KEGG   ORTHOLOGY: K04430Help
Entry
K04430                      KO                                     

Name
MAP2K4, MKK4
Definition
mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
Pathway
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04620  Toll-like receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04668  TNF signaling pathway
ko04912  GnRH signaling pathway
ko04926  Relaxin signaling pathway
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05142  Chagas disease (American trypanosomiasis)
ko05161  Hepatitis B
ko05164  Influenza A
ko05166  HTLV-I infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05418  Fluid shear stress and atherosclerosis
Module
M00688  MAPK (JNK) signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04013 MAPK signaling pathway - fly
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04012 ErbB signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04668 TNF signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04664 Fc epsilon RI signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04926 Relaxin signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
 09160 Human Diseases
  09165 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09167 Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05166 HTLV-I infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05164 Influenza A
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05161 Hepatitis B
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05169 Epstein-Barr virus infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05142 Chagas disease (American trypanosomiasis)
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00688  MAPK (JNK) signaling
     K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE7 family
   K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
BRITE hierarchy
Other DBs
GO: 0004708
Genes
HSA: 6416(MAP2K4)
PTR: 455065(MAP2K4)
PPS: 100991495(MAP2K4)
GGO: 101143954(MAP2K4) 101154090
PON: 100439299(MAP2K4)
NLE: 100587718(MAP2K4)
MCC: 718155(MAP2K4)
MCF: 102125035(MAP2K4)
CSAB: 103242403(MAP2K4)
RRO: 104672345(MAP2K4)
RBB: 108517313(MAP2K4)
CJC: 100386168(MAP2K4)
SBQ: 101037589(MAP2K4)
MMU: 26398(Map2k4)
RNO: 287398(Map2k4)
CGE: 100770977(Map2k4)
NGI: 103752052(Map2k4)
HGL: 101705822(Map2k4)
CCAN: 109693003(Map2k4)
OCU: 100344852(MAP2K4)
TUP: 102493856(MAP2K4)
CFA: 489508(MAP2K4)
AML: 100475919(MAP2K4)
UMR: 103660510(MAP2K4)
ORO: 101386473(MAP2K4)
FCA: 101086432(MAP2K4)
PTG: 102966812(MAP2K4)
AJU: 106986552(MAP2K4)
BTA: 526469(MAP2K4)
BOM: 102287278(MAP2K4)
BIU: 109573969(MAP2K4)
PHD: 102333652(MAP2K4)
CHX: 102175799(MAP2K4)
OAS: 101115045(MAP2K4)
SSC: 100520100(MAP2K4)
CFR: 102513578(MAP2K4)
CDK: 105095916(MAP2K4)
BACU: 103012105(MAP2K4)
LVE: 103091203(MAP2K4)
OOR: 101270607(MAP2K4)
ECB: 100073094(MAP2K4)
EPZ: 103567795
EAI: 106845730(MAP2K4)
MYB: 102244251(MAP2K4)
MYD: 102769098(MAP2K4)
HAI: 109389137(MAP2K4)
RSS: 109460161(MAP2K4)
PALE: 102894945(MAP2K4)
LAV: 100655007(MAP2K4)
TMU: 101349700
MDO: 100019828(MAP2K4)
SHR: 100931587(MAP2K4)
OAA: 100091407
GGA: 417312(MAP2K4)
MGP: 100544828(MAP2K4)
CJO: 107322213(MAP2K4)
APLA: 101805315(MAP2K4)
ACYG: 106047193(MAP2K4)
TGU: 100219801(MAP2K4)
GFR: 102037348(MAP2K4)
FAB: 101822010(MAP2K4)
PHI: 102102585(MAP2K4)
PMAJ: 107212510(MAP2K4)
CCW: 104695676(MAP2K4)
FPG: 101918161(MAP2K4)
FCH: 102047307(MAP2K4)
CLV: 102085780(MAP2K4)
EGZ: 104133811(MAP2K4)
AAM: 106496868(MAP2K4)
ASN: 102379245(MAP2K4)
AMJ: 102577347(MAP2K4)
PSS: 102452927(MAP2K4)
CMY: 102929430
CPIC: 101939128(MAP2K4)
ACS: 100556629(map2k4)
PVT: 110075065(MAP2K4)
PBI: 103061657(MAP2K4)
GJA: 107123125(MAP2K4)
XLA: 399471(map2k4.L) 431908(map2k4.S)
XTR: 100135013(map2k4)
NPR: 108801499(MAP2K4)
DRE: 403052(map2k4a) 568951(map2k4b)
SANH: 107654000(map2k4) 107695698
IPU: 108272999(map2k4) 108274195
AMEX: 103042940 103045018(map2k4)
NCC: 104946717(map2k4) 104947390
OLA: 101161098 101174917(map2k4)
XMA: 102225231 102232155(map2k4)
NFU: 107397308(map2k4) 107397353
CSEM: 103382416(map2k4) 103392559
LCF: 108873371(map2k4) 108890897
SFM: 108940146(map2k4)
LCM: 102352547(MAP2K4)
CMK: 103175698(map2k4)
CIN: 778672(mapkk4)
SPU: 589763
APLC: 110976118
SKO: 100329105
DME: Dmel_CG9738(Mkk4)
DSI: Dsimw501_GD20857(Dsim_GD20857)
MDE: 101894864
AAG: 5580276
AME: 410575(MAPKK4)
BIM: 100747905
BTER: 100652087
SOC: 105196567
AEC: 105148189
ACEP: 105627432
PBAR: 105430971
HST: 105185937
CFO: 105249095
LHU: 105671428
PGC: 109859606
NVI: 100119456
TCA: 662917
DPA: 109538313
NVL: 108569750
BMOR: 101735877
PMAC: 106718060
PRAP: 110993585
PXY: 105391083
API: 100161114
DNX: 107170671
ZNE: 110836450
FCD: 110859794
CEL: CELE_F42G10.2(mkk-4) CELE_VZC374L.1(sek-6)
CBR: CBG01940(Cbr-mkk-4)
BMY: Bm1_10515
TSP: Tsp_00085
CRG: 105345787
MYI: 110442146
OBI: 106873711
SHX: MS3_10235
EPA: 110238540
HMG: 100200909
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7716521
  Authors
Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M
  Title
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.
  Journal
Science 268:286-90 (1995)
DOI:10.1126/science.7716521
  Sequence
[hsa:6416]

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