK signaling pathway - yeast
    K04409  PAK1; p21-activated kinase 1
   04012 ErbB signaling pathway
    K04409  PAK1; p21-activated kinase 1
   04392 Hippo signaling pathway - multiple species
    K04409  PAK1; p21-activated kinase 1
   04024 cAMP signaling pathway
    K04409  PAK1; p21-activated kinase 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04409  PAK1; p21-activated kinase 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04409  PAK1; p21-activated kinase 1
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K04409  PAK1; p21-activated kinase 1
   04650 Natural killer cell mediated cytotoxicity
    K04409  PAK1; p21-activated kinase 1
   04660 T cell receptor signaling pathway
    K04409  PAK1; p21-activated kinase 1
   04666 Fc gamma R-mediated phagocytosis
    K04409  PAK1; p21-activated kinase 1
   04062 Chemokine signaling pathway
    K04409  PAK1; p21-activated kinase 1
  09158 Development
   04360 Axon guidance
    K04409  PAK1; p21-activated kinase 1
 09160 Human Diseases
  09161 Cancers
   05205 Proteoglycans in cancer
    K04409  PAK1; p21-activated kinase 1
   05211 Renal cell carcinoma
    K04409  PAK1; p21-activated kinase 1
  09167 Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04409  PAK1; p21-activated kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04409  PAK1; p21-activated kinase 1
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04409  PAK1; p21-activated kinase 1
   03036 Chromosome and associated proteins
    K04409  PAK1; p21-activated kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04409  PAK1; p21-activated kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE20 family
   K04409  PAK1; p21-activated kinase 1
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K04409  PAK1; p21-activated kinase 1
 Endocytosis
  Macropinocytosis
   Kinases
    K04409  PAK1; p21-activated kinase 1
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Sister chromatid separation proteins
   Aurora kinases
    Regulators of Aurora kinases
     K04409  PAK1; p21-activated kinase 1
BRITE hierarchy
Other DBs
COG: COG0515
Genes
HSA: 5058(PAK1)
PTR: 451439(PAK1)
PPS: 100973579(PAK1)
GGO: 101138276(PAK1)
PON: 100449316(PAK1)
NLE: 100588769(PAK1)
MCC: 698585(PAK1)
MCF: 101866132(PAK1)
CSAB: 103248093(PAK1)
RRO: 104664316(PAK1)
RBB: 108543210(PAK1)
CJC: 100392970(PAK1)
SBQ: 101042666(PAK1)
MMU: 18479(Pak1)
RNO: 29431(Pak1)
CGE: 100767503(Pak1)
NGI: 103743005(Pak1)
HGL: 101713465(Pak1)
OCU: 100352056(PAK1)
TUP: 102495430(PAK1)
CFA: 607885(PAK1)
AML: 100472811(PAK1)
UMR: 103678069(PAK1)
ORO: 101365642(PAK1)
FCA: 101087171(PAK1)
PTG: 102963927(PAK1)
AJU: 106976449(PAK1)
BTA: 533729(PAK1)
BOM: 102285596(PAK1)
BIU: 109554525(PAK1)
PHD: 102331930
CHX: 102180827(PAK1)
OAS: 101111756(PAK1)
SSC: 100525766(PAK1)
CFR: 102514942(PAK1)
CDK: 105097456(PAK1)
BACU: 103010714(PAK1)
LVE: 103072869(PAK1)
OOR: 101288086(PAK1)
ECB: 100063217(PAK1)
EPZ: 103553799(PAK1)
EAI: 106842897(PAK1)
MYB: 102240321(PAK1) 102257226
MYD: 102755302(PAK1)
HAI: 109376015(PAK1)
RSS: 109444772(PAK1)
PALE: 102880323(PAK1)
TMU: 101343358
MDO: 100018336(PAK1)
SHR: 100928883(PAK1)
OAA: 100086384(PAK1)
GGA: 419083(PAK1)
MGP: 100543242
CJO: 107308538(PAK1)
APLA: 101795474(PAK1)
ACYG: 106039890(PAK1)
TGU: 100190755(PAK1)
GFR: 102033628(PAK1) 102033882
FAB: 101820258(PAK1)
PHI: 102109199(PAK1)
PMAJ: 107200206(PAK1) 107215873
CCW: 104690290(PAK1)
FPG: 101923101(PAK1)
FCH: 102053816(PAK1)
CLV: 102084510(PAK1)
EGZ: 104124741(PAK1)
AAM: 106495371(PAK1)
ASN: 102367767(PAK1)
AMJ: 102576325(PAK1)
PSS: 102457223(PAK1)
CMY: 102936072(PAK1)
CPIC: 101936332(PAK1)
ACS: 100554656 100568195(pak1)
PVT: 110088575(PAK1)
GJA: 107118386(PAK1)
XLA: 398126(pak1.S) 398782
XTR: 100135731(pak1)
NPR: 108794638
DRE: 373103(pak1)
SRX: 107735921
SGH: 107594372(pak1) 107600821
CCAR: 109110512
IPU: 108264802(pak1)
AMEX: 103037975(pak1)
TRU: 101064146(pak1)
NCC: 104949351
MZE: 101483196(pak1)
OLA: 101164663(pak1)
XMA: 102217297(pak1)
PRET: 103475087(pak1)
NFU: 107379762(pak1)
CSEM: 103377945(pak1)
LCF: 108882370(pak1)
HCQ: 109510807
SASA: 100380347(pak3) 106612881
ELS: 105010576(pak1)
SFM: 108921266 108924646(pak1)
LCM: 102349047(PAK1)
CMK: 103172337
CIN: 100178153
SPU: 592256
APLC: 110985992
SKO: 100367190
DME: Dmel_CG10295(Pak) Dmel_CG14895(Pak3)
DPO: Dpse_GA10224(Dpse_Pak1) Dpse_GA13332(Dpse_Pak3)
DSI: Dsimw501_GD19869(Dsim_GD19869) Dsimw501_GD20287(Dsim_GD20287)
AAG: 5575304
AME: 551659 724453(Pak)
API: 100160077
DNX: 107169134
CEL: CELE_C09B8.7(pak-1) CELE_Y38F1A.10(max-2)
CBR: CBG02802(Cbr-max-2) CBG14818(Cbr-pak-1)
BMY: Bm1_34325
CRG: 105339997
OBI: 106875408
EPA: 110251135
ADF: 107330408
AQU: 100631850
SCE: YHL007C(STE20)
ERC: Ecym_2434
KMX: KLMA_30058(STE20)
NCS: NCAS_0A05050(NCAS0A05050) NCAS_0A12350(NCAS0A12350)
NDI: NDAI_0A03870(NDAI0A03870) NDAI_0K02100(NDAI0K02100)
TPF: TPHA_0G03290(TPHA0G03290)
TBL: TBLA_0I00280(TBLA0I00280)
TDL: TDEL_0A02720(TDEL0A02720)
KAF: KAFR_0A01760(KAFR0A01760) KAFR_0D03390(KAFR0D03390)
PIC: PICST_84188(CST20)
CAL: CAALFM_C502340CA(CST20)
CDU: CD36_52140(CST20)
CAUR: QG37_03001
SLB: AWJ20_1432(STE20)
NCR: NCU03894(stk-4)
NTE: NEUTE1DRAFT88085(NEUTE1DRAFT_88085)
SMP: SMAC_06321(putative ste20)
MGR: MGG_12821
MAW: MAC_02685
MAJ: MAA_02118
CMT: CCM_05107
MBE: MBM_08123
ANI: AN2067.2
ANG: ANI_1_592094(An11g04320)
ABE: ARB_05261
TVE: TRV_02300
PNO: SNOG_12486(SNOG_12485)
PTE: PTT_13099
ZTR: MYCGRDRAFT_85661(MgSte20)
SPO: SPBC1604.14c(shk1)
CNE: CNF00140
CNB: CNBF4570
ABP: AGABI1DRAFT118842(AGABI1DRAFT_118842)
ABV: AGABI2DRAFT205902(AGABI2DRAFT_205902)
WSE: WALSEDRAFT_13665(Ste20p)
MGL: MGL_0010
DDI: DDB_G0267450(pakC)
DFA: DFA_04841(mkcC) DFA_05233(mkcA) DFA_08719(mkcD)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8805275
  Authors
Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J
  Title
Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway.
  Journal
Curr Biol 6:598-605 (1996)
DOI:10.1016/S0960-9822(02)00546-8
  Sequence
[hsa:5058]
Reference
  Authors
Zhao ZS, Lim JP, Ng YW, Lim L, Manser E
  Title
The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.
  Journal
Mol Cell 20:237-49 (2005)
DOI:10.1016/j.molcel.2005.08.035
Reference
PMID:1464311
  Authors
Leberer E, Dignard D, Harcus D, Thomas DY, Whiteway M
  Title
The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.
  Journal
EMBO J 11:4815-24 (1992)
  Sequence
[sce:YHL007C]

KEGG   ORTHOLOGY: K04410Help
Entry
K04410                      KO                                     

Name
PAK2
Definition
p21-activated kinase 2 [EC:2.7.11.1]
Pathway
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04360  Axon guidance
ko04510  Focal adhesion
ko04660  T cell receptor signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05170  Human immunodeficiency virus 1 infection
ko05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04410  PAK2; p21-activated kinase 2
   04010 MAPK signaling pathway
    K04410  PAK2; p21-activated kinase 2
   04012 ErbB signaling pathway
    K04410  PAK2; p21-activated kinase 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04410  PAK2; p21-activated kinase 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04410  PAK2; p21-activated kinase 2
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K04410  PAK2; p21-activated kinase 2
  09158 Development
   04360 Axon guidance
    K04410  PAK2; p21-activated kinase 2
 09160 Human Diseases
  09161 Cancers
   05211 Renal cell carcinoma
    K04410  PAK2; p21-activated kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04410  PAK2; p21-activated kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04410  PAK2; p21-activated kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE20 family
   K04410  PAK2; p21-activated kinase 2
BRITE hierarchy
Genes
HSA: 5062(PAK2)
PTR: 460965(PAK2)
PPS: 100989051(PAK2)
GGO: 101130725(PAK2)
PON: 100439815(PAK2) 100453746
NLE: 100601244(PAK2)
MCC: 710314(PAK2)
MCF: 102115437(PAK2)
CSAB: 103242063(PAK2)
RRO: 104676374(PAK2)
RBB: 108542265(PAK2)
CJC: 100405552(PAK2)
SBQ: 101035351(PAK2)
MMU: 224105(Pak2)
RNO: 100910732 29432(Pak2)
CGE: 100751503(Pak2)
NGI: 103738502(Pak2)
HGL: 101710712(Pak2)
CCAN: 109690046(Pak2)
OCU: 100009535(PAK2)
TUP: 102472173(PAK2)
CFA: 612814(PAK2)
AML: 100475388(PAK2)
UMR: 103678928(PAK2)
ORO: 101369067(PAK2)
FCA: 101082845(PAK2)
PTG: 102968498(PAK2)
AJU: 106987894(PAK2)
BTA: 513673(PAK2)
BOM: 102282641(PAK2)
PHD: 102344188(PAK2)
CHX: 102176919(PAK2)
OAS: 101123517(PAK2)
SSC: 100511837(PAK2)
CFR: 102504877(PAK2)
CDK: 105101281(PAK2)
BACU: 103005053 103006340(PAK2)
LVE: 103082256(PAK2)
OOR: 101272383(PAK2)
ECB: 100060183(PAK2)
EPZ: 103559943(PAK2)
EAI: 106848316(PAK2)
MYB: 102250137(PAK2)
MYD: 102752411(PAK2)
HAI: 109387639(PAK2)
RSS: 109443346(PAK2)
PALE: 102886796(PAK2)
LAV: 100664379(PAK2)
TMU: 101355178
MDO: 100015796(PAK2)
SHR: 100914804(PAK2)
OAA: 100075896(PAK2)
GGA: 424860(PAK2)
MGP: 100541412(PAK2)
CJO: 107317911(PAK2)
APLA: 101794632(PAK2)
ACYG: 106039215(PAK2)
TGU: 100229114(PAK2)
GFR: 102034742(PAK2)
FAB: 101810304(PAK2)
PHI: 102107441(PAK2)
PMAJ: 107208951(PAK2)
CCW: 104696713(PAK2)
FPG: 101910950(PAK2)
FCH: 102046818(PAK2)
CLV: 102088494(PAK2)
EGZ: 104131279(PAK2)
AAM: 106492613(PAK2)
ASN: 102385322(PAK2)
AMJ: 102571099(PAK2)
PSS: 102452394(PAK2)
CMY: 102943108(PAK2)
CPIC: 101946525(PAK2)
ACS: 100561625(pak2)
PVT: 110075278(PAK2)
PBI: 103051423(PAK2)
GJA: 107113978(PAK2)
XLA: 108717139 399090(pak2.S)
XTR: 733718(pak2)
NPR: 108790159(PAK2)
DRE: 266749(pak2a) 325034(pak2b)
IPU: 108267562 108271286(pak2)
AMEX: 103022965(pak2) 103038595
TRU: 101072607 101075040(pak2)
LCO: 104919114(pak2) 104939638
NCC: 104962686(pak2)
MZE: 101473947 101482829(pak2)
OLA: 101167280(pak2) 101169249
XMA: 102222129 102229449(pak2)
PRET: 103458433 103463803(pak2)
NFU: 107392096 107393427(pak2)
CSEM: 103376672(pak2) 103379106
LCF: 108875038 108879127(pak2)
HCQ: 109517331 109532388(pak2)
ELS: 105011658(pak2) 105019806
LCM: 102367003(PAK2)
CMK: 103172351 103172733(pak2)
TSP: Tsp_07847
OBI: 106869191
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7744004
  Authors
Martin GA, Bollag G, McCormick F, Abo A
  Title
A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.
  Journal
EMBO J 14:1970-8 (1995)
  Sequence
[hsa:5062]

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