KEGG   ORTHOLOGY: K04427Help
Entry
K04427                      KO                                     

Name
MAP3K7, TAK1
Definition
mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
Pathway
ko04010  MAPK signaling pathway
ko04013  MAPK signaling pathway - fly
ko04064  NF-kappa B signaling pathway
ko04140  Autophagy - animal
ko04152  AMPK signaling pathway
ko04214  Apoptosis - fly
ko04310  Wnt signaling pathway
ko04380  Osteoclast differentiation
ko04520  Adherens junction
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04624  Toll and Imd signaling pathway
ko04657  IL-17 signaling pathway
ko04660  T cell receptor signaling pathway
ko04668  TNF signaling pathway
ko05140  Leishmaniasis
ko05145  Toxoplasmosis
ko05162  Measles
ko05168  Herpes simplex infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05418  Fluid shear stress and atherosclerosis
Module
M00686  Toll-like receptor signaling
M00688  MAPK (JNK) signaling
M00689  MAPK (p38) signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04013 MAPK signaling pathway - fly
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04310 Wnt signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04064 NF-kappa B signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04668 TNF signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04152 AMPK signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09143 Cell growth and death
   04214 Apoptosis - fly
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04624 Toll and Imd signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04621 NOD-like receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04622 RIG-I-like receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04660 T cell receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04657 IL-17 signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09158 Development
   04380 Osteoclast differentiation
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
 09160 Human Diseases
  09165 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09167 Infectious diseases
   05162 Measles
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05168 Herpes simplex infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05169 Epstein-Barr virus infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05145 Toxoplasmosis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05140 Leishmaniasis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00688  MAPK (JNK) signaling
     K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
    M00689  MAPK (p38) signaling
     K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
    M00686  Toll-like receptor signaling
     K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  MLK family
   K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
BRITE hierarchy
Other DBs
GO: 0004709
Genes
HSA: 6885(MAP3K7)
PTR: 462888(MAP3K7)
PPS: 100974026(MAP3K7)
GGO: 101144707(MAP3K7)
PON: 100171454(MAP3K7)
NLE: 100596471(MAP3K7)
MCC: 703101(MAP3K7)
MCF: 102140498(MAP3K7)
CSAB: 103240115(MAP3K7)
RRO: 104657888(MAP3K7)
RBB: 108539499(MAP3K7)
CJC: 100403175(MAP3K7)
SBQ: 101045636(MAP3K7)
MMU: 26409(Map3k7)
RNO: 100910771 313121(Map3k7)
CGE: 100774341(Map3k7)
NGI: 103739547(Map3k7)
HGL: 101718269(Map3k7)
CCAN: 109698497(Map3k7)
OCU: 100343571(MAP3K7)
TUP: 102477331(MAP3K7)
CFA: 102156745(MAP3K7)
AML: 100466506(MAP3K7)
UMR: 103660092(MAP3K7)
ORO: 101376824(MAP3K7)
FCA: 101095899(MAP3K7)
PTG: 102963341(MAP3K7)
AJU: 106983077(MAP3K7)
BTA: 529146(MAP3K7)
BOM: 102264816(MAP3K7)
BIU: 109563902(MAP3K7)
PHD: 102316264(MAP3K7)
CHX: 102172719(MAP3K7)
OAS: 101108056(MAP3K7)
SSC: 100135663(MAP3K7)
CFR: 102519538(MAP3K7)
CDK: 105095522(MAP3K7)
BACU: 103019299(MAP3K7)
LVE: 103075340(MAP3K7)
OOR: 101283961(MAP3K7)
ECB: 100065841(MAP3K7)
EPZ: 103548805(MAP3K7)
EAI: 106847421(MAP3K7)
MYB: 102254118(MAP3K7)
MYD: 102763957(MAP3K7)
HAI: 109389465(MAP3K7)
RSS: 109453514(MAP3K7)
PALE: 102882452(MAP3K7)
LAV: 100667170(MAP3K7)
TMU: 101346094
MDO: 100019975(MAP3K7)
SHR: 100920997(MAP3K7)
OAA: 100076229(MAP3K7)
GGA: 421808(MAP3K7)
MGP: 100539749(MAP3K7)
CJO: 107311964(MAP3K7)
APLA: 101800996(MAP3K7)
ACYG: 106035399(MAP3K7)
TGU: 100221443(MAP3K7)
GFR: 102039929(MAP3K7)
FAB: 101814532(MAP3K7)
PHI: 102107403(MAP3K7)
PMAJ: 107201717(MAP3K7)
CCW: 104692210(MAP3K7)
FPG: 101917746(MAP3K7)
FCH: 102058816(MAP3K7)
CLV: 110354865
EGZ: 104135405(MAP3K7)
AAM: 106489690(MAP3K7)
ASN: 102386999(MAP3K7)
AMJ: 102569201(MAP3K7)
CMY: 102936052(MAP3K7)
CPIC: 101931315(MAP3K7)
ACS: 100554725(map3k7)
PVT: 110074609(MAP3K7)
PBI: 103067633(MAP3K7)
GJA: 107114874(MAP3K7)
XLA: 379399(map3k7.S) 399459(map3k7.L)
XTR: 100101764(map3k7)
NPR: 108800110(MAP3K7)
DRE: 553788(map3k7)
IPU: 108256841(map3k7)
AMEX: 103039333(map3k7)
TRU: 101063524(map3k7)
LCO: 104924081(map3k7) 104928162
MZE: 101475992 101484924(map3k7)
OLA: 101164271(map3k7) 105356874
XMA: 102226534(map3k7) 102232287
PRET: 103457977(map3k7) 103458953
NFU: 107395980(map3k7)
CSEM: 103380691(map3k7)
LCF: 108897885 108899288(map3k7)
HCQ: 109509350(map3k7) 109529256
BPEC: 110154967 110171242(map3k7)
ELS: 105015746 105017873(map3k7)
SFM: 108929345(map3k7)
LCM: 102358159(MAP3K7)
CMK: 103178276(map3k7)
CIN: 778771(tak1/mapkkk7)
SPU: 590951
APLC: 110983312
SKO: 100313751
DME: Dmel_CG18492(Tak1) Dmel_CG31421(Takl1) Dmel_CG4803(Takl2)
DSI: Dsimw501_GD18431(Dsim_GD18431) Dsimw501_GD20035(Dsim_GD20035)
DYA: Dyak_GE15342(Dyak_Tak1)
MDE: 101898114
AAG: 5568685
AME: 413809(Tak1)
BIM: 100746656
BTER: 100631093
SOC: 105207936
AEC: 105150983
ACEP: 105619960
PBAR: 105427629
HST: 105187438
CFO: 105256050
LHU: 105676340
PGC: 109853437
NVI: 100120628
TCA: 656961(Tak1)
DPA: 109538196
NVL: 108560912
BMOR: 101744000
PMAC: 106721022
PRAP: 110998182
PXY: 105380044
API: 100159713
DNX: 107169096
ZNE: 110836178
FCD: 110853786
TUT: 107362121
CEL: CELE_F52F12.3(mom-4) CELE_Y105C5A.24(Y105C5A.24)
CBR: CBG03852(Cbr-mom-4)
BMY: Bm1_26085
CRG: 105332318
MYI: 110455078
OBI: 106880926
SHX: MS3_10386
EPA: 110249937
ADF: 107335569
BOE: 106339201
CPAP: 110806865
CCAJ: 109817926
CAM: 101505952
OEU: 111411346
SMIN: v1.2.003218.t1(symbB.v1.2.003218.t1) v1.2.003218.t2(symbB.v1.2.003218.t2) v1.2.005256.t1(symbB.v1.2.005256.t1) v1.2.010154.t1(symbB.v1.2.010154.t1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9079627
  Authors
Shirakabe K, Yamaguchi K, Shibuya H, Irie K, Matsuda S, Moriguchi T, Gotoh Y, Matsumoto K, Nishida E
  Title
TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase.
  Journal
J Biol Chem 272:8141-4 (1997)
DOI:10.1074/jbc.272.13.8141
  Sequence
[hsa:6885]
Reference
PMID:9480845
  Authors
Sakurai H, Shigemori N, Hasegawa K, Sugita T
  Title
TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism.
  Journal
Biochem Biophys Res Commun 243:545-9 (1998)
DOI:10.1006/bbrc.1998.8124
  Sequence
[hsa:6885]

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