KEGG   ORTHOLOGY: K04426Help
Entry
K04426                      KO                                     

Name
MAP3K5, ASK1
Definition
mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
Pathway
ko01524  Platinum drug resistance
ko04010  MAPK signaling pathway
ko04013  MAPK signaling pathway - fly
ko04071  Sphingolipid signaling pathway
ko04141  Protein processing in endoplasmic reticulum
ko04210  Apoptosis
ko04214  Apoptosis - fly
ko04530  Tight junction
ko04668  TNF signaling pathway
ko04714  Thermogenesis
ko04722  Neurotrophin signaling pathway
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05418  Fluid shear stress and atherosclerosis
Module
M00688  MAPK (JNK) signaling
M00689  MAPK (p38) signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04013 MAPK signaling pathway - fly
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04668 TNF signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04071 Sphingolipid signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04214 Apoptosis - fly
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09159 Environmental adaptation
   04714 Thermogenesis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
 09160 Human Diseases
  09163 Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09165 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09166 Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09168 Drug resistance
   01524 Platinum drug resistance
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00688  MAPK (JNK) signaling
     K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
    M00689  MAPK (p38) signaling
     K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE11 family
   K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
BRITE hierarchy
Other DBs
GO: 0004709
Genes
HSA: 4217(MAP3K5)
PTR: 463023(MAP3K5)
PPS: 100991014(MAP3K5)
GGO: 101147354(MAP3K5)
PON: 100458776(MAP3K5)
NLE: 100587332(MAP3K5)
MCC: 711382(MAP3K5)
MCF: 101925657(MAP3K5)
CSAB: 103240310(MAP3K5)
RRO: 104675014(MAP3K5)
RBB: 108522968(MAP3K5)
CJC: 100406322(MAP3K5)
SBQ: 101034123(MAP3K5)
MMU: 26408(Map3k5)
RNO: 365057(Map3k5)
CGE: 100752376(Map3k5)
NGI: 103724902(Map3k5)
HGL: 101712051(Map3k5)
CCAN: 109697041(Map3k5)
OCU: 100340498(MAP3K5)
TUP: 102495244(MAP3K5)
CFA: 476215(MAP3K5)
AML: 100475304(MAP3K5)
UMR: 103663496(MAP3K5)
ORO: 101374728(MAP3K5)
FCA: 101082912(MAP3K5)
PTG: 102960317(MAP3K5)
AJU: 106983673(MAP3K5)
BTA: 537380(MAP3K5)
BOM: 102276849(MAP3K5)
BIU: 109563980(MAP3K5)
PHD: 102319571(MAP3K5)
CHX: 102172156(MAP3K5)
OAS: 101121018(MAP3K5)
SSC: 100622769(MAP3K5)
CFR: 102522243(MAP3K5)
CDK: 105092037(MAP3K5)
BACU: 102999328(MAP3K5)
OOR: 101277232(MAP3K5)
ECB: 100073186(MAP3K5)
EPZ: 103556363(MAP3K5)
EAI: 106837192(MAP3K5)
MYB: 102256847(MAP3K5)
MYD: 102771311(MAP3K5)
HAI: 109385622(MAP3K5)
RSS: 109447951(MAP3K5)
PALE: 102888994(MAP3K5)
LAV: 100658813(MAP3K5)
TMU: 101346612
MDO: 100031527(MAP3K5)
SHR: 100917439(MAP3K5)
OAA: 100081079(MAP3K5)
GGA: 421688(MAP3K5)
MGP: 100551250(MAP3K5)
CJO: 107311662(MAP3K5)
APLA: 101799109(MAP3K5) 101803181
ACYG: 106032515(MAP3K5)
TGU: 100224192(MAP3K5)
GFR: 102034507(MAP3K5)
FAB: 101813811(MAP3K5)
PHI: 102104081(MAP3K5)
PMAJ: 107201551(MAP3K5)
CCW: 104689448(MAP3K5)
FPG: 101911552(MAP3K5)
FCH: 102057038(MAP3K5)
CLV: 102085051(MAP3K5)
EGZ: 104131143(MAP3K5)
AAM: 106497979(MAP3K5)
ASN: 102375722(MAP3K5)
AMJ: 102573024(MAP3K5)
PSS: 102451227(MAP3K5)
CMY: 102936034(MAP3K5)
CPIC: 101943963(MAP3K5)
ACS: 100551616(map3k5)
PVT: 110071741(MAP3K5)
PBI: 103052010(MAP3K5)
GJA: 107117647
XLA: 108717885
XTR: 100497692(map3k5)
NPR: 108787404(MAP3K5)
DRE: 100005496(si:ch211-1i11.3) 555703(map3k5)
AMEX: 103033000(map3k5) 103038360
TRU: 101061432(map3k5) 101071039
LCO: 104919600 104926153(map3k5)
MZE: 101473117(map3k5) 101482122
OLA: 101167985 101175702(map3k5)
XMA: 102232260 102232771(map3k5)
PRET: 103457283(map3k5) 103477798
NFU: 107377786(map3k5) 107379353
CSEM: 103381109(map3k5) 103388011
LCF: 108888903(map3k5) 108899499
HCQ: 109523559 109528311(map3k5)
BPEC: 110172206(map3k5) 110174291
ELS: 105017906(map3k5) 105019305
SFM: 108919179 108929292(map3k5)
LCM: 102346861(MAP3K5) 102352283(MAP3K6)
CMK: 103178324(map3k5) 103187330
SPU: 592507(MAP3K5)
APLC: 110974397
SKO: 102803495
DME: Dmel_CG4720(Ask1)
DPO: Dpse_GA18383(Dpse_Pk92B)
DER: Dere_GG23570(Dere_Pk92B)
DSI: Dsimw501_GD19320(Dsim_GD19320)
DWI: Dwil_GK22362(Dwil_Pk92B)
MDE: 101891452
AAG: 5570419
AME: 408533
BIM: 100742125
BTER: 100644945
SOC: 105200278
AEC: 105143801
ACEP: 105626733
PBAR: 105427967
HST: 105181813
CFO: 105257525
LHU: 105675456
PGC: 109857237
NVI: 100123601
TCA: 661249
NVL: 108566093
BMOR: 100529210(ask1)
PMAC: 106714693
PRAP: 110996751
PXY: 105384192
DNX: 107163715
ZNE: 110830933
FCD: 110853908
TUT: 107372197
CEL: CELE_F59A6.1(nsy-1)
CBR: CBG02299(Cbr-nsy-1)
BMY: Bm1_16860
TSP: Tsp_00404
CRG: 105338968
MYI: 110447054
HMG: 100206765
AQU: 100631731
DZI: 111306536
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Matsuzawa A, Nishitoh H, Tobiume K, Takeda K, Ichijo H
  Title
Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.
  Journal
Antioxid Redox Signal 4:415-25 (2002)
DOI:10.1089/15230860260196218
Reference
PMID:8940179
  Authors
Wang XS, Diener K, Jannuzzi D, Trollinger D, Tan TH, Lichenstein H, Zukowski M, Yao Z
  Title
Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.
  Journal
J Biol Chem 271:31607-11 (1996)
DOI:10.1074/jbc.271.49.31607
  Sequence
[hsa:4217]

DBGET integrated database retrieval system